Cyclin-dependent kinase 2/cyclin E Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Alvocidib	IC50	170.0 [1]
	Olomoucine	IC50	7000.0 [1]
	Seliciclib	IC50	100.0 [1], 520.0 [2], 650.0 [3], 700.0 [4]
	Arcyriaflavin a	IC50	530.0 [1], 897.0 [2], 900.0 [3]
	Staurosporine	IC50	1.0 [1], 12.0 [2], 20.0 [3]
	4-[(E)-(3,5-Diamino-1h-Pyrazol-4-Yl)diazenyl]phenol	IC50	3500.0 [1], 20000.0 [2]
	4-[(E)-(3,5-Diamino-1h-Pyrazol-4-Yl)diazenyl]phenol	Ki	13300.0 [1]
	2-Amino-5-thio-substituted thiazole 25	IC50	5.0 [1], 5000.0 [2]
	6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one	IC50	1000.0 [1]
	Sns-032	IC50	48.0 [1], 48000.0 [2]
	3,5-Diamino-4-phenylazopyrazole	IC50	22000.0 [1], 100000.0 [2]
	Unii-09RR39UU4V	IC50	3.0 [1], 3000.0 [2]
	(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-phenylmethanone	IC50	110.0 [1]
	2-N-(4-Aminocyclohexyl)-6-N-[(4-phenylphenyl)methyl]-9-propan-2-ylpurine-2,6-diamine	IC50	100.0 [1]
	3-(4-Methoxyphenyl)-2H-indeno[1,2-c]pyrazol-4-one	IC50	26000.0 [1]
	Indenopyrazole 5g	IC50	270.0 [1]
	2-Amino-5-thio-substituted thiazole 31	IC50	26.0 [1], 26000.0 [2]
	Indenopyrazole 6a	IC50	38.0 [1]
	Indenopyrazole 6j	IC50	12.0 [1], 14.0 [2]
	Indolocarbazole deriv. 4b	IC50	140.0 [1], 144.0 [2]
	Indenopyrazole deriv. 5	IC50	80.0 [1], 240.0 [2]
	4-[(3-Nitrophenyl)hydrazono]-4H-pyrazole-3,5-diamine	IC50	23000.0 [1], 68000.0 [2]
	[2-[(3,5-Diamino-1H-pyrazol-4-yl)diazenyl]phenyl]methanol	IC50	17000.0 [1], 77000.0 [2]
	3-[(3,5-Diamino-1H-pyrazol-4-yl)diazenyl]phenol	IC50	6000.0 [1], 51000.0 [2]
	4-[(2-Nitrophenyl)diazenyl]-1H-pyrazole-3,5-diamine	IC50	6100.0 [1], 22000.0 [2]
	BMS-387032 analog 27	IC50	22000.0 [1], 150000.0 [2]
	Bisindolylmaleimide i	IC50	10180.0 [1]
	K252a	IC50	260.0 [1]
	Bisindolylmaleimide IV	IC50	11690.0 [1]
	Purvalanol B	IC50	9.0 [1]
	Purvalanol A	IC50	35.0 [1]
	Bms-754807	IC50	1035.0 [1]
	Cvt-313	IC50	500.0 [1]
	28-Oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-3,5-dione	IC50	680.0 [1]
	4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol	IC50	400.0 [1]
	Cdk4 Inhibitor	IC50	520.0 [1]
	Butyrolactonei	IC50	1500.0 [1]
	3-Amino-6-{4-[(4-Methylpiperazin-1-Yl)sulfonyl]phenyl}-N-Pyridin-3-Ylpyrazine-2-Carboxamide	Ki	540.0 [1]
	Bms-265246	IC50	9.0 [1]
	N-[4-[(4-Amino-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methyl]-1,3-thiazol-2-yl]acetamide	IC50	50.0 [1]
	N-(3-Cyclopropyl-1H-pyrazol-5-YL)-2-(2-naphthyl)acetamide	IC50	92.0 [1]
	(2S)-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-oxopyrrolidin-1-yl)phenyl]propanamide	IC50	55.0 [1]
	2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-chromen-4-one	IC50	90.0 [1]
	5-(2-Aminopyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamide	IC50	2700.0 [1]
	[4-(2-Amino-4-methyl-thiazol-5-YL)-pyrimidin-2-YL]-(3-nitro-phenyl)-amine	Ki	2.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 68	IC50	39.0 [1]
	8-(2-Bicyclo[2.2.1]heptanyl)-2-[4-[4-(3-hydroxypropyl)piperidin-1-yl]anilino]pyrido[2,3-d]pyrimidin-7-one	IC50	165.0 [1]
	(2R)-2-[[6-[(4-Phenylphenyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]butan-1-ol	IC50	600.0 [1]
	3-(4-Morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol;hydrochloride	IC50	28000.0 [1]
	N-(3-((2-Acetamidothiazol-4-yl)methyl)-5-(cyanomethylthio)-4H-1,2,4-triazol-4-yl)-4-chlorobenzamide	IC50	1140.0 [1]
	N-[3-[(2-Benzamido-1,3-thiazol-4-yl)methyl]-5-(cyanomethylsulfanyl)-1,2,4-triazol-4-yl]-4-chlorobenzamide	IC50	1340.0 [1]
	4-Chloro-N-[3-[[2-[(2-chloroacetyl)amino]-1,3-thiazol-4-yl]methyl]-5-(2-hydrazinyl-2-oxoethyl)sulfanyl-1,2,4-triazol-4-yl]benzamide	IC50	890.0 [1]
	N-[3-[(2-Acetamido-1,3-thiazol-4-yl)methyl]-5-(2-hydrazinyl-2-oxoethyl)sulfanyl-1,2,4-triazol-4-yl]-4-chlorobenzamide	IC50	624.0 [1]
	N-[3-[(2-Benzamido-1,3-thiazol-4-yl)methyl]-5-(2-hydrazinyl-2-oxoethyl)sulfanyl-1,2,4-triazol-4-yl]-4-chlorobenzamide	IC50	468.0 [1]
	3-[[4-[[4-[(4-Chlorobenzoyl)amino]-5-(2-hydrazinyl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]methyl]-1,3-thiazol-2-yl]amino]propanoic acid	IC50	6342.0 [1]
	N-[3-[2-[(2E)-2-Benzylidenehydrazinyl]-2-oxoethyl]sulfanyl-5-[[2-[(2-chloroacetyl)amino]-1,3-thiazol-4-yl]methyl]-1,2,4-triazol-4-yl]-4-chlorobenzamide	IC50	51.0 [1]
	N-[3-[(2-Acetamido-1,3-thiazol-4-yl)methyl]-5-[2-[(2E)-2-benzylidenehydrazinyl]-2-oxoethyl]sulfanyl-1,2,4-triazol-4-yl]-4-chlorobenzamide	IC50	512.0 [1]
	3-Methyl-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione	IC50	1000.0 [1]
	8-Ethyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	410.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 35	IC50	950.0 [1]
	3,13-Diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17,19,21,23-decaene-12,14-dione	IC50	275.0 [1]
	Meridianin E	IC50	1800.0 [1]
	2-N-(4-Aminocyclohexyl)-9-cyclopentyl-6-N-[(4-phenylphenyl)methyl]purine-2,6-diamine	IC50	90.0 [1]
	SQ-67563 Analog 21g	IC50	36.0 [1]
	Acylsemicarbazide deriv. 3aa	IC50	9.0 [1]
	5-(2-Chlorophenyl)-7-nitro-1,10-dihydropyrazolo[3,4-b][1,4]benzodiazepine	IC50	70.0 [1]
	pi-103 (Hydrochloride)	IC50	100000.0 [1]
	2-[trans-(4-Aminocyclohexyl)amino]-6-(benzyl-amino)-9-cyclopentylpurine	IC50	48.0 [1]
	6-Hydroxy-3-methoxy-4-phenylbenzo[4,3-b]pyridine	Ki	24000.0 [1]
	4-Phenyl-3-phenylmethoxy-[1]benzofuro[2,3-b]pyridin-6-ol	Ki	6400.0 [1]
	N-[5-Amino-1-[(4-methoxyphenyl)methyl]pyrazol-4-yl]-5-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-2-methylbenzamide	IC50	2.13 [1]
	1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-	IC50	1950.0 [1]
	1H-Pyrrole-2,5-dione, 3,4-bis(1-methyl-1H-indol-3-yl)-	IC50	580.0 [1]
	Flavopiridol analogue 19	IC50	3930.0 [1]
	Flavopiridol analogue 18	IC50	2110.0 [1]
	Flavopiridol analogue 22	IC50	6590.0 [1]
	Flavopiridol analogue 23	IC50	1070.0 [1]
	Flavopiridol analogue 24	IC50	40400.0 [1]
	Indenopyrazole 11k	IC50	18.0 [1]
	BMS-387032 analog 19	IC50	83000.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 23	IC50	1200.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 40	IC50	112.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 42	IC50	58.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 66	IC50	270.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 70	IC50	20.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 71	IC50	4550.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 37	IC50	5000.0 [1]
	2-Aminoquinazoline 31	IC50	5000.0 [1]
	Pyrido[2,3-d]pyrimidin-7-one 3	IC50	246.0 [1]
	Pyrido[2,3-d]pyrimidin-7-one 30	IC50	365.0 [1]
	Indolocarbazole deriv. 4c	IC50	200.0 [1]
	12,13-Dihydro-2,10-dimethoxy-5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione	IC50	1000.0 [1]
	Bis-indolylmaleimide deriv. 8j	IC50	1610.0 [1]
	Indolocarbazole deriv. 4j	IC50	60.0 [1]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3e	IC50	2860.0 [1]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3k	IC50	1070.0 [1]
	Indolocarbazole deriv. 12d	IC50	4.0 [1]
	Indolocarbazole deriv. 13a	IC50	972.0 [1]
	Indolocarbazole deriv. 13f	IC50	1060.0 [1]
	Carbazole deriv. 1	IC50	97000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Cyclin-dependent kinase 2/cyclin E Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-2-cyclin-e-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Cyclin-dependent kinase 2/cyclin E Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-2-cyclin-e-inhibitors-ic50-ki.
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