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Cytochrome P450 1A2 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
alpha-NaphthoflavoneIC5030.0 [1]
alpha-NaphthoflavoneKi20.0 [1]
FurafyllineIC502419.0 [1]
FurafyllineKi68000.0 [1]
QuercetinIC501550.0 [1], 4097.0 [2], 20000.0 [3]
ChrysinIC5054.0 [1], 84.0 [2], 570.0 [3]
ChrysinKi500.0 [1]
HomoeriodictyolIC504000.0 [1], 37768.0 [2], 37800.0 [3]
2,3',4,5'-TetramethoxystilbeneIC503000.0 [1], 3100.0 [2]
AuglurantIC501000.0 [1], 2900.0 [2]
4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-(pyrimidin-4-ylmethyl)benzamideIC5010000.0 [1], 50118.72 [2]
1-(4-Pyridyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-oneIC501090.0 [1], 1120.0 [2], 1820.0 [3]
VerapamilIC5030000.0 [1], 50000.0 [2]
HaloperidolIC5030000.0 [1], 50000.0 [2]
LinezolidIC5020000.0 [1]
DuloxetineIC505300.0 [1]
NicardipineIC5013300.0 [1], 30000.0 [2]
PentamidineIC50100000.0 [1]
4-[(7-Chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol;hydrochlorideIC5015000.0 [1]
BepridilIC5030000.0 [1], 50000.0 [2]
DolutegravirIC50100000.0 [1]
DaclatasvirIC50100000.0 [1]
SaxagliptinIC5050000.0 [1]
7-EthoxyresorufinIC50500.0 [1]
AcacetinIC5080.0 [1], 251.0 [2]
6-Chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indolineIC50100000.0 [1]
ShogaolIC502500.0 [1], 20700.0 [2]
PleconarilIC5010000.0 [1], 50118.72 [2]
DesethylamodiaquineIC5028000.0 [1]
KaempferideIC50509.0 [1], 3000.0 [2]
S1RAIC5010000.0 [1]
Bms-536924IC5034000.0 [1]
ParadolIC507100.0 [1], 19600.0 [2]
4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amineIC5010000.0 [1], 50000.0 [2]
(1S,3S,5S)-2-[(2S)-2-Amino-2-(3,5-dihydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrileIC50200000.0 [1]
IsoquineIC5023000.0 [1]
(S)-7-Hydroxy-2-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-8-(3-methylbut-2-en-1-yl)chroman-4-oneIC5020000.0 [1]
2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamideIC50100000.0 [1]
SB 221284IC5013.0 [1]
2,3-Dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamideIC504300.0 [1]
4-Methoxy-3-(1-methylpiperidin-4-yl)oxy-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]benzamideIC5030000.0 [1]
N-(4-(Trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-carboxamideIC5013000.0 [1]
(3R)-N-Isoquinolin-3-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amineIC5040000.0 [1]
2-(2-(4-Tert-Butylphenylthio)ethyl)-1H-imidazoleIC50680.0 [1]
CID 46244454IC5010000.0 [1]
1-Cyclohexyl-2-(furan-3-yl)-N-[(1S)-2-(5-hydroxy-1H-indol-3-yl)-1-(1,3-thiazol-4-yl)ethyl]benzimidazole-5-carboxamideIC5030000.0 [1]
3-(1-Naphthyl)-1-(4-pyridinyl)-2-propen-1-oneIC5028.0 [1], 35.0 [2]
(E)-3-(2-Chlorophenyl)-1-(1H-pyrrol-2-yl)prop-2-en-1-oneIC50700.0 [1], 900.0 [2]
N-[4-[(1R,2R)-2-(Dimethylamino)-1-imidazol-1-ylpropyl]phenyl]-1,3-benzothiazol-2-amineIC508300.0 [1]
LinaprazanIC5050000.0 [1], 100000.0 [2]
4-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-(6-imidazol-1-yl-4-methyl-1H-benzimidazol-2-yl)-1H-pyridin-2-oneIC5018.0 [1], 40.0 [2]
3-[(E)-[3-[(E)-2-[4-[(Dimethylamino)methyl]phenyl]ethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
[3-[4-[[(3S,5R)-3,5-Dimethylpiperazin-1-yl]methyl]phenyl]pyridin-2-yl]-[4-(4-fluoroanilino)piperidin-1-yl]methanoneIC5023000.0 [1], 100000.0 [2]
MCH-1 antagonist 1IC5010000.0 [1]
Methyl 3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propanoateIC501200.0 [1]
2-PyridinecarboxaMide, N-(5-fluoro-2-pyridinyl)-4-[(5-fluoro-3-pyridinyl)oxy]-6-Methyl-IC50200.0 [1]
6-Chloro-7-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridineIC5010000.0 [1], 50000.0 [2]
1-(4-Butoxy-phenyl)-1H-imidazoleIC507.0 [1]
(2R)-2-(2,4-Difluorophenyl)-2-[(2R,5R)-5-(2,3-dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-N,N-dimethylacetamideIC5064000.0 [1], 100000.0 [2]
3-[(E)-[3-[(E)-2-Pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
5-Methoxy-3-[(E)-[3-[(E)-2-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]ethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
1-Ethyl-6-pyridin-3-yl-3,4-dihydroquinolin-2(1H)-oneIC503480.0 [1]
1-[(2-Chloroquinolin-3-yl)methyl]-6-fluoro-5-methyl-3-(2-oxo-1H-pyridin-3-yl)indole-2-carboxylic acidIC5050000.0 [1]
1-[4-[3-[(2R)-2-Methylpyrrolidin-1-yl]propoxy]phenyl]-2-morpholin-4-ylethanoneIC5030000.0 [1]
7-[(cis-4-Aminocyclohexyl)amino]-5-Bromo-1-Benzofuran-2-Carboxylic AcidIC5010000.0 [1]
[(8R)-3-[2-(2,4-Difluorophenyl)-1,3-thiazol-4-yl]-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(4-thiophen-2-ylphenyl)methanoneIC5021000.0 [1]
2-[(2S)-2-(4-Fluorophenyl)morpholin-4-yl]-3-methyl-6-pyrimidin-4-ylpyrimidin-4-oneIC5029400.0 [1]
[(8R)-8-Methyl-3-(2-methyl-1,3-thiazol-4-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(4-thiophen-2-ylphenyl)methanoneIC5026000.0 [1]
[(8R)-8-Methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(4-thiophen-2-ylphenyl)methanoneIC5067000.0 [1]
2-Phenyl-8H-pyrano[2,3-h]chromen-4-oneIC5059.0 [1]
2-Phenyl-8H-pyrano[2,3-h]chromen-4-oneKi58.0 [1]
5-Hydroxy-2-phenyl-8H-pyrano[2,3-h]chromen-4-oneIC5014.0 [1]
5-Hydroxy-2-phenyl-8H-pyrano[2,3-h]chromen-4-oneKi14.0 [1]
(1s,2s)-N-[4-(Phenylsulfonyl)phenyl]-2-(Pyridin-3-Yl)cyclopropanecarboxamideIC5010000.0 [1]
N-[[4-(6-Methylpyridin-3-yl)sulfonylphenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC5010000.0 [1]
N-[[5-(1-Propan-2-ylpyrazol-4-yl)sulfonylpyridin-2-yl]methyl]furo[2,3-c]pyridine-2-carboxamideIC5010000.0 [1]
N-(5-Fluoropyridin-2-yl)-6-(5-fluoropyridin-3-yl)oxy-[1,2,4]triazolo[1,5-a]pyridine-8-carboxamideIC5015100.0 [1]
3-(2-Methoxyphenyl)-1-(1H-pyrrole-2-yl)-2-propene-1-oneIC501100.0 [1]
4-[3-(4-Methoxyphenyl)acryloyl]pyridineIC5012000.0 [1]
(E)-3-(4-Ethoxy-3,5-dimethoxyphenyl)-1-pyridin-4-ylprop-2-en-1-oneIC502210.0 [1], 2580.0 [2]
(E)-3-(3,5-Dimethoxyphenyl)-1-pyridin-4-ylprop-2-en-1-oneIC5028.0 [1]
(E)-1-(1H-Pyrrol-2-yl)-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-oneIC5020000.0 [1]
(E)-3-(3-Ethoxy-4,5-dimethoxyphenyl)-1-pyridin-4-ylprop-2-en-1-oneIC501320.0 [1], 1530.0 [2]
(E)-3-(3,4-Diethoxy-5-methoxyphenyl)-1-pyridin-4-ylprop-2-en-1-oneIC50780.0 [1], 820.0 [2]
(E)-1-Pyridin-4-yl-3-(3,4,5-triethoxyphenyl)prop-2-en-1-oneIC501090.0 [1], 1190.0 [2]
[6-Fluoro-3-[[2-fluoro-3-(sulfamoylamino)phenyl]methyl]-4-methyl-2-oxochromen-7-yl] N,N-dimethylcarbamateIC50100000.0 [1]
(E)-3-(1,3-Benzodioxol-5-yl)-1-pyridin-4-ylprop-2-en-1-oneIC501500.0 [1]
5-Methyl-3-[4-[[1-(6-methylpyridazin-3-yl)azetidin-3-yl]methoxy]phenyl]-1,2,4-oxadiazoleIC5010000.0 [1], 50118.72 [2]
(E)-3-(3-Methoxyphenyl)-1-pyridin-4-ylprop-2-en-1-oneIC5020.0 [1]
(E)-3-(2-Methoxyphenyl)-1-pyridin-4-ylprop-2-en-1-oneIC5032.0 [1]
N-[[4-Fluoro-2-(trifluoromethyl)phenyl]methyl]-5-methoxy-2-pyridin-2-ylpyrimidin-4-amineIC505000.0 [1]
5-Methoxy-2-pyridin-2-yl-N-[(2,4,6-trifluorophenyl)methyl]pyrimidin-4-amineIC505000.0 [1]
N-[(2-Fluorophenyl)methyl]-5-methoxy-2-pyridin-2-ylpyrimidin-4-amineIC505000.0 [1]
(E)-1-Pyridin-4-yl-3-(2,3,4-trimethoxyphenyl)prop-2-en-1-oneIC50104.0 [1], 200.0 [2]
(E)-3-(3,4-Dimethoxyphenyl)-1-pyridin-4-ylprop-2-en-1-oneIC50120.0 [1]
2',3,4,4'-Tetramethoxy-trans-stilbeneIC50337.0 [1], 100000.0 [2]
PropranololIC5010000.0 [1]
Cyclosporin AIC50100000.0 [1]
MelatoninKi12000.0 [1]
NicotineIC504100000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cytochrome P450 1A2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/cytochrome-p450-1a2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Cytochrome P450 1A2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cytochrome-p450-1a2-inhibitors-ic50-ki.
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