Coagulation factor VII/tissue factor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Benzamide	Ki	49000000.0 [1]
	3-Amino-5-[1-[2-[(4-carbamimidoylphenyl)methylamino]-2-oxoethyl]-3-chloro-6-oxo-5-(propan-2-ylamino)pyrazin-2-yl]benzoic acid	IC50	16.0 [1]
	N-[(4-Carbamimidoylphenyl)methyl]-2-[6-(3,5-diaminophenyl)-2-oxo-3-(propan-2-ylamino)pyridin-1-yl]acetamide	IC50	52.0 [1]
	N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-2-oxo-6-phenyl-3-(2-phenylethylamino)pyrazin-1-yl]acetamide	IC50	630.0 [1]
	7-Chloro-3,4-dihydroisoquinolin-1(2H)-one	Ki	8900000.0 [1]
	2-[3-(5-Carbamimidoyl-1H-indol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]acetic Acid	Ki	3.0 [1]
	2-[3-(Benzylamino)-5-chloro-2-oxo-6-phenylpyrazin-1-yl]-N-[(4-carbamimidoylphenyl)methyl]acetamide	IC50	770.0 [1]
	(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-cyclopropylsulfonyl-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dione	Ki	0.16 [1]
	(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6(21),7,9,16(20),17-hexaene-3,12-dione	Ki	400.0 [1]
	(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-ethylsulfonyl-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaene-3,12-dione	Ki	8.0 [1]
	(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-ethylsulfonyl-17-methyl-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dione	Ki	1.6 [1]
	(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-N-(benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamide	Ki	9.7 [1], 11.0 [2]
	(11R)-11-[(1-Aminoisoquinolin-6-yl)amino]-16-cyclopropylsulfonyl-13-methyl-2,13-diazatricyclo[13.3.1.16,10]icosa-1(19),6(20),7,9,15,17-hexaene-3,12-dione	Ki	5.0 [1], 58.0 [2]
	(5R)-5-[(1-Amino-4-fluoroisoquinolin-6-yl)amino]-19-cyclopropylsulfonyl-3,13-dimethyl-3,13,15-triazatricyclo[14.3.1.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaene-4,14-dione	Ki	14.0 [1], 200.0 [2]
	(5R,11R)-5-[(1-Amino-4-fluoroisoquinolin-6-yl)amino]-19-cyclopropylsulfonyl-9-methoxy-3,11,13-trimethyl-3,13,15-triazatricyclo[14.3.1.16,10]henicosa-1(19),6(21),7,9,16(20),17-hexaene-4,14-dione	Ki	3.8 [1], 5.0 [2]
	Arachidonic acid	IC50	105000.0 [1]
	Nicotinamide	Ki	8000000.0 [1]
	Oleic acid	IC50	80000.0 [1]
	Linoleic acid	IC50	41000.0 [1]
	Eicosapentaenoic acid	IC50	78000.0 [1]
	Linolenic acid	IC50	30000.0 [1]
	Dihomo-gamma-linolenic acid	IC50	75000.0 [1]
	Benzamidine	Ki	240000.0 [1]
	gamma-Linolenic acid	IC50	30000.0 [1]
	Palmitoleic acid	IC50	120000.0 [1]
	Ginkgolic acid	IC50	32000.0 [1]
	1-Hydroxyisoquinoline	Ki	19000000.0 [1]
	Myristoleic acid	IC50	66000.0 [1]
	1-Aminoisoquinoline	Ki	4000000.0 [1]
	2,4-Dichlorobenzyl alcohol	Ki	13000000.0 [1]
	Eicosadienoic acid	IC50	52000.0 [1]
	11,14,17-Eicosatrienoic acid	IC50	100000.0 [1]
	1-(1-Naphthyl)ethanol	Ki	16000000.0 [1]
	5-Chloroindole-2-carboxylic acid	Ki	3500000.0 [1]
	5-Chloroindole	Ki	4300000.0 [1]
	4-Chloro-2-methoxyphenol	Ki	16000000.0 [1]
	5-Chlorobenzotriazole	Ki	8700000.0 [1]
	(Z)-2-(Heptadec-10-en-1-yl)-6-hydroxybenzoic acid	IC50	68000.0 [1]
	CID 9845742	IC50	340.0 [1]
	2-[2-(3-Aminophenyl)-3-chloro-5-(cyclobutylamino)-6-oxopyrazin-1-yl]-N-[(4-carbamimidoylphenyl)methyl]acetamide	IC50	20.0 [1]
	CID 10181104	IC50	2800.0 [1]
	2-[3-(6-Carbamimidoyl-1H-benzimidazol-2-yl)-5-(5-fluoro-2-hydroxyphenyl)-4-hydroxyphenyl]butanedioic acid	Ki	4.0 [1]
	4-Bromo-2-methoxyphenol	Ki	13000000.0 [1]
	2-[3-(5-Carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]acetic acid	Ki	15.0 [1]
	2-[3-(5-Carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]butanedioic acid	Ki	22.0 [1]
	2-[2-[(4-Carbamimidoylphenyl)carbamoyl]phenyl]-5-(2-methylpropylcarbamoyl)benzoic acid	IC50	0.12 [1]
	N-(Benzenesulfonyl)-2-(4-carbamimidoylanilino)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamide	Ki	1.3 [1]
	2-[(4-Carbamimidoylphenyl)amino]-2-(3,5-diethoxyphenyl)acetic acid	Ki	190.0 [1]
	6-Methyl-N-(4-methylphenyl)-2-oxochromene-3-carboxamide	IC50	50000.0 [1]
	Methyl 1H-indole-4-carboxylate	Ki	13000000.0 [1]
	(2S)-N-[(4-Carbamimidoylphenyl)methyl]-2-[[(2R)-2-(ethylsulfonylamino)-3-(4-phenylphenyl)propanoyl]amino]pentanediamide	IC50	93.0 [1]
	(6S)-N-[(4-Carbamimidoylphenyl)methyl]-4-oxo-8,8-dipropyl-3-(propylamino)-6,7-dihydropyrrolo[1,2-a]pyrimidine-6-carboxamide	Ki	620.0 [1]
	(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-3-(3,3-dimethylbutan-2-ylamino)-8,8-dimethyl-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamide	Ki	84.0 [1]
	2-[(2-Amino-3H-benzimidazol-5-yl)amino]-N-(benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamide	Ki	670.0 [1]
	2-[(1-Aminoisoquinolin-6-yl)amino]-2-(3-ethoxy-4-propan-2-yloxyphenyl)-N-(3-hydroxyphenyl)sulfonylacetamide	Ki	26.0 [1]
	(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-3-(ethylamino)-8,8-dimethyl-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamide	Ki	19.0 [1]
	(6S)-3-(Tert-butylamino)-N-[(4-carbamimidoylphenyl)methyl]-1-chloro-8,8-dimethyl-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamide	Ki	68.0 [1]
	N-(Benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)-2-(isoquinolin-6-ylamino)acetamide	Ki	70.0 [1]
	2-[(1-Aminoisoquinolin-6-yl)amino]-N-(3-aminophenyl)sulfonyl-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamide	Ki	48.0 [1]
	3-[[2-[(1-Aminoisoquinolin-6-yl)amino]-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetyl]sulfamoyl]benzamide	Ki	18.0 [1]
	2-(2-Fluorophenyl)pyrido[2,3-d][1,3]oxazin-4-one	IC50	2800.0 [1]
	2-(2-Fluorophenyl)pyrazino[2,3-d][1,3]oxazin-4-one	IC50	200000.0 [1]
	(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-8,8-dimethyl-3-[(5-methylfuran-2-yl)methylamino]-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamide	Ki	190.0 [1]
	2-[(4-Aminoquinazolin-7-yl)amino]-N-(benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamide	Ki	390.0 [1]
	2-[5-(5-Carbamimidoyl-1H-indol-2-yl)-6-hydroxy-3'-nitro-biphenyl-3-yl]-succinic acid	Ki	1.0 [1]
	(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-3-(cyclopropylamino)-8,8-dimethyl-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamide	Ki	37.0 [1]
	2-[(3-Amino-1H-indazol-6-yl)amino]-N-(benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamide	Ki	2900.0 [1]
	2-[(1-Aminoisoquinolin-6-yl)amino]-2-(3-ethoxy-4-propan-2-yloxyphenyl)-N-(4-hydroxyphenyl)sulfonylacetamide	Ki	7.0 [1]
	(6S)-N-[(4-Carbamimidoylphenyl)methyl]-4-oxo-3-(propylamino)-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carboxamide	Ki	186.0 [1]
	2-Hydroxy-3-(5-amidino-1H-indole-2-yl)-3'-aminobiphenyl-5-acetic acid	Ki	12.0 [1]
	(6S)-N-[(4-Carbamimidoylphenyl)methyl]-8,8-diethyl-4-oxo-3-(propylamino)-6,7-dihydropyrrolo[1,2-a]pyrimidine-6-carboxamide	Ki	75.0 [1]
	2-[(1-Aminoisoquinolin-6-yl)amino]-N-benzyl-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamide	Ki	930.0 [1]
	2-[(1-Aminoisoquinolin-6-yl)amino]-N-(benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamide	Ki	16.0 [1]
	(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-8,8-dimethyl-4-oxo-3-(propan-2-ylamino)-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamide	Ki	17.0 [1]
	2-[(1-Aminoisoquinolin-6-yl)amino]-2-(3-ethoxy-4-propan-2-yloxyphenyl)-N-(4-methylphenyl)sulfonylacetamide	Ki	197.0 [1]
	2-Hydroxy-3-(5-amidino-1H-indole-2-yl)biphenyl-5-acetic acid	Ki	41.0 [1]
	(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-3-[[1-(hydroxymethyl)cyclopentyl]amino]-8,8-dimethyl-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamide	Ki	70.0 [1]
	2-(2,6-Difluoro-phenyl)-7-nitro-benzo[d][1,3]oxazin-4-one	IC50	820.0 [1]
	(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-8,8-dimethyl-3-(methylamino)-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamide	Ki	24.0 [1]
	H-D-Pro-Phe-Arg-chloromethylketone	IC50	1500.0 [1]
	(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-3-(cyclobutylamino)-4-oxo-8,8-dipropyl-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamide	Ki	28.0 [1]
	2-[(3-Amino-1,2-benzoxazol-6-yl)amino]-N-(benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamide	Ki	1940.0 [1]
	2-[(1-Aminoisoquinolin-6-yl)amino]-N-(4-aminophenyl)sulfonyl-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamide	Ki	9.0 [1]
	(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-8,8-dimethyl-3-(2-methylpropylamino)-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamide	Ki	43.0 [1]
	(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-3-(cyclobutylamino)-8,8-dimethyl-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamide	Ki	23.0 [1]
	2-[(8Z,11Z)-Heptadeca-8,11-dienyl]-6-hydroxybenzoic acid	IC50	33000.0 [1]
	N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-3-(2-methoxyethylamino)-2-oxo-6-phenylpyrazin-1-yl]acetamide	IC50	880.0 [1]
	N-[(4-Carbamimidoylphenyl)methyl]-2-[3-chloro-2-[3-(methylamino)phenyl]-6-oxo-5-(2-phenylethylamino)pyrazin-1-yl]acetamide	IC50	600.0 [1]
	N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-2-oxo-6-phenyl-3-[2-[3-(trifluoromethyl)phenyl]ethylamino]pyrazin-1-yl]acetamide	IC50	30000.0 [1]
	N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-3-[2-(dimethylamino)ethylamino]-2-oxo-6-phenylpyrazin-1-yl]acetamide	IC50	20900.0 [1]
	2-[5-Chloro-2-oxo-6-phenyl-3-(2-phenylethylamino)pyrazin-1-yl]-N-(2-pyridin-4-ylethyl)acetamide	IC50	100000.0 [1]
	N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-3-(2-hydroxyethylamino)-2-oxo-6-phenylpyrazin-1-yl]acetamide	IC50	500.0 [1]
	N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-3-(cyclohexylamino)-2-oxo-6-phenylpyrazin-1-yl]acetamide	IC50	1400.0 [1]
	N-(1H-Benzimidazol-2-ylmethyl)-2-[5-chloro-2-oxo-6-phenyl-3-(2-phenylethylamino)pyrazin-1-yl]acetamide	IC50	100000.0 [1]
	N-[(4-Carbamimidoylphenyl)methyl]-2-[3-chloro-2-[3-(methanesulfonamido)phenyl]-6-oxo-5-(2-phenylethylamino)pyrazin-1-yl]acetamide	IC50	600.0 [1]
	3-[1-[2-[(4-Carbamimidoylphenyl)methylamino]-2-oxoethyl]-3-chloro-6-oxo-5-(propan-2-ylamino)pyrazin-2-yl]benzoic acid	IC50	360.0 [1]
	N-[(4-Carbamimidoylphenyl)methyl]-2-[3-chloro-2-methyl-6-oxo-5-(2-phenylethylamino)pyrazin-1-yl]acetamide	IC50	4280.0 [1]
	N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-2-oxo-3-(2-phenylethylamino)-6-[2-(trifluoromethyl)phenyl]pyrazin-1-yl]acetamide	IC50	2700.0 [1]
	N-[(3-Carbamimidoylphenyl)methyl]-2-[2-oxo-6-phenyl-3-(2-phenylethylamino)pyrazin-1-yl]acetamide	IC50	30000.0 [1]
	N-[(4-Carbamimidoylphenyl)methyl]-2-[3-chloro-5-(cyclobutylamino)-2-(3-hydroxyphenyl)-6-oxopyrazin-1-yl]acetamide	IC50	200.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Coagulation factor VII/tissue factor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/coagulation-factor-vii-tissue-factor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Coagulation factor VII/tissue factor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/coagulation-factor-vii-tissue-factor-inhibitors-ic50-ki.
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