 | Dinaciclib | IC50 | 4.0 [1], 178.0 [2] |
 | Sns-032 | IC50 | 4.0 [1], 458.0 [2], 550.0 [3] |
| Sns-032 | Ki | 4.0 [1] |
 | Alvocidib | IC50 | 20.0 [1] |
| Alvocidib | Ki | 3.0 [1] |
 | Palbociclib | IC50 | 794.33 [1], 892.0 [2] |
 | 2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one | IC50 | 34.0 [1] |
 | 4-N-[5-[(5-Tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]cyclohexane-1,4-diamine | IC50 | 355.0 [1], 10000.0 [2] |
 | 2-[4-[4-(4,5-Difluoro-8-methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2,4,6,10,13,15-heptaen-11-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclohexyl]acetic acid | IC50 | 58.0 [1], 82.0 [2] |
 | 4-[4-(8-Methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2,4,6,10,13,15-heptaen-11-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclohexane-1-carboxylic acid | IC50 | 120.0 [1], 150.0 [2] |
 | 3-[4-(4-Fluoro-8-methyl-8,13,15-triazatetracyclo[9.6.1.02,7.014,18]octadeca-1(18),2(7),3,5,11,14,16-heptaen-12-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclobutane-1-carboxylic acid | IC50 | 150.0 [1], 160.0 [2] |
 | 4-[4-(16-Fluoro-8-methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2,4,6,10,13,15-heptaen-11-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclohexane-1-carboxylic acid | IC50 | 63.0 [1], 80.0 [2] |
 | 2-[4-[4-(8-Methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2,4,6,10,13,15-heptaen-11-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclohexyl]acetic acid | IC50 | 90.0 [1], 110.0 [2] |
 | 2-[4-[4-(4-Fluoro-8-methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2(7),3,5,10,13,15-heptaen-11-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclohexyl]acetic acid | IC50 | 48.0 [1], 64.0 [2] |
 | 3-[4-[(9S)-9-Ethyl-4-fluoro-8-methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2(7),3,5,10,13,15-heptaen-11-yl]-3,6-dihydro-2H-pyridin-1-yl]cyclobutane-1-carboxylic acid | IC50 | 110.0 [1] |
 | 2-[4-[4-(16-Fluoro-8-methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2,4,6,10,13,15-heptaen-11-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclohexyl]acetic acid | IC50 | 71.0 [1], 73.0 [2] |
 | [[2,3-Difluoro-5-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamide | IC50 | 2.0 [1], 3.0 [2] |
 | Ethyl N-[[3-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]carbamate | IC50 | 8.0 [1], 38.0 [2] |
 | 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amine | IC50 | 7.0 [1], 106.0 [2] |
 | Ethyl N-[[3-[[5-fluoro-4-(4-fluoro-2-phenylmethoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]carbamate | IC50 | 9.0 [1], 12.0 [2] |
 | 5-Fluoro-4-(4-fluoro-2-phenylmethoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amine | IC50 | 5.0 [1], 8.0 [2] |
 | [[3-[[5-Fluoro-4-(4-fluoro-2-phenylmethoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamide | IC50 | 25.0 [1], 35.0 [2] |
 | 1-[[3-[[5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]-3-methylurea | IC50 | 7.0 [1], 23.0 [2] |
 | Ethyl N-[[3-fluoro-5-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]carbamate | IC50 | 8.0 [1], 12.0 [2] |
 | 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[3-fluoro-5-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amine | IC50 | 9.0 [1], 37.0 [2] |
 | [[3-[[5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamide | IC50 | 7.0 [1], 11.0 [2] |
 | [Ethyl-[[3-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl]-oxo-lambda6-sulfanylidene]cyanamide | IC50 | 2.0 [1], 9.0 [2] |
 | N-[3-[(Ethylsulfonimidoyl)methyl]phenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amine | IC50 | 7.0 [1], 125.0 [2] |
 | N-[3,4-Difluoro-5-[(methylsulfonimidoyl)methyl]phenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amine | IC50 | 4.0 [1], 57.0 [2] |
 | [[3-Bromo-5-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamide | IC50 | 2.0 [1], 4.0 [2] |
 | N-[3-Bromo-5-[(methylsulfonimidoyl)methyl]phenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amine | IC50 | 3.0 [1], 4.0 [2] |
 | [[3-[[5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]-5-methoxyphenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamide | IC50 | 1.0 [1], 4.0 [2] |
 | 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[3-methoxy-5-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amine | IC50 | 4.0 [1], 6.0 [2] |
 | [[3-[[4-(2-Ethoxy-4-fluorophenyl)-5-fluoropyrimidin-2-yl]amino]-5-fluorophenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamide | IC50 | 5.0 [1], 8.0 [2] |
 | 4-(2-Ethoxy-4-fluorophenyl)-5-fluoro-N-[3-fluoro-5-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amine | IC50 | 5.0 [1], 73.0 [2] |
 | [[3-[[5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]-5-(trifluoromethyl)phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamide | IC50 | 4.0 [1] |
 | 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]-5-(trifluoromethyl)phenyl]pyrimidin-2-amine | IC50 | 2.0 [1], 3.0 [2] |
 | N-[3-[(Ethylsulfonimidoyl)methyl]-5-fluorophenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amine | IC50 | 5.0 [1], 45.0 [2] |
 | [[3-[[5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]-5-(1,1,2,2,2-pentafluoroethyl)phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamide | IC50 | 8.0 [1], 25.0 [2] |
 | 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]-5-(1,1,2,2,2-pentafluoroethyl)phenyl]pyrimidin-2-amine | IC50 | 5.0 [1], 6.0 [2] |
 | [Cyclopropyl-[[3-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl]-oxo-lambda6-sulfanylidene]cyanamide | IC50 | 2.0 [1], 5.0 [2] |
 | N-[3-[(Cyclopropylsulfonimidoyl)methyl]phenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amine | IC50 | 14.0 [1], 279.0 [2] |
 | [Cyclopropyl-[[3-fluoro-5-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl]-oxo-lambda6-sulfanylidene]cyanamide | IC50 | 4.0 [1], 6.0 [2] |
 | N-[3-[(Cyclopropylsulfonimidoyl)methyl]-5-fluorophenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amine | IC50 | 7.0 [1], 51.0 [2] |
 | 5-Fluoro-4-[4-fluoro-2-[(4-fluorophenyl)methoxy]phenyl]-N-[3-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amine | IC50 | 4.0 [1], 5.0 [2] |
 | [[3-Chloro-5-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamide | IC50 | 2.0 [1], 4.0 [2] |
 | N-[3-Chloro-5-[(methylsulfonimidoyl)methyl]phenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amine | IC50 | 5.0 [1], 7.0 [2] |
 | [[3-[[5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]-5-methylphenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamide | IC50 | 2.0 [1], 3.0 [2] |
 | 2-Methoxyethyl N-[[3-fluoro-5-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]carbamate | IC50 | 3.0 [1] |
 | 4-(3,4-Dihydro-2H-chromen-8-yl)-5-fluoro-N-[3-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amine | IC50 | 8.0 [1], 67.0 [2] |
 | Ethyl N-[[3-[[4-(3,4-dihydro-2H-chromen-8-yl)-5-fluoropyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]carbamate | IC50 | 14.0 [1] |
 | Ethyl N-[[3-[[4-(2,3-dihydro-1-benzofuran-7-yl)-5-fluoropyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]carbamate | IC50 | 9.0 [1], 10.0 [2] |
 | 2-[4-[4-[4-(5-Fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydro-2H-pyridin-1-yl]cyclohexyl]acetic acid | IC50 | 57.0 [1], 71.0 [2] |
 | Sulfuretin | IC50 | 2160.0 [1] |
 | 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide | IC50 | 10.0 [1] |
 | Pik-75 | IC50 | 1.4 [1] |
 | (16E)-14-Methyl-20-oxa-5,7,14,27-tetrazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(27),3,5,8,10,12(26),16,21,23-decaene | IC50 | 3.0 [1] |
 | 4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine | Ki | 480.0 [1] |
 | BS-181 | IC50 | 2180.0 [1] |
 | 4-[(E)-(3,5-Diamino-1h-Pyrazol-4-Yl)diazenyl]phenol | IC50 | 350.0 [1] |
 | Cdk/Crk Inhibitor | IC50 | 9.0 [1] |
 | Ilorasertib | IC50 | 10000.0 [1] |
 | Atuveciclib Racemate | IC50 | 385.0 [1] |
 | 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl)amino]pyridin-4-Yl}benzamide | Ki | 111.0 [1] |
 | 2-(2-Amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one | IC50 | 29.0 [1] |
 | Cyc065 | IC50 | 100.0 [1] |
 | [4-(2-Amino-4-methyl-thiazol-5-YL)-pyrimidin-2-YL]-(3-nitro-phenyl)-amine | Ki | 4.0 [1] |
 | (7S)-2-(2-Aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one | IC50 | 28.0 [1] |
 | 7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile | Ki | 1644.0 [1] |
 | (2~{R},3~{S})-3-[[9-Propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-ol | IC50 | 107.0 [1] |
 | 1-(4-(4-(4-(4-Methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone | Ki | 448.0 [1] |
 | (2R)-1-[4-[4-[(5-Chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-3,5-dimethylpyrazol-1-yl]piperidin-1-yl]-2-hydroxypropan-1-one | IC50 | 450.0 [1] |
 | N-{4-[(7-Hydroxy-6-Methoxyquinazolin-4-Yl)amino]phenyl}benzamide | IC50 | 30000.0 [1] |
 | N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamide | IC50 | 5330.0 [1] |
 | 5-(2-Aminopyrimidin-4-yl)-2-(2,4-dichlorophenyl)-1H-pyrrole-3-carboxamide | IC50 | 10.0 [1] |
 | N-(5-(2-(Cyclohexyloxy)pyrimidin-4-yl)thiazol-2-yl)pyridin-2-amine | IC50 | 2.5 [1] |
 | 5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide | IC50 | 10000.0 [1] |
 | N-[4-(2,4-Dimethyl-thiazol-5-YL)-pyrimidin-2-YL]-N',N'-dimethyl-benzene-1,4-diamine | Ki | 575.0 [1] |
 | 3-Methyl-5-pyridin-3-yl-2H-indazole | IC50 | 630.96 [1] |
 | BMS-387032 analog 19 | IC50 | 550.0 [1] |
 | 1-(4-(4-(4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone | Ki | 1153.0 [1] |
 | 4-(2,4-Dimethylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine | Ki | 10000.0 [1] |
 | N-Ethyl-4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine | Ki | 559.0 [1] |
 | N,4-Dimethyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine | Ki | 2605.0 [1] |
 | 5-(((5-(Tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-amine | IC50 | 10000.0 [1] |
 | 2-(2-Aminopyrimidin-4-yl)-7-(propan-2-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one | IC50 | 31.0 [1] |
 | 4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine | Ki | 11.0 [1] |
 | N-(4-(4-(2-(Ethylamino)-4-methylthiazol-5-yl)pyrimidin-2-ylamino)benzyl)acetamide | Ki | 9.0 [1] |
 | N-Ethyl-4-methyl-5-(2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)thiazol-2-amine | Ki | 564.0 [1] |
 | N,4-Dimethyl-5-(2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)thiazol-2-amine | Ki | 6.0 [1] |
 | 4-(2,4-Dimethylthiazol-5-yl)-N-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrimidin-2-amine | Ki | 1472.0 [1] |
 | N-[4-[[7-(2-Amino-2-oxoethoxy)-6-methoxyquinazolin-4-yl]amino]phenyl]benzamide | IC50 | 30000.0 [1] |
 | N-[4-[(4-Hydroxy-3-methoxybenzoyl)amino]phenyl]pyridine-2-carboxamide | IC50 | 30000.0 [1] |
 | N-(4-Benzamidophenyl)-4-hydroxy-3-methoxybenzamide | IC50 | 30000.0 [1] |
 | 2-Amino-N-(4-benzamidophenyl)-4-hydroxy-5-methoxybenzamide | IC50 | 30000.0 [1] |
 | 2-[4-[(4-Benzamidophenyl)carbamoyl]-2-methoxyphenoxy]acetic acid | IC50 | 30000.0 [1] |
 | N-[4-[[3-(2,4-Dioxo-1H-pyrimidin-5-yl)benzoyl]amino]phenyl]pyridine-2-carboxamide | IC50 | 30000.0 [1] |
 | N-[4-[[3-(2,4-Dioxo-1H-pyrimidin-5-yl)-4-methoxybenzoyl]amino]phenyl]pyridine-2-carboxamide | IC50 | 30000.0 [1] |
 | N-[4-[[3-(2,4-Dioxo-1,3-diazinan-1-yl)-5-methoxybenzoyl]amino]phenyl]pyridine-2-carboxamide | IC50 | 30000.0 [1] |
 | N-[4-[[3-(2,4-Dioxo-1H-pyrimidin-5-yl)-5-methoxybenzoyl]amino]phenyl]piperidine-2-carboxamide | IC50 | 30000.0 [1] |
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