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Cytochrome P450 2E1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
SaxagliptinIC5050000.0 [1]
ShogaolIC5076100.0 [1], 99600.0 [2]
S1RAIC5010000.0 [1]
(1S,3S,5S)-2-[(2S)-2-Amino-2-(3,5-dihydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrileIC50200000.0 [1]
(5-Pyrid-3-ylthien-2-YL)methylamineIC5040200.0 [1]
(5-Pyrid-3-ylthien-2-YL)methylamineKi20100.0 [1]
(5-(Pyridin-3-YL)furan-2-YL)methanamineIC50172000.0 [1]
(5-(Pyridin-3-YL)furan-2-YL)methanamineKi86000.0 [1]
3-(1H-Imidazol-4-yl)pyridineIC5025500.0 [1]
3-(1H-Imidazol-4-yl)pyridineKi12800.0 [1]
Pyridine, 3-(1-methyl-1H-imidazol-4-yl)-IC504100.0 [1]
Pyridine, 3-(1-methyl-1H-imidazol-4-yl)-Ki2000.0 [1]
3-(4-Methylthiophen-3-yl)pyridineIC506300.0 [1]
3-(4-Methylthiophen-3-yl)pyridineKi3100.0 [1]
3-(2-Methyl-1H-imidazol-1-yl)pyridineIC50109000.0 [1]
3-(2-Methyl-1H-imidazol-1-yl)pyridineKi54500.0 [1]
3-(3-Methylthiophen-2-yl)pyridineIC506900.0 [1]
3-(3-Methylthiophen-2-yl)pyridineKi3500.0 [1]
3-(3-Thienyl)pyridineIC50400000.0 [1]
3-(3-Thienyl)pyridineKi400000.0 [1]
Diethyldithiocarbamic acidIC50850.0 [1]
IvacaftorIC5020000.0 [1]
TariquidarIC50100000.0 [1]
OrteronelIC5030000.0 [1]
RimegepantIC5020000.0 [1]
(8)-GingerolIC5093200.0 [1]
4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amineIC5050000.0 [1]
1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanoneIC50200000.0 [1]
CID 11570626IC50100000.0 [1]
3,3'-BipyridineIC50300000.0 [1]
ContezolidIC509600.0 [1]
VidupiprantIC5030000.0 [1]
N-[4-[3-(6-Methylpyridin-3-yl)-1,2,4-triazol-1-yl]phenyl]-4-(3-morpholin-4-ylphenyl)pyrimidin-2-amineIC5050000.0 [1]
3-(4-Methyl-1,3-thiazol-2-yl)pyridineKi9600.0 [1]
MorphothiadinIC5020000.0 [1]
2-((Pyridin-2-ylmethyl)thio)-1H-benzo[d]imidazoleIC5050000.0 [1]
Methyl[3-(pyridin-3-yl)prop-2-yn-1-yl]amineKi117000.0 [1]
1-(3-Hydroxyazetidin-1-yl)-2-(6-hydroxy-2-phenyl-2-adamantyl)ethanoneIC5040000.0 [1]
N'-[(1-Tert-butyltetrazol-5-yl)-(4-chlorophenyl)methyl]-N-(7-chloroquinolin-4-yl)ethane-1,2-diamineIC5020000.0 [1]
3-PhenylthiopheneKi9700.0 [1]
Dimethyl[3-(pyridin-3-yl)prop-2-yn-1-yl]amineKi400000.0 [1]
3-[[4-[(2-Pyridyl)amino]butyrylamino]acetylamino]-3-(3-nitrophenyl)propionic acidIC50850.0 [1]
2-Fluoro-5-(3-methylthiophen-2-yl)pyridineKi184000.0 [1]
N,N-Dimethyl(5-(pyridin-3-yl)furan-2-yl)methanamineKi400000.0 [1]
N-Methyl(5-(pyridin-3-yl)furan-2-yl)methanamineKi400000.0 [1]
3-(Pyridin-3-yl)prop-2-yn-1-amineKi10500.0 [1]
Dimethyl({[5-(pyridin-3-yl)thiophen-2-yl]methyl})amineKi400000.0 [1]
N-Methyl-(5-pyrid-3-ylthien-2-yl)methylamineKi400000.0 [1]
(5-Phenylthiophen-2-yl)methanamineKi40.0 [1]
2-(Ethylsulfanyl)-6-methoxy-1h-benzimidazoleIC5050000.0 [1]
7-[(3-Chlorophenyl)methoxy]-4-(methylaminomethyl)chromen-2-one;methanesulfonic acidIC505000.0 [1]
6-Methyl-2-(pyridin-2-ylmethylsulfanyl)-1H-benzimidazoleIC5050000.0 [1]
2-(3,5-Dimethoxybenzylthio)-6-methoxy-1H-benzo[d]imidazoleIC5050000.0 [1]
6-Methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d]imidazoleIC5050000.0 [1]
3-(2-Thienyl)pyridineIC504100.0 [1]
1-(4-Pyridyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-oneIC5010000.0 [1]
5-(Pyridin-3-yl)thiophene-2-carbaldehydeIC5034300.0 [1]
3-(1-Benzyl-1H-imidazol-4-yl)pyridineIC50580.0 [1]
Bis-(5-pyridin-3-yl-thiophen-2-ylmethyl)-amineIC50860.0 [1]
2-Thiophenecarboxaldehyde, 5-(3-pyridinyl)-, oximeIC504200.0 [1]
(NZ)-N-[(5-pyridin-3-ylfuran-2-yl)methylidene]hydroxylamineIC50400000.0 [1]
Pyridine, 2-fluoro-5-(3-thienyl)-IC507200.0 [1]
(NE)-N-[(5-pyridin-3-ylfuran-2-yl)methylidene]hydroxylamineIC50400000.0 [1]
Pyridine, 2-fluoro-5-(4-methyl-3-thienyl)-IC50368000.0 [1]
2-[[2-[7-Chloro-1-(oxan-4-ylmethyl)indol-3-yl]-1,3-thiazol-4-yl]methyl-propan-2-ylamino]ethanolIC50100000.0 [1]
3-(1-Ethyl-1H-imidazol-4-yl)pyridineIC5080000.0 [1]
(2S,3S,4S,5R,6S)-6-[2-[4-[4-(Tert-butylcarbamoyl)-2-[(2-chloro-4-cyclopropylphenyl)sulfonylamino]phenoxy]-5-chloro-2-fluorophenyl]acetyl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acidKi30000.0 [1]
2-[[3-[4-[[2-[[1-[3-[3-(Cyclohexylamino)propylamino]propyl]triazol-4-yl]methylamino]-6-methylpyrimidin-4-yl]amino]piperidin-1-yl]-3-oxopropyl]amino]acetic acidIC50100000.0 [1]
1-(3-Pyridin-3-ylisoxazol-5-YL)methanamineKi38900.0 [1]
2-Furanmethanethiol, 5-(3-pyridinyl)-Ki50.0 [1]
Pyridine, 3-[5-(1,3-dithiolan-2-yl)-2-furanyl]-Ki600.0 [1]
3-Methyl-4-phenylthiopheneKi400000.0 [1]
(3-(Pyridin-3-yl)-1H-pyrazol-5-yl)methanamineKi400000.0 [1]
(5-Phenylfuran-2-yl)methanamineKi800.0 [1]
S-(5-(Pyridin-3-yl)furan-2-yl)methyl ethanethioateKi200.0 [1]
3-(5-((Methylthio)methyl)furan-2-yl)pyridineKi800.0 [1]
3-(Pyridin-3-yl)prop-2-yn-1-amine dihydrochlorideIC5019000.0 [1]
2,4-Difluoro-N-[2-methoxy-5-[4-methyl-2-(methylamino)-8-(oxan-4-yloxy)quinazolin-6-yl]pyridin-3-yl]benzenesulfonamideIC5010000.0 [1]
2,4-Difluoro-N-[2-methoxy-5-[4-methyl-2-(methylamino)-8-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]pyridin-3-yl]benzenesulfonamideIC5010000.0 [1]
N-[5-[2-Amino-4-methyl-8-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamideIC5010000.0 [1]
N-[5-[2-Amino-4-methyl-8-(oxan-4-yloxy)quinazolin-6-yl]-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamideIC5010000.0 [1]
3-(Pyridin-3-yl)propan-1-amineKi400000.0 [1]
1-(2-Bromophenyl)sulfonyl-5-methoxy-3-[(4-methylpiperazin-1-yl)methyl]indole;methanesulfonic acid;hydrateIC5010000.0 [1]
2-(6-Methoxy-2-methylquinolin-4-yl)oxy-N-(4-pentylphenyl)acetamideIC5030000.0 [1]
2-(Pyridin-2-ylmethylsulfanyl)-3H-benzimidazol-5-amineIC5050000.0 [1]
[5-(4-Methoxypyridin-3-yl)thiophen-2-yl]methanamine;dihydrochlorideIC504500.0 [1]
3-(4-Methylpyridin-3-yl)prop-2-yn-1-amine;dihydrochlorideIC5019000.0 [1]
3-(4-Propylpyridin-3-yl)prop-2-yn-1-amine;dihydrochlorideIC5032000.0 [1]
3-(4-Ethylpyridin-3-yl)prop-2-yn-1-amine;dihydrochlorideIC5015000.0 [1]
[5-(4-Methylpyridin-3-yl)furan-2-yl]methanamine;dihydrochlorideIC5012000.0 [1]
3-(4-Pyridin-3-ylpyridin-3-yl)prop-2-yn-1-amine;trihydrochlorideIC5045000.0 [1]
[5-(4-Pyridin-4-ylpyridin-3-yl)thiophen-2-yl]methanamine;trihydrochlorideIC5031000.0 [1]
[5-(4-Ethylpyridin-3-yl)furan-2-yl]methanamine;dihydrochlorideIC50920.0 [1]
3-[4-(Furan-3-yl)pyridin-3-yl]prop-2-yn-1-amine;dihydrochlorideIC504200.0 [1]
3-(4-Methoxypyridin-3-yl)prop-2-yn-1-amine;dihydrochlorideIC5018000.0 [1]
[5-(4-Pyrimidin-5-ylpyridin-3-yl)furan-2-yl]methanamine;tetrahydrochlorideIC5050000.0 [1]
[5-(4-Propylpyridin-3-yl)furan-2-yl]methanamine;dihydrochlorideIC501900.0 [1]
[5-(4-Pyridin-3-ylpyridin-3-yl)furan-2-yl]methanamine;trihydrochlorideIC5031000.0 [1]
[5-[4-(Furan-3-yl)pyridin-3-yl]furan-2-yl]methanamine;dihydrochlorideIC501300.0 [1]
[5-[4-(Furan-2-yl)pyridin-3-yl]thiophen-2-yl]methanamine;dihydrochlorideIC503100.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cytochrome P450 2E1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/cytochrome-p450-2e1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Cytochrome P450 2E1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cytochrome-p450-2e1-inhibitors-ic50-ki.
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