Cyclin-dependent kinase 7/ cyclin H Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Seliciclib	IC50	500.0 [1]
	Sns-032	IC50	62.0 [1]
	4-[(E)-(3,5-Diamino-1h-Pyrazol-4-Yl)diazenyl]phenol	IC50	26000.0 [1]
	(2R)-2-{[4-(Benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol	IC50	43.0 [1], 500.0 [2]
	[4-(2-Amino-4-methyl-thiazol-5-YL)-pyrimidin-2-YL]-(3-nitro-phenyl)-amine	Ki	70.0 [1]
	Staurosporine	IC50	910.0 [1]
	Alvocidib	IC50	400.0 [1]
	Harmine	IC50	10000.0 [1]
	Palbociclib	Ki	5000.0 [1]
	Milciclib	IC50	150.0 [1]
	O6-Cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	IC50	4400.0 [1]
	4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine	Ki	10000.0 [1]
	Pha-793887	IC50	10.0 [1]
	BS-181	IC50	21.0 [1]
	Leucettine L41	IC50	10000.0 [1]
	RGB-286638 free base	IC50	2.0 [1]
	Cdk/Crk Inhibitor	IC50	71.0 [1]
	(2S,3S)-3-((7-(Benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)butane-1,2,4-triol	IC50	250.0 [1]
	Leucettamine B	IC50	10000.0 [1]
	CID 71561915	Ki	91.0 [1]
	3,5-Diamino-4-phenylazopyrazole	IC50	100000.0 [1]
	Cyc065	IC50	193.0 [1]
	3-[[5-Cyano-4-[4-Methyl-2-(Methylamino)-1,3-Thiazol-5-Yl]pyrimidin-2-Yl]amino]benzenesulfonamide	Ki	114.0 [1]
	(2R)-2-[[9-Propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]butan-1-ol	IC50	180.0 [1]
	Cyclapolin 9	IC50	100000.0 [1]
	(2R)-2-[[9-Propan-2-yl-6-(pyridin-2-ylmethylamino)purin-2-yl]amino]butan-1-ol	IC50	40.0 [1]
	(2-Methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-(3-nitro-phenyl)-amine	Ki	790.0 [1]
	(2R)-2-[[9-Propan-2-yl-6-(pyridin-4-ylmethylamino)purin-2-yl]amino]butan-1-ol	IC50	740.0 [1]
	4-[4-Methyl-2-(methylamino)-1,3-thiazol-5-yl]-2-[3-(morpholine-4-carbonyl)anilino]pyrimidine-5-carbonitrile	Ki	1870.0 [1]
	4-(4-Methyl-2-(methylamino)thiazol-5-yl)-2-(3-nitrophenylamino)pyrimidine-5-carbonitrile	Ki	260.0 [1]
	2-Bromo-N-(2,5-dichlorothiophen-3-yl)sulfonyl-N-phenylacetamide	IC50	33400.0 [1]
	(2r)-2-{[7-(Benzylamino)-3-(Propan-2-Yl)-1h-Pyrazolo[4,3-D]pyrimidin-5-Yl]amino}butan-1-Ol	IC50	160.0 [1]
	2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 30	Ki	417.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	2-[3-(4-Acetyl-1,4-diazepan-1-yl)anilino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Ki	210.0 [1]
	2-[3-(1,4-Diazepan-1-yl)anilino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Ki	46.0 [1]
	N-Methyl-5-[2-(3-nitroanilino)pyrimidin-4-yl]-4-phenyl-1,3-thiazol-2-amine	Ki	5000.0 [1]
	4-Methyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide	IC50	400.0 [1]
	2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-, 3-oxide	IC50	100000.0 [1]
	3-[[4-[4-[(3-Chlorophenyl)amino]-1,3,5-triazin-2-yl]-2-pyridinyl]amino]-1-Propanol	IC50	126.0 [1]
	(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-ol	IC50	3900.0 [1]
	(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-ol	IC50	5800.0 [1]
	(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-ol	IC50	2400.0 [1]
	(3RS,4R)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-2,2-dimethyl-hexan-3-ol	IC50	3700.0 [1]
	(3S)-3-[[6-(Benzylamino)-9-propan-2-ylpurin-2-yl]amino]pentan-2-ol	IC50	690.0 [1]
	(3S)-3-[[6-(Benzylamino)-9-propan-2-ylpurin-2-yl]amino]-2-methylpentan-2-ol	IC50	2000.0 [1]
	(3RS,4R)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-hexan-3-ol	IC50	1200.0 [1]
	(3RS,4S)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-2-methyl-hexan-3-ol	IC50	3000.0 [1]
	(R)-3-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-2-methyl-pentan-2-ol	IC50	3700.0 [1]
	(4R)-4-[[6-(Benzylamino)-9-propan-2-ylpurin-2-yl]amino]-2-methylhexan-3-ol	IC50	4400.0 [1]
	(3RS,4S)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-2,2-dimethyl-hexan-3-ol	IC50	4300.0 [1]
	(3RS,4S)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-hexan-3-ol	IC50	1100.0 [1]
	(3S)-3-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol	IC50	4300.0 [1]
	(3R)-3-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol	IC50	4200.0 [1]
	(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-ol	IC50	1200.0 [1]
	(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-ol	IC50	2600.0 [1]
	(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-ol	IC50	3300.0 [1]
	(2-Methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-phenyl-amine	Ki	2200.0 [1]
	4-N,4-N-Dimethyl-1-N-(2-methyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-8-yl)benzene-1,4-diamine	Ki	60.0 [1]
	(6-Chloro-pyridin-3-yl)-(2-methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-amine	Ki	1400.0 [1]
	(2-Methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-(4-morpholin-4-yl-phenyl)-amine	Ki	1000.0 [1]
	8-N-(3-Nitrophenyl)-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazoline-2,8-diamine	Ki	140.0 [1]
	8-N-Phenyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazoline-2,8-diamine	Ki	1200.0 [1]
	4-(2-Methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-ylamino)-phenol	Ki	300.0 [1]
	Methyl-(2-methyl-thiazolo[4,5-h]quinazolin-8-yl)-(3-nitro-phenyl)-amine	Ki	10000.0 [1]
	2-Methyl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amine	Ki	10000.0 [1]
	3-(2-Methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-ylamino)-phenol	Ki	53.0 [1]
	(2-Methyl-thiazolo[4,5-h]quinazolin-8-yl)-phenyl-amine	Ki	10000.0 [1]
	(6-Methoxy-pyridin-3-yl)-(2-methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-amine	Ki	1100.0 [1]
	(2-Methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-(4-trifluoromethyl-phenyl)-amine	Ki	10000.0 [1]
	Methyl-(2-methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-(3-nitro-phenyl)-amine	Ki	1800.0 [1]
	N,4-Dimethyl-5-[2-(4-methyl-3-morpholin-4-ylsulfonylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine	Ki	150.0 [1]
	(3R)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol	IC50	3100.0 [1]
	(3S)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol	IC50	2500.0 [1]
	3-[[4-[4-Methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide	Ki	1960.0 [1]
	(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-ol	IC50	1100.0 [1]
	(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-ol	IC50	1500.0 [1]
	(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-ol	IC50	2200.0 [1]
	(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-ol	IC50	3500.0 [1]
	(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-ol	IC50	1600.0 [1]
	(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-ol	IC50	3500.0 [1]
	4-Methyl-5-[2-[(5-morpholin-4-ylpyridin-2-yl)amino]pyrimidin-4-yl]-N-propan-2-yl-1,3-thiazol-2-amine	Ki	5000.0 [1]
	N-Cyclopentyl-4-methyl-5-[2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-1,3-thiazol-2-amine	Ki	1108.0 [1]
	N-Cyclopentyl-5-[5-fluoro-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amine	Ki	790.0 [1]
	N-Cyclopentyl-5-[2-[[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]amino]-5-fluoropyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amine	Ki	630.0 [1]
	N-Cyclopentyl-N,4-dimethyl-5-[2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-1,3-thiazol-2-amine	Ki	3200.0 [1]
	N-Cyclopentyl-5-[2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-amine	Ki	194.0 [1]
	N-Cyclopentyl-5-[2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-amine	Ki	189.0 [1]
	4-Methyl-N-phenyl-5-[2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-1,3-thiazol-2-amine	Ki	1660.0 [1]
	4-[6-[[4-[2-(Cyclopentylamino)-4-(trifluoromethyl)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]pyridin-3-yl]piperazine-1-carbaldehyde	Ki	1900.0 [1]
	4-Methyl-5-[2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-N-propan-2-yl-1,3-thiazol-2-amine	Ki	760.0 [1]
	1-[4-[6-[[4-[4-Methyl-2-(propan-2-ylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]pyridin-3-yl]piperazin-1-yl]ethanone	Ki	4385.0 [1]
	N-Cyclopentyl-4-methyl-5-[2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-1,3-thiazol-2-amine	Ki	865.0 [1]
	N-Cyclopentyl-5-[2-[[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]amino]-5-fluoropyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amine	Ki	685.0 [1]
	5-[2-[[5-(4-Aminopiperidin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-N-cyclopentyl-4-methyl-1,3-thiazol-2-amine	Ki	1187.0 [1]
	1-[4-[6-[[4-[2-(Cyclopentylamino)-4-methyl-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]pyridin-3-yl]piperazin-1-yl]ethanone	Ki	3453.0 [1]
	N-Cyclopentyl-5-[2-[[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amine	Ki	780.0 [1]
	N-Cyclopentyl-5-[2-[[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]amino]pyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amine	Ki	211.0 [1]
	N,4-Dimethyl-5-[2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-N-phenyl-1,3-thiazol-2-amine	Ki	5000.0 [1]
	5-[2-[[5-(1,4-Diazepan-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-4-methyl-N-propan-2-yl-1,3-thiazol-2-amine	Ki	1160.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Cyclin-dependent kinase 7/ cyclin H Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-7-cyclin-h-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Cyclin-dependent kinase 7/ cyclin H Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-7-cyclin-h-inhibitors-ic50-ki.
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