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Cyclin-dependent kinase 6 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
PalbociclibIC5016.0 [1], 21.0 [2]
AbemaciclibIC501.9 [1], 7.8 [2], 10.0 [3]
QuercetinIC5025000.0 [1]
ApigeninIC501700.0 [1]
KaempferolIC5022000.0 [1]
LuteolinIC50300000.0 [1]
AlvocidibIC5080.0 [1]
ChrysinIC506000.0 [1]
FisetinIC50850.0 [1]
RibociclibIC506.0 [1], 39.0 [2]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC5012.0 [1]
FascaplysinIC503400.0 [1]
SulfuretinIC502440.0 [1]
4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-5-indolyl]amino]-4-pyrimidinyl]amino]-1-cyclohexanolIC505600.0 [1]
N'-(Pyrrolidino[2,1-B]isoindolin-4-ON-8-YL)-N-(pyridin-2-YL)ureaIC5071.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi1549.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
2-Bromo-N-(2,5-dichlorothiophen-3-yl)sulfonyl-N-phenylacetamideIC5020000.0 [1]
N-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-4-(thieno[2,3-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamideIC503.33 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydropyrrolo[1,2-a]benzimidazol-7-yl)pyrimidin-2-amineIC500.9 [1]
5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydropyrrolo[1,2-a]benzimidazol-7-yl)-N-[5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl]pyrimidin-2-amineIC504.0 [1]
5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydropyrrolo[1,2-a]benzimidazol-7-yl)-N-[5-(piperazin-1-ylmethyl)pyridin-2-yl]pyrimidin-2-amineIC503.7 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(5-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-7-yl)pyrimidin-2-amineIC50244.1 [1]
6-(7-Fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)-N-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]pyrazin-2-yl]pyrimidin-4-amineIC502.3 [1]
N-[5-[(1-Ethylpiperidin-4-yl)methyl]pyrazin-2-yl]-6-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-4-amineIC502.9 [1]
5-[(4-Ethylpiperazin-1-yl)methyl]-N-[4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyridin-2-yl]pyridin-2-amineIC502.9 [1]
5-[(4-Ethylpiperazin-1-yl)methyl]-N-[4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyridin-2-yl]pyrazin-2-amineIC501.6 [1]
6-[(4-Ethylpiperazin-1-yl)methyl]-N-[4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyridin-2-yl]pyridazin-3-amineIC5023.6 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyrazin-2-yl]-6-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-4-amineIC502.7 [1]
6-(7-Fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)-N-[5-[[4-(2,2,2-trifluoroethyl)piperazin-1-yl]methyl]pyrazin-2-yl]pyrimidin-4-amineIC505.8 [1]
N-[5-[(4-Cyclopentylpiperazin-1-yl)methyl]pyrazin-2-yl]-6-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-4-amineIC501.8 [1]
6-(7-Fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)-N-[5-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]pyrazin-2-yl]pyrimidin-4-amineIC501.6 [1]
N-[5-[[4-(Cyclopropylmethyl)piperazin-1-yl]methyl]pyrazin-2-yl]-6-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-4-amineIC502.2 [1]
5-[(4-Ethylpiperazin-1-yl)methyl]-N-[5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyridin-2-yl]pyrazin-2-amineIC501.6 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-6-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-4-amineIC504.4 [1]
N-[5-(1-Ethylpiperidin-4-yl)oxypyrazin-2-yl]-6-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-4-amineIC504.0 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]-6-methylpyridin-2-yl]-5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydropyrrolo[1,2-a]benzimidazol-7-yl)pyrimidin-2-amineIC5046.0 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(5-fluoro-2,2-dimethyl-1,3-dihydropyrrolo[1,2-a]benzimidazol-7-yl)pyrimidin-2-amineIC5036.0 [1]
5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydropyrrolo[1,2-a]benzimidazol-7-yl)-N-[5-[[4-(2-fluoroethyl)piperazin-1-yl]methyl]pyridin-2-yl]pyrimidin-2-amineIC5011.2 [1]
5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydropyrrolo[1,2-a]benzimidazol-7-yl)-N-[6-methyl-5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl]pyrimidin-2-amineIC50271.0 [1]
N-[5-[(4-Cyclopropylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydropyrrolo[1,2-a]benzimidazol-7-yl)pyrimidin-2-amineIC5019.0 [1]
4-(2-Ethyl-5-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-7-yl)-N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoropyrimidin-2-amineIC50339.0 [1]
5-Fluoro-4-(5-fluoro-1-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-7-yl)-N-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridin-2-yl]pyrimidin-2-amineIC5012.7 [1]
4-(1-Ethyl-5-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-7-yl)-N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoropyrimidin-2-amineIC5022.0 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(5-fluoro-1-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-7-yl)pyrimidin-2-amineIC5028.0 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]-6-methylpyridin-2-yl]-5-fluoro-4-(5-fluoro-1-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-7-yl)pyrimidin-2-amineIC50178.0 [1]
5-Fluoro-4-(5-fluoro-1-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-7-yl)-N-[5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl]pyrimidin-2-amineIC50275.0 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(5-fluoro-2-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-7-yl)pyrimidin-2-amineIC50392.0 [1]
4-(1-Ethyl-5-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-7-yl)-5-fluoro-N-[5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl]pyrimidin-2-amineIC502.4 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-4-(5-fluoro-1-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-7-yl)pyrimidin-2-amineIC50752.0 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(4-fluoro-7,8,9,10-tetrahydro-6H-azepino[1,2-a]benzimidazol-2-yl)pyrimidin-2-amineIC50247.8 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-4-(5-fluoro-1,1-dimethyl-2,3-dihydropyrrolo[1,2-a]benzimidazol-7-yl)pyrimidin-2-amineIC5017.4 [1]
N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(6-fluoro-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-8-yl)pyrimidin-2-amineIC5045.6 [1]
4-(1,1-Dimethyl-2,3-dihydropyrrolo[1,2-a]benzimidazol-7-yl)-N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoropyrimidin-2-amineIC5015.8 [1]
5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydropyrrolo[1,2-a]benzimidazol-7-yl)-N-[6-methyl-5-(piperazin-1-ylmethyl)pyridin-2-yl]pyrimidin-2-amineIC5018.7 [1]
Clk1-IN-1IC5010000.0 [1]
6-Acetyl-8-cyclopentyl-2-[[5-[4-[2-(3-methoxypropylamino)acetyl]piperazin-1-yl]pyridin-2-yl]amino]-5-methylpyrido[2,3-d]pyrimidin-7-oneIC5018.0 [1]
6-Acetyl-8-cyclopentyl-2-[[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]amino]-5-methylpyrido[2,3-d]pyrimidin-7-oneIC5034.0 [1]
Acetyloxymethyl 4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazine-1-carboxylateIC5028.0 [1]
6-Acetyl-2-[[5-[4-[2-(2-aminoethylamino)acetyl]piperazin-1-yl]pyridin-2-yl]amino]-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-oneIC5023.0 [1]
4-Chloro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-isoquinolin-6-ylpyridin-2-yl]phenolIC501000.0 [1]
4-Fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenolIC501000.0 [1]
5-Fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenolIC501000.0 [1]
4-Chloro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenolIC501000.0 [1]
4-[(2-Methyl-6-propan-2-ylthieno[2,3-d]pyrimidin-4-yl)amino]-N-[4-(morpholin-4-ylmethyl)phenyl]-1H-pyrazole-5-carboxamideIC5033.21 [1]
N-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-4-[(2-methyl-6-propan-2-ylthieno[2,3-d]pyrimidin-4-yl)amino]-1H-pyrazole-5-carboxamideIC5019.24 [1]
4-[(2-Methylthieno[2,3-d]pyrimidin-4-yl)amino]-N-(4-piperazin-1-ylphenyl)-1H-pyrazole-5-carboxamideIC5084.31 [1]
N-[2-(Dimethylamino)ethyl]-N-methyl-4-[(8-methylsulfanyl-5,6-dihydropyrimido[4,5-f]quinazolin-2-yl)amino]benzamideIC505000.0 [1]
5-(2-Cyclohexyloxy-6-methylpyrimidin-4-yl)-N-[5-[(4-methylpiperazin-1-yl)methyl]pyrazin-2-yl]-1,3-thiazol-2-amineIC507.8 [1]
4-(2-Chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-iumIC5010000.0 [1]
9-Cyclopentyl-N-(5-Piperazin-1-Ylpyridin-2-Yl)pyrido[4,5]pyrrolo[1,2-D]pyrimidin-2-AmineIC504.4 [1]
8-Cyclopentyl-5-[(5-piperazin-1-ylpyridin-2-yl)amino]-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaene-10-carbonitrileIC5013.4 [1]
10-Chloro-8-cyclopentyl-N-(5-piperazin-1-ylpyridin-2-yl)-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amineIC504.3 [1]
8-(4-Methylcyclohexyl)-N-(5-piperazin-1-ylpyridin-2-yl)-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amineIC504.4 [1]
8-Cyclopentyl-5-[(5-piperazin-1-ylpyridin-2-yl)amino]-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,12-pentaen-10-oneIC5011.0 [1]
8-Cyclopentyl-10-fluoro-N-(5-piperazin-1-ylpyridin-2-yl)-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amineIC5017.0 [1]
8-Cyclohexyl-N-(5-piperazin-1-ylpyridin-2-yl)-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amineIC5013.1 [1]
8-(4,4-Dimethylcyclohexyl)-N-(5-piperazin-1-ylpyridin-2-yl)-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amineIC501.1 [1]
(2S)-2-[5-[(5-Piperazin-1-ylpyridin-2-yl)amino]-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-8-yl]propan-1-olIC5029.0 [1]
8-Cyclopentyl-N-(5-piperazin-1-ylpyridin-2-yl)-4,6,8,10,11-pentazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amineIC5013.0 [1]
8-Cyclopentyl-10-methyl-N-(5-piperazin-1-ylpyridin-2-yl)-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amineIC5047.0 [1]
4-[5-[(5-Piperazin-1-ylpyridin-2-yl)amino]-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-8-yl]cyclohexan-1-olIC505.9 [1]
(3R)-1-[2-[4-(4-Acetylphenyl)piperazin-1-yl]-2-oxoethyl]-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamideIC5050000.0 [1]
N-[(4-Methoxyphenyl)carbamothioyl]-1,3-diphenylpyrazole-4-carboxamideIC5050.0 [1]
N-[(4-Methoxyphenyl)carbamothioyl]-3-(4-methylphenyl)-1-phenylpyrazole-4-carboxamideIC5043.0 [1]
3-(4-Chlorophenyl)-N-[(4-methoxyphenyl)carbamothioyl]-1-phenylpyrazole-4-carboxamideIC5042.0 [1]
3-(4-Fluorophenyl)-N-[(4-methoxyphenyl)carbamothioyl]-1-phenylpyrazole-4-carboxamideIC5033.0 [1]
3-(4-Methoxyphenyl)-N-[(4-methoxyphenyl)carbamothioyl]-1-phenylpyrazole-4-carboxamideIC5029.0 [1]
(3S,4S)-3-Methoxy-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-oneIC50242.6 [1]
8-Cyclopentyl-N-(2-piperazin-1-ylpyrimidin-5-yl)-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amineIC501.1 [1]
9-Cycloheptyl-N-(5-piperazin-1-ylpyridin-2-yl)pyrimido[4,5-b]indol-2-amineIC503.1 [1]
3-N-(8-Cyclopentyl-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-yl)-6-N-[(3S)-pyrrolidin-3-yl]pyridazine-3,6-diamineIC5015.1 [1]
8-Cyclopentyl-N-[5-[3-(trifluoromethyl)piperazin-1-yl]pyridin-2-yl]-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amineIC5021.0 [1]
8-Cyclopentyl-N-[5-(piperazin-1-ylmethyl)pyridin-2-yl]-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amineIC5033.0 [1]
8-Cyclopentyl-N-[6-(3,6-dihydro-2H-pyridin-1-yl)pyridazin-3-yl]-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amineIC5040.0 [1]
(3R)-1-[6-[[8-[(2R)-Butan-2-yl]-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-yl]amino]pyridin-3-yl]pyrrolidin-3-olIC5050.0 [1]
8-(2-Methoxyethyl)-N-(6-piperazin-1-ylpyridazin-3-yl)-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amineIC50400.0 [1]
N-(8-Cyclopentyl-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-yl)-4-(piperazin-1-ylmethyl)-1,3-thiazol-2-amineIC506.2 [1]
8-Cyclopentyl-11-methoxy-N-(5-piperazin-1-ylpyridin-2-yl)-4,6,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-amineIC5016.0 [1]
(2R)-1-[5-[[5-[4-(Dimethylamino)piperidin-1-yl]pyridin-2-yl]amino]-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-8-yl]propan-2-olIC50314.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cyclin-dependent kinase 6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-6-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Cyclin-dependent kinase 6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-6-inhibitors-ic50-ki.
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