Name: Cyclophilin A Inhibitors (IC50, Ki)
Creator: AAT Bioquest
License: https://www.aatbio.com/tou.html

Cyclophilin A Inhibitors (IC50, Ki)

Structure	Compound Name	Standard Type	Standard Values (in nM)
	Cyclosporin A	IC50	9.6 ^[1]
	Cyclosporin A	Ki	12.2 ^[1]
	2-[[(2R,5S,8S,11S,14S,17S,23S,26S,29S,32S)-17-Ethyl-14-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-4,7,10,13,19,22,28,32-octamethyl-5,8,23,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-11,26-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacont-2-yl]methoxy]-N-[4-[[4-[[2-[[(2R,5S,8S,11S,14S,17S,23S,26S,29S,32S)-17-ethyl-14-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-4,7,10,13,19,22,28,32-octamethyl-5,8,23,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-11,26-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacont-2-yl]methoxy]acetyl]amino]phenyl]diazenyl]phenyl]acetamide	IC50	30.0 ^[1], 206.0 ^[2], 266.0 ^[3], 487.0 ^[4]
	2-[[(2R,5S,8S,11S,14S,17S,23S,26S,29S,32S)-17-Ethyl-14-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-4,7,10,13,19,22,28,32-octamethyl-5,8,23,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-11,26-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacont-2-yl]methoxy]-N-(4-phenyldiazenylphenyl)acetamide	IC50	2.79 ^[1], 4.75 ^[2], 147.0 ^[3], 227.0 ^[4]
	Scy-635	IC50	9.48 ^[1], 1549.0 ^[2]
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References

This online resource may be cited as follows

MLA	"Quest Database™ Cyclophilin A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 4 Dec. 2025, https://www.aatbio.com/data-sets/cyclophilin-a-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, December 4). Quest Database™ Cyclophilin A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclophilin-a-inhibitors-ic50-ki.
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