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CDK2/Cyclin A Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
StaurosporineIC501.7 [1]
AlvocidibIC50106.0 [1], 161.4 [2], 405.0 [3]
PalbociclibIC50230.0 [1], 10000.0 [2]
PalbociclibKi5000.0 [1]
4-{[4-Amino-5-(2-Nitrobenzoyl)-1,3-Thiazol-2-Yl]amino}benzenesulfonamideIC501.1 [1], 1.5 [2], 20.0 [3]
SeliciclibIC5072.0 [1], 3490.0 [2]
IndirubinIC502200.0 [1], 7500.0 [2]
FascaplysinIC50250000.0 [1], 500000.0 [2]
Sns-032IC5038.0 [1], 52.0 [2]
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamideIC5047.0 [1]
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamideKi44.0 [1]
RohitukineIC507300.0 [1]
4-(4-Methoxy-1h-Pyrrolo[2,3-B]pyridin-3-Yl)pyrimidin-2-AmineIC5011.0 [1]
Tert-butyl 6-[2-chloro-4-(3-methylimidazol-4-yl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylateIC50100000.0 [1]
4-(1H-Pyrrolo[2,3-B]pyridin-3-YL)pyrimidin-2-amineIC5090.0 [1]
N2-(2-Methoxy-4-(1-Methyl-1h-Pyrazol-4-Yl)phenyl)-N8-Neopentylpyrido[3,4-D]pyrimidine-2,8-DiamineKi230.0 [1]
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoic acidIC501010.0 [1], 16100.0 [2]
N-[3-[6-[(4-Acetamidocyclohexyl)amino]purin-9-yl]cyclobutyl]-6-methylpyridine-2-carboxamideIC50112.0 [1], 160.0 [2]
N-[4-[(5-Cyanopyridin-2-yl)amino]cyclohexyl]-N-[4-(1-methylpyrazol-4-yl)phenyl]acetamideIC50470.0 [1], 100000.0 [2]
4-{[4-Amino-5-(Pyridin-3-Ylcarbonyl)-1,3-Thiazol-2-Yl]amino}benzenesulfonamideIC500.9 [1], 20.0 [2]
HarmineIC5010000.0 [1]
Abemaciclib mesylateIC50500.0 [1]
DinaciclibIC501.0 [1]
EntrectinibIC501000.0 [1]
6-Cyclohexylmethyloxy-5-nitroso-pyrimidine-2,4-diamineIC502200.0 [1]
O6-Cyclohexylmethoxy-2-(4'-sulphamoylanilino) purineIC506.0 [1]
CercosporamideIC50770.0 [1]
CID 46209401IC50580.0 [1]
CID 23643976IC50224.0 [1]
Leucettine L41IC5010000.0 [1]
CID 44556162IC50100000.0 [1]
4-[(E)-(3,5-Diamino-1h-Pyrazol-4-Yl)diazenyl]phenolIC5013100.0 [1]
9-Cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-oneIC5036000.0 [1]
CID 56649281IC50159.0 [1]
Oxindole-Based Inhibitor 22IC502.3 [1]
5-[2,4-Dihydroxy-6-(4-Nitrophenoxy)phenyl]-N-(1-Methylpiperidin-4-Yl)-1,2-Oxazole-3-CarboxamideIC5010.0 [1]
[4-Amino-2-(Phenylamino)-1,3-Thiazol-5-Yl](Phenyl)methanoneIC50930.0 [1]
Oxindole-Based Inhibitor 81IC501.6 [1]
8-N-(2,2-Dimethylpropyl)-2-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineKi510.0 [1]
(3Z)-3-[(3E)-3-(2,3-Dihydroxypropoxyimino)indolin-2-ylidene]indolin-2-oneIC50540.0 [1]
N-[2-(1H-Indol-3-yl)ethyl]-N-methyl-4-phenylbenzamideIC50521000.0 [1]
Oxindole-Based Inhibitor 27IC502.5 [1]
Oxindole-Based Inhibitor 31IC503.4 [1]
Oxindole-Based Inhibitor 49IC5016.0 [1]
Oxindole-Based Inhibitor 50IC5043.0 [1]
Oxindole-Based Inhibitor 56IC504.5 [1]
5-Methoxy-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-olIC50210.0 [1]
Cyc065IC505.0 [1]
(2R)-2-{[4-(Benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-olIC5043.0 [1]
8-Anilino-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC502.0 [1]
8-Anilino-N,1-dimethyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5037.0 [1]
2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamideIC5010000.0 [1]
TC Mps1 12IC508800.0 [1]
[4-Amino-2-(methylamino)-1,3-thiazol-5-yl](phenyl)methanoneIC5095000.0 [1]
{[(2,6-Difluorophenyl)carbonyl]amino}-N-piperidin-4-yl-1H-pyrazole-3-carboxamideIC50140.0 [1]
Oxindole-Based Inhibitor 79IC507.1 [1]
[4-Amino-2-(prop-2-en-1-ylamino)-1,3-thiazol-5-yl](5-chlorothiophen-2-yl)methanoneIC5012000.0 [1]
{[(2,6-Difluorophenyl)carbonyl]amino}-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamideIC503.0 [1]
(2-Allylamino-4-aminothiazol-5-yl)(4-methoxyphenyl)methanoneIC5035000.0 [1]
N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 45IC5021.0 [1]
Pyrido-[2,3-d]-pyrimidin-7-one 35IC50439.0 [1]
2,2-Dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-1-[(1R)-1-phenylethyl]-3H-quinazolin-4-oneIC501000.0 [1]
4-[(2-Fluoro-6-methoxybenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamideIC5035.0 [1]
N-(2-(1H-Indol-3-yl)ethyl)-4-chloro-N-methylbenzamideIC50731000.0 [1]
N-(2-(1H-Indol-3-yl)ethyl)-4-tert-butyl-N-methylbenzamideIC50658000.0 [1]
CDK12 inhibitor 2IC50100000.0 [1]
2-N-(4-Aminocyclohexyl)-8-propan-2-yl-4-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazine-2,4-diamineIC5068.0 [1]
4-[[[4-[5-Chloro-2-[[4-(2-methoxyethylamino)cyclohexyl]amino]pyridin-4-yl]-1,3-thiazol-2-yl]amino]methyl]oxane-4-carbonitrileIC502860.0 [1]
CID 134815860Ki147.0 [1]
4-[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]benzonitrileKi140.0 [1]
3-[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]benzonitrileKi11.0 [1]
3-[6-Chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]benzonitrileKi750.0 [1]
4-[6-Chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]benzonitrileKi170.0 [1]
(2R,3R,4S,5S,6R)-2-[2-[(E)-[2-(2-Hydroxy-5-methoxy-1H-indol-3-yl)indol-3-ylidene]amino]oxyethoxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC50840.0 [1]
(4Z)-2-[4-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]anilino]-4-(1,3-benzodioxol-5-ylmethylidene)-1H-imidazol-5-oneIC5010000.0 [1]
[4-Amino-2-(Tert-Butylamino)-1,3-Thiazol-5-Yl](Phenyl)methanoneIC50100000.0 [1]
4-(4-Propoxy-1h-Pyrrolo[2,3-B]pyridin-3-Yl)pyrimidin-2-AmineIC503.0 [1]
Meriolin 9IC5010000.0 [1]
Meriolin 2IC5018.0 [1]
(4E)-N-(4-Fluorophenyl)-4-[(phenylcarbonyl)imino]-4H-pyrazole-3-carboxamideIC50140.0 [1]
N-(4-Fluorophenyl)-4-[(2-phenylacetyl)amino]-1H-pyrazole-5-carboxamideIC501600.0 [1]
4-(Cyclohexanecarbonylamino)-N-(4-fluorophenyl)-1H-pyrazole-5-carboxamideIC5090.0 [1]
N-(Cyclopropylmethyl)-4-[(2,6-difluorobenzoyl)amino]-1H-pyrazole-5-carboxamideIC5025.0 [1]
N-Cyclohexyl-4-[(2,6-difluorobenzoyl)amino]-1H-pyrazole-5-carboxamideIC5012.0 [1]
4-[(2,6-Difluorobenzoyl)amino]-N-(4-hydroxycyclohexyl)-1H-pyrazole-5-carboxamideIC5019.0 [1]
N-(4-Aminocyclohexyl)-4-[(2,6-difluorobenzoyl)amino]-1H-pyrazole-5-carboxamideIC5038.0 [1]
N-Piperidin-4-yl-4-[(2,4,6-trifluorobenzoyl)amino]-1H-pyrazole-5-carboxamideIC50750.0 [1]
4-[(2-Chloro-6-fluorobenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamideIC50110.0 [1]
1-Methyl-8-(4-morpholin-4-ylanilino)-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC50330.0 [1]
Ethyl 8-anilino-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylateIC502000.0 [1]
1-Methyl-8-[4-(4-methylpiperazin-1-yl)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC501.0 [1]
8-Anilino-1,4,4-trimethyl-5H-pyrazolo[4,3-h]quinazoline-3-carboxamideIC504.0 [1]
[4-Amino-2-(Phenylamino)-1,3-Thiazol-5-Yl](3-Methoxyphenyl)methanoneIC503100.0 [1]
4-[4-Methyl-2-(methylamino)-1,3-thiazol-5-yl]-2-[3-(morpholine-4-carbonyl)anilino]pyrimidine-5-carbonitrileKi199.0 [1]
2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]acetic acidIC5018880.0 [1]
2-(2-Fluorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-oneIC50356.5 [1]
5,7-Dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-2-phenylchromen-4-oneIC50196.0 [1]
2-(4-Fluorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-oneIC50129.1 [1]
2-(4-Bromophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-oneIC50223.5 [1]
5,7-Dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-2-[4-(trifluoromethyl)phenyl]chromen-4-oneIC50301.9 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ CDK2/Cyclin A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/cdk2-cyclin-a-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ CDK2/Cyclin A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cdk2-cyclin-a-inhibitors-ic50-ki.
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