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Cysteinyl leukotriene receptor Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propylchromene-2-carboxylic acidIC5035.0 [1], 50.12 [2], 510.0 [3], 4000.0 [4]
7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propylchromene-2-carboxylic acidKi1000.0 [1]
ZafirlukastIC505.0 [1]
ZafirlukastKi0.3 [1], 2.0 [2]
MontelukastIC500.43 [1], 0.64 [2]
PranlukastIC500.04 [1]
PranlukastKi0.8 [1]
Sodium;7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propylchromene-2-carboxylateIC50100.0 [1]
Sodium;7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propylchromene-2-carboxylateKi2007.0 [1]
TomelukastKi600.0 [1], 800.0 [2]
alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanolIC50510.0 [1]
alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanolKi700.0 [1]
Cyclopentyl N-[1-[[4-(benzenesulfonylcarbamoyl)-2-methoxyphenyl]methyl]indazol-6-yl]carbamateIC501.0 [1]
Cyclopentyl N-[1-[[4-(benzenesulfonylcarbamoyl)-2-methoxyphenyl]methyl]indazol-6-yl]carbamateKi0.2 [1]
RitolukastIC506000.0 [1]
RitolukastKi35.0 [1]
2-((3-(3-(1H-Tetrazol-5-yl)propoxy)phenoxy)methyl)quinolineIC5079.0 [1]
2-((3-(3-(1H-Tetrazol-5-yl)propoxy)phenoxy)methyl)quinolineKi42.0 [1]
4-Hexyl-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamideIC50208.93 [1], 210.0 [2]
4-Heptyl-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamideIC5070.0 [1], 70.79 [2]
4-Octyl-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamideIC50100.0 [1]
4-Nonyl-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamideIC50158.49 [1], 160.0 [2]
4-Decyl-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamideIC50500.0 [1], 501.19 [2]
4-Pentoxy-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamideIC50100.0 [1]
4-Hexoxy-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamideIC5012.88 [1], 13.0 [2]
4-Heptoxy-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamideIC508.91 [1], 9.0 [2]
4-Octoxy-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamideIC5014.0 [1], 14.13 [2]
4-Nonoxy-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamideIC5019.95 [1], 20.0 [2]
4-Hexyl-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamideIC5015.0 [1], 15.14 [2]
4-Heptyl-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamideIC504.17 [1], 4.2 [2]
4-Octyl-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamideIC505.5 [1]
4-Nonyl-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamideIC507.0 [1], 7.08 [2]
4-Hexoxy-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamideIC500.85 [1], 0.86 [2]
4-Heptoxy-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamideIC500.5 [1]
4-Octoxy-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamideIC505.5 [1]
4-Nonoxy-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamideIC507.4 [1], 7.41 [2]
4-[4-(2-Quinolylmethoxy)phenoxy]butyric acidIC50800.0 [1]
4-[4-(2-Quinolylmethoxy)phenoxy]butyric acidKi1200.0 [1]
2-[4-[4-(1H-Tetrazol-5-yl)butyl]phenoxymethyl]quinolineIC5036.0 [1]
2-[4-[4-(1H-Tetrazol-5-yl)butyl]phenoxymethyl]quinolineKi18.0 [1]
2-[1-[[(1R)-1-[3-[(E)-2-(5-Ethyl-6-methylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC502.7 [1], 50.4 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(6,7-Dihydro-5H-cyclopenta[b]pyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.5 [1], 4.5 [2]
2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(8-methyl-5,6,7,8-tetrahydroquinolin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.51 [1], 0.63 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(6-Butyl-5-methylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.5 [1], 0.9 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(5,7-Dihydrothieno[3,4-b]pyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.21 [1], 2.1 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(6,6-Dimethyl-5,7-dihydrocyclopenta[b]pyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.34 [1], 0.43 [2]
2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(5-methyl-6-propan-2-ylpyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC504.7 [1], 4.9 [2]
2-[1-[[(1R)-1-[3-[(E)-2-[6-Ethyl-5-(trifluoromethyl)pyridin-2-yl]ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC5025.2 [1], 36.9 [2]
2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(5,6,7,8-tetrahydroquinolin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.19 [1], 1.8 [2]
2-[4-[3-(1H-Tetrazol-5-yl)propoxy]phenoxymethyl]quinolineIC50250.0 [1]
2-[4-[3-(1H-Tetrazol-5-yl)propoxy]phenoxymethyl]quinolineKi69.0 [1]
4-[3-(2-Quinolylmethoxy)phenoxy]butyric acidIC50240.0 [1]
4-[3-(2-Quinolylmethoxy)phenoxy]butyric acidKi130.0 [1]
2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.58 [1], 1.8 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(7,7-Dimethyl-5,6-dihydrocyclopenta[b]pyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.35 [1], 0.87 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dihydrothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.74 [1], 4.8 [2]
2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(5-methyl-6-propylpyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.5 [1], 0.7 [2]
2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-[5-methyl-6-(2-methylpropyl)pyridin-2-yl]ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC501.2 [1], 1.4 [2]
2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(7-methyl-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.73 [1], 1.35 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(8,8-Dimethyl-6,7-dihydro-5H-quinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.75 [1], 2.6 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(7,7-Dimethyl-6,8-dihydro-5H-quinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.17 [1], 0.19 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(6-Ethyl-5-methylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.8 [1], 3.4 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(5-Chloro-6-ethylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC501.2 [1], 1.7 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(5,6-Dimethylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.9 [1], 24.8 [2]
2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-thieno[3,2-b]pyridin-5-ylethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC501.31 [1], 20.4 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(2-Chlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.57 [1], 0.72 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Difluorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.26 [1], 0.42 [2]
2-[1-[[(1R)-1-[3-[2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)cyclopropyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC509.12 [1], 10.9 [2]
2-[1-[[(1R)-1-[3-[(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)methoxy]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.42 [1], 2.2 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(hydroxymethyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.48 [1]
2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC501.21 [1], 4.12 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[4-(1-hydroxycyclobutyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.29 [1], 0.58 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[3-(1-hydroxycyclobutyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.24 [1], 0.44 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[4-(trifluoromethyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC501.43 [1], 3.84 [2]
2-[1-[[(1R)-1-[3-[(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)oxymethyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC50150.0 [1]
2-[1-[[(1R)-1-[3-[2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.42 [1], 3.21 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(trifluoromethyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.87 [1], 1.95 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-(4-fluorophenyl)propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.65 [1], 1.09 [2]
2-[1-[[(1R)-3-(4-Bromophenyl)-1-[3-[(E)-2-(2,3-dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC501.03 [1], 1.95 [2]
2-[1-[[(1R)-3-(2-Bromophenyl)-1-[3-[(E)-2-(2,3-dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC501.93 [1], 2.6 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-phenylpropyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.34 [1], 0.37 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(1-hydroxycyclobutyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.34 [1], 0.74 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[4-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.2 [1], 0.56 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.34 [1], 0.89 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(3-Chlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.54 [1], 1.58 [2]
MK-571 sodiumKi0.2 [1]
PobilukastKi5.0 [1]
N-(p-Amylcinnamoyl)anthranilic acidIC5014000.0 [1]
4-((3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl)-gamma-oxobenzenebutanoic acidKi6200.0 [1]
5-(2-(8-Phenyloctyl)phenyl)-4,6-dithianonanedioic acidKi245.0 [1]
2-((4-((2-(1H-Tetrazol-5-ylmethyl)phenyl)methoxy)phenoxy)methyl)quinolineKi3.0 [1]
Iralukast sodiumKi26.0 [1]
1-(2-Hydroxy-3-propyl-4-((4-(1H-tetrazol-5-ylmethyl)phenoxy)methyl)phenyl)ethanoneIC5010.0 [1]
(E)-2-(2-(Quinolin-2-yl)vinyl)phenolIC5050000.0 [1]
Benzenepropanoic acid, beta-((2-carboxyethyl)thio)-2-(8-phenyloctyl)-, (betaS)-Ki60.0 [1]
5-(2-Dodecylphenyl)-4,6-dithianonanedioic acidKi445.0 [1]
N-[5-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]-4-chloro-2-methylphenyl]-2H-tetrazole-5-carboxamideIC501000.0 [1]
4-[(E)-2-(Quinolin-2-yl)ethenyl]phenolIC5050000.0 [1]
Cyclopentyl N-[3-[[4-(benzenesulfonylcarbamoyl)-2-methoxyphenyl]methyl]-1-methylindol-5-yl]carbamateKi0.8 [1]
Butanoic acid, 2,2-diethyl-4-((3-((7-fluoro-2-quinolinyl)methoxy)phenyl)amino)-4-oxo-IC500.2 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cysteinyl leukotriene receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/cysteinyl-leukotriene-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Cysteinyl leukotriene receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cysteinyl-leukotriene-receptor-inhibitors-ic50-ki.
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