Cyclin-dependent kinase 2/cyclin E1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Seliciclib	IC50	170.0 [1]
	Imatinib	IC50	10000.0 [1], 100000.0 [2]
	Alvocidib	IC50	130.0 [1], 170.0 [2], 282.0 [3]
	Olomoucine	IC50	5000.0 [1], 7079.46 [2]
	Indirubin	IC50	2200.0 [1], 7500.0 [2]
	Fascaplysin	IC50	50000.0 [1], 250000.0 [2]
	Sns-032	IC50	48.0 [1]
	4-(2,4-Dimethyl-1,3-thiazol-5-YL)pyrimidin-2-amine	IC50	6456.54 [1]
	4-(2,4-Dimethyl-1,3-thiazol-5-YL)pyrimidin-2-amine	Ki	6500.0 [1]
	2-Aminoquinazoline 26	IC50	320.0 [1], 323.59 [2]
	2-Aminoquinazoline 8	IC50	2550.0 [1], 2570.4 [2]
	2-Aminoquinazoline 10	IC50	4365.16 [1], 4400.0 [2]
	2-Aminoquinazoline 20	IC50	250.0 [1], 251.19 [2]
	1'-(4-Fluorophenyl)-1'-hydroxy-6-(5-methyl-1H-pyrazol-4-yl)spiro[1,3-dihydrothieno[3,2-d]pyrimidine-2,4'-cyclohexane]-4-one	IC50	960.0 [1], 10000.0 [2]
	1'-Cyclohexyl-1'-hydroxy-6-(5-methyl-1H-pyrazol-4-yl)spiro[1,3-dihydrothieno[3,2-d]pyrimidine-2,4'-cyclohexane]-4-one	IC50	2200.0 [1], 10000.0 [2]
	6-(Benzimidazol-1-yl)-N-[5-[2-(dimethylamino)ethoxy]pyridin-2-yl]pyrimidin-4-amine	IC50	580.0 [1], 2800.0 [2]
	Staurosporine	IC50	1.88 [1]
	Lapatinib	IC50	20000.0 [1]
	Indigo	IC50	1000.0 [1]
	Palbociclib	IC50	9200.0 [1]
	6-Dimethylaminopurine	Ki	1096.48 [1]
	Dehydroabietic acid	IC50	36290.0 [1]
	Tyrphostin A23	Ki	616.6 [1]
	Abemaciclib	Ki	504.0 [1]
	Doramapimod	IC50	30000.0 [1]
	Indirubin-3'-monoxime	IC50	700.0 [1]
	Silmitasertib	IC50	1800.0 [1]
	Met Kinase Inhibitor	Ki	489.78 [1]
	Dinaciclib	IC50	2.0 [1]
	Hymenialdisine	IC50	40.0 [1]
	4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide	Ki	510.0 [1]
	RepSox	IC50	100000.0 [1]
	9H-Purine-2,6-diamine, N2-(2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-, cis-	IC50	17.0 [1]
	O6-Cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Ki	1.05 [1]
	Olomoucine II	IC50	50.0 [1]
	4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine	Ki	390.0 [1]
	Pha-793887	IC50	8.0 [1]
	BS-181	IC50	1800.0 [1]
	CID 23643976	IC50	2540.0 [1]
	Cdk4 Inhibitor	IC50	520.0 [1]
	RGB-286638 free base	IC50	2.0 [1]
	4-[(E)-(3,5-Diamino-1h-Pyrazol-4-Yl)diazenyl]phenol	IC50	20000.0 [1]
	Cdk2 Inhibitor II	Ki	107.15 [1]
	Nms-P937 (nms1286937)	IC50	10000.0 [1]
	(2S,3S)-3-((7-(Benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)butane-1,2,4-triol	IC50	3.0 [1]
	7-Butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine	Ki	0.52 [1]
	(3Z)-3-[(3E)-3-Hydroxyiminoindolin-2-ylidene]-5-nitro-indolin-2-one	IC50	7.35 [1]
	(2Z)-5'-Bromo-2,3'-biindole-2',3(1H,1'H)-dione ammoniate	IC50	1000.0 [1]
	(2R)-2-({9-(1-Methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol	IC50	62.0 [1]
	4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-5-indolyl]amino]-4-pyrimidinyl]amino]-1-cyclohexanol	IC50	50000.0 [1]
	(3Z)-3-[(3E)-3-(2,3-Dihydroxypropoxyimino)indolin-2-ylidene]indolin-2-one	IC50	210.0 [1]
	8-[2-Methoxy-5-(4-methylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	347.0 [1]
	Indirubin E804	IC50	230.0 [1]
	5-Methoxy-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol	IC50	54.0 [1]
	(2R)-2-{[4-(Benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol	IC50	43.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 68	IC50	38.9 [1]
	1-(Dimethylamino)-3-[4-[[4-(2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino]phenoxy]propan-2-ol	IC50	32.36 [1]
	(2R)-2-[[9-Propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]butan-1-ol	IC50	170.0 [1]
	Cyclapolin 9	IC50	100000.0 [1]
	3-Acetyl-6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b]pyridine	IC50	100000.0 [1]
	2-(4-Methylpiperazino)-6-(4-methoxybenzylamino)-9-isopropyl-9H-purine	IC50	890.0 [1]
	4,6-Bis anilino pyrimidine deriv. 6	IC50	95499.26 [1]
	Imidazo[1,2-a]pyridine deriv. 5	IC50	36.31 [1]
	5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1,3-dimethylpyrazolo[4,3-e][1,2,4]triazine	IC50	50000.0 [1]
	5-(2-Ethoxy-5-piperazin-1-ylsulfonylphenyl)-1,3-dimethylpyrazolo[4,3-e][1,2,4]triazine	IC50	50000.0 [1]
	4-[3-(1,3-Dimethylpyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxyphenyl]sulfonylmorpholine	IC50	50000.0 [1]
	5-(2-Ethoxy-5-piperidin-1-ylsulfonylphenyl)-1,3-dimethylpyrazolo[4,3-e][1,2,4]triazine	IC50	25000.0 [1]
	5-(2-Ethoxy-5-pyrrolidin-1-ylsulfonylphenyl)-1,3-dimethylpyrazolo[4,3-e][1,2,4]triazine	IC50	50000.0 [1]
	5-[5-(1,4-Diazepan-1-ylsulfonyl)-2-ethoxyphenyl]-1,3-dimethylpyrazolo[4,3-e][1,2,4]triazine	IC50	44300.0 [1]
	N-(2-Aminoethyl)-3-(1,3-dimethylpyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxybenzenesulfonamide	IC50	50000.0 [1]
	3-(1,3-Dimethylpyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxy-N-(2-morpholin-4-ylethyl)benzenesulfonamide	IC50	50000.0 [1]
	3-(1,3-Dimethylpyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxy-N-(2-hydroxyethyl)benzenesulfonamide	IC50	50000.0 [1]
	(2~{R},3~{S})-3-[[9-Propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-ol	IC50	30.0 [1]
	(2R)-2-[[9-Propan-2-yl-6-(pyridin-2-ylmethylamino)purin-2-yl]amino]butan-1-ol	IC50	60.0 [1]
	[4-(4-Methyl-2-methylamino-thiazol-5-yl)-pyrimidin-2-yl]-(4-piperazin-1-yl-phenyl)-amine	IC50	218.78 [1]
	2-N-(4-Aminocyclohexyl)-9-cyclopentyl-6-N-[(4-phenylphenyl)methyl]purine-2,6-diamine	IC50	26.0 [1]
	(2-Methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-(3-nitro-phenyl)-amine	Ki	23.0 [1]
	4-(6-Chlorobenzothiazol-2-yl)thiophene-2-sulfonamide	IC50	861.0 [1]
	4-(1,3-Benzothiazol-2-Yl)thiophene-2-Sulfonamide	IC50	4500.0 [1]
	3-(1,3-Dimethylpyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxy-N,N-diethylbenzenesulfonamide	IC50	50000.0 [1]
	Chembl4127271	IC50	279.6 [1]
	Chembl4126973	IC50	378.2 [1]
	Chembl4125887	IC50	313.5 [1]
	Chembl4129065	IC50	405.0 [1]
	Chembl4127110	IC50	276.5 [1]
	Ethyl 4-hydroxy-2-(4-pyridyl)-1,3-thiazole-5-carboxylate	IC50	125000.0 [1]
	(2R,3R,4S,5S,6R)-2-[2-[(E)-[2-(2-Hydroxy-5-methoxy-1H-indol-3-yl)indol-3-ylidene]amino]oxyethoxy]-6-(hydroxymethyl)oxane-3,4,5-triol	IC50	90.0 [1]
	(3E)-3-[(4-Hydroxyphenyl)methylidene]-1-[(3E)-3-[(4-hydroxyphenyl)methylidene]-2-oxo-3a,4-dihydrocyclopenta[b]indol-1-yl]cyclopenta[b]indol-2-one	Ki	371.54 [1]
	(17Z)-20-Oxa-5,7,13,27-tetrazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(27),3,5,8(26),9,11,17,21,23-decaen-14-one	IC50	2600.0 [1]
	(2R)-2-[[9-Propan-2-yl-6-(pyridin-4-ylmethylamino)purin-2-yl]amino]butan-1-ol	IC50	480.0 [1]
	2-(2,3-Dihydro-1-Benzofuran-5-Yl)-N-[2-(Piperazin-1-Yl)phenyl]-1,3-Thiazole-4-Carboxamide	IC50	210.0 [1]
	Ethyl 4-hydroxy-2-phenyl-1,3-thiazole-5-carboxylate	IC50	125000.0 [1]
	(2R)-2-[[6-(Benzylamino)-9-isopropyl-purin-2-yl]amino]butanoic acid	IC50	1300.0 [1]
	2-[trans-(4-Aminocyclohexyl)amino]-6-(benzyl-amino)-9-cyclopentylpurine	IC50	48.0 [1]
	6-Hydroxy-3-methoxy-4-phenylbenzo[4,3-b]pyridine	IC50	80000.0 [1]
	Ethyl 4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxylate	IC50	125000.0 [1]
	N-(5-Isopropyl-thiazol-2-yl)-isobutyramide	IC50	318.0 [1]
	N-(5-(2-(Cyclohexyloxy)pyrimidin-4-yl)thiazol-2-yl)pyridin-2-amine	IC50	14.13 [1]
	N-[4-(2-Methylimidazo[1,2-A]pyridin-3-YL)-2-pyrimidinyl]acetamide	IC50	2884.03 [1]
	N-[4-(2,4-Dimethyl-thiazol-5-YL)-pyrimidin-2-YL]-N',N'-dimethyl-benzene-1,4-diamine	IC50	220.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Cyclin-dependent kinase 2/cyclin E1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-2-cyclin-e1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Cyclin-dependent kinase 2/cyclin E1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-2-cyclin-e1-inhibitors-ic50-ki.
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