CDK12/Cyclin K Inhibitors (IC50, Ki)

Name: CDK12/Cyclin K Inhibitors (IC50, Ki)
Creator: AAT Bioquest
License: https://www.aatbio.com/tou.html

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3-Benzyl-1-[4-[(5-cyanopyridin-2-yl)amino]cyclohexyl]-1-[4-(1-methylpyrazol-4-yl)phenyl]urea	IC50	63.0 ^[1], 30000.0 ^[2]
	N-[4-[(5-Cyanopyridin-2-yl)amino]cyclohexyl]-N-[4-(1-methylpyrazol-4-yl)phenyl]acetamide	IC50	130.0 ^[1], 30000.0 ^[2]
	Staurosporine	IC50	53.0 ^[1]
	CDK12 inhibitor 2	IC50	52.0 ^[1]
	N-[4-(1-Methylpyrazol-4-yl)phenyl]-N-[4-(quinazolin-2-ylamino)cyclohexyl]acetamide	IC50	13.0 ^[1]
	3-Benzyl-1-[4-[(5-cyanopyridin-2-yl)amino]cyclohexyl]-1-[4-(1-methyl-2-oxopyridin-4-yl)phenyl]urea	IC50	44.0 ^[1]
	N-[4-[(5-Cyanopyridin-2-yl)amino]cyclohexyl]-N-[4-(1-methylpyrazol-4-yl)phenyl]methanesulfonamide	IC50	110.0 ^[1]
	Benzyl N-[4-[(5-cyanopyridin-2-yl)amino]cyclohexyl]-N-[4-(1-methylpyrazol-4-yl)phenyl]carbamate	IC50	640.0 ^[1]
	1-[4-[(5-Cyanopyridin-2-yl)amino]cyclohexyl]-3-ethyl-1-[4-(1-methylpyrazol-4-yl)phenyl]urea	IC50	460.0 ^[1]
	6-[[1-[4-(1-Methylpyrazol-4-yl)phenyl]sulfonylpiperidin-4-yl]amino]pyridine-3-carbonitrile	IC50	360.0 ^[1]
	N-[1-[4-(1-Methylpyrazol-4-yl)phenyl]sulfonylpiperidin-4-yl]pyridin-2-amine	IC50	30000.0 ^[1]
	3-Benzyl-1-[4-[(5-cyanopyridin-2-yl)amino]cyclohexyl]-1-(4-pyridin-3-ylphenyl)urea	IC50	59.0 ^[1]
	3-Benzyl-1-[4-[(5-cyanopyridin-2-yl)amino]cyclohexyl]-1-phenylurea	IC50	63.0 ^[1]
	Methyl N-[4-[(5-cyanopyridin-2-yl)amino]cyclohexyl]-N-[4-(1-methylpyrazol-4-yl)phenyl]carbamate	IC50	200.0 ^[1]
	6-[[1-[4-(1-Methylpyrazol-4-yl)benzoyl]piperidin-4-yl]amino]pyridine-3-carbonitrile	IC50	23000.0 ^[1]
	2-[[1-[4-(1-Methylpyrazol-4-yl)phenyl]sulfonylpiperidin-4-yl]amino]pyridine-4-carbonitrile	IC50	30000.0 ^[1]
	4-[[1-[4-(1-Methylpyrazol-4-yl)phenyl]sulfonylpiperidin-4-yl]amino]benzonitrile	IC50	30000.0 ^[1]
	6-[[1-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]piperidin-4-yl]amino]pyridine-3-carbonitrile	IC50	16000.0 ^[1]
	3-Benzyl-1-[4-[(5-cyanopyridin-2-yl)amino]cyclohexyl]-1-[4-(1-methyl-6-oxopyridin-2-yl)phenyl]urea	IC50	310.0 ^[1]
	6-[[4-[4-(1-Methylpyrazol-4-yl)anilino]cyclohexyl]amino]pyridine-3-carbonitrile	IC50	8600.0 ^[1]
	[(2S,3S,4S,5R)-5-(6-Bromo-5-carbamoyl-4-imino-7H-pyrrolo[2,3-d]pyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl 2-methylpropanoate	IC50	110.0 ^[1]
	1-[4-[(5-Cyanopyridin-2-yl)amino]cyclohexyl]-3-(cyclohexylmethyl)-1-[4-(1-methylpyrazol-4-yl)phenyl]urea	IC50	99.0 ^[1]
	6-[[1-[4-(1-Methylpyrazol-4-yl)phenyl]sulfonylpiperidin-4-yl]amino]pyridine-2-carbonitrile	IC50	30000.0 ^[1]
	N-[4-[(5-Cyanopyridin-2-yl)amino]cyclohexyl]-N-[4-(1-methylpyrazol-4-yl)phenyl]-3-phenylpropanamide	IC50	160.0 ^[1]
	3-Benzyl-1-[4-[(5-cyanopyridin-2-yl)amino]cyclohexyl]-1-[4-(1-methyl-2-oxopyridin-3-yl)phenyl]urea	IC50	250.0 ^[1]
	5-Methoxy-N-[1-[4-(1-methylpyrazol-4-yl)phenyl]sulfonylpiperidin-4-yl]pyridin-2-amine	IC50	30000.0 ^[1]
	6-[Methyl-[1-[4-(1-methylpyrazol-4-yl)phenyl]sulfonylpiperidin-4-yl]amino]pyridine-3-carbonitrile	IC50	30000.0 ^[1]
	N-[1-[4-(1-Methylpyrazol-4-yl)phenyl]sulfonylpiperidin-4-yl]-5-(trifluoromethyl)pyridin-2-amine	IC50	1800.0 ^[1]

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References

This online tool may be cited as follows

MLA	"Quest Database™ CDK12/Cyclin K Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/cdk12-cyclin-k-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ CDK12/Cyclin K Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cdk12-cyclin-k-inhibitors-ic50-ki.
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CDK12/Cyclin K Inhibitors (IC50, Ki)

References

This online tool may be cited as follows

MLA

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