Cyclin-dependent kinase 1/cyclin B Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Alvocidib	IC50	200.0 [1]
	Kenpaullone	IC50	400.0 [1]
	Staurosporine	IC50	2.52 [1], 3.2 [2], 6.0 [3], 12.0 [4], 30.0 [5]
	Olomoucine	IC50	7000.0 [1], 163000.0 [2]
	Seliciclib	IC50	450.0 [1], 650.0 [2]
	Alsterpaullone	IC50	34.99 [1], 35.0 [2]
	Purvalanol A	IC50	4.0 [1], 50.0 [2]
	7,12-Dihydro-9-(trifluoromethyl)indolo[3,2-d][1]benzazepine-6(5H)-one	IC50	399.94 [1], 400.0 [2]
	Paullone Analog 46	IC50	34994.52 [1], 35000.0 [2]
	Bisindolylmaleimide i	IC50	2300.0 [1], 19000.0 [2]
	Indirubin	IC50	6500.0 [1], 10000.0 [2]
	4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	IC50	10000.0 [1], 100000.0 [2]
	6-Bromoindirubin-3'-oxime	IC50	320.0 [1]
	Indirubin-3'-monoxime	IC50	18.0 [1], 180.0 [2]
	Purvalanol B	IC50	6.0 [1]
	1-Azakenpaullone	IC50	2000.0 [1]
	Hymenialdisine	IC50	22.0 [1]
	Arcyriaflavin a	IC50	1100.0 [1], 1130.0 [2]
	Paullone	IC50	6998.42 [1], 7000.0 [2]
	4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol	IC50	150.0 [1]
	Indirubin deriv. 8a	IC50	63000.0 [1]
	9H-Purin-6-amine, 9-(1-methylethyl)-N-(phenylmethyl)-	IC50	3600.0 [1], 113000.0 [2]
	9-Cyanopaullone	IC50	23.99 [1], 24.0 [2]
	9-Methyl-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one	IC50	1999.86 [1], 2000.0 [2]
	Paullone Analog 34	IC50	319.89 [1], 320.0 [2]
	Thieno analogue of kenpaullone	IC50	599.79 [1], 600.0 [2]
	3-Isopropyl-7-(2-hydroxybenzylamino)-1H-pyrazolo[4,3-d]pyrimidine	IC50	440.0 [1], 54000.0 [2]
	9-Chloro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one	IC50	599.79 [1], 600.0 [2]
	11-Chloro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one	IC50	1399.59 [1], 1400.0 [2]
	9-Fluoro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one	IC50	1599.56 [1], 1600.0 [2]
	9-Bromo-4-hydroxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5h)-one	IC50	39994.47 [1], 40000.0 [2]
	2,3-Dimethoxy-7,12-dihydro-9-bromoindolo[3,2-d][1]benzazepine-6(5H)-one	IC50	199.99 [1], 200.0 [2]
	4-Methoxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5h)-one	IC50	429536.43 [1], 430000.0 [2]
	9-Bromo-4-methoxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5h)-one	IC50	250000.0 [1], 250034.54 [2]
	2,3-Dimethoxy-7,12-dihydro-9-(trifluoromethyl)indolo[3,2-d][1]benzazepine-6(5H)-one	IC50	279.9 [1], 280.0 [2]
	8,10-Dichloro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5h)-one	IC50	2500.0 [1], 2500.35 [2]
	2-Amino-5-thio-substituted thiazole 25	IC50	40.0 [1]
	(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-phenylmethanone	IC50	150.0 [1]
	Paullone Analog 8	IC50	46.99 [1], 47.0 [2]
	Paullone Analog 22	IC50	6194.41 [1], 6200.0 [2]
	Paullone Analog 23	IC50	269.77 [1], 270.0 [2]
	Paullone Analog 32	IC50	4295.36 [1], 4300.0 [2]
	Paullone Analog 39	IC50	19998.62 [1], 20000.0 [2]
	6-Phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 37	IC50	850.0 [1]
	1-[6-(4-Methoxybenzylamino)-9-isopropyl-9H-purine-2-yl]-3-methyl-1-pentyne-3-ol	IC50	230.0 [1]
	C-2 Alkynylated purine deriv. 4e	IC50	60.0 [1]
	(9-Isopropyl-9H-purin-6-yl)-(4-methoxy-benzyl)-amine	IC50	3800.0 [1], 167000.0 [2]
	3-Isopropyl-7-(benzylamino)-1H-pyrazolo[4,3-d]pyrimidine	IC50	1200.0 [1], 66000.0 [2]
	3-Isopropyl-7-(3-hydroxybenzylamino)-1H-pyrazolo[4,3-d]pyrimidine	IC50	1700.0 [1], 88000.0 [2]
	3-Isopropyl-7-(3-chlorophenylamino)-1H-pyrazolo[4,3-d]pyrimidine	IC50	900.0 [1], 18400.0 [2]
	3-Isopropyl-7-(2-furanylmethylamino)-1H-pyrazolo[4,3-d]pyrimidine	IC50	2500.0 [1], 167000.0 [2]
	3-Isopropyl-7-(4-methoxybenzylamino)-1H-pyrazolo[4,3-d]pyrimidine	IC50	2300.0 [1], 46000.0 [2]
	3-Isopropyl-7-(3-hydroxy-4-methoxybenzylamino)-1H-pyrazolo[4,3-d]pyrimidine	IC50	1100.0 [1], 26000.0 [2]
	Furan-2-ylmethyl-(9-isopropyl-9H-purin-6-yl)-amine	IC50	9100.0 [1], 167000.0 [2]
	2,3-Dimethoxy-7,12-dihydro-9-cyanoindolo[3,2-d][1]benzazepine-6(5H)-one	IC50	43.95 [1], 44.0 [2]
	3-Isopropyl-7-(pentylamino)-1H-pyrazolo[4,3-d]pyrimidine	IC50	1200.0 [1], 61000.0 [2]
	(3-Chloro-phenyl)-(9-isopropyl-9H-purin-6-yl)-amine	IC50	5900.0 [1], 54000.0 [2]
	5-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-2-methoxy-phenol	IC50	4500.0 [1], 104000.0 [2]
	3-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-phenol	IC50	3100.0 [1], 167000.0 [2]
	2-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-phenol	IC50	4400.0 [1], 125000.0 [2]
	(9-Isopropyl-9H-purin-6-yl)-pentyl-amine	IC50	6900.0 [1], 144000.0 [2]
	(9-Isopropyl-9H-purin-6-yl)-(3-methyl-but-2-enyl)-amine	IC50	17000.0 [1], 167000.0 [2]
	N-(3-Methylbut-2-enyl)-3-propan-2-yl-2H-pyrazolo[4,3-d]pyrimidin-7-amine	IC50	4500.0 [1], 152000.0 [2]
	Paullone Analog 38	IC50	3198.9 [1], 3200.0 [2]
	Paullone Analog 41	IC50	699.84 [1], 700.0 [2]
	Paullone Analogue 55	IC50	699.84 [1], 700.0 [2]
	Paullone Analogue 57	IC50	599.79 [1], 600.0 [2]
	3-[[4-[4-[(3-Chlorophenyl)amino]-1,3,5-triazin-2-yl]-2-pyridinyl]amino]-1-Propanol	IC50	21.0 [1], 10000.0 [2]
	3-Isopropyl-7-(4-hydroxybenzylamino)-1H-pyrazolo[4,3-d]pyrimidine	IC50	1800.0 [1], 112000.0 [2]
	3-Isopropyl-7-(2-bromobenzylamino)-1H-pyrazolo[4,3-d]pyrimidine	IC50	11000.0 [1], 29000.0 [2]
	4-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-phenol	IC50	4000.0 [1], 167000.0 [2]
	(2-Bromo-benzyl)-(9-isopropyl-9H-purin-6-yl)-amine	IC50	23000.0 [1], 49000.0 [2]
	1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f	IC50	4.8 [1]
	Quercetin	IC50	75000.0 [1]
	Apigenin	IC50	4000.0 [1]
	Kaempferol	IC50	41000.0 [1]
	Luteolin	IC50	6200.0 [1]
	Harmine	IC50	18000.0 [1]
	Chrysin	IC50	7100.0 [1]
	Indigo	IC50	100000.0 [1]
	Fisetin	IC50	790.0 [1]
	Bisindolylmaleimide IV	IC50	18000.0 [1]
	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione	IC50	550.0 [1]
	Chir-99021	IC50	8800.0 [1]
	Silmitasertib	IC50	56.0 [1]
	3-(3-Chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	IC50	900.0 [1]
	2-Phenylindole	IC50	100000.0 [1]
	Sns-032	IC50	480.0 [1]
	(3Z)-3-(1H-Imidazol-5-ylmethylene)-5-methoxy-1H-indol-2(3H)-one	IC50	22.0 [1]
	4-({5-Amino-1-[(2,6-Difluorophenyl)carbonyl]-1h-1,2,4-Triazol-3-Yl}amino)benzenesulfonamide	IC50	6.0 [1]
	Bohemine	IC50	1100.0 [1]
	6-Cyclohexylmethyloxy-5-nitroso-pyrimidine-2,4-diamine	Ki	2500.0 [1]
	6-O-Cyclohexylmethyl guanine	IC50	7000.0 [1]
	O6-Cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	IC50	9.5 [1]
	4-Amino-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-7-Yl-Cyclopentane	IC50	50000.0 [1]
	Olomoucine II	IC50	20.0 [1]
	Aminopurvalanol A	IC50	35.0 [1]
	4-(1H-Indol-3-yl)pyrimidin-2-amine	IC50	150000.0 [1]
	Cdk4 Inhibitor	IC50	2100.0 [1]
	3-(2-Aminopyrimidin-4-yl)-1H-indol-4-ol	IC50	2500.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Cyclin-dependent kinase 1/cyclin B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-1-cyclin-b-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Cyclin-dependent kinase 1/cyclin B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-1-cyclin-b-inhibitors-ic50-ki.
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