Cyclin-dependent kinase 4/cyclin D Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Alvocidib	IC50	100.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 68	IC50	7.0 [1], 9.0 [2]
	(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-phenylmethanone	IC50	25000.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 45	IC50	210.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 35	IC50	5.0 [1]
	6-Acetyl-8-cyclopentyl-5-methyl-2-(4-piperazin-1-yl-phenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	2.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 71	IC50	34.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 37	IC50	6.0 [1]
	Palbociclib	IC50	11.0 [1]
	Sns-032	IC50	925.0 [1]
	Bms-265246	IC50	230.0 [1]
	8-(2-Bicyclo[2.2.1]heptanyl)-2-[4-[4-(3-hydroxypropyl)piperidin-1-yl]anilino]pyrido[2,3-d]pyrimidin-7-one	IC50	8.0 [1]
	2-Amino-5-thio-substituted thiazole 25	IC50	690.0 [1]
	8-Ethyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	620.0 [1]
	8-Ethyl-2-(4-fluorophenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	1238.0 [1]
	SQ-67563 Analog 21g	IC50	690.0 [1]
	6-Bromo-8-cyclopentyl-2-(4-piperazin-1-ylanilino)pyrido[2,3-d]pyrimidin-7-one	IC50	2.0 [1]
	Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-ethyl-2-(ethylamino)-	IC50	11967.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 15	IC50	4325.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 16	IC50	5250.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 17	IC50	3300.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 18	IC50	40000.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 19	IC50	40000.0 [1]
	8-Ethyl-2-(3-fluorophenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	1400.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 22	IC50	1168.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 23	IC50	7833.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 24	IC50	40000.0 [1]
	8-Ethyl-2-(4-methoxyphenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	600.0 [1]
	8-Ethyl-2-(4-hydroxyphenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	585.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 27	IC50	4083.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 28	IC50	1825.0 [1]
	8-Ethyl-2-[4-(2-methoxyethoxy)phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	2333.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 30	IC50	160.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 32	IC50	2750.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 34	IC50	300.0 [1]
	8-Ethyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	85.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 38	IC50	5480.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 39	IC50	145.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 40	IC50	553.0 [1]
	8-Sec-Butyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	190.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 42	IC50	1495.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 43	IC50	297.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 44	IC50	159.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 46	IC50	47.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 47	IC50	182.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 49	IC50	1667.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 50	IC50	13500.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 51	IC50	940.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 52	IC50	4150.0 [1]
	8-(2-Methoxyethyl)-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	2860.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 54	IC50	7800.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 55	IC50	5000.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 56	IC50	31000.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 57	IC50	45.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 58	IC50	0.7 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 59	IC50	11.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 60	IC50	4.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 62	IC50	2100.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 63	IC50	1650.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 64	IC50	175.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 65	IC50	140.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 66	IC50	32.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 67	IC50	13.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 70	IC50	4.0 [1]
	2-Aminoquinazoline 31	IC50	14.0 [1]
	Pyrido[2,3-d]pyrimidin-7-one 3	IC50	10.0 [1]
	Pyrido[2,3-d]pyrimidin-7-one 30	IC50	5.0 [1]
	SQ-67563 Analog 21e	IC50	24000.0 [1]
	SQ-67563 Analog 21f	IC50	21000.0 [1]
	SQ-67563 Analog 21i	IC50	310.0 [1]
	SQ-67563 Analog 21j	IC50	370.0 [1]
	SQ-67563 Analog 21k	IC50	230.0 [1]
	4-(Isopentyloxy)-5-benzoyl-1H-pyrazolo[3,4-b]pyridine	IC50	25000.0 [1]
	5-[(5-Tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-N-pyridin-4-yl-1,3-thiazol-2-amine	IC50	30.0 [1]
	2-[4-[2-(Dimethylamino)ethoxy]anilino]-8-ethylpyrido[2,3-d]pyrimidin-7-one	IC50	330.0 [1]
	6-Butoxy-8-cyclopentyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one	IC50	1760.0 [1]
	6-Acetyl-8-cyclopentyl-2-[[5-(3,5-dimethylmorpholin-4-yl)pyridin-2-yl]amino]-5-methylpyrido[2,3-d]pyrimidin-7-one	IC50	30.0 [1]
	2-Aminothiazole 3	IC50	1090.0 [1]
	2-Aminothiazole 6	IC50	78.0 [1]
	2-Aminothiazole 7	IC50	9.0 [1]
	2-Aminothiazole 8	IC50	130.0 [1]
	3-[[6-[[5-[(5-Tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]amino]pyridin-3-yl]methylamino]-2,2-dimethylpropan-1-ol	IC50	26.0 [1]
	2-Aminothiazole 23	IC50	233.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 33	IC50	1400.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 35	IC50	300.0 [1]
	C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 36	IC50	900.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 48	IC50	38.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 61	IC50	450.0 [1]
	N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 69	IC50	6.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 18	IC50	5000.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 19	IC50	920.0 [1]
	8-Cyclopentyl-2-(pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	145.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 20	IC50	15.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 21	IC50	13.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 17	IC50	16.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 22	IC50	51.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 23	IC50	19.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 24	IC50	27.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 25	IC50	22.0 [1]
	Pyrido-[2,3-d]-pyrimidin-7-one 26	IC50	13.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Cyclin-dependent kinase 4/cyclin D Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-4-cyclin-d-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Cyclin-dependent kinase 4/cyclin D Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-4-cyclin-d-inhibitors-ic50-ki.
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