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Cytochrome P450 24A1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
KetoconazoleIC50500.0 [1]
KetoconazoleKi33.0 [1], 35.0 [2]
(1,1'-Biphenyl)-4-carboxamide, 4'-chloro-N-((2R)-2-(1H-imidazol-1-yl)-2-phenylethyl)-IC5015.0 [1], 15.1 [2], 15.2 [3]
CID 9982767IC506.5 [1], 7.4 [2], 28.0 [3]
4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]-N-(2-imidazol-1-yl-2-phenylethyl)benzamideIC50110.0 [1]
N-(2-Imidazol-1-yl-2-phenylethyl)-4-[(E)-2-phenylethenyl]benzamideIC50300.0 [1], 400.0 [2]
LiarozoleIC502.3 [1]
6-Methoxy-2-(2-methylbenzyl)-3,4-dihydro-2H-naphthalen-1-oneIC50900.0 [1]
2-Bromo-Benzylidene TetraloneIC50122000.0 [1]
CID 44445025IC507.4 [1]
(2E)-6-Methoxy-2-(2-methylbenzylidene)-3,4-dihydronaphthalen-1(2H)-oneIC50480100.0 [1]
2-(2-Bromobenzyl)-6-methoxy-tetraloneIC5016300.0 [1]
4-(4-Chlorophenyl)-N-(2-imidazol-1-yl-2-phenylethyl)benzamideIC5015.0 [1]
(1R,3S,5Z)-5-[(2E)-2-[(1R,3As,7aR)-1-[(2R)-4-[(4-fluorophenyl)sulfonimidoyl]butan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diolIC5028.0 [1]
(1R,3R)-5-[(2E)-2-[(1R,3As,7aR)-1-[(2S)-1-imidazol-1-ylpropan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diolKi21.0 [1]
[(4R)-4-[(1R,3As,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]pentyl] 4-methylbenzenesulfonateKi39.0 [1]
(1R,3R)-5-[(2E)-2-[(1R,3As,7aR)-7a-methyl-1-[(2R)-4-(phenylsulfonimidoyl)butan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diolIC5013.0 [1]
(1R,3S,5Z)-5-[(2E)-2-[(1R,3As,7aR)-7a-methyl-1-[(2R)-1-[1-(phenylsulfonimidoyl)cyclopropyl]propan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diolIC5020.5 [1]
LunacalcipolIC5027.0 [1]
(1R,3S,5Z)-5-[(2E)-2-[(1R,3As,7aR)-1-[(E,2S)-4-fluoro-4-(phenylsulfonimidoyl)but-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diolIC501000.0 [1]
(1R,3S,5Z)-5-[(2E)-2-[(1R,3As,7aR)-7a-methyl-1-[(E,2S)-4-(phenylsulfonimidoyl)but-3-en-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diolIC501000.0 [1]
(1S,3Z)-3-[(2E)-2-[(1R,3As,7aR)-7a-methyl-1-[(2R)-4-(phenylsulfonimidoyl)butan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-olIC5075.0 [1]
(1R,3S,5Z)-5-[(2E)-2-[(1R,3As,7aR)-1-[(2R)-4-(benzenesulfonyl)butan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diolIC5028.0 [1]
4-[(E)-2-(4-Fluorophenyl)ethenyl]-N-(2-imidazol-1-yl-2-phenylethyl)benzamideIC50260.0 [1]
N-(2-Imidazol-1-yl-2-phenylethyl)-4-[(E)-2-(4-methoxyphenyl)ethenyl]benzamideIC50340.0 [1]
N-(2-Imidazol-1-yl-2-phenylethyl)-4-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzamideIC50140.0 [1]
4-[2-(4-Fluorophenyl)ethyl]-N-(2-imidazol-1-yl-2-phenylethyl)benzamideIC50510.0 [1]
N-(2-Imidazol-1-yl-2-phenylethyl)-4-(phenylsulfamoyl)benzamideIC501300.0 [1]
1-[4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenyl]-4,4-dimethylpentan-3-oneIC502100.0 [1]
[1-[4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenyl]-4,4-dimethylpentan-3-yl] imidazole-1-carboxylateIC50160.0 [1]
[4,4-Dimethyl-1-[4-[(E)-2-phenylethenyl]phenyl]pentan-3-yl] methanesulfonateIC505600.0 [1]
[1-[4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenyl]-4,4-dimethylpentan-3-yl] methanesulfonateIC505400.0 [1]
[1-[4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenyl]-4,4-dimethylpentan-3-yl] 4-methylbenzenesulfonateIC502900.0 [1]
(Z)-2-Imidazol-1-yl-4,4-dimethyl-1-[4-[(E)-2-phenylethenyl]phenyl]pent-1-en-3-oneIC50180.0 [1]
2-Imidazol-1-yl-4,4-dimethyl-1-[4-(2-phenylethyl)phenyl]pentan-3-oneIC50600.0 [1]
1-(3-Imidazol-1-ylpropyl)-4-[(E)-2-phenylethenyl]indoleKi26.0 [1]
4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]-1-(3-imidazol-1-ylpropyl)indoleKi31.0 [1]
1-(4-Imidazol-1-ylbutyl)-4-[(E)-2-phenylethenyl]indoleKi14.0 [1]
4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]-1-(4-imidazol-1-ylbutyl)indoleKi14.0 [1]
1-(3-Imidazol-1-ylpropyl)-5-[(E)-2-phenylethenyl]indoleKi37.0 [1]
1-(4-Imidazol-1-ylbutyl)-5-[(E)-2-phenylethenyl]indoleKi37.0 [1]
4-Methyl-N-[3-[4-[(E)-2-phenylethenyl]indol-1-yl]propyl]benzenesulfonamideKi340.0 [1]
N-[3-[4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]indol-1-yl]propyl]-4-methylbenzenesulfonamideKi730.0 [1]
4-Methyl-N-[4-[4-[(E)-2-phenylethenyl]indol-1-yl]butyl]benzenesulfonamideKi230.0 [1]
N-[4-[4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]indol-1-yl]butyl]-4-methylbenzenesulfonamideKi740.0 [1]
3-[4-[(E)-2-Phenylethenyl]indol-1-yl]propyl benzenesulfinateKi540.0 [1]
3-[4-[(E)-2-Phenylethenyl]indol-1-yl]propyl 4-methylbenzenesulfonateKi640.0 [1]
3-[4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]indol-1-yl]propyl 4-methylbenzenesulfonateKi1190.0 [1]
N-[2-Imidazol-1-yl-2-[4-(trifluoromethyl)phenyl]ethyl]-4-[(E)-2-phenylethenyl]benzamideIC50180.0 [1]
N-[2-Imidazol-1-yl-2-[2-(trifluoromethyl)phenyl]ethyl]-4-[(E)-2-phenylethenyl]benzamideIC50350.0 [1]
N-[2-Imidazol-1-yl-2-(4-methoxyphenyl)ethyl]-4-[(E)-2-phenylethenyl]benzamideIC50110.0 [1]
N-(2-Imidazol-1-yl-2-phenylethyl)-3-[(E)-2-[2-(trifluoromethyl)phenyl]ethenyl]benzamideIC50340.0 [1]
N-(2-Imidazol-1-yl-2-phenylethyl)-3-[(E)-2-phenylethenyl]benzamideIC50190.0 [1]
N-[2-Imidazol-1-yl-2-[4-(trifluoromethyl)phenyl]ethyl]-3-[(E)-2-phenylethenyl]benzamideIC50150.0 [1]
N-[2-(4-Chlorophenyl)-2-imidazol-1-ylethyl]-3-[(E)-2-phenylethenyl]benzamideIC50160.0 [1]
N-[2-(4-Chlorophenyl)-2-imidazol-1-ylethyl]-4-[(E)-2-phenylethenyl]benzamideIC50210.0 [1]
N-[2-(4-Chlorophenyl)-2-imidazol-1-ylethyl]-4-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]benzamideIC50120.0 [1]
N-[1-(2,4-Dichlorophenyl)-2-imidazol-1-ylethyl]-5-(dimethylamino)naphthalene-1-sulfonamideIC504480.0 [1]
5-Methyl-4-[(3-methyl-5-oxo-1,2-dihydropyrazol-4-yl)-[3-(pyridin-4-ylmethoxy)phenyl]methyl]-1,2-dihydropyrazol-3-oneIC502600.0 [1]
N-[2-(3,4-Dimethylphenyl)-2-imidazol-1-ylethyl]-4-[(E)-2-phenylethenyl]benzamideIC50310.0 [1]
5-Methyl-4-[(3-methyl-5-oxo-1,2-dihydropyrazol-4-yl)-[4-(pyridin-4-ylmethoxy)phenyl]methyl]-1,2-dihydropyrazol-3-oneIC502500.0 [1]
2-(2,4-Dichlorophenyl)-1-[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanyl-3-imidazol-1-ylpropan-2-olIC5010000.0 [1]
N-(2-Imidazol-1-yl-2-phenylethyl)-1-benzofuran-2-carboxamideIC504000.0 [1]
N-[2-(4-Fluorophenyl)-2-imidazol-1-ylethyl]-1-benzofuran-2-carboxamideIC502800.0 [1]
(E)-2-(2-Trifluoromethylbenzylidene)-6-methoxy-tetraloneIC5011220.0 [1]
(E)-2-(2-Ethylbenzylidene)-6-methoxy-tetraloneIC5010760.0 [1]
2-(2-Trifluoromethylbenzyl)-6-methoxy-tetraloneIC502080.0 [1]
(2E)-6-Methoxy-2-[[2-[(E)-2-phenylethenyl]phenyl]methylidene]-3,4-dihydronaphthalen-1-oneIC505080.0 [1]
2-(Biphenyl-2-ylmethyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-oneIC50127600.0 [1]
6-Methoxy-2-[[2-[(E)-2-phenylethenyl]phenyl]methyl]-3,4-dihydro-2H-naphthalen-1-oneIC50342800.0 [1]
2-(2-Phenethylbenzyl)-6-methoxy-tetraloneIC5025570.0 [1]
2-(2-Ethylbenzyl)-6-methoxy-tetraloneIC501920.0 [1]
N-(2-Imidazol-1-yl-2-phenylethyl)-6-methoxy-1-benzofuran-2-carboxamideIC5036900.0 [1]
N-(2-Imidazol-1-yl-2-phenylethyl)-5-nitro-1-benzofuran-2-carboxamideIC506400.0 [1]
N-[2-(4-Chlorophenyl)-2-imidazol-1-ylethyl]-1-benzofuran-2-carboxamideIC5010600.0 [1]
4-Bromo-N-(2-imidazol-1-yl-2-phenylethyl)benzamideIC5023000.0 [1]
4-Benzyl-N-(2-imidazol-1-yl-2-phenylethyl)benzamideIC5072000.0 [1]
(2E)-6-Methoxy-2-[(2-phenylphenyl)methylidene]-3,4-dihydronaphthalen-1-oneIC50111100.0 [1]
(1R,3R)-5-[(2E)-2-[(1R,3As,7aR)-1-[(2R)-5-(cyclopropylamino)pentan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diolKi42.0 [1]
(1R,3S,5Z)-5-[(2E)-2-[(1R,3As,7aR)-7a-methyl-1-[(E,2R)-4-(phenylsulfonimidoyl)but-3-en-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diolIC50549.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cytochrome P450 24A1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/cytochrome-p450-24a1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Cytochrome P450 24A1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cytochrome-p450-24a1-inhibitors-ic50-ki.
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