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Cytochrome P450 2C19 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
(1S,2R)-2-Phenylcyclopropan-1-amine;(1R,2S)-2-phenylcyclopropan-1-amineIC505950.0 [1]
VoriconazoleIC505250.0 [1], 8700.0 [2], 15000.0 [3]
VoriconazoleKi5100.0 [1]
alpha-NaphthoflavoneIC5010000.0 [1], 20000.0 [2]
KetoconazoleIC5010100.0 [1], 19000.0 [2]
ModafinilIC5011000.0 [1]
(S)-(+)-N-3-BenzylnirvanolIC50138.0 [1], 211.0 [2], 294.0 [3]
4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-(pyrimidin-4-ylmethyl)benzamideIC507943.28 [1], 10000.0 [2], 50118.72 [3]
VerapamilIC5021800.0 [1], 30000.0 [2]
HaloperidolIC502870.0 [1], 50000.0 [2]
TiclopidineIC501300.0 [1], 28400.0 [2]
FluconazoleIC508200.0 [1]
SertralineIC50310.0 [1], 22500.0 [2]
DuloxetineIC504100.0 [1]
MiconazoleIC5017900.0 [1], 18000.0 [2]
NicardipineIC50560.0 [1], 3300.0 [2]
PentamidineIC50100000.0 [1]
ParnateIC503040.0 [1], 5000.0 [2]
TranylcypromineIC503100.0 [1], 5000.0 [2]
4-[(7-Chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol;hydrochlorideIC5085000.0 [1]
BepridilIC50100.0 [1], 32200.0 [2]
GingerolIC5010900.0 [1], 30700.0 [2]
DolutegravirIC50100000.0 [1]
BenzbromaroneIC5018200.0 [1]
BenzbromaroneKi3700.0 [1]
SaxagliptinIC5050000.0 [1]
(10)-GingerolIC506600.0 [1], 13600.0 [2]
PleconarilIC5010000.0 [1], 50118.72 [2]
DesethylamodiaquineIC5054000.0 [1]
S1RAIC5010000.0 [1]
Bms-536924IC502000.0 [1]
ParadolIC503600.0 [1], 17600.0 [2]
TemsavirIC5025000.0 [1], 40000.0 [2]
(8)-GingerolIC508100.0 [1], 12500.0 [2]
3-(5-(4-(1H-Imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acidIC50770.0 [1]
4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amineIC5010000.0 [1], 50000.0 [2]
(1S,3S,5S)-2-[(2S)-2-Amino-2-(3,5-dihydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrileIC50200000.0 [1]
IsoquineIC5039000.0 [1]
2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamideIC50100000.0 [1]
2,3-Dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamideIC5020000.0 [1]
(3R)-N-Isoquinolin-3-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amineIC5040000.0 [1]
TGR5 Receptor AgonistIC50316.23 [1]
2-(2-(4-Tert-Butylphenylthio)ethyl)-1H-imidazoleIC508.5 [1]
CID 46244454IC5010000.0 [1]
1-Cyclohexyl-2-(furan-3-yl)-N-[(1S)-2-(5-hydroxy-1H-indol-3-yl)-1-(1,3-thiazol-4-yl)ethyl]benzimidazole-5-carboxamideIC502400.0 [1]
3-(1-Naphthyl)-1-(4-pyridinyl)-2-propen-1-oneIC5010000.0 [1], 20000.0 [2]
(E)-3-(2-Chlorophenyl)-1-(1H-pyrrol-2-yl)prop-2-en-1-oneIC5010000.0 [1], 20000.0 [2]
1-Cyano-3-(2-methyl-1-benzofuran-5-yl)-2-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]guanidineIC5040000.0 [1], 200000.0 [2]
Bms-344577IC5051000.0 [1], 200000.0 [2]
2-(4-Fluorophenyl)-N-[6-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]-1-methylbenzimidazol-4-amineIC503500.0 [1]
2-((Pyridin-2-ylmethyl)thio)-1H-benzo[d]imidazoleIC5050000.0 [1]
2-((Pyridin-2-ylmethyl)thio)-1H-benzo[d]imidazoleKi50.0 [1]
N-[4-[(1R,2R)-2-(Dimethylamino)-1-imidazol-1-ylpropyl]phenyl]-1,3-benzothiazol-2-amineIC50350.0 [1], 5900.0 [2]
LinaprazanIC50100000.0 [1]
(5-Pyrid-3-ylthien-2-YL)methylamineIC502000.0 [1]
(5-Pyrid-3-ylthien-2-YL)methylamineKi1000.0 [1]
(5-(Pyridin-3-YL)furan-2-YL)methanamineIC5022000.0 [1]
(5-(Pyridin-3-YL)furan-2-YL)methanamineKi11000.0 [1]
3-[(E)-[3-[(E)-2-[4-[(Dimethylamino)methyl]phenyl]ethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC501000.0 [1]
[3-[4-[[(3S,5R)-3,5-Dimethylpiperazin-1-yl]methyl]phenyl]pyridin-2-yl]-[4-(4-fluoroanilino)piperidin-1-yl]methanoneIC5023000.0 [1], 100000.0 [2]
N-(2,4-Dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperidine-1-carboxamideIC5019000.0 [1]
MCH-1 antagonist 1IC5010000.0 [1]
3-(1H-Imidazol-4-yl)pyridineIC5053500.0 [1]
3-(1H-Imidazol-4-yl)pyridineKi26800.0 [1]
Methyl 3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propanoateIC50100.0 [1], 1500.0 [2]
(E)-3-[4-[[1-[(3-Cyclopentyl-1-methyl-2-pyridin-2-ylindole-6-carbonyl)amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoic acidIC502900.0 [1]
6-Chloro-7-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridineIC5030.0 [1], 10000.0 [2]
1-(4-Butoxy-phenyl)-1H-imidazoleIC507.0 [1]
Pyridine, 3-(1-methyl-1H-imidazol-4-yl)-IC50122100.0 [1]
Pyridine, 3-(1-methyl-1H-imidazol-4-yl)-Ki61000.0 [1]
3-(4-Methylthiophen-3-yl)pyridineIC5024900.0 [1]
3-(4-Methylthiophen-3-yl)pyridineKi12500.0 [1]
(2R)-2-(2,4-Difluorophenyl)-2-[(2R,5R)-5-(2,3-dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-N,N-dimethylacetamideIC5038000.0 [1], 100000.0 [2]
2-((4'-Chlorobiphenyl-2-yl)methylsulfinyl)acetamideIC5019000.0 [1], 112000.0 [2]
2-(Ethylsulfanyl)-6-methoxy-1h-benzimidazoleIC5050000.0 [1]
2-(Ethylsulfanyl)-6-methoxy-1h-benzimidazoleKi42500.0 [1]
3-[(E)-[3-[(E)-2-Pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC50130.0 [1]
5-Methoxy-3-[(E)-[3-[(E)-2-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]ethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC50800.0 [1], 1600.0 [2]
3-(2-Methyl-1H-imidazol-1-yl)pyridineIC50300000.0 [1]
3-(2-Methyl-1H-imidazol-1-yl)pyridineKi300000.0 [1]
3-(3-Methylthiophen-2-yl)pyridineIC5020100.0 [1]
3-(3-Methylthiophen-2-yl)pyridineKi10100.0 [1]
4-(1-(2,4-Dichlorobenzylcarbamoyl)piperidin-4-yloxy)benzoic acidIC5030000.0 [1]
1-[(2-Chloroquinolin-3-yl)methyl]-6-fluoro-5-methyl-3-(2-oxo-1H-pyridin-3-yl)indole-2-carboxylic acidIC5050000.0 [1]
6-Methyl-2-(pyridin-2-ylmethylsulfanyl)-1H-benzimidazoleIC5050.0 [1]
6-Methyl-2-(pyridin-2-ylmethylsulfanyl)-1H-benzimidazoleKi20.0 [1]
2-(3,5-Dimethoxybenzylthio)-6-methoxy-1H-benzo[d]imidazoleIC5050000.0 [1]
2-(3,5-Dimethoxybenzylthio)-6-methoxy-1H-benzo[d]imidazoleKi70.0 [1]
6-Methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d]imidazoleIC5050000.0 [1]
6-Methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d]imidazoleKi60.0 [1]
1-[4-[3-[(2R)-2-Methylpyrrolidin-1-yl]propoxy]phenyl]-2-morpholin-4-ylethanoneIC5030000.0 [1]
7-[(cis-4-Aminocyclohexyl)amino]-5-Bromo-1-Benzofuran-2-Carboxylic AcidIC5010000.0 [1]
[(8R)-3-[2-(2,4-Difluorophenyl)-1,3-thiazol-4-yl]-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(4-thiophen-2-ylphenyl)methanoneIC504000.0 [1]
CID 56593147IC5020000.0 [1]
(2'S,3R)-5-Methoxy-2'-[3-[(E)-2-[4-(morpholin-4-ylmethyl)phenyl]ethenyl]-1H-indazol-6-yl]spiro[1H-indole-3,1'-cyclopropane]-2-oneIC501200.0 [1], 2100.0 [2]
(2'S,3R)-2'-[3-[(E)-2-[4-(Morpholin-4-ylmethyl)phenyl]ethenyl]-1H-indazol-6-yl]spiro[1H-indole-3,1'-cyclopropane]-2-oneIC50800.0 [1], 1800.0 [2]
(2'S,3R)-2'-[3-[(E)-2-[4-[(Dimethylamino)methyl]phenyl]ethenyl]-1H-indazol-6-yl]spiro[1H-indole-3,1'-cyclopropane]-2-oneIC501000.0 [1]
(2'S,3R)-5-Methoxy-2'-[3-[(E)-2-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]ethenyl]-1H-indazol-6-yl]spiro[1H-indole-3,1'-cyclopropane]-2-oneIC501500.0 [1], 1600.0 [2]
(2'S,3R)-2'-[3-[(E)-2-[4-[(Dimethylamino)methyl]phenyl]ethenyl]-1H-indazol-6-yl]-5-methoxyspiro[1H-indole-3,1'-cyclopropane]-2-oneIC50750.0 [1], 2000.0 [2]
3-(3-Thienyl)pyridineIC50111200.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cytochrome P450 2C19 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/cytochrome-p450-2c19-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Cytochrome P450 2C19 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cytochrome-p450-2c19-inhibitors-ic50-ki.
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