CREB-binding protein/Histone acetyltransferase p300 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Curcumin	IC50	25000.0 [1]
	N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[(3S)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]acetamide	IC50	121.0 [1], 760.0 [2]
	N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[(3S)-6-(methylcarbamoylamino)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamide	IC50	170.0 [1], 470.0 [2]
	N-Benzyl-N-[(1R)-1-cyclopropyl-2,2,2-trifluoroethyl]-2-[(3R)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]acetamide	IC50	32.0 [1], 45.0 [2]
	N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[(3R)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]acetamide	IC50	25.0 [1], 47.0 [2]
	1-[3-[4-(1-Methylpyrazol-4-yl)anilino]-1-[(3R)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	20.0 [1], 730.0 [2]
	3-[[5-Acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]amino]-N-propan-2-ylbenzamide	IC50	30.0 [1], 960.0 [2]
	1-[1-(Cyclopropylmethyl)-3-[3-(1-methylpyrazol-4-yl)anilino]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	20.0 [1], 340.0 [2]
	1-[1-(Cyclopropylmethyl)-3-(3-pyridin-3-ylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	30.0 [1], 500.0 [2]
	1-[1-(Cyclopropylmethyl)-3-(3-pyridin-4-ylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	20.0 [1], 280.0 [2]
	CID 121373027	IC50	20.0 [1], 430.0 [2]
	1-[1-Methyl-3-[4-(1-methylpyrazol-4-yl)anilino]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	40.0 [1], 980.0 [2]
	3-[[5-Acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]amino]-N-methylbenzamide	IC50	70.0 [1], 2000.0 [2]
	1-[1-(Cyclopropylmethyl)-3-(3-pyridin-2-ylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	30.0 [1], 560.0 [2]
	1-[1-(Cyclopropylmethyl)-3-[3-(1H-pyrazol-4-yl)anilino]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	30.0 [1], 330.0 [2]
	1-[1-(Cyclopropylmethyl)-3-[3-(1,2-oxazol-4-yl)anilino]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	30.0 [1], 540.0 [2]
	1-[1-(Cyclopropylmethyl)-3-[3-(2-methylpyrazol-3-yl)anilino]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	30.0 [1], 980.0 [2]
	CID 121373164	IC50	30.0 [1], 980.0 [2]
	1-[3-[4-(1-Methylpyrazol-4-yl)anilino]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	30.0 [1], 760.0 [2]
	3-[[5-Acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]amino]-N-ethylbenzamide	IC50	40.0 [1], 1500.0 [2]
	1-[1-(Cyclopropylmethyl)-3-(3-phenylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	10.0 [1], 2500.0 [2]
	3-[[5-Acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]amino]-N-propylbenzamide	IC50	30.0 [1], 1300.0 [2]
	1-[3-[4-(1-Methylpyrazol-4-yl)anilino]-1-(oxetan-3-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	40.0 [1], 1200.0 [2]
	N-Benzyl-2-[(3R)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide	IC50	60.0 [1], 101.0 [2]
	(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one	IC50	25000.0 [1]
	[[(3R)-4-[[3-[2-[2-[[(5S)-5-Acetamido-6-amino-6-oxohexyl]amino]-2-oxoethyl]sulfanylethylamino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methyl hydrogen phosphate	Ki	19.0 [1]
	(4r)-6-(1-Tert-Butyl-1h-Pyrazol-4-Yl)-4-Methyl-1,3,4,5-Tetrahydro-2h-1,5-Benzodiazepin-2-One	IC50	470.0 [1]
	(4r)-4-Methyl-1,3,4,5-tetrahydro-2h-1,5-benzodiazepin-2-one	IC50	14000.0 [1]
	1-(3-Phenylazanyl-1,4,6,7-Tetrahydropyrazolo[4,3-C]pyridin-5-Yl)ethanone	IC50	620.0 [1]
	2-(6-Acetamido-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl)-N-benzyl-N-(1-cyclopropylethyl)acetamide	IC50	780.0 [1]
	N-Benzyl-2-(7-cyano-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl)-N-(1-cyclopropylethyl)acetamide	IC50	27800.0 [1]
	1'-[2-[Benzyl(1-cyclopropylethyl)amino]-2-oxoethyl]-2',5'-dioxospiro[2,3-dihydroindene-1,4'-imidazolidine]-5-carboxamide	IC50	4860.0 [1]
	N-Benzyl-2-(6-cyclopropyl-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl)-N-(1-cyclopropylethyl)acetamide	IC50	1710.0 [1]
	N-Benzyl-2-(6-cyano-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl)-N-(1-cyclopropylethyl)acetamide	IC50	2500.0 [1]
	N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[6-(methylcarbamoylamino)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamide	IC50	240.0 [1]
	Methyl N-[1'-[2-[benzyl-[(1S)-1-cyclopropylethyl]amino]-2-oxoethyl]-2',5'-dioxospiro[2,3-dihydroindene-1,4'-imidazolidine]-5-yl]carbamate	IC50	1000.0 [1]
	N-Benzyl-N-(1-cyclopropylethyl)-2-(6-methoxy-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl)acetamide	IC50	1600.0 [1]
	N-Benzyl-N-(1-cyclopropylethyl)-2-[6-(hydroxymethyl)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamide	IC50	14000.0 [1]
	N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[6-(methanesulfonamido)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamide	IC50	16000.0 [1]
	1'-[2-[Benzyl(1-cyclopropylethyl)amino]-2-oxoethyl]-2',5'-dioxospiro[2,3-dihydroindene-1,4'-imidazolidine]-4-carboxamide	IC50	17900.0 [1]
	N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-(2,5-dioxo-4-phenylimidazolidin-1-yl)acetamide	IC50	7600.0 [1]
	N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[4-(2-methylphenyl)-2,5-dioxoimidazolidin-1-yl]acetamide	IC50	2700.0 [1]
	1-[3-(3-Methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	340.0 [1]
	Methyl 3-[(5-acetyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-3-yl)amino]benzoate	IC50	110.0 [1]
	1-[3-(3-Methylanilino)-1-(pyridin-2-ylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	90.0 [1]
	1-[3-(3-Methylanilino)-1-(pyridin-3-ylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	140.0 [1]
	1-[1-(Cyclopropylmethyl)-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	60.0 [1]
	1-[1-(2-Hydroxyethyl)-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	310.0 [1]
	1-[3-(3-Methylanilino)-1-(pyridin-4-ylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	200.0 [1]
	1-[1-Methyl-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	200.0 [1]
	1-[1-Benzyl-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	140.0 [1]
	3-[5-Acetyl-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propanenitrile	IC50	220.0 [1]
	3-[[5-Acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]amino]-N-(2-methoxyethyl)benzamide	IC50	4400.0 [1]
	1-[1-Cyclopropyl-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	150.0 [1]
	3-[[5-Acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]amino]-N,N-dimethylbenzamide	IC50	360.0 [1]
	1-[1-Ethyl-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	90.0 [1]
	1-[1-(2-Methoxyethyl)-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	230.0 [1]
	1-[3-[2-Fluoro-4-(1-methylpyrazol-4-yl)anilino]-1-[(3R)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	400.0 [1]
	1-[3-(3-Methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]propan-1-one	IC50	1400.0 [1]
	1-[1-(2-Cyclopropylethyl)-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	180.0 [1]
	1-[3-(3-Fluoroanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	430.0 [1]
	1-[3-(4-Methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	300.0 [1]
	1-[3-[3-(Trifluoromethyl)anilino]-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	100.0 [1]
	N-(3-Methylphenyl)-5-methylsulfonyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-3-amine	IC50	5000.0 [1]
	1-[3-[3-(Difluoromethoxy)anilino]-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	160.0 [1]
	Methyl 4-[(5-acetyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-3-yl)amino]benzoate	IC50	140.0 [1]
	1-[3-(3-Methoxyanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	340.0 [1]
	2,2,2-Trifluoro-1-[3-(3-methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	4300.0 [1]
	1-[3-(4-Fluoroanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	910.0 [1]
	1-[3-(4-Ethylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	250.0 [1]
	1-[3-(2-Methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	1200.0 [1]
	1-[3-(3-Ethylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	190.0 [1]
	1-[3-(3-Methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]butan-1-one	IC50	5000.0 [1]
	1-[3-(2-Fluoroanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	1400.0 [1]
	Cyclopropyl-[3-(3-methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]methanone	IC50	4100.0 [1]
	1-[3-(3-Methylanilino)-1-propyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	70.0 [1]
	Chembl4167931	IC50	1600.0 [1]
	N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[(3R)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamide	IC50	5060.0 [1]
	N-Benzyl-N-[(1R)-1-cyclopropylethyl]-2-[(3R)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamide	IC50	13000.0 [1]
	N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[(3S)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamide	IC50	510.0 [1]
	N-Benzyl-N-[(1R)-1-cyclopropylethyl]-2-[(3S)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamide	IC50	990.0 [1]
	Chembl4159813	IC50	5100.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 82 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ CREB-binding protein/Histone acetyltransferase p300 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/creb-binding-protein-histone-acetyltransferase-p300-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ CREB-binding protein/Histone acetyltransferase p300 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/creb-binding-protein-histone-acetyltransferase-p300-inhibitors-ic50-ki.
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