Cyclin-C/Cyclin-dependent kinase 19 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	8-(3-Chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one	IC50	6.0 [1]
	Senexin B	IC50	4.2 [1]
	[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(3-methoxyazetidin-1-yl)methanone	IC50	5.6 [1]
	8-[2-Azanyl-3-Chloranyl-5-(1-Methylindazol-5-Yl)pyridin-4-Yl]-2,8-Diazaspiro[4.5]decan-1-One	IC50	2.6 [1]
	8-[3-(3-Azanyl-2~{h}-Indazol-6-Yl)-5-Chloranyl-Pyridin-4-Yl]-2,8-Diazaspiro[4.5]decan-1-One	IC50	3.3 [1]
	8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one	IC50	1.8 [1]
	5-[5-Chloro-4-[1-(2-methoxyethyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxide	IC50	18.4 [1]
	8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-methyl-2,3,8-triazaspiro[4.5]dec-1-en-4-one	IC50	1.0 [1]
	8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one	IC50	8.4 [1]
	8-[3-Chloro-5-[4-[1-(2-hydroxyethyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	IC50	2.5 [1]
	8-[3-[4-(1-Methylpyrazol-4-yl)phenyl]-5-(trifluoromethyl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one	IC50	7.8 [1]
	8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	5.6 [1]
	8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2-methyl-1,3,8-triazaspiro[4.5]dec-1-en-4-one	IC50	4.8 [1]
	8-[3-Chloro-5-[4-[1-(2-hydroxy-2-methylpropyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	IC50	1.4 [1]
	8-[3-Fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	IC50	3.0 [1]
	8-[3-Chloro-5-[3-(methylamino)-1H-indazol-6-yl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	IC50	3.2 [1]
	[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-(3-methoxyazetidin-1-yl)methanone	IC50	18.8 [1]
	[(3R)-3-Hydroxypyrrolidin-1-yl]-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanone	IC50	4.0 [1]
	N-Methyl-3-[(1-methylindazol-5-yl)methyl]-2H-indazole-5-carboxamide	IC50	26.0 [1]
	8-Methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxylic acid	IC50	12.0 [1]
	8-Methoxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	2.8 [1]
	8-Pyridin-3-yloxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	2.7 [1]
	8-Methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	1.3 [1]
	8-Methylsulfonyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	110.0 [1]
	8-Methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carbonitrile	IC50	46.0 [1]
	8-Pyridin-2-yloxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	25.0 [1]
	8-Methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2,3]benzothiadiazole-6-carboxamide	IC50	130.0 [1]
	8-Phenoxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	0.55 [1]
	8-(6-Aminopyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	1.1 [1]
	Cdk8/19-IN-1	IC50	0.99 [1]
	8-Methylsulfinyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	150.0 [1]
	8-[6-[(2-Hydroxy-2-methylpropyl)carbamoyl]pyridin-3-yl]oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	2.4 [1]
	8-(2-Methylpyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	0.77 [1]
	8-[6-(Methylcarbamoyl)pyridin-3-yl]oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	1.0 [1]
	8-(2-Methyl-1-oxidopyridin-1-ium-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	9.3 [1]
	8-[6-(2-Methoxyethylcarbamoyl)-2-methylpyridin-3-yl]oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	1.3 [1]
	8-(4-Methylpyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	6.6 [1]
	8-Methylsulfanyl-N-(1,2-oxazol-3-yl)-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	15.0 [1]
	8-(6-Methylpyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	1.3 [1]
	N-Methyl-8-methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	22.0 [1]
	8-[6-(Methylamino)pyridin-3-yl]oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	0.36 [1]
	8-[6-(2-Ethoxyethylcarbamoyl)pyridin-3-yl]oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	1.9 [1]
	8-Methylsulfanyl-N-(1,2-thiazol-3-yl)-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	93.0 [1]
	8-(6-Acetamidopyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	0.57 [1]
	N,N-Dimethyl-8-methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	120.0 [1]
	8-(5-Methylpyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	9.2 [1]
	8-Methylsulfanyl-N-phenyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	700.0 [1]
	8-(6-Carbamoylpyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	0.97 [1]
	8-Methylsulfanyl-N-pyridin-2-yl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	400.0 [1]
	N-(1-Methylpyrazol-3-yl)-8-methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	65.0 [1]
	8-[6-(Dimethylcarbamoyl)pyridin-3-yl]oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide	IC50	21.0 [1]
	(E)-3-[4-(1-Cyclopropylpyrazol-4-yl)pyridin-3-yl]-N-[4-(morpholin-4-ylmethyl)phenyl]prop-2-enamide	IC50	7.6 [1]
	(E)-N-[4-(Morpholin-4-ylmethyl)phenyl]-3-[4-(1H-pyrazol-4-yl)pyridin-3-yl]prop-2-enamide	IC50	100.0 [1]
	3-[4-(1-Methylpyrazol-4-yl)pyridin-3-yl]-N-[4-(morpholin-4-ylmethyl)phenyl]propanamide	IC50	50.0 [1]
	(E)-3-[4-(1-Methylpyrazol-4-yl)pyridin-3-yl]-N-[4-(morpholin-4-ylmethyl)phenyl]prop-2-enamide	IC50	15.0 [1]
	3-[4-(1-Cyclopropylpyrazol-4-yl)pyridin-3-yl]-N-[4-(morpholin-4-ylmethyl)phenyl]propanamide	IC50	41.0 [1]
	8-[3-(1-Methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)-5-(trifluoromethyl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	IC50	1.9 [1]
	5-[5-Chloro-4-(1-methyl-1,8-diazaspiro[4.5]decan-8-yl)pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxide	IC50	22.7 [1]
	5-[5-Chloro-4-[1-(3-methoxypropyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxide	IC50	90.7 [1]
	8-[3-Chloro-5-(2,2-dioxo-1,3-dihydro-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	IC50	2.5 [1]
	8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	IC50	1.8 [1]
	8-[3-Chloro-5-[4-[1-(2-pyrrolidin-1-ylethyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	IC50	20.6 [1]
	8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one	IC50	7.5 [1]
	8-Methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzoxazole-6-carboxamide	IC50	71.0 [1]
	1-Methyl-8-methylsulfanyl-4,5-dihydrothieno[3,4-g]indazole-6-carboxamide	IC50	19.0 [1]
	8-Methylsulfanyl-4,5-dihydro-1H-thieno[3,4-g]indazole-6-carboxamide	IC50	3100.0 [1]
	Unii-6lgr0ryy5Q	IC50	10.0 [1]
	8-[2-Amino-3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dione	IC50	3.3 [1]
	8-[2-Amino-3-chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one	IC50	2.1 [1]
	8-[2-Amino-3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one	IC50	5.7 [1]
	8-[2-Amino-3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	IC50	3.5 [1]
	8-[2-Amino-3-chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	IC50	3.1 [1]
	8-[2-Amino-5-[4-(1-methylpyrazol-4-yl)phenyl]-3-(trifluoromethyl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one	IC50	9.5 [1]
	8-[2-Amino-3-fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	IC50	2.7 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 74 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Cyclin-C/Cyclin-dependent kinase 19 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/cyclin-c-cyclin-dependent-kinase-19-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Cyclin-C/Cyclin-dependent kinase 19 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-c-cyclin-dependent-kinase-19-inhibitors-ic50-ki.
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