Corticotropin releasing factor receptor 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine	IC50	4.0 [1], 50.0 [2]
	3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine	Ki	3.5 [1], 7.8 [2], 8.3 [3], 12.0 [4]
	Butyl-(2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo(2,3-d)pyrimidin-4-yl)ethylamine	IC50	11.0 [1], 15.85 [2]
	CID 9909468	IC50	39.81 [1], 82.0 [2]
	CID 9909468	Ki	1.7 [1], 1.8 [2], 2.0 [3]
	Antalarmin	IC50	18.62 [1]
	Antalarmin	Ki	0.84 [1], 2.51 [2], 3.1 [3], 32.0 [4]
	Nbi 27914	Ki	1.7 [1], 2.0 [2]
	3-(4-Methoxy-2-methylphenyl)-2,5-dimethyl-N-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-amine	IC50	10.0 [1]
	3-(4-Methoxy-2-methylphenyl)-2,5-dimethyl-N-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-amine	Ki	1.0 [1], 1.5 [2]
	Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-propyl-amine	IC50	5.0 [1], 16.0 [2]
	Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-propyl-amine	Ki	1.58 [1], 1.7 [2]
	Pexacerfont	IC50	4.5 [1], 6.1 [2], 340.0 [3], 10000.0 [4]
	Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-propyl-amine	IC50	29.0 [1]
	Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-propyl-amine	Ki	1.3 [1], 1.6 [2], 3.2 [3]
	8-(2,4-Dichlorophenyl)-2-methyl-N,N-dipropylquinolin-4-amine	IC50	17.0 [1]
	8-(2,4-Dichlorophenyl)-2-methyl-N,N-dipropylquinolin-4-amine	Ki	0.9 [1]
	3-[5-(Dimethylamino)-3-methylpyridin-2-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine	IC50	150.0 [1], 160.0 [2]
	3-[5-(Dimethylamino)-3-methylpyridin-2-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine	Ki	10.0 [1]
	2,5-Dimethyl-3-(3-methyl-5-nitropyridin-2-yl)-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine	IC50	180.0 [1]
	2,5-Dimethyl-3-(3-methyl-5-nitropyridin-2-yl)-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine	Ki	9.1 [1]
	N-Butyl-N-ethyl-1,5-dimethyl-3-(2,4-dichlorophenyl)-1H-pyrazolo[4,3-b]pyridine-7-amine	IC50	16.0 [1]
	N-Butyl-N-ethyl-1,5-dimethyl-3-(2,4-dichlorophenyl)-1H-pyrazolo[4,3-b]pyridine-7-amine	Ki	2.0 [1]
	1-(2-Methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipropylisoquinolin-4-amine	IC50	12.0 [1]
	1-(2-Methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipropylisoquinolin-4-amine	Ki	6.0 [1], 12.0 [2]
	2-[2,6-Dimethoxy-4-(methoxymethyl)phenyl]-3,8-dimethyl-N,N-dipropylquinolin-5-amine	IC50	70.0 [1], 88.0 [2]
	2-[2,6-Dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methylquinolin-5-amine	IC50	184.0 [1], 381.0 [2]
	3-Chloro-2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methylquinolin-5-amine	IC50	45.0 [1], 81.0 [2]
	2-[2,6-Dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-3-fluoro-8-methylquinolin-5-amine	IC50	131.0 [1], 144.0 [2]
	2-[2,6-Dimethoxy-4-(methoxymethyl)phenyl]-N-ethyl-N-(2-methoxyethyl)-3,8-dimethylquinolin-5-amine	IC50	23.0 [1], 109.0 [2]
	2-[2,6-Dimethoxy-4-(methoxymethyl)phenoxy]-3-methyl-N,N-dipropylquinolin-5-amine	IC50	138.0 [1], 163.0 [2]
	Dibutyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-amine	IC50	5.0 [1], 15.8 [2]
	Dibutyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-amine	Ki	0.62 [1]
	4-Chloro-2-(2,4-dichloro-6-methylphenoxy)-7-(1-ethylpropyl)-1-methyl-1H-benzimidazole	IC50	4.1 [1], 22.0 [2], 32.0 [3], 44.0 [4]
	4-(1-Ethyl-propoxy)-3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-pyridine	IC50	6.8 [1], 92.0 [2]
	4-(1-Ethyl-propoxy)-3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-pyridine	Ki	8.5 [1]
	3-(2,4-Dichlorophenyl)-9-heptan-4-yl-6-methyl-1,2,5,9-tetrazatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraene	Ki	4.0 [1], 4.5 [2], 5.01 [3]
	CID 44388660	IC50	0.9 [1]
	CID 44388660	Ki	0.8 [1]
	7-Chloro-2-N-(4-chloro-2-methoxy-6-methylphenyl)-4-N,4-N-diethyl-3-methylbenzimidazole-2,4-diamine	IC50	9.5 [1], 24.0 [2]
	2-N-(Cyclopropylmethyl)-6-methyl-2-N-propyl-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamine	Ki	57.0 [1]
	3-(2-Bromo-4-propan-2-ylphenyl)-N,N-bis(2-methoxyethyl)-5-methyltriazolo[4,5-d]pyrimidin-7-amine	Ki	3.7 [1]
	2-(4-Chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methyl-5-pentan-3-yloxypyrimidine	IC50	7.0 [1]
	2-(4-Chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methyl-5-pentan-3-yloxypyrimidine	Ki	9.0 [1]
	N-Butyl-N-ethyl-2,3,6-trimethyl-1-(2,4,6-trimethylphenyl)pyrrolo[2,3-b]pyridin-4-amine	IC50	16.0 [1]
	N-Butyl-N-ethyl-2,3,6-trimethyl-1-(2,4,6-trimethylphenyl)pyrrolo[2,3-b]pyridin-4-amine	Ki	2.6 [1]
	7-Chloro-2-N-(4-chloro-2-methoxy-6-methylphenyl)-3-methyl-4-N,4-N-dipropylbenzimidazole-2,4-diamine	IC50	9.5 [1], 88.0 [2]
	Pyrazolo(1,5-a)pyrimidin-7-amine, 3-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)-2,5-dimethyl-N-propyl-	IC50	76.0 [1]
	Pyrazolo(1,5-a)pyrimidin-7-amine, 3-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)-2,5-dimethyl-N-propyl-	Ki	3.4 [1]
	N-(2-Chloro-4,6-dimethylphenyl)-1-(1,3-dimethoxypropan-2-yl)-6-methyltriazolo[4,5-c]pyridin-4-amine;methanesulfonic acid	IC50	75.0 [1], 79.0 [2]
	N-(2-Chloro-4,6-dimethylphenyl)-1-(1,3-dimethoxypropan-2-yl)-6-methyltriazolo[4,5-c]pyridin-4-amine;methanesulfonic acid	Ki	3.3 [1]
	CP-154526 hydrochloride	Ki	1.6 [1], 2.7 [2]
	(10S)-9-(Cyclopropylmethyl)-3-(2,4-dichlorophenyl)-10-ethyl-6-methyl-1,2,5,9-tetrazatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraene	IC50	79.43 [1]
	(10S)-9-(Cyclopropylmethyl)-3-(2,4-dichlorophenyl)-10-ethyl-6-methyl-1,2,5,9-tetrazatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraene	Ki	3.16 [1]
	7,9,11,20,22,24-Hexahydroxy-13,16-dimethyloctacyclo[13.11.1.12,10.03,8.04,25.019,27.021,26.014,28]octacosa-1(27),2(28),3,6,8,10,12,14,16,19,21,23,25-tridecaene-5,18-dione	IC50	300.0 [1]
	4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine;hydrochloride	Ki	2.0 [1]
	3-(4-Chloro-2-morpholinothiazol-5-yl)-2,6-dimethyl-8-(pentan-3-yl)imidazo[1,2-b]pyridazine	Ki	0.2 [1]
	E-2508 Free base	IC50	23.0 [1], 50.0 [2]
	3-Methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-6-methyl-N-pentan-3-ylpyrazin-2-amine	IC50	93.0 [1]
	3-Methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-6-methyl-N-pentan-3-ylpyrazin-2-amine	Ki	1.0 [1]
	2-[Ethyl(2-bromo-4-isopropylphenyl)amino]-4-morpholino-6-methylpyrimidine	Ki	22.0 [1], 63.0 [2]
	N,N-Bis(2-methoxyethyl)-2,7-dimethyl-8-(4-(76Br)bromanyl-2-chlorophenyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine	Ki	2.0 [1]
	[3-(2,4-Dichloro-phenyl)-2,5-dimethyl-2H-pyrazolo[4,3-d]pyrimidin-7-yl]-dipropyl-amine	Ki	2.0 [1]
	N-Butyl-3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-N-(oxan-4-yl)pyrazolo[5,1-b][1,3]thiazol-7-amine	IC50	7.1 [1], 70.0 [2]
	4-N-(Cyclopropylmethyl)-2,5-dimethyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine	Ki	2.3 [1]
	[5-(2,4-Dichloro-phenyl)-1-methyl-1H-[1,2,4]triazol-3-yl]-dicyclopropylmethyl-propyl-amine	Ki	9.0 [1], 9.2 [2]
	(2-Bromo-4,6-dimethoxy-phenyl)-(4,6-dimethyl-pyrimidin-2-yl)-ethyl-amine	Ki	12.0 [1]
	5-Bromo-4-N-(cyclopropylmethyl)-2-methyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine	Ki	2.0 [1]
	[5-(2,4-Dichloro-phenyl)-1H-[1,2,4]triazol-3-yl]-dicyclopropylmethyl-propyl-amine	Ki	2400.0 [1], 4500.0 [2]
	9-(2-Bromo-4-propan-2-ylphenyl)-6-[butyl(ethyl)amino]-2,7-dimethylpurin-8-one	Ki	5.0 [1]
	4-(3,6-Dihydro-2H-pyridin-1-yl)-6-methyl-N-(2,4,6-trimethylphenyl)-1,3,5-triazin-2-amine	Ki	1050.0 [1]
	2-N-Benzyl-6-methyl-2-N-propyl-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamine	Ki	490.0 [1]
	2-N-Benzyl-2-N-butyl-6-methyl-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamine	Ki	1050.0 [1]
	N-(Cyclopropylmethyl)-5-ethyl-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine	Ki	3.8 [1]
	6-Methyl-2-N,2-N-bis(prop-2-enyl)-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamine	Ki	115.0 [1]
	4-N-(Cyclopropylmethyl)-2-methyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine	Ki	30.0 [1]
	2-N-Benzyl-2-N-ethyl-6-methyl-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamine	Ki	1470.0 [1]
	6-Methyl-N,N-dipropyl-N'-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamine	Ki	130.0 [1]
	2-[Ethyl(2-bromo-4-isopropylphenyl)amino]-4-(dipropylamino)-6-methylpyrimidine	Ki	9.0 [1]
	6-Methyl-4-N-[[4-(trifluoromethyl)phenyl]methyl]-2-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamine	Ki	1690.0 [1]
	2,5-Dimethyl-4-N,4-N-dipropyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine	Ki	2.5 [1]
	2-N-(Cyclopropylmethyl)-6-ethyl-2-N-propyl-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamine	Ki	10000.0 [1]
	2-N,2-N-Dibutyl-6-methyl-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamine	Ki	490.0 [1]
	N-(Cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trimethylphenyl)pyrimidine-4,6-diamine	Ki	1390.0 [1]
	3-(5-Amino-3-methylpyridin-2-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine	Ki	85.0 [1]
	[5-(2,4-Dichloro-phenyl)-2-methyl-2H-[1,2,4]triazol-3-yl]-dicyclopropylmethyl-propyl-amine	Ki	10000.0 [1]
	[5-(2,4-Dichloro-phenyl)-1-ethyl-1H-[1,2,4]triazol-3-yl]-dicyclopropylmethyl-propyl-amine	Ki	80.0 [1]
	[5-(4-Chloro-2-methoxy-phenyl)-1-methyl-1H-[1,2,4]triazol-3-yl]-dicyclopropylmethyl-propyl-amine	Ki	26.0 [1], 28.0 [2]
	[3-(2,4-Dimethoxy-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine	Ki	1.1 [1], 2.8 [2]
	N-Ethyl-N-propyl-2,5-dimethyl-3-(2,4-dichlorophenyl)-2H-pyrazolo[4,3-d]pyrimidine-7-amine	Ki	3.0 [1]
	3-(2,4-Dichlorophenyl)-N,N-bis(2-methoxyethyl)-2,5-dimethylpyrazolo[4,3-d]pyrimidin-7-amine	Ki	3.0 [1]
	Butyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-2H-pyrazolo[4,3-d]pyrimidin-7-yl]-ethyl-amine	Ki	2.0 [1]
	2-N,6-Dimethyl-2-N-(2-phenylethyl)-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamine	Ki	2100.0 [1]
	[5-(2,4-Dichloro-phenyl)-1-methyl-1H-[1,2,4]triazol-3-yl]-dipropyl-amine	Ki	2600.0 [1], 3400.0 [2]
	2-[Ethyl(2-bromo-4-isopropylphenyl)amino]-4-(butylethylamino)-6-methylpyrimidine	Ki	18.0 [1], 19.0 [2]
	CID 44593730	IC50	2.0 [1]
	N-(2-Methoxyethyl)-1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-N-propylpyrazolo[3,4-d]pyrimidin-4-amine	Ki	13.0 [1]
	2-[2,6-Dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-3,8-dimethylquinolin-5-amine	IC50	24.0 [1], 79.0 [2]
	Pyrazolo(1,5-a)pyrimidin-7-amine, N-butyl-3-(2,4-dichlorophenyl)-N-ethyl-2,5-dimethyl-	Ki	5.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 99 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Corticotropin releasing factor receptor 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/corticotropin-releasing-factor-receptor-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Corticotropin releasing factor receptor 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/corticotropin-releasing-factor-receptor-1-inhibitors-ic50-ki.
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