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CREB-binding protein Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Sgc-cbp30IC5064.0 [1], 79.0 [2], 80.0 [3], 125.0 [4], 2800.0 [5]
(3R)-N-[3-(7-Methoxy-3,4-dihydro-2H-quinolin-1-yl)propyl]-3-methyl-2-oxo-3,4-dihydro-1H-quinoxaline-5-carboxamideIC50323.0 [1], 580.0 [2], 10000.0 [3]
1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]propan-1-oneIC50170.0 [1], 440.0 [2], 10000.0 [3]
PF-Cbp1IC50130.0 [1], 190.0 [2], 10000.0 [3]
Tert-butyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetateIC509600.0 [1], 10000.0 [2]
IscheminIC505000.0 [1]
(4R)-4-Methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)indazol-5-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-oneIC5030.0 [1]
3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-N-methyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamideIC500.94 [1], 6.2 [2]
4-[2-[5-(3,5-Dimethyl-1,2-oxazol-4-yl)-2-[2-(4-methoxyphenyl)ethyl]-4,6-dimethylbenzimidazol-1-yl]ethyl]morpholineIC5010600.0 [1]
2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-oneIC502490.0 [1], 2500.0 [2]
1-[3-[2-Fluoro-4-(1-methylpyrazol-4-yl)anilino]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5020.0 [1], 410.0 [2]
1-[3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-piperidin-4-yl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC501.5 [1], 690.0 [2]
1-[3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-(1-methylpiperidin-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC502.0 [1], 98.0 [2]
1-[3-[7-Methyl-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC504.4 [1], 120.0 [2]
1-[3-[6-(1-Methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5016.0 [1], 320.0 [2]
3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamideIC501.0 [1], 28.0 [2]
1-[3-[7-Methoxy-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC504.7 [1], 140.0 [2]
1-[4-[5-Acetyl-3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]piperidin-1-yl]ethanoneIC501.0 [1], 53.0 [2]
1-[3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-(1,1-dioxothian-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC501.2 [1], 41.0 [2]
1-[3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC501.1 [1], 12.0 [2]
1-[1-Cyclohexyl-3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC503.1 [1], 45.0 [2]
1-[3-[7-Chloro-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC504.3 [1], 68.0 [2]
1-[3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-(1-methylsulfonylpiperidin-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC501.2 [1], 46.0 [2]
2-[(4-Chlorophenyl)methyl]-[1,2]thiazolo[5,4-b]pyridin-3-oneIC501950.0 [1]
1-[3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC501.4 [1], 37.0 [2]
1-[3-[6-(1-Methylpyrazol-4-yl)-7-(trifluoromethyl)-3,4-dihydro-2H-quinolin-1-yl]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC501.5 [1], 39.0 [2]
3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-N-ethyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamideIC5031.0 [1], 530.0 [2]
3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-N,N-dimethyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamideIC50310.0 [1], 3700.0 [2]
5-(3,5-Dimethyl-1,2-Oxazol-4-Yl)-1-[2-(Morpholin-4-Yl)ethyl]-2-(2-Phenylethyl)-1h-BenzimidazoleIC50240.0 [1], 160000.0 [2]
(4R)-4-(4-Chlorophenyl)-1-cyclopropyl-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-3-methyl-4H-pyrrolo[3,4-c]pyrazol-6-oneIC503700.0 [1], 37000.0 [2]
4-(3H-Benzimidazol-5-yl)-3,5-dimethyl-1,2-oxazoleIC503980.0 [1], 4000.0 [2]
4-(4-Chloro-2-fluorophenyl)-5-(1,5-dimethyl-6-oxopyridin-3-yl)-1-ethyl-3-methyl-4H-pyrrolo[3,4-c]pyrazol-6-oneIC50630.0 [1]
(4R)-4-(4-Chlorophenyl)-1-cyclopropyl-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-(hydroxymethyl)-4H-pyrrolo[3,4-c]pyrazol-6-oneIC501400.0 [1], 14000.0 [2]
CurcuminIC5025000.0 [1]
(-)-Epigallocatechin gallateIC5050000.0 [1]
1-Methyl-2-pyrrolidinoneIC502300000.0 [1]
(6S,9As)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-8-(naphthalen-1-ylmethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamideIC503000.0 [1]
ApabetaloneIC5010000.0 [1]
4-[(2s,4r)-1-Acetyl-4-[(4-Chlorophenyl)amino]-2-Methyl-1,2,3,4-Tetrahydroquinolin-6-Yl]benzoic AcidIC5031622.78 [1]
Methyl indole-3-carboxylateIC5099000.0 [1]
4-Methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-oneIC5032000.0 [1]
N-(4-Chlorophenyl)-2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetamideIC50440.0 [1]
Coumarin, 3-amino-4-(1-pyrrolidinyl)-IC5050000.0 [1]
4-[(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-pyridin-2-ylbenzenesulfonamideKi2180.0 [1]
1-(5-Hydroxynaphtho[1,2-b]furan-3-yl)ethanoneIC5041360.0 [1]
3-Methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-oneIC50200000.0 [1]
N-(9-Acetylcarbazol-3-yl)acetamideIC5050000.0 [1]
3-Methyl-3,4-Dihydroquinazolin-2(1h)-OneIC5029400.0 [1]
Coumarin, 3-amino-4-anilino-IC5050000.0 [1]
3,5 Dimethyl-4-Phenyl-1,2-OxazoleIC50200000.0 [1]
CID 122705990IC501710.0 [1]
6-Methyl-6,7-dihydro-9H-5-oxa-9-azabenzocyclohepten-8-oneIC5010000.0 [1]
2-Methyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-oneIC507000.0 [1]
1-[3-(3,5-Dimethyl-1,2-oxazol-4-yl)-5-ethoxyphenyl]ethanolIC5028100.0 [1]
2-(4-Chlorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-oneIC505280.0 [1]
4-[(2-Amino-3-chloro-4-hydroxy-5-methylphenyl)diazenyl]-N-pyridin-2-ylbenzenesulfonamideKi5590.0 [1]
4-Cyano-N-(1,3-diethyl-2-oxoquinolin-6-yl)benzenesulfonamideIC50100000.0 [1]
N,2-Dimethyl-5-(3-methyl[1,2,4]triazolo[3,4-a]phthalazin-6-yl)benzenesulfonamideIC501584.89 [1]
1,3,4,5-Tetrahydro-2H-1,5-benzodiazepin-2-oneIC50200000.0 [1]
5-Methyl-N-(1-methyl-2-oxo-3,4-dihydroquinolin-6-yl)thiophene-2-sulfonamideIC5023000.0 [1]
1-(4-Benzoyl-1-phenyl-1H-pyrazole-3-yl)ethanoneIC5050000.0 [1]
1-[5-(2-Methoxyethyl)-4-methylthiophen-2-yl]sulfonyl-3-[4-methoxy-6-(methylcarbamoylamino)pyridin-2-yl]ureaIC50270.0 [1]
3-(3,5-Dimethyl-1,2-Oxazol-4-Yl)-5-Ethoxybenzoic AcidIC5032200.0 [1]
CID 71624782IC502480.0 [1]
N-[3-(3-Methyl-4-Oxo-4,5,6,7-Tetrahydro-2h-Isoindol-1-Yl)-4-Phenoxyphenyl]methanesulfonamideIC501000.0 [1]
(4r)-4-Methyl-1,3,4,5-tetrahydro-2h-1,5-benzodiazepin-2-oneIC5027000.0 [1]
N-[5-(3-Methyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-2-morpholin-4-ylphenyl]methanesulfonamideIC50630.96 [1]
1-[2-(2,4-Difluorophenoxy)-5-methylsulfonylphenyl]-3-methyl-2,5,6,7-tetrahydropyrrolo[3,4-c]pyridin-4-oneIC501000.0 [1]
3-[(5-Acetyl-2-Ethoxyphenyl)carbamoyl]benzoic AcidIC508700.0 [1]
1-(3-Phenylazanyl-1,4,6,7-Tetrahydropyrazolo[4,3-C]pyridin-5-Yl)ethanoneIC50740.0 [1]
Butyrolactone 3IC50500000.0 [1]
3-Methyl-6-amino-2(3H)-benzothiazoloneIC50100000.0 [1]
3-{[3-(Ethoxycarbonyl)-6-(methoxycarbonyl)-4-quinolyl]amino}benzoic acidIC50230.0 [1]
1-Acetyl-N-(3-acetylphenyl)indole-3-carboxamideIC5025370.0 [1]
Methyl 3-[(1-acetylindole-3-carbonyl)amino]benzoateIC503390.0 [1]
Ethyl 3-(3-acetylindol-1-yl)propanoateIC5039550.0 [1]
3-[(5-Acetyl-2-ethoxyphenyl)carbamoyl]-5-(oxan-2-yloxymethyl)benzoic acidIC501000.0 [1]
2-[(5-Acetyl-2-ethoxyphenyl)carbamoyl]benzoic acidIC5064000.0 [1]
Methyl 3-[(5-acetyl-2-ethoxyphenyl)carbamoyl]benzoateIC505000.0 [1]
3-[(5-Acetyl-2-cyclopropylphenyl)carbamoyl]benzoic acidIC5015000.0 [1]
3-[(5-Acetyl-2-propoxyphenyl)carbamoyl]benzoic acidIC507400.0 [1]
3-[(5-Acetyl-2-ethoxyphenyl)carbamoyl]-5-(methoxymethyl)benzoic acidIC502000.0 [1]
3-[(5-Acetyl-2-ethoxyphenyl)carbamoyl]-5-(hydroxymethyl)benzoic acidIC503000.0 [1]
N-(5-Acetyl-2-ethoxyphenyl)-3-(tetrazol-1-yl)benzamideIC507500.0 [1]
3-[(5-Acetyl-2-ethoxyphenyl)carbamoyl]-5-pyridin-4-ylbenzoic acidIC503000.0 [1]
N-Methyl-7-pyrrolidin-2-ylpyrazolo[1,5-a]pyrimidine-3-carboxamideIC5032000.0 [1]
4-[2-[5-(3,5-Dimethyl-1,2-oxazol-4-yl)-2-[2-(4-methoxyphenyl)ethyl]benzimidazol-1-yl]ethyl]morpholineIC50120.0 [1]
(4r)-4-Methyl-7-[(1r)-1-Phenylethoxy]-1,3,4,5-Tetrahydro-2h-1,5-Benzodiazepin-2-OneIC504100.0 [1]
CID 121271742IC5077.0 [1]
CID 121271756IC50250.0 [1]
(4R)-6-(3-Cyclopropyl-1-methylindazol-5-yl)-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-oneIC5033.0 [1]
(2R)-2-Ethyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-oneIC50120000.0 [1]
(4R)-4-Methyl-6-[1-(1-phenylethyl)pyrazol-4-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-oneIC50160.0 [1]
(4R)-6-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-oneIC503.4 [1]
(4R)-4-Methyl-N-[3-(1,3-oxazol-5-yl)phenyl]-2-oxo-1,3,4,5-tetrahydro-1,5-benzodiazepine-6-carboxamideIC5039.0 [1]
(4R)-6-(3,4-Dimethoxyphenyl)-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-oneIC50130.0 [1]
(4r)-6-[3-(Benzyloxy)phenyl]-4-Methyl-1,3,4,5-Tetrahydro-2h-1,5-Benzodiazepin-2-OneIC50110.0 [1]
(4R)-4-Methyl-6-(1-methylindazol-5-yl)-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-oneIC50240.0 [1]
1-[3-Anilino-1-(cyclopropylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50150.0 [1]
1-[3-[7-(1-Methylpyrazol-4-yl)-2,3,4,5-tetrahydro-1-benzazepin-1-yl]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC501800.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ CREB-binding protein Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/creb-binding-protein-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ CREB-binding protein Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/creb-binding-protein-inhibitors-ic50-ki.
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