Cyclin-dependent kinase 4/G1/S-specific cyclin-E1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Abemaciclib	IC50	2.0 [1]
	Cyc065	IC50	232.0 [1]
	N-[5-Fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]-6-(2-methoxyethyl)-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	3.2 [1]
	6-Ethyl-N-[5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	1.5 [1]
	6-(2-Fluoroethyl)-N-[5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	10.0 [1]
	1-[2-[[5-Fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]-2-hydroxyethanone	IC50	3.6 [1]
	6-Ethyl-N-[6-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-4-yl]-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	8.4 [1]
	1-[2-[[5-Fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]propan-2-ol	IC50	2.1 [1]
	N-[4-(3-Cyclopentyl-7-fluoro-2-methylbenzimidazol-5-yl)-5-fluoropyrimidin-2-yl]-6-ethyl-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	6.7 [1]
	1-[2-[[5-Fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]-2-(4-methylpiperazin-1-yl)ethanone	IC50	1.6 [1]
	6-Ethyl-N-[4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyridin-2-yl]-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	9.8 [1]
	6-(1-Ethylpiperidin-4-yl)-N-[5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	1.4 [1]
	N-[4-(3-Cyclohexyl-7-fluoro-2-methylbenzimidazol-5-yl)-5-fluoropyrimidin-2-yl]-6-ethyl-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	8.4 [1]
	N-[4-(3-Cyclobutyl-7-fluoro-2-methylbenzimidazol-5-yl)-5-fluoropyrimidin-2-yl]-6-ethyl-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	7.8 [1]
	N-[5-Fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]-6-(1-propan-2-ylpiperidin-4-yl)-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	2.3 [1]
	N-[5-Fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]-6-(1-methylpiperidin-4-yl)-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	1.5 [1]
	6-Ethyl-N-[5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyridin-2-yl]-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	2.8 [1]
	6-[(1-Ethylpiperidin-4-yl)methyl]-N-[5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	3.1 [1]
	1-[2-[[5-Fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]-2-pyrrolidin-1-ylpropan-1-one	IC50	1.0 [1]
	2-(Dimethylamino)-1-[2-[[5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]ethanone	IC50	2.2 [1]
	1-[2-[[5-Fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]-2-hydroxypropan-1-one	IC50	5.2 [1]
	2-Ethyl-N-[5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]-3,4-dihydro-1H-isoquinolin-6-amine	IC50	1.4 [1]
	N-[5-Fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]-6-[1-(2-methoxyethyl)piperidin-4-yl]-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	1.8 [1]
	6-[1-(Cyclopropylmethyl)piperidin-4-yl]-N-[5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	2.1 [1]
	1-[4-[2-[[5-Fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]piperidin-1-yl]-2-methylpropan-2-ol	IC50	1.2 [1]
	N-[4-(3-Butan-2-yl-7-fluoro-2-methylbenzimidazol-5-yl)-5-fluoropyrimidin-2-yl]-6-ethyl-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	2.0 [1]
	6-Ethyl-N-[5-fluoro-4-[7-fluoro-2-methyl-3-(oxolan-3-yl)benzimidazol-5-yl]pyrimidin-2-yl]-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	16.8 [1]
	6-Ethyl-N-[5-fluoro-4-[7-fluoro-2-methyl-3-(2-methylpropyl)benzimidazol-5-yl]pyrimidin-2-yl]-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	6.4 [1]
	N-[4-[3-(Cyclopropylmethyl)-7-fluoro-2-methylbenzimidazol-5-yl]-5-fluoropyrimidin-2-yl]-6-ethyl-7,8-dihydro-5H-1,6-naphthyridin-2-amine	IC50	3.8 [1]
	N-[[5-[3-(4,6-Difluoro-1H-benzimidazol-2-yl)-1H-indazol-4-yl]-4-methylpyridin-3-yl]methyl]ethanamine	IC50	1.0 [1]
	[2-[[5-Fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]-(1-methylpiperidin-4-yl)methanone	IC50	2.5 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 31 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Cyclin-dependent kinase 4/G1/S-specific cyclin-E1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-4-g1-s-specific-cyclin-e1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Cyclin-dependent kinase 4/G1/S-specific cyclin-E1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-4-g1-s-specific-cyclin-e1-inhibitors-ic50-ki.
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