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Chymase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
ChymostatinIC509.36 [1], 43.0 [2]
ChymostatinKi13.1 [1]
2-Amino-4-[(1R)-1-[[(6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acidIC50300.0 [1]
Ethyl N-[(2S)-6-amino-1-oxo-1-[5-[[4-(2-phenylethoxy)phenyl]methyl]-1,2,4-oxadiazol-3-yl]hexan-2-yl]carbamateKi150000.0 [1]
Methyl 2-[2-[[2-[5-amino-2-(4-fluorophenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-3-phenylpropanoyl]-1,3-benzoxazole-5-carboxylateKi3.68 [1], 22.6 [2]
Methyl 2-[2-[[2-[5-amino-2-(3-methoxyphenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-3-phenylpropanoyl]-1,3-benzoxazole-5-carboxylateKi1.12 [1], 4.85 [2]
3-[[2,2-Difluoro-4-[[(2S)-1-[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]pyrrolidine-2-carbonyl]amino]-3-oxo-5-phenylpentanoyl]amino]benzoic acidKi5.6 [1]
Benzhydryl (6R,7R)-7-methoxy-7-[(2-methoxybenzoyl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylateIC50550.0 [1]
(3-Methylphenyl)methyl (6R,7R)-7-[[2-(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylateIC5050.0 [1], 500.0 [2]
2-[5-[[(6R,7R)-7-[[2-(4-Hydroxyphenyl)acetyl]amino]-7-methoxy-2-[(3-methylphenyl)methoxycarbonyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-en-3-yl]methylsulfanyl]tetrazol-1-yl]acetic acidIC5070.0 [1], 72.0 [2]
5-Chloro-3-methyl-N-(4-propylsulfonylphenyl)-1-benzothiophene-2-sulfonamideIC50909.0 [1], 10600.0 [2]
(3-Methylphenyl)methyl (6R,7R)-7-[[2-(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylateIC5077.0 [1], 440.0 [2]
(3-Methylphenyl)methyl (6R,7R)-7-[[2-(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-methyl-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylateIC5010000.0 [1]
Benzhydryl (6R,7R)-7-[[2-(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylateIC50250.0 [1]
Benzhydryl (6R,7R)-7-[[2-[4-(dimethylamino)phenyl]acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylateIC50410.0 [1]
4-{3-[(4-Methyl-1-Benzothiophen-3-Yl)methyl]-2-Oxo-2,3-Dihydro-1h-Benzimidazol-1-Yl}butanoic AcidIC5097.0 [1], 180.0 [2]
4-[[(6R,7R)-7-[(2-Ethoxybenzoyl)amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carbonyl]oxymethyl]benzoic acidIC5027.0 [1]
4-[[2-[5-Amino-2-(3-chlorophenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-N-benzyl-2,2-difluoro-3-oxo-5-phenylpentanamideKi2.62 [1], 28.0 [2]
6-(5-Chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepan-2,5-dioneIC5034.0 [1]
2-Amino-4-[(1R)-1-[[(6S)-6-[(5-chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acidIC50140.0 [1], 170.0 [2]
3-((R)-1-((R)-6-(5-Chloro-2-methoxybenzyl)-2,5-dioxo-1,4-diazepane-4-carboxamido)propyl)benzoic acidIC50200.0 [1], 240.0 [2]
5-[(1R)-1-[[(6R)-6-[(5-Chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carbonyl]amino]propyl]pyridine-3-carboxylic acidIC50380.0 [1], 1300.0 [2]
6-[(5-Chloro-2-methoxyphenyl)methyl]-3,7-dioxo-N-[(2R)-1-oxo-1-(2H-tetrazol-5-ylamino)butan-2-yl]-1,4-diazepane-1-carboxamideIC50260.0 [1]
BortezomibIC501190.0 [1]
OxindoleIC501000000.0 [1]
TelaprevirIC5026.0 [1]
BoceprevirIC5032.0 [1]
Tosylphenylalanyl chloromethyl ketoneIC503300.0 [1]
VaborbactamIC501000000.0 [1]
DelanzomibIC503530.0 [1]
Z-L-Phe chloromethyl ketoneIC50400.0 [1]
5-ChlorooxindoleIC501000000.0 [1]
(1R,21S,24S)-21-Tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.14,7.06,11]heptacosa-6(11),7,9-triene-24-carboxamideIC5010000.0 [1]
6-ChloroindoleIC50340000.0 [1]
Jnj-10311795Ki2.3 [1]
6-(3,5-Difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrileIC5089125.09 [1]
Grassystatin AIC5010000.0 [1]
Z-Ile-Glu-Pro-Phe-OmeKi3.0 [1]
4-({1-[(4-Methyl-1-Benzothiophen-3-Yl)methyl]-1h-Benzimidazol-2-Yl}sulfanyl)butanoic AcidIC5022.0 [1]
Methyl 2-[(2S)-2-[[2-[5-amino-2-(3-methoxyphenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-3-phenylpropanoyl]-1,3-benzoxazole-5-carboxylateKi4.8 [1]
2-[(E)-3-Phenylprop-2-enylidene]cyclopent-4-ene-1,3-dioneIC5012000.0 [1]
2-Amino-4-[(1R)-1-[[(6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-7-oxo-3-(phenoxyamino)-5,6-dihydro-2H-1,4-diazepine-1-carbonyl]amino]propyl]benzoic acidIC508.9 [1]
N-[2-(Diaminomethylideneamino)oxyethyl]-2-[3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-2-oxopyrazin-1-yl]acetamideKi26000.0 [1]
1,3-Dibenzyl-1,3-diazetidine-2,4-dioneIC504.0 [1]
[3-[(4-Cyanobenzoyl)amino]-2,2-dimethyl-5-phenylpentanoyl] 3-[(4-cyanobenzoyl)amino]-2,2-dimethyl-5-phenylpentanoateIC50270.0 [1]
7-Chloroindolin-2-oneIC501000000.0 [1]
(6S)-6-[(5-Chloro-2-methoxyphenyl)methyl]-4-(4-chlorophenyl)sulfonyl-1,4-diazepane-2,5-dioneIC5027.0 [1]
6-ChlorooxindoleIC50470000.0 [1]
3-(3,4-Dichloro-benzenesulfonyl)-1-(3,4-dimethyl-phenyl)-imidazolidine-2,4-dioneIC5020.0 [1]
6-Chloro-1-methylindolin-2-oneIC501000000.0 [1]
MethyllideroneIC5030000.0 [1]
3-(Methylsulfonyl)-4-(3-methyl-5-chlorobenzo[b]thiophene-2-ylsulfonylamino)benzoic acid methyl esterIC50203.0 [1]
[4-[3-(Aminomethyl)phenyl]piperidin-1-yl]-[5-(2-phenylethynyl)furan-2-yl]methanoneIC50100000.0 [1]
2-[5-[[(6R,7R)-7-Methoxy-7-[(2-methoxybenzoyl)amino]-2-[(3-methylphenyl)methoxycarbonyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-en-3-yl]methylsulfanyl]tetrazol-1-yl]acetic acidIC506.0 [1]
3-[[2,2-Difluoro-4-[[(2S)-1-[(2S)-3-methyl-2-(3-phenylpropanoylamino)butanoyl]pyrrolidine-2-carbonyl]amino]-3-oxo-5-phenylpentanoyl]amino]benzoic acidKi1.3 [1]
1,3-Bis(1,3-benzodioxole-5-ylmethyl)-1,3-diazetidine-2,4-dioneIC500.85 [1]
3-(4-Chlorophenyl)sulfonyl-1-(3,4-dichlorophenyl)imidazolidine-2,4-dioneIC5023.0 [1]
N-(4-Acetyl-2-methylsulfonylphenyl)-5-fluoro-3-methyl-1-benzothiophene-2-sulfonamideIC5082.0 [1]
N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(2-fluoro-phenyl)-propionamideIC50360.0 [1]
(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-nonanoylamino]-3-phenyl-propionic acid ethyl esterIC50360.0 [1]
3-(4-Chlorophenyl)sulfonyl-1-(3,4-dimethylphenyl)imidazolidine-2,4-dioneIC5035.0 [1]
3-(3,4-Dimethoxy-benzenesulfonyl)-1-(3,4-dimethyl-phenyl)-imidazolidine-2,4-dioneIC5022.0 [1]
2-(1-Methoxy-3-phenyl-2-propenylidene)-4-cyclopentene-1,3-dioneIC501700.0 [1]
2-[5-Amino-2-(3-methylphenyl)-6-oxopyrimidin-1-yl]-N-(4,4,4-trifluoro-3-oxo-1-phenylbutan-2-yl)acetamideKi50.6 [1]
(2,5-Dioxo-3-phenylimidazolidin-1-yl)methyl benzoateIC50100000.0 [1]
4-(2,5-Dioxo-3-phenyl-imidazolidine-1-sulfonyl)-benzonitrileIC5040.0 [1]
3-(3,4-Dimethyl-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dioneIC5030.0 [1]
3-(4-Chlorophenyl)sulfonyl-1-pyridin-2-ylimidazolidine-2,4-dioneIC5018000.0 [1]
3-(3,4-Dimethyl-benzenesulfonyl)-1-(3,4-dimethyl-phenyl)-imidazolidine-2,4-dioneIC5060.0 [1]
2-[5-Amino-2-(4-fluorophenyl)-6-oxopyrimidin-1-yl]-N-[1-oxo-3-phenyl-1-(1,3-thiazol-2-yl)propan-2-yl]acetamideKi3850.0 [1]
(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-heptanoylamino]-3-phenyl-propionic acid ethyl esterIC50510000.0 [1]
4-[[2-[5-Amino-2-(3-methylphenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-2,2-difluoro-N-methyl-3-oxo-5-phenylpentanamideKi90.7 [1]
2-[5-Amino-2-(4-fluorophenyl)-6-oxopyrimidin-1-yl]-N-[1-(1,3-benzoxazol-2-yl)-1-oxo-3-phenylpropan-2-yl]acetamideKi125.0 [1]
4-[[2-[5-Amino-2-(3-methylphenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-2,2-difluoro-N,N-dimethyl-3-oxo-5-phenylpentanamideKi489.0 [1]
4-[[2-[5-Amino-2-(3-methylphenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-N-(2-amino-2-oxoethyl)-2,2-difluoro-3-oxo-5-phenylpentanamideKi12.0 [1]
Methyl 2-[2-[[2-(5-amino-6-oxo-2-phenylpyrimidin-1-yl)acetyl]amino]-3-phenylpropanoyl]-1,3-benzoxazole-5-carboxylateKi5.57 [1]
2-[2-[[2-[5-Amino-2-(4-fluorophenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-3-phenylpropanoyl]-1,3-benzoxazole-5-carboxylic acidKi76.0 [1]
1-Phenyl-3-(toluene-4-sulfonyl)-imidazolidine-2,4-dioneIC502600.0 [1]
3-(4-Bromo-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dioneIC50170.0 [1]
3-(4-Chloro-benzenesulfonyl)-1-(4-phenoxy-phenyl)-imidazolidine-2,4-dioneIC5028000.0 [1]
4-[[2-[5-Amino-2-(3-methylphenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-2,2-difluoro-3-oxo-5-phenylpentanoic acidKi10000.0 [1]
(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-nonanoylamino]-3-phenyl-propionic acid propyl esterIC503200.0 [1]
Methyl 2-[2-[[2-[5-amino-2-(3-chlorophenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-3-phenylpropanoyl]-1,3-benzoxazole-5-carboxylateKi26.1 [1]
4-[[2-[5-Amino-2-(3-methylphenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-N-[2-(diethylamino)-2-oxoethyl]-2,2-difluoro-3-oxo-5-phenylpentanamideKi9.32 [1]
4-[[2-[5-Amino-2-(3-methylphenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-N-[2-(azepan-1-yl)-2-oxoethyl]-2,2-difluoro-3-oxo-5-phenylpentanamideKi3.56 [1]
3-(4-Methoxy-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dioneIC50550.0 [1]
3-[3-(4-Methylpiperazine-1-carbonyl)phenyl]sulfonyl-1-phenylimidazolidine-2,4-dioneIC50900.0 [1]
2-[[4-[[2-[5-Amino-2-(3-methylphenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-2,2-difluoro-3-oxo-5-phenylpentanoyl]amino]acetic acidKi16.9 [1]
Methyl 2-[2-[[2-[5-amino-2-(3-aminophenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-3-phenylpropanoyl]-1,3-benzoxazole-5-carboxylateKi5.6 [1]
2-[3-(4-Chlorophenyl)sulfonyl-2,4-dioxoimidazolidin-1-yl]benzoic acidIC503300.0 [1]
4-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-benzoic acidIC50100000.0 [1]
2-[5-Amino-2-(4-fluorophenyl)-6-oxopyrimidin-1-yl]-N-[1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-1-oxo-3-phenylpropan-2-yl]acetamideKi60.6 [1]
Methyl 2-[2-[[2-[5-amino-2-(3-methylphenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-3-phenylpropanoyl]-1,3-benzoxazole-5-carboxylateKi44.2 [1]
Methyl 2-[2-[[2-[5-amino-2-(4-fluorophenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-3-phenylpropanoyl]-1,3-benzoxazole-6-carboxylateKi56.3 [1]
3-(2,5-Dioxo-3-phenyl-imidazolidine-1-sulfonyl)-benzonitrileIC5068.0 [1]
3-(4-Chlorophenyl)-1-(4-chlorophenyl)sulfonylimidazolidine-2,4-dioneIC50100000.0 [1]
1-(3,4-Dichlorophenyl)-3-(3,4-dichlorophenyl)sulfonylimidazolidine-2,4-dioneIC50170.0 [1]
3-(4-Chlorobenzoyl)-1-phenylimidazolidine-2,4-dioneIC50100000.0 [1]
1-Phenyl-3-phenylmethanesulfonyl-imidazolidine-2,4-dioneIC50100000.0 [1]
3-(4-Fluoro-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dioneIC50370.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Chymase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/chymase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ Chymase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/chymase-inhibitors-ic50-ki.
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