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CDK6/cyclin D3 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
AbemaciclibIC505.0 [1], 10.0 [2]
AbemaciclibKi8.2 [1]
PalbociclibIC5019.0 [1]
PalbociclibKi27.0 [1]
StaurosporineIC50116.0 [1]
AlvocidibIC50395.0 [1]
SeliciclibIC5010000.0 [1]
OlomoucineIC50250000.0 [1]
RibociclibIC5028.0 [1]
Abemaciclib mesylateIC5010.0 [1]
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamideIC50200.0 [1]
9H-Purine-2,6-diamine, N2-(2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-, cis-IC501000.0 [1]
RGB-286638 free baseIC502.0 [1]
Cdk/Crk InhibitorIC50282.0 [1]
(3Z)-3-[(3E)-3-(2,3-Dihydroxypropoxyimino)indolin-2-ylidene]indolin-2-oneIC5075.0 [1]
TrilaciclibIC505.64 [1]
5-Methoxy-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-olIC50160.0 [1]
8-Anilino-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5058.0 [1]
8-Anilino-N,1-dimethyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC501020.0 [1]
(2R,3R,4S,5S,6R)-2-[2-[(E)-[2-(2-Hydroxy-5-methoxy-1H-indol-3-yl)indol-3-ylidene]amino]oxyethoxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC50410.0 [1]
1-Methyl-8-(4-morpholin-4-ylanilino)-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC50350.0 [1]
Ethyl 8-anilino-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylateIC507360.0 [1]
1-Methyl-8-[4-(4-methylpiperazin-1-yl)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5010.0 [1]
8-Anilino-1,4,4-trimethyl-5H-pyrazolo[4,3-h]quinazoline-3-carboxamideIC502520.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-[3-(1,4-Diazepan-1-yl)anilino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrileIC505000.0 [1]
CID 71553154IC5030000.0 [1]
LerociclibIC504.7 [1]
3-[[4-[4-[(3-Chlorophenyl)amino]-1,3,5-triazin-2-yl]-2-pyridinyl]amino]-1-PropanolIC50356.0 [1]
6-(1-Ethylpiperidin-4-yl)-N-[5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]-7,8-dihydro-5H-1,6-naphthyridin-2-amineIC501.6 [1]
4-Methyl-5-[2-[(5-morpholin-4-ylpyridin-2-yl)amino]pyrimidin-4-yl]-N-propan-2-yl-1,3-thiazol-2-amineKi82.0 [1]
N-Cyclopentyl-4-methyl-5-[2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-1,3-thiazol-2-amineKi34.0 [1]
N-Cyclopentyl-5-[2-[[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]amino]-5-fluoropyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amineKi31.0 [1]
N-Cyclopentyl-5-[5-fluoro-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amineKi7.0 [1]
4-Methyl-5-[2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-N-phenyl-1,3-thiazol-2-amineKi485.0 [1]
N-Cyclopentyl-4-methyl-5-[2-[(5-morpholin-4-ylpyridin-2-yl)amino]pyrimidin-4-yl]-1,3-thiazol-2-amineKi30.0 [1]
N-Cyclopentyl-5-[2-[(5-morpholin-4-ylpyridin-2-yl)amino]pyrimidin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-amineKi11.0 [1]
N-Cyclopentyl-5-[2-[[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]amino]-5-fluoropyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amineKi14.0 [1]
N-Cyclopentyl-N,4-dimethyl-5-[2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-1,3-thiazol-2-amineKi10.0 [1]
N-Cyclopentyl-5-[2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-amineKi2.0 [1]
N-Cyclopentyl-5-[5-fluoro-2-[[5-(4-methylsulfonylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amineKi101.0 [1]
N-Cyclopentyl-5-[2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-amineKi3.0 [1]
4-Methyl-N-phenyl-5-[2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-1,3-thiazol-2-amineKi66.0 [1]
4-[6-[[4-[2-(Cyclopentylamino)-4-(trifluoromethyl)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]pyridin-3-yl]piperazine-1-carbaldehydeKi7.0 [1]
4-Methyl-5-[2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-N-propan-2-yl-1,3-thiazol-2-amineKi15.0 [1]
1-[4-[6-[[4-[4-Methyl-2-(propan-2-ylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]pyridin-3-yl]piperazin-1-yl]ethanoneKi105.0 [1]
N-Cyclopentyl-4-methyl-5-[2-[(5-piperidin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-1,3-thiazol-2-amineKi257.0 [1]
1-[4-[6-[[4-[2-[Cyclopentyl(methyl)amino]-4-methyl-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]pyridin-3-yl]piperazin-1-yl]ethanoneKi31.0 [1]
N-Cyclopentyl-4-methyl-5-[2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-1,3-thiazol-2-amineKi9.0 [1]
N-Cyclopentyl-5-[2-[[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]amino]-5-fluoropyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amineKi6.0 [1]
5-[2-[[5-(4-Aminopiperidin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-N-cyclopentyl-4-methyl-1,3-thiazol-2-amineKi133.0 [1]
4-(3,3-Diethyl-7-fluoro-2-methylindol-5-yl)-5-fluoro-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]pyrimidin-2-amineIC509.0 [1]
CDK4/6/1 InhibitorIC501.0 [1]
2-[4-[6-[[5-Fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)pyrimidin-2-yl]amino]pyridin-3-yl]piperazin-1-yl]ethanolIC506.0 [1]
4-(3-Ethyl-2,3-dimethylindol-5-yl)-5-fluoro-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amineIC5010.0 [1]
5-Fluoro-4-(7-fluoro-2,3,3-trimethylindol-5-yl)-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amineIC5043.0 [1]
4-(3-Ethyl-7-fluoro-2,3-dimethylindol-5-yl)-5-fluoro-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amineIC503.0 [1]
5-Fluoro-4-(2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amineIC504.0 [1]
4-(3,3-Diethyl-7-fluoro-2-methylindol-5-yl)-5-fluoro-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amineIC503.0 [1]
4-(3-Ethyl-7-fluoro-2,3-dimethylindol-5-yl)-5-fluoro-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]pyrimidin-2-amineIC501.0 [1]
N-[5-(4-Ethylpiperazin-1-yl)pyridin-2-yl]-5-fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)pyrimidin-2-amineIC5016.0 [1]
4-(3-Ethyl-2,3-dimethylindol-5-yl)-5-fluoro-N-(5-piperidin-4-ylpyridin-2-yl)pyrimidin-2-amineIC5016.0 [1]
4-(3-Ethyl-2,3-dimethylindol-5-yl)-5-fluoro-N-[5-(1-methylpiperidin-4-yl)pyridin-2-yl]pyrimidin-2-amineIC509.0 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2,3,3-trimethylindol-5-yl)pyrimidin-2-amineIC50159.0 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)pyrimidin-2-amineIC507.0 [1]
4-(3-Ethyl-7-fluoro-2,3-dimethylindol-5-yl)-N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoropyrimidin-2-amineIC5026.0 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)pyrimidin-2-amineIC5086.0 [1]
N-[5-(1-Ethylpiperidin-4-yl)pyridin-2-yl]-5-fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)pyrimidin-2-amineIC504.0 [1]
4-(3-Ethyl-7-fluoro-2,3-dimethylindol-5-yl)-N-[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]-5-fluoropyrimidin-2-amineIC5065.0 [1]
N-[5-(4-Ethylpiperazin-1-yl)pyridin-2-yl]-5-fluoro-4-(2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)pyrimidin-2-amineIC5052.0 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7'-fluoro-2'-methylspiro[cyclobutane-1,3'-indole]-5'-yl)pyrimidin-2-amineIC502147.0 [1]
5-Fluoro-4-(2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)-N-(5-piperidin-4-ylpyridin-2-yl)pyrimidin-2-amineIC504.0 [1]
4-(3-Ethyl-7-fluoro-2,3-dimethylindol-5-yl)-5-fluoro-N-[5-(1-methylpiperidin-4-yl)pyridin-2-yl]pyrimidin-2-amineIC509.0 [1]
5-Fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)-N-(5-piperidin-4-ylpyridin-2-yl)pyrimidin-2-amineIC500.4 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)pyrimidin-2-amineIC502.0 [1]
5-Fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]pyrimidin-2-amineIC5088.0 [1]
5-Fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amineIC506.0 [1]
5-Fluoro-N-[5-(1-methylpiperidin-4-yl)pyridin-2-yl]-4-(2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)pyrimidin-2-amineIC504.0 [1]
4-(3,3-Diethyl-7-fluoro-2-methylindol-5-yl)-N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoropyrimidin-2-amineIC5047.0 [1]
N-[5-(1-Ethylpiperidin-4-yl)pyridin-2-yl]-5-fluoro-4-(2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)pyrimidin-2-amineIC5028.0 [1]
5-Fluoro-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-(2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)pyrimidin-2-amineIC509.0 [1]
4-(3-Ethyl-2,3-dimethylindol-5-yl)-5-fluoro-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]pyrimidin-2-amineIC505.0 [1]
4-(3-Ethyl-2,3-dimethylindol-5-yl)-N-[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]-5-fluoropyrimidin-2-amineIC504.0 [1]
5-Fluoro-4-(7-fluoro-2,3,3-trimethylindol-5-yl)-N-[5-(1-methylpiperidin-4-yl)pyridin-2-yl]pyrimidin-2-amineIC5059.0 [1]
4-(3-Ethyl-7-fluoro-2,3-dimethylindol-5-yl)-N-[5-(1-ethylpiperidin-4-yl)pyridin-2-yl]-5-fluoropyrimidin-2-amineIC5012.0 [1]
4-(3-Ethyl-7-fluoro-2,3-dimethylindol-5-yl)-5-fluoro-N-(5-piperidin-4-ylpyridin-2-yl)pyrimidin-2-amineIC506.0 [1]
2-[4-[6-[[5-Fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)pyrimidin-2-yl]amino]pyridin-3-yl]piperidin-1-yl]ethanolIC500.5 [1]
6-N-(3-Amino-5-chlorophenyl)-2-N-[(3R)-piperidin-3-yl]-9-propan-2-ylpurine-2,6-diamineIC501000.0 [1]
6-N-(3-Amino-5-chlorophenyl)-2-N-[(1R,2S)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamineIC501000.0 [1]
N-[3-[[2-[[(1R,2S)-2-Aminocyclohexyl]amino]-9-propan-2-ylpurin-6-yl]amino]-5-chlorophenyl]acetamideIC501000.0 [1]
6-N-(3-Amino-5-chlorophenyl)-2-N-[(1S,2S)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamineIC501000.0 [1]
6-N-(3-Amino-5-chlorophenyl)-2-N-[(1R,2R)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamineIC501000.0 [1]
N-[3-[[2-[[(1S,2R)-2-Aminocyclohexyl]amino]-9-propan-2-ylpurin-6-yl]amino]-5-chlorophenyl]acetamideIC501000.0 [1]
2-N-[(1S,2R)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamineIC501000.0 [1]
2-N-[(1R,2R)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamineIC501000.0 [1]
2-N-[(1S,2S)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamineIC501000.0 [1]
6-N-(3-Amino-5-chlorophenyl)-2-N-[(1S,2R)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamineIC501000.0 [1]
2-N-[(1R,2S)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamineIC501000.0 [1]
6-N-(3-Amino-5-chlorophenyl)-9-propan-2-yl-2-N-[(3S)-pyrrolidin-3-yl]purine-2,6-diamineIC501000.0 [1]
6-N-(3-Amino-5-chlorophenyl)-2-N-[(3S)-piperidin-3-yl]-9-propan-2-ylpurine-2,6-diamineIC501000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ CDK6/cyclin D3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/cdk6-cyclin-d3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ CDK6/cyclin D3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cdk6-cyclin-d3-inhibitors-ic50-ki.
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