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Complement factor B Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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CompstatinIC503400.0 [1], 12000.0 [2]
(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-4-methylpentanamideIC5019000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC50600.0 [1], 50000.0 [2]
2-[2-(5-Methoxy-7-methyl-1H-indol-4-yl)propan-2-yl]-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC5030.0 [1], 40.0 [2]
(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-4-methylpentanamideIC5019000.0 [1]
Ac-RLTbaLAR-HIC50250.0 [1]
4-[(1R)-3-[4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-1-(ethylamino)-3-oxopropyl]benzonitrileIC501.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-formamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4,4-dimethylpentanamideIC50250.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5019000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5023000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-fluorophenyl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5013000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC504000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC505000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-cyclohexylbutanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC505000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5012000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC503000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC503000.0 [1]
(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC507000.0 [1]
2-[2,2,2-Trifluoro-1-(2-methoxy-4,6-dimethylphenyl)-1-(methylamino)ethyl]-3H-benzimidazole-5-carbonitrileIC5023.0 [1]
2-[1-Amino-2,2,2-trifluoro-1-(5-methoxy-7-methyl-1H-indol-4-yl)ethyl]-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC50140.0 [1]
2-[Hydroxy-(5-methoxy-7-methyl-1H-indol-4-yl)methyl]-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC50700.0 [1]
2-[1-Hydroxy-1-(5-methoxy-7-methyl-1H-indol-4-yl)ethyl]-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC50130.0 [1]
2-[2,2,2-Trifluoro-1-(5-methoxy-7-methyl-1H-indol-4-yl)-1-(methylamino)ethyl]-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC5030.0 [1]
2-[1-Amino-1-(5-methoxy-7-methyl-1H-indol-4-yl)ethyl]-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC501380.0 [1]
2-[1-(5-Methoxy-7-methyl-1H-indol-4-yl)-1-(methylamino)ethyl]-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC503135.0 [1]
2-[1-(5-Ethyl-7-methyl-1H-indol-4-yl)-2,2,2-trifluoro-1-hydroxyethyl]-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC50100.0 [1]
2-[1-(5-Ethyl-7-methyl-1H-indol-4-yl)-1-(methylamino)ethyl]-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC50540.0 [1]
2-[(5-Cyclopropyl-7-methyl-1H-indol-4-yl)-hydroxymethyl]-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC50460.0 [1]
2-[1-(5-Cyclopropyl-7-methyl-1H-indol-4-yl)-1-hydroxyethyl]-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC5060.0 [1]
2-[1-Amino-1-(5-cyclopropyl-7-methyl-1H-indol-4-yl)-2,2,2-trifluoroethyl]-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC5090.0 [1]
2-[1-Methoxy-1-(5-methoxy-7-methyl-1H-indol-4-yl)ethyl]-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC5030.0 [1]
Items per page: 1 - 10 of 31
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References

This online tool may be cited as follows

MLA

"Quest Database™ Complement factor B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/complement-factor-b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ Complement factor B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/complement-factor-b-inhibitors-ic50-ki.
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