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Cytochrome P450 11B2 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
FadrozoleIC501.0 [1]
KetoconazoleIC5081.0 [1]
MetyraponeIC5072.0 [1]
OsilodrostatIC500.2 [1]
4-[(5r)-5,6,7,8-Tetrahydroimidazo[1,5-A]pyridin-5-Yl]benzonitrileIC504.0 [1]
3-(6-Methoxynaphthalen-2-yl)pyridineIC506.2 [1]
3-(Naphthalen-2-yl)pyridineIC5028.0 [1]
5-Imidazol-1-ylmethyl-2-phenyl-pyridineIC501423.0 [1], 2768.0 [2]
EtomidateIC500.1 [1], 1.7 [2]
5-Imidazol-1-ylmethyl-2-naphthalen-1-yl-pyridineIC50656.0 [1], 2075.0 [2]
AbirateroneIC501750.0 [1], 1751.0 [2]
6-(Pyridin-3-yl)-3,4-dihydroquinolin-2(1H)-oneIC5028.0 [1]
6-Pyridin-3-yl-2-naphthonitrileIC502.9 [1], 3.0 [2]
3-(5-Imidazol-1-ylmethyl-pyridin-2-yl)-phenylamineIC503407.0 [1]
6-Pyridin-3-yl-1-azatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-trien-11-oneIC501.1 [1]
3-(1-Chloro-7-methoxy-2-naphthyl)pyridineIC5029.0 [1]
2-Fluoro-4-(5-imidazol-1-ylmethyl-pyridin-2-yl)-phenolIC50237.0 [1]
1-(Naphthalen-2-yl)-1H-imidazoleIC5038.0 [1], 38.5 [2], 39.0 [3]
2-Benzo[b]thiophen-3-yl-5-imidazol-1-ylmethyl-pyridineIC501157.0 [1]
2-(5-Imidazol-1-ylmethyl-pyridin-2-yl)-phenylamineIC502114.0 [1]
3-Imidazol-1-ylmethyl-2-thiophen-2-yl-pyridineIC50251.0 [1]
2-Bromo-3-imidazol-1-ylmethyl-pyridineIC50911.0 [1]
3-(6-Methoxy-3,4-dihydronaphthalen-2-yl)pyridineIC502.0 [1], 2.1 [2]
5-Imidazol-1-ylmethyl-2-thiophen-3-yl-pyridineIC501017.0 [1], 3265.0 [2]
4-(5-Imidazol-1-ylmethyl-pyridin-2-yl)-phenylamineIC50528.0 [1]
1H-Imidazole, 1-(3-methoxy-2-naphthalenyl)-IC5019.0 [1], 19.1 [2], 40.0 [3]
1-BenzylimidazoleIC50456.0 [1], 1819.7 [2]
1-(4-Chlorobenzyl)-1H-imidazoleIC5046.0 [1], 1000.0 [2]
2-Phenyl-5-(5-methyl-3-pyridinylmethyl)pyridineIC5033.0 [1]
7-Benzyloxy-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-oneIC50289.0 [1]
4-[(5S)-5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrileIC5040.0 [1], 171.0 [2]
1-Methyl-6-pyridin-3-yl-3,4-dihydroquinolin-2(1H)-oneIC502.6 [1]
6-Pyridin-3-ylnaphthalen-2-olIC5023.0 [1]
1-Imidazol-1-ylmethylxanthen-9-oneIC50114.3 [1]
3-[4-(Pyridin-4-ylmethyl)phenyl]anilineIC50921.0 [1]
4-[4-(Pyridin-4-ylmethyl)phenyl]benzene-1,2-diolIC50948.0 [1]
1-(5-Pyridin-3-yl-2,3-dihydroindol-1-yl)ethanoneIC505.0 [1], 60.0 [2]
7-Pyridin-3-yl-2H-1,4-benzothiazin-3(4H)-oneIC5012.0 [1]
1-Ethyl-6-pyridin-3-yl-3,4-dihydroquinolin-2(1H)-oneIC5022.0 [1]
2-(3,4-Dimethoxy-phenyl)-5-imidazol-1-ylmethyl-pyridineIC501000.0 [1]
5-Imidazol-1-ylmethyl-2-(2-methoxy-phenyl)pyridineIC504391.0 [1]
2-(3,4-Difluoro-phenyl)-5-imidazol-1-ylmethyl-pyridineIC501665.0 [1]
5-Imidazol-1-ylmethyl-2-(4-methoxy-phenyl)pyridineIC501000.0 [1]
2-(4-Fluoro-phenyl)-5-imidazol-1-ylmethyl-pyridineIC502153.0 [1]
4-[4-(Pyridin-4-ylmethyl)phenyl]benzene-1,2-diamineIC50367.0 [1], 368.0 [2]
3-[4-(Pyridin-4-ylmethyl)phenyl]phenolIC50261.0 [1]
2-Fluoro-4-[4-(pyridin-4-ylmethyl)phenyl]phenolIC50110.0 [1], 210.0 [2]
2-[(1S)-1-(4-Chlorophenyl)ethyl]-4-(2-methylpropyl)-1,4-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxideIC509.4 [1]
1-[2-[(1S)-1-(4-Chlorophenyl)ethyl]-3,3-dioxo-1,4-dihydroimidazo[5,1-d][1,2,5]thiadiazin-4-yl]-2-methylpropan-2-olIC5011.4 [1]
Cyp11B2-IN-1IC501.4 [1], 2.3 [2]
6-[Cyclopropyl(imidazol-1-yl)methyl]-1-azatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-trien-11-oneIC5024.0 [1]
7-Methoxy-6-pyridin-3-yl-3,4-dihydro-1H-quinolin-2-oneIC50268.0 [1]
9-Fluoro-1-methyl-7-(4-methyl-3-pyridyl)-4,5-dihydro[1,2,4]triazolo[4,3-a]quinolineIC504.2 [1]
7-Isoquinolin-4-yl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolineIC505.0 [1]
9-Fluoro-7-(5-fluoropyridin-3-yl)-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolineIC5089.0 [1], 89.7 [2]
7-Phenylmethoxy-6-pyridin-3-yl-3,4-dihydro-1H-quinolin-2-oneIC5022.0 [1]
7-[5-(2-Methoxypropan-2-yl)pyridin-3-yl]-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolineIC505.0 [1], 19.0 [2]
(3-Methoxyphenyl)-(5-pyridin-3-yl-2,3-dihydroindol-1-yl)methanoneIC505.0 [1], 607.0 [2]
1-(6-Methoxy-2-naphthyl)-1h-imidazoleIC50218.0 [1]
3-(5-Chloro-6-methoxy-2-naphthyl)pyridineIC5013.0 [1]
3-(1,5-Dichloro-6-methoxy-2-naphthyl)pyridineIC5028.0 [1]
3-(6-Ethoxynaphthalen-2-yl)pyridineIC5012.0 [1]
3-(6-Bromonaphthalen-2-yl)pyridineIC5015.0 [1]
Methyl 6-pyridin-3-yl-2-naphthoateIC5072.0 [1], 73.0 [2]
3-(5-Bromo-6-methoxy-2-naphthyl)pyridineIC5033.0 [1]
4-(1-Imidazolylmethyl)pyridineIC501000.0 [1]
3-Methyl-2-(3-pyridyl)indoleIC503.0 [1], 21.0 [2]
3-(1-Imidazolylmethyl)pyridineIC501000.0 [1]
N-[[5-(6-Chloro-1-methylpyrrolo[2,3-b]pyridin-2-yl)pyridin-3-yl]methyl]ethanesulfonamideIC501.1 [1], 7.0 [2]
1,3-Dimethyl-2-(pyridin-3-yl)indoleIC501.4 [1], 9.0 [2]
5-Imidazol-1-ylmethyl-2-naphthalen-2-yl-pyridineIC50782.0 [1]
Pyridine, 2-(3-furanyl)-5-(1H-imidazol-1-ylmethyl)-IC502832.0 [1]
2,3-Di-furan-2-yl-5-imidazol-1-ylmethyl-pyridineIC50830.0 [1]
2-(2-Fluoro-phenyl)-5-imidazol-1-ylmethyl-pyridineIC501736.0 [1]
5-(5-Imidazol-1-ylmethyl-pyridin-2-yl)-thiophene-2-carbaldehydeIC50968.0 [1]
5-(Imidazol-1-ylmethyl)-2-thiophen-2-ylpyridineIC501243.0 [1]
N-[[5-(6-Chloro-3-cyano-1-methylindol-2-yl)pyridin-3-yl]methyl]ethanesulfonamideIC503.7 [1], 5.8 [2]
[5-(3-Cyano-1-methylindol-2-yl)pyridin-3-yl] N,N-dimethylsulfamateIC502.0 [1], 39.0 [2]
6-Chloro-1-methyl-2-pyridin-3-ylindole-3-carbonitrileIC502.5 [1], 4.0 [2]
1-Methyl-2-pyridin-3-yl-1H-indole-3-carbonitrileIC5011.0 [1], 90.0 [2]
N-[5-(6-Chloro-3-cyano-1-methylindol-2-yl)pyridin-3-yl]ethanesulfonamideIC5011.0 [1], 13.0 [2]
N-[[5-(6-Chloro-1-methylpyrrolo[3,2-c]pyridin-2-yl)pyridin-3-yl]methyl]ethanesulfonamideIC5022.0 [1], 169.0 [2]
3-Imidazol-1-ylmethyl-pyridine-2-carbonitrileIC501000.0 [1]
3-(1H-Inden-2-yl)pyridineIC5013.0 [1], 13.5 [2]
3-(3,4-Dihydronaphthalen-2-yl)pyridineIC507.0 [1]
3-(1-Methyl-3,4-dihydronaphthalen-2-yl)pyridineIC507.0 [1]
3-(1-Ethyl-3,4-dihydronaphthalen-2-yl)pyridineIC5030.0 [1]
3-(3-Methyl-3,4-dihydronaphthalen-2-yl)pyridineIC505.0 [1]
3-(4-Methyl-3,4-dihydronaphthalen-2-yl)pyridineIC5013.0 [1]
2-Furan-2-yl-5-imidazol-1-ylmethyl-pyridineIC505159.0 [1]
2-(3-Fluoro-phenyl)-5-imidazol-1-ylmethyl-pyridineIC501000.0 [1]
2-(5-Chloro-thiophen-2-yl)-5-imidazol-1-ylmethyl-pyridineIC50929.0 [1]
4-(5-Imidazol-1-ylmethyl-pyridin-2-yl)-benzonitrileIC501000.0 [1]
5-Imidazol-1-ylmethyl-2,3-diphenyl-pyridineIC50851.0 [1]
3-(5-Imidazol-1-ylmethyl-pyridin-2-yl)-benzonitrileIC501000.0 [1]
5-(Imidazol-1-ylmethyl)-2-pyridin-3-ylpyridineIC503955.0 [1]
5-(Imidazol-1-ylmethyl)-2-(6-methoxypyridin-3-yl)pyridineIC501000.0 [1]
4-(5-Imidazol-1-ylmethyl-pyridin-2-yl)-isoquinolineIC50914.0 [1]
5-(5-Imidazol-1-ylmethyl-pyridin-2-yl)-2-methyl-phenylamineIC501000.0 [1]
5-(Imidazol-1-ylmethyl)-2-pyridin-4-ylpyridineIC50487.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cytochrome P450 11B2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/cytochrome-p450-11b2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Cytochrome P450 11B2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cytochrome-p450-11b2-inhibitors-ic50-ki.
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