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CD22 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[4-(4-hydroxyphenyl)phenyl]methylamino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC50240.0 [1], 530.0 [2]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[2-[4-(4-hydroxyphenyl)phenyl]acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC50900.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-3-[(3,5-Dimethoxyphenyl)methylamino]-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC5024760.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-3-(Cyclohexylmethylamino)-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC5037700.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[(4-phenylphenyl)methylamino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC50470.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[2-(4-phenylphenyl)ethylamino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC505480.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[4-(4-phenylphenyl)butylamino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC506220.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-3-[[4-(4-Carboxyphenyl)phenyl]methylamino]-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC5043000.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-3-[[4-(3-Carboxyphenyl)phenyl]methylamino]-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC507480.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[4-(3-hydroxyphenyl)phenyl]methylamino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC501730.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[4-(2-hydroxyphenyl)phenyl]methylamino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC50230.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[4-(4-methoxyphenyl)phenyl]methylamino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC501760.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[4-(4-methylphenyl)phenyl]methylamino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC509830.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[4-[4-(trifluoromethyl)phenyl]phenyl]methylamino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC5045000.0 [1]
(2R,4S,5R,6R)-4-Hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acidIC50148330.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-3-Amino-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC5085000.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-3-Benzamido-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC50125160.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[(2-hydroxybenzoyl)amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC50192670.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-3-[(5-Chloro-2-hydroxybenzoyl)amino]-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC50115850.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-(pyridine-3-carbonylamino)propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC50132320.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-3-(Cyclohexanecarbonylamino)-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC5016000.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-3-(Hexanoylamino)-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC5040850.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-(3-phenylpropanoylamino)propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC5010400.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[3-(4-hydroxyphenyl)propanoylamino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC507650.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-(4-pyren-4-ylbutanoylamino)propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC5021060.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-(naphthalene-2-carbonylamino)propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC502600.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-3-[(2,2-Diphenylacetyl)amino]-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC508850.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[(4-phenylbenzoyl)amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC501100.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[2-(4-phenylphenyl)acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC503700.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[(2-naphthalen-2-ylacetyl)amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC501000.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[4-(4-hydroxyphenyl)benzoyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC50400.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[2-[4-(3-hydroxyphenyl)phenyl]acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC504300.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-3-[[4-(3-Carboxyphenyl)benzoyl]amino]-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC507130.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-3-[[4-(4-Carboxyphenyl)benzoyl]amino]-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC5073250.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-3-(Benzylamino)-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC50122570.0 [1]
(2R,4S,5R,6R)-5-Acetamido-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-[4-(2-trimethylsilylethoxy)phenoxy]oxan-2-yl]methoxy]oxane-2-carboxylic acidIC50683330.0 [1]
(2R,4S,5R,6R)-4-Hydroxy-5-[(2-hydroxyacetyl)amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]-2-[[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(2-trimethylsilylethoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acidIC50550000.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[2-[4-(4-hydroxyphenyl)phenyl]acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-phenylmethoxyoxane-2-carboxylic acidIC50130.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[4-(4-hydroxyphenyl)phenyl]methylamino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-phenylmethoxyoxane-2-carboxylic acidIC50820.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[2-[4-(4-hydroxyphenyl)phenyl]acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[(4-phenylphenyl)methoxy]oxane-2-carboxylic acidIC5070.0 [1]
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[4-(4-hydroxyphenyl)phenyl]methylamino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[(4-phenylphenyl)methoxy]oxane-2-carboxylic acidIC501120.0 [1]
Items per page: 1 - 10 of 41
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References

This online tool may be cited as follows

MLA

"Quest Database™ CD22 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/cd22-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ CD22 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cd22-inhibitors-ic50-ki.
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