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Ceramide glucosyltransferase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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AMP-DeoxynojirimycinIC50150.0 [1]
MiglustatIC5020000.0 [1], 22000.0 [2], 25000.0 [3], 50000.0 [4]
N-[(1R,2S)-1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamideIC502.0 [1], 16.0 [2]
N-[(1R,2S)-1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]nonanamideIC502.0 [1], 9.0 [2]
LucerastatIC5010000.0 [1]
(2S,3R,4R,5S)-1-[5-(1-Adamantylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC50100.0 [1], 150.0 [2]
(2S,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triolIC5010000.0 [1], 12000.0 [2]
(2R,3S,4R,5S)-1-[5-(1-Adamantylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC50500.0 [1]
1-(2,4-Dichlorophenyl)-N-[(2S)-3-(1H-indol-3-yl)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]cyclopropane-1-carboxamideIC506.0 [1], 10.0 [2]
2-[2-Chloro-4-(trifluoromethyl)phenoxy]-N-[(2R)-1-(4-methylpiperazin-1-yl)-1-oxo-3-phenylmethoxypropan-2-yl]pyridine-3-carboxamideIC501.0 [1], 2.0 [2]
2-[2-Chloro-4-(trifluoromethyl)phenoxy]-N-[(2R)-3-[(4-fluorophenyl)methoxy]-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]pyridine-3-carboxamideIC507.0 [1], 13.0 [2]
1-(2,4-Dichlorophenyl)-N-[(2S)-1-(4-methylpiperazin-1-yl)-1-oxo-3-phenylmethoxypropan-2-yl]cyclopropane-1-carboxamideIC5090.0 [1], 330.0 [2]
N-[(2S)-3-(4-Chlorophenyl)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]-1-(2,4-dichlorophenyl)cyclopropane-1-carboxamideIC503.0 [1], 10.0 [2]
N-[(2S)-3-(4-Bromophenyl)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]-1-(2,4-dichlorophenyl)cyclopropane-1-carboxamideIC507.0 [1], 14.0 [2]
2-[2-Chloro-4-(trifluoromethyl)phenoxy]-N-[(2R)-1-[(3R)-3-(methylamino)pyrrolidin-1-yl]-1-oxo-3-phenylmethoxypropan-2-yl]pyridine-3-carboxamideIC505.0 [1], 16.0 [2]
2-[2-Chloro-4-(trifluoromethyl)phenoxy]-N-[(2R)-3-[(2-methyl-1,3-oxazol-5-yl)methoxy]-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]pyridine-3-carboxamideIC5020.0 [1], 50.0 [2]
2-[2-Chloro-4-(trifluoromethyl)phenoxy]-N-[(2R)-3-(2,3-dihydro-1,4-benzodioxin-6-ylmethoxy)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]pyridine-3-carboxamideIC500.3 [1], 1.0 [2]
N-[(2R)-1-[[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]amino]-1-oxo-3-phenylmethoxypropan-2-yl]-2-[2-chloro-4-(trifluoromethyl)phenoxy]pyridine-3-carboxamideIC504.0 [1], 5.0 [2]
N-[(2R)-1-[[(3R)-1-Azabicyclo[2.2.2]octan-3-yl]amino]-1-oxo-3-phenylmethoxypropan-2-yl]-2-[2-chloro-4-(trifluoromethyl)phenoxy]pyridine-3-carboxamideIC507.0 [1], 12.0 [2]
1-(2,4-Dichlorophenyl)-N-[(2S)-3-(2,4-dichlorophenyl)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]cyclopropane-1-carboxamideIC504.0 [1], 12.0 [2]
1-(2,4-Dichlorophenyl)-N-[(2S)-3-(2,4-dichlorophenyl)-1-[2-(dimethylamino)ethyl-methylamino]-1-oxopropan-2-yl]cyclopropane-1-carboxamideIC502.0 [1], 120.0 [2]
N-[(2S)-3-(4-Bromophenyl)-1-[2-(dimethylamino)ethyl-methylamino]-1-oxopropan-2-yl]-1-(2,4-dichlorophenyl)cyclopropane-1-carboxamideIC504.0 [1], 10.0 [2]
N-[(2S)-1-[(1R,5S)-3-Amino-8-azabicyclo[3.2.1]octan-8-yl]-3-(2,4-dichlorophenyl)-1-oxopropan-2-yl]-1-(2,4-dichlorophenyl)cyclopropane-1-carboxamideIC502.0 [1], 4.0 [2]
N-[(2S)-1-[(1R,5S)-3-Amino-8-azabicyclo[3.2.1]octan-8-yl]-3-(4-bromophenyl)-1-oxopropan-2-yl]-1-(2,4-dichlorophenyl)cyclopropane-1-carboxamideIC503.0 [1], 40.0 [2]
N-[(2S)-1-[(1R,5S)-3-Amino-8-azabicyclo[3.2.1]octan-8-yl]-3-(2,4-dichlorophenyl)-1-oxopropan-2-yl]-1-[4-(trifluoromethoxy)phenyl]cyclopropane-1-carboxamideIC503.0 [1], 8.0 [2]
N-[(2S)-1-[(1S,5R)-3-Amino-8-azabicyclo[3.2.1]octan-8-yl]-3-(4-bromophenyl)-1-oxopropan-2-yl]-1-[4-(trifluoromethoxy)phenyl]cyclopropane-1-carboxamideIC502.0 [1], 15.0 [2]
1-DeoxynojirimycinIC50100000.0 [1]
MiglitolIC501000000.0 [1]
N-[(1R,2R)-1-Hydroxy-3-(4-morpholinyl)-1-phenylpropan-2-yl]decanamideIC5023000.0 [1]
MigalastatIC50100000.0 [1]
EliglustatIC5016.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonylpiperidine-3,4,5-triolIC501600.0 [1]
Genz-123346 free baseIC509.0 [1]
N-(1-Adamantyl)-6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]hexanamideIC501000.0 [1]
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3R,4R,5S)-IC509000.0 [1]
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3S,4R,5S)-IC50100000.0 [1]
(2R,3R,4R,5S)-1-[4,4-Difluoro-5-[(4-phenylphenyl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC5060.0 [1]
(2S,3R,4R,5S)-1-[5-[(3-Fluoro-4-phenylphenyl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC502.5 [1]
N-[1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]hexadecanamideIC5090.0 [1]
N-[1-Hydroxy-1-(4-hydroxyphenyl)-3-pyrrolidin-1-ylpropan-2-yl]hexadecanamideIC5090.0 [1]
(2S,3S,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triolIC50100000.0 [1]
(2R,3S,4R,5S)-2-(Hydroxymethyl)-1-[5-[(4-phenylphenyl)methoxy]pentyl]piperidine-3,4,5-triolIC50100.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-phenyl-3-(trifluoromethyl)phenyl]methoxy]pentyl]piperidine-3,4,5-triolIC5025.0 [1]
(2S,3R,4R,5S)-1-[5-[(2-Fluoro-4-phenylphenyl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC505.0 [1]
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(4-phenylphenyl)methoxy]pentyl]piperidine-3,4,5-triolIC508.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-phenyl-2-(trifluoromethyl)phenyl]methoxy]pentyl]piperidine-3,4,5-triolIC5025.0 [1]
(2R,3R,4R,5S)-1-[5-[(2-Fluoro-4-phenylphenyl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC5025.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(4-phenylphenyl)methoxy]pentyl]piperidine-3,4,5-triolIC5050.0 [1]
(2R,3R,4R,5S)-1-[5-[(3-Fluoro-4-phenylphenyl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC5025.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(2-phenylphenyl)methoxy]pentyl]piperidine-3,4,5-triolIC5050.0 [1]
(2R,3R,4R,5S)-1-[2,2-Difluoro-5-[(4-phenylphenyl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC501250.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(4-pyridin-3-ylphenyl)methoxy]pentyl]piperidine-3,4,5-triolIC502000.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(5-phenylpyridin-2-yl)methoxy]pentyl]piperidine-3,4,5-triolIC50200.0 [1]
(2R,3R,4R,5S)-1-[5-[[4-(2-Fluoropyridin-4-yl)phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC50150.0 [1]
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-phenyl-2-(trifluoromethyl)phenyl]methoxy]pentyl]piperidine-3,4,5-triolIC503.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-(2-methoxyphenyl)phenyl]methoxy]pentyl]piperidine-3,4,5-triolIC5050.0 [1]
2-[4-[5-[(2R,3R,4R,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)piperidin-1-yl]pentoxymethyl]phenyl]benzonitrileIC50150.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-(3-methylphenyl)phenyl]methoxy]pentyl]piperidine-3,4,5-triolIC50100.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-(3-methoxyphenyl)phenyl]methoxy]pentyl]piperidine-3,4,5-triolIC50150.0 [1]
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-phenyl-3-(trifluoromethyl)phenyl]methoxy]pentyl]piperidine-3,4,5-triolIC503.0 [1]
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(2-phenylphenyl)methoxy]pentyl]piperidine-3,4,5-triolIC5025.0 [1]
(2R,3R,4R,5S)-1-[5-(Cyclohexylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC50500.0 [1]
(2R,3R,4R,5S)-1-[6-(1-Adamantylmethoxy)hexyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC50300.0 [1]
(2R,3R,4R,5S)-1-[5-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC501000.0 [1]
(2R,3R,4R,5S)-1-[5-(2-Adamantylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC50300.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-(5-phenylmethoxypentyl)piperidine-3,4,5-triolIC50750.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-(naphthalen-2-ylmethoxy)pentyl]piperidine-3,4,5-triolIC503.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-(pyren-1-ylmethoxy)pentyl]piperidine-3,4,5-triolIC503.0 [1]
(2S,3R,4R,5S)-1-[5-(Cyclohexylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC5070.0 [1]
N-(1-Adamantyl)-6-[(2S,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]hexanamideIC50400.0 [1]
(2S,3R,4R,5S)-1-[6-(1-Adamantylmethoxy)hexyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC50250.0 [1]
(2S,3R,4R,5S)-1-[5-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC501000.0 [1]
(2S,3R,4R,5S)-1-[5-(2-Adamantylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC5080.0 [1]
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienoxy]pentyl]piperidine-3,4,5-triolIC502500.0 [1]
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-(5-phenylmethoxypentyl)piperidine-3,4,5-triolIC50200.0 [1]
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-(naphthalen-2-ylmethoxy)pentyl]piperidine-3,4,5-triolIC503.0 [1]
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-(pyren-1-ylmethoxy)pentyl]piperidine-3,4,5-triolIC503.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-(4-methylphenyl)phenyl]methoxy]pentyl]piperidine-3,4,5-triolIC50100.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-(2-methylphenyl)phenyl]methoxy]pentyl]piperidine-3,4,5-triolIC5025.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-(4-methoxyphenyl)phenyl]methoxy]pentyl]piperidine-3,4,5-triolIC5025.0 [1]
4-[4-[5-[(2R,3R,4R,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)piperidin-1-yl]pentoxymethyl]phenyl]benzonitrileIC50150.0 [1]
3-[4-[5-[(2R,3R,4R,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)piperidin-1-yl]pentoxymethyl]phenyl]benzonitrileIC5050.0 [1]
(2R,3R,4R,5S)-1-[5-[[4-(4-Fluorophenyl)phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC5025.0 [1]
(2R,3R,4R,5S)-1-[5-[[4-(3-Fluorophenyl)phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC5025.0 [1]
(2R,3R,4R,5S)-1-[5-[[4-(2-Fluorophenyl)phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC5075.0 [1]
(2R,3R,4R,5S)-1-[5-[[4-(4-Chlorophenyl)phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC5025.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-[4-(trifluoromethyl)phenyl]phenyl]methoxy]pentyl]piperidine-3,4,5-triolIC5020.0 [1]
(2R,3R,4R,5S)-1-[5-[[4-[3,5-Bis(trifluoromethyl)phenyl]phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC5020.0 [1]
(2R,3R,4R,5S)-1-[5-[[4-(1,3-Benzodioxol-5-yl)phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC5025.0 [1]
(2R,3R,4R,5S)-1-[5-[[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC5040.0 [1]
(2R,3R,4R,5S)-1-[5-[[4-(3,4-Dihydro-2H-1,5-benzodioxepin-7-yl)phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC5025.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(4-pyridin-4-ylphenyl)methoxy]pentyl]piperidine-3,4,5-triolIC502000.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(4-pyrimidin-5-ylphenyl)methoxy]pentyl]piperidine-3,4,5-triolIC502000.0 [1]
(2R,3R,4R,5S)-1-[5-[[4-(6-Fluoropyridin-3-yl)phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC50750.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(3-phenylphenyl)methoxy]pentyl]piperidine-3,4,5-triolIC5075.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(1S)-1-(4-phenylphenyl)ethoxy]pentyl]piperidine-3,4,5-triolIC5070.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(1R)-1-(4-phenylphenyl)ethoxy]pentyl]piperidine-3,4,5-triolIC5060.0 [1]
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(1S)-1-(4-phenylphenyl)ethoxy]pentyl]piperidine-3,4,5-triolIC5040.0 [1]
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(1R)-1-(4-phenylphenyl)ethoxy]pentyl]piperidine-3,4,5-triolIC5030.0 [1]
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(3-phenylphenyl)methoxy]pentyl]piperidine-3,4,5-triolIC5070.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Ceramide glucosyltransferase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/ceramide-glucosyltransferase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ Ceramide glucosyltransferase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ceramide-glucosyltransferase-inhibitors-ic50-ki.
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