Cyclin-dependent kinase 2/cyclin A Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Seliciclib	IC50	700.0 [1]
	Seliciclib	Ki	250.0 [1]
	Olomoucine	IC50	7000.0 [1], 10000.0 [2]
	Alvocidib	IC50	70.0 [1], 1500.0 [2]
	Alvocidib	Ki	190.0 [1]
	6-O-Cyclohexylmethyl guanine	IC50	17000.0 [1]
	6-O-Cyclohexylmethyl guanine	Ki	12000.0 [1]
	Harmine	IC50	30000.0 [1], 35000.0 [2]
	Kenpaullone	IC50	680.0 [1], 780.0 [2]
	Purvalanol A	IC50	30.0 [1], 70.0 [2]
	6-Cyclohexylmethyloxy-5-nitroso-pyrimidine-2,4-diamine	IC50	2200.0 [1]
	4-[(E)-(3,5-Diamino-1h-Pyrazol-4-Yl)diazenyl]phenol	IC50	69000.0 [1]
	4-[(E)-(3,5-Diamino-1h-Pyrazol-4-Yl)diazenyl]phenol	Ki	69000.0 [1]
	N-(3-Cyclopropyl-1H-pyrazol-5-YL)-2-(2-naphthyl)acetamide	IC50	37.0 [1]
	(2S)-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-oxopyrrolidin-1-yl)phenyl]propanamide	IC50	37.0 [1]
	8-Anilino-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	2.0 [1]
	8-Anilino-N,1-dimethyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	19.0 [1]
	3-[[5-Cyano-4-[4-Methyl-2-(Methylamino)-1,3-Thiazol-5-Yl]pyrimidin-2-Yl]amino]benzenesulfonamide	Ki	4.0 [1]
	(2S)-6-Amino-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]hexanamide	IC50	39.0 [1], 140.0 [2]
	4-[5-(Piperidin-1-ylmethyl)-4-(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)triazol-1-yl]-1,2,5-oxadiazol-3-amine	IC50	250000.0 [1]
	8-Anilino-1-methyl-N-phenyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	574.0 [1]
	9H-Purin-2-amine, 6-(3-cyclohexen-1-ylmethoxy)-	IC50	13000.0 [1], 19000.0 [2]
	Pyrido-[2,3-d]-pyrimidin-7-one 35	IC50	439.0 [1]
	6-Acetyl-8-cyclopentyl-5-methyl-2-(4-piperazin-1-yl-phenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	230.0 [1]
	2-N-(4-Aminocyclohexyl)-6-N-[(4-phenylphenyl)methyl]-9-propan-2-ylpurine-2,6-diamine	IC50	400.0 [1]
	3-Methyl-N-[3-(1-methylpyrazol-4-yl)-5-piperidin-3-ylpyrazolo[1,5-a]pyrimidin-7-yl]-1,2-thiazol-5-amine	IC50	40000.0 [1]
	1-Methyl-8-(2-methylanilino)-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	3.0 [1]
	4-(4-Methyl-2-(methylamino)thiazol-5-yl)-2-(3-nitrophenylamino)pyrimidine-5-carbonitrile	Ki	1.0 [1]
	8-(2-Methoxyanilino)-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	41.0 [1], 90.0 [2]
	1-Methyl-8-(2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	1762.0 [1], 10000.0 [2]
	Pyrido-[2,3-d]-pyrimidin-7-one 37	IC50	5000.0 [1]
	3-(1-Methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine	IC50	6100.0 [1]
	3-Bromo-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine	IC50	86.0 [1]
	2-[3-(1,4-Diazepan-1-yl)anilino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Ki	568.0 [1]
	N-Methyl-5-[2-(3-nitroanilino)pyrimidin-4-yl]-4-phenyl-1,3-thiazol-2-amine	Ki	5000.0 [1]
	Staurosporine	Ki	4.0 [1]
	Ellagic acid	IC50	3390.0 [1]
	5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole	Ki	65000.0 [1]
	Palbociclib	IC50	5000.0 [1]
	o6-Benzylguanine	IC50	35000.0 [1]
	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione	IC50	269.0 [1]
	Indazole	IC50	185000.0 [1]
	Doramapimod	IC50	30000.0 [1]
	3-(3-Chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	IC50	380.0 [1]
	Sotrastaurin	IC50	2300.0 [1]
	Purvalanol B	IC50	6.0 [1]
	2,3,4,6-Tetrahydroxy-5H-benzo[7]annulen-5-one	IC50	17000.0 [1]
	4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine	IC50	2380.0 [1]
	N3-(4-Fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine	Ki	10000.0 [1]
	6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine	IC50	160.0 [1]
	Hymenialdisine	IC50	70.0 [1]
	4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide	IC50	47.0 [1]
	4-({5-Amino-1-[(2,6-Difluorophenyl)carbonyl]-1h-1,2,4-Triazol-3-Yl}amino)benzenesulfonamide	IC50	2.0 [1]
	(16E)-14-Methyl-20-oxa-5,7,14,27-tetrazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(27),3,5,8,10,12(26),16,21,23-decaene	IC50	13.0 [1]
	O6-Cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	IC50	5.4 [1]
	Paullone	IC50	2700.0 [1]
	4-[(7-Hydroxy-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-yl)methylideneamino]-N-pyridin-2-ylbenzenesulfonamide	IC50	10.0 [1]
	Pha-793887	IC50	8.0 [1]
	Leucettine L41	IC50	30000.0 [1]
	Aigialomycin D	IC50	21000.0 [1]
	CID 44556162	IC50	10000.0 [1]
	4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol	IC50	120.0 [1]
	3-(2-Aminopyrimidin-4-yl)-1H-indol-4-ol	IC50	3100.0 [1]
	JNK Inhibitor V	IC50	1400.0 [1]
	6-Butoxy-9H-purin-2-amine	IC50	48000.0 [1]
	Cdk1/2 Inhibitor III	IC50	0.5 [1]
	Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate	IC50	71000.0 [1]
	Nms-P937 (nms1286937)	IC50	10000.0 [1]
	Leucettamine B	IC50	10000.0 [1]
	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	IC50	8200.0 [1]
	CID 71561915	Ki	3.0 [1]
	1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one	IC50	7000.0 [1]
	1-[2-(2,6-Dichlorobenzyl)-4-thiazolyl]-3-morpholinourea	IC50	10000.0 [1]
	2-Chloro-5-[4-(3-chloro-phenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-ylamino]-benzoic acid	IC50	10000.0 [1]
	4-(4-Methoxy-1h-Pyrrolo[2,3-B]pyridin-3-Yl)pyrimidin-2-Amine	IC50	11.0 [1]
	3-{[(Z)-(2-Oxo-1,2-dihydro-3H-indol-3-ylidene)-methyl]amino}benzenesulfonamide	IC50	10000.0 [1]
	3,4-Dichloro-N-[2-(2-chlorophenyl)-5-hydroxy-4-oxochromen-8-yl]benzamide	IC50	217000.0 [1]
	2,4-Pyrimidinediamine, 5-nitroso-6-(phenylmethoxy)-	IC50	27000.0 [1]
	3,5-Diamino-4-phenylazopyrazole	IC50	100000.0 [1]
	8-[2-Methoxy-5-(4-methylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	355.0 [1]
	N'-(Pyrrolidino[2,1-B]isoindolin-4-ON-8-YL)-N-(pyridin-2-YL)urea	IC50	78.0 [1]
	3,5-Dichloro-N-[2-(2-chlorophenyl)-5-hydroxy-4-oxochromen-8-yl]-2-hydroxybenzenesulfonamide	IC50	94000.0 [1]
	11-(2-Pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(24),2(27),3,5,8(26),9,11,16,21(25),22-decaene	IC50	3900.0 [1]
	2-(2-Amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one	IC50	219.0 [1]
	N-[2-(1H-Indol-3-yl)ethyl]-N-methyl-4-phenylbenzamide	IC50	521000.0 [1]
	4-(1H-Pyrrolo[2,3-B]pyridin-3-YL)pyrimidin-2-amine	IC50	90.0 [1]
	N-[4-[(2-Hydroxy-1H-indol-3-yl)methylideneamino]phenyl]methanesulfonamide	IC50	8000.0 [1]
	3-[[4-(1,2,4-Triazol-1-yl)phenyl]iminomethyl]-1H-indol-2-ol	IC50	7200.0 [1]
	2-Anilino-6-cyclohexylmethoxypurine	IC50	970.0 [1]
	O6-Allylguanine	IC50	78000.0 [1]
	5-(2-Aminopyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamide	IC50	2800.0 [1]
	9H-Purin-2-amine, 6-(2-propyn-1-yloxy)-	IC50	90000.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 68	IC50	14.0 [1]
	8-(2-Bicyclo[2.2.1]heptanyl)-2-[4-[4-(3-hydroxypropyl)piperidin-1-yl]anilino]pyrido[2,3-d]pyrimidin-7-one	IC50	209.0 [1]
	Purine, 2-amino-6-propoxy-	IC50	67000.0 [1]
	1H-Purin-2-amine, 6-(1-methylethoxy)-	IC50	75000.0 [1]
	(2R)-2-[[6-[(4-Phenylphenyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]butan-1-ol	IC50	2000.0 [1]
	{[(2,6-Difluorophenyl)carbonyl]amino}-N-piperidin-4-yl-1H-pyrazole-3-carboxamide	IC50	140.0 [1]
	(2Z)-3-[3-Bromo-5-[3-bromo-5-[(2Z)-3-[2-(3-bromo-4-hydroxyphenyl)ethylamino]-2-hydroxyimino-3-oxopropyl]-2-hydroxyphenyl]-4-hydroxyphenyl]-N-[2-(3-bromo-4-hydroxyphenyl)ethyl]-2-hydroxyiminopropanamide	IC50	1600.0 [1]
	5-Propan-2-yl-7,8-dihydro-6H-indeno[1,2-b]indole-9,10-dione	IC50	35000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Cyclin-dependent kinase 2/cyclin A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-2-cyclin-a-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Cyclin-dependent kinase 2/cyclin A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-2-cyclin-a-inhibitors-ic50-ki.
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