Cyclin-dependent kinase 4/cyclin D1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Palbociclib	IC50	10.0 [1]
	Palbociclib	Ki	3.0 [1]
	Alvocidib	IC50	150.0 [1]
	Staurosporine	IC50	6.6 [1], 18.3 [2], 20.3 [3], 59.0 [4]
	Abemaciclib	IC50	2.0 [1], 5.0 [2]
	Abemaciclib	Ki	0.6 [1], 2.0 [2]
	Arcyriaflavin a	IC50	140.0 [1], 160.0 [2], 163.0 [3]
	Seliciclib	IC50	13500.0 [1], 14210.0 [2], 27000.0 [3], 100000.0 [4]
	Fascaplysin	IC50	350.0 [1], 410.0 [2], 550.0 [3]
	4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide	IC50	67.0 [1], 200.0 [2]
	4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide	Ki	67.0 [1]
	N-[2-(1H-Indol-3-yl)ethyl]-N-methyl-4-phenylbenzamide	IC50	6000.0 [1], 6200.0 [2]
	6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one	IC50	830.0 [1]
	Olomoucine	IC50	1000000.0 [1]
	Purvalanol B	IC50	10000.0 [1]
	Purvalanol A	IC50	850.0 [1]
	Sns-032	IC50	925.0 [1]
	28-Oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-3,5-dione	IC50	540.0 [1]
	CID 23643976	IC50	63.0 [1]
	Cdk4 Inhibitor	IC50	76.0 [1]
	4-[(E)-(3,5-Diamino-1h-Pyrazol-4-Yl)diazenyl]phenol	IC50	13500.0 [1]
	CID 56649281	IC50	3.8 [1], 3.87 [2]
	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	IC50	9900.0 [1], 14000.0 [2]
	N-(2-(1H-Indol-3-yl)ethyl)-4-chloro-N-methylbenzamide	IC50	38000.0 [1]
	N-(2-(1H-Indol-3-yl)ethyl)-4-tert-butyl-N-methylbenzamide	IC50	49000.0 [1]
	3-(4-Methoxyphenyl)-2H-indeno[1,2-c]pyrazol-4-one	IC50	45000.0 [1]
	Indenopyrazole 5g	IC50	450.0 [1]
	Indenopyrazole 6a	IC50	480.0 [1]
	Indenopyrazole 6j	IC50	13.0 [1], 20.0 [2]
	2-Aminoquinazoline 31	IC50	7.0 [1], 14.0 [2]
	Indolocarbazole deriv. 4b	IC50	42.0 [1], 120.0 [2]
	Indolocarbazole deriv. 4c	IC50	74.0 [1], 110.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3e	IC50	136.0 [1], 171.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3k	IC50	393.0 [1], 407.0 [2]
	Indolocarbazole deriv. 12d	IC50	4.0 [1], 48.0 [2]
	Indolocarbazole deriv. 13a	IC50	13.0 [1], 47.0 [2]
	Indolocarbazole deriv. 13f	IC50	11.0 [1], 45.0 [2]
	Indenopyrazole deriv. 5	IC50	200.0 [1], 400.0 [2]
	N-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-4-(thieno[2,3-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide	IC50	3.33 [1], 10.0 [2]
	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoic acid	IC50	16100.0 [1], 25120.0 [2]
	Pyrazolo[3,4-d]pyrimidin-4-one deriv. 4w	IC50	2100.0 [1]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3a	IC50	22.0 [1], 36.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3b	IC50	22.0 [1], 47.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3c	IC50	19.0 [1], 59.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3d	IC50	71.0 [1], 81.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3f	IC50	155.0 [1], 216.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3h	IC50	39.0 [1], 84.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3l	IC50	519.0 [1], 680.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3m	IC50	11.0 [1], 38.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3n	IC50	13.0 [1], 38.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3o	IC50	9.0 [1], 76.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3p	IC50	11.0 [1], 29.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3q	IC50	18.0 [1], 48.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3r	IC50	22.0 [1], 101.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3s	IC50	17.0 [1], 37.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3t	IC50	9.0 [1], 33.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3u	IC50	36.0 [1], 67.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3v	IC50	6.0 [1], 53.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3w	IC50	10.0 [1], 44.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3x	IC50	187.0 [1], 378.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3y	IC50	25.0 [1], 123.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3aa	IC50	40.0 [1], 62.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3bb	IC50	75.0 [1], 82.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3cc	IC50	40.0 [1], 168.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3dd	IC50	2.0 [1], 28.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3ee	IC50	16.0 [1], 67.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3ff	IC50	18.0 [1], 32.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3hh	IC50	6.0 [1], 50.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3II	IC50	7.0 [1], 42.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3jj	IC50	25.0 [1], 92.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3kk	IC50	12.0 [1], 66.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3ll	IC50	42.0 [1], 96.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3mm	IC50	90.0 [1], 134.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3nn	IC50	24.0 [1], 47.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3oo	IC50	12.0 [1], 54.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3pp	IC50	45.0 [1], 92.0 [2]
	Indolo[6,7-a]pyrrolo[3,4-c]carbazole deriv. 3ss	IC50	346.0 [1], 448.0 [2]
	Indolocarbazole deriv. 11e	IC50	23.0 [1], 84.0 [2]
	Indolocarbazole deriv. 11f	IC50	33.0 [1], 135.0 [2]
	Indolocarbazole deriv. 11h	IC50	21.0 [1], 35.0 [2]
	Indolocarbazole deriv. 11m	IC50	23.0 [1], 63.0 [2]
	Indolocarbazole deriv. 12b	IC50	13.0 [1], 77.0 [2]
	Indolocarbazole deriv. 12g	IC50	14.0 [1], 95.0 [2]
	Indolocarbazole deriv. 12h	IC50	28.0 [1], 72.0 [2]
	Indolocarbazole deriv. 12j	IC50	21.0 [1], 69.0 [2]
	Indolocarbazole deriv. 12k	IC50	47.0 [1], 190.0 [2]
	Indolocarbazole deriv. 13b	IC50	5.0 [1], 51.0 [2]
	Indolocarbazole deriv. 13c	IC50	15.0 [1], 49.0 [2]
	Indolocarbazole deriv. 13d	IC50	8.0 [1], 45.0 [2]
	Indolocarbazole deriv. 13e	IC50	23.0 [1], 39.0 [2]
	Indolocarbazole deriv. 13h	IC50	10.0 [1], 33.0 [2]
	Indolocarbazole deriv. 13j	IC50	15.0 [1], 54.0 [2]
	Indolocarbazole deriv. 13k	IC50	24.0 [1], 82.0 [2]
	Indolocarbazole deriv. 13m	IC50	5.0 [1], 53.0 [2]
	Indolocarbazole deriv. 14g	IC50	35.0 [1], 52.0 [2]
	Indolocarbazole deriv. 14h	IC50	19.0 [1], 40.0 [2]
	Indolocarbazole deriv. 14j	IC50	43.0 [1], 56.0 [2]
	Indolocarbazole deriv. 14l	IC50	24.0 [1], 34.0 [2]
	Indolocarbazole deriv. 14m	IC50	19.0 [1], 49.0 [2]
	8-(4-Methylcyclohexyl)-N-(5-piperazin-1-ylpyridin-2-yl)-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amine	IC50	1.0 [1], 7.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Cyclin-dependent kinase 4/cyclin D1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-4-cyclin-d1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Cyclin-dependent kinase 4/cyclin D1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-4-cyclin-d1-inhibitors-ic50-ki.
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