D-3-phosphoglycerate dehydrogenase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Ethanone, 2-(morpholin-4-yl)-1-phenyl-2-thioxo-	IC50	30900.0 [1]
	Ethanone, 2-(morpholin-4-yl)-1-phenyl-2-thioxo-	Ki	27000.0 [1], 40000.0 [2]
	1-(4-Fluorophenyl)-2-morpholino-2-thioxoethanone	IC50	43300.0 [1], 64400.0 [2], 68900.0 [3], 100000.0 [4]
	2-Morpholino-1-(4-nitrophenyl)-2-thioxoethanone	IC50	6000.0 [1], 7600.0 [2], 17600.0 [3], 22800.0 [4], 35100.0 [5]
	1-(4-Iodophenyl)-2-morpholin-4-yl-2-sulfanylideneethanone	IC50	7100.0 [1], 9300.0 [2], 19600.0 [3], 25700.0 [4], 177700.0 [5]
	1-(3-Chlorophenyl)-2-morpholin-4-yl-2-sulfanylideneethanone	IC50	100000.0 [1], 200000.0 [2]
	1-(2-Chlorophenyl)-2-morpholin-4-yl-2-sulfanylideneethanone	IC50	100000.0 [1], 200000.0 [2]
	1-(4-Chlorophenyl)-2-morpholino-2-thioxoethan-1-one	IC50	6600.0 [1], 8700.0 [2], 15500.0 [3], 21000.0 [4], 50500.0 [5]
	4-Chloro-N-(2-nitrophenyl)benzamide	IC50	57500.0 [1], 75200.0 [2], 83000.0 [3], 100000.0 [4]
	1-(4-Bromophenyl)-2-morpholino-2-thioxoethanone	IC50	7900.0 [1], 16900.0 [2], 20400.0 [3], 37200.0 [4], 130700.0 [5]
	(3,4-Dichlorophenyl)(morpholino)methanethione	IC50	5600.0 [1], 7000.0 [2], 16000.0 [3], 19100.0 [4], 24300.0 [5]
	N-(4-Methylpyridin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide	IC50	5400.0 [1], 14100.0 [2], 15300.0 [3], 17200.0 [4]
	Ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate	IC50	7000.0 [1], 33000.0 [2]
	CID 118796328	IC50	2500.0 [1]
	N-(4,6-Dimethyl-2-pyridinyl)-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarbothioamide	IC50	3700.0 [1]
	N-(4,6-Dimethylpyridin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide	IC50	6300.0 [1], 6500.0 [2]
	3-Phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide	IC50	50000.0 [1]
	5-(2-Hydroxyphenyl)-N-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxamide	IC50	100000.0 [1]
	PHGDH-inactive	IC50	57000.0 [1]
	N-(3-Methylphenyl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide	IC50	57000.0 [1]
	4-[(1S)-1-[[5-Chloro-6-[2-(2-hydroxyethylamino)-2-oxoethoxy]-1H-indole-2-carbonyl]amino]-2-hydroxyethyl]benzoic acid	IC50	1400.0 [1]
	N-Pyridin-2-yl-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide	IC50	6800.0 [1]
	N-(4,6-Dimethylpyridin-2-yl)-4-[6-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide	IC50	11000.0 [1]
	4-[3-(Trifluoromethyl)phenyl]-N-[4-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide	IC50	6400.0 [1]
	N-Pyridin-4-yl-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide	IC50	14000.0 [1]
	N-Quinolin-2-yl-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide	IC50	10000.0 [1]
	Methyl 2-[[4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioyl]amino]pyridine-4-carboxylate	IC50	13000.0 [1]
	N-(4,6-Dimethylpyridin-2-yl)-4-[[3-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide	IC50	5300.0 [1]
	5-(2-Hydroxyphenyl)-N-[4-(piperidin-1-ylsulfonyl)phenyl]-1H-pyrazole-3-carboxamide	IC50	100000.0 [1]
	N-(4,6-Dimethylpyridin-2-yl)-4-pyridin-2-ylpiperazine-1-carbothioamide	IC50	37000.0 [1]
	N-Pyridin-3-yl-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide	IC50	8900.0 [1]
	N-(4-Methylpyrimidin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide	IC50	37000.0 [1]
	N-(4-Methylquinolin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide	IC50	21000.0 [1]
	N-[4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-3-phenyl-1H-pyrazole-5-carboxamide	IC50	50000.0 [1]
	4-Methyl-3-phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide	IC50	100000.0 [1]
	3-Phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1,2-oxazole-5-carboxamide	IC50	100000.0 [1]
	3-(2-Aminopyridin-3-yl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide	IC50	100000.0 [1]
	N-[4-[Methyl(pyrimidin-2-yl)sulfamoyl]phenyl]-3-phenyl-1H-pyrazole-5-carboxamide	IC50	100000.0 [1]
	2-[5-[[4-(Pyrimidin-2-ylsulfamoyl)phenyl]carbamoyl]-1H-pyrazol-3-yl]benzoic acid	IC50	100000.0 [1]
	3-Phenyl-N-[4-(pyridin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide	IC50	50000.0 [1]
	2-Methyl-5-phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]pyrazole-3-carboxamide	IC50	50000.0 [1]
	3-(2-Methoxyphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide	IC50	50000.0 [1]
	3-(2-Fluorophenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide	IC50	50000.0 [1]
	Chembl4128162	IC50	50000.0 [1]
	Chembl4125915	IC50	10000.0 [1]
	Chembl4128958	IC50	21000.0 [1]
	Chembl4125786	IC50	8700.0 [1]
	Chembl4127077	IC50	33000.0 [1]
	2-Morpholin-4-yl-1-(3-nitrophenyl)-2-sulfanylideneethanone	IC50	88100.0 [1]
	1-(2-Bromophenyl)-2-morpholin-4-yl-2-sulfanylideneethanone	IC50	160700.0 [1]
	1-(3-Fluorophenyl)-2-morpholin-4-yl-2-sulfanylideneethanone	IC50	200000.0 [1]
	2-Morpholin-4-yl-1-(2-nitrophenyl)-2-sulfanylideneethanone	IC50	200000.0 [1]
	1-(3-Bromophenyl)-2-morpholin-4-yl-2-sulfanylideneethanone	IC50	200000.0 [1]
	1-(2-Fluorophenyl)-2-morpholin-4-yl-2-sulfanylideneethanone	IC50	200000.0 [1]
	2-Morpholin-4-yl-1-(4-phenylphenyl)-2-sulfanylideneethanone	IC50	200000.0 [1]
	1-(3-Iodophenyl)-2-morpholin-4-yl-2-sulfanylideneethanone	IC50	200000.0 [1]
	1-(2-Iodophenyl)-2-morpholin-4-yl-2-sulfanylideneethanone	IC50	200000.0 [1]
	Chembl4127715	IC50	31000.0 [1]
	Chembl4127154	IC50	8300.0 [1]
	Chembl4125702	IC50	5800.0 [1]
	Chembl4126631	IC50	9900.0 [1]
	Chembl4128967	IC50	12000.0 [1]
	Chembl4127244	IC50	19000.0 [1]
	Chembl4129229	IC50	5700.0 [1]
	Chembl4125871	IC50	6300.0 [1]
	Chembl4129573	IC50	41000.0 [1]
	Chembl4128626	IC50	22000.0 [1]
	Chembl4126125	IC50	30000.0 [1]
	Chembl4128755	IC50	20000.0 [1]
	Chembl4130080	IC50	20000.0 [1]
	Chembl4126815	IC50	17000.0 [1]
	Chembl4126283	IC50	26000.0 [1]
	Chembl4127255	IC50	15000.0 [1]
	Chembl4125843	IC50	40000.0 [1]
	Chembl4129970	IC50	39000.0 [1]
	Chembl4128606	IC50	38000.0 [1]
	Chembl4128309	IC50	9200.0 [1]
	Chembl4127362	IC50	11000.0 [1]
	Chembl4128834	IC50	11000.0 [1]
	Chembl4127018	IC50	6500.0 [1]
	Chembl4128252	IC50	11000.0 [1]
	Chembl4129623	IC50	10000.0 [1]
	Chembl4126002	IC50	7200.0 [1]
	Chembl4128391	IC50	7700.0 [1]
	Chembl4130136	IC50	17000.0 [1]
	2,4-Dihydroxy-N'-[(E)-(2-hydroxy-5-nitrophenyl)methylidene]benzohydrazide	IC50	34800.0 [1]
	3-(2-Hydroxyphenyl)-N-[4-[methyl(pyrimidin-2-yl)sulfamoyl]phenyl]-1H-pyrazole-5-carboxamide	IC50	100000.0 [1]
	1-(3-Phenyl-1H-pyrazole-5-carbonyl)-N-pyrimidin-2-yl-2,3,3a,7a-tetrahydroindole-5-sulfonamide	IC50	100000.0 [1]
	3-(2-Hydroxyphenyl)-N-[4-(pyridin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide	IC50	100000.0 [1]
	N-[4-(Furan-2-ylmethylsulfamoyl)phenyl]-3-(2-hydroxyphenyl)-1H-pyrazole-5-carboxamide	IC50	100000.0 [1]
	3-(2-Hydroxyphenyl)-N-[4-(3-morpholin-4-ylpropylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide	IC50	100000.0 [1]
	N-(4,6-Dimethylpyridin-2-yl)-4-[1-[4-(trifluoromethyl)phenyl]ethyl]piperazine-1-carbothioamide	IC50	8000.0 [1]
	1-(4,6-Dimethylpyridin-2-yl)-3-[2-[[4-(trifluoromethyl)phenyl]methylamino]ethyl]thiourea	IC50	9700.0 [1]
	1-(4,6-Dimethylpyridin-2-yl)-3-[2-[methyl-[[4-(trifluoromethyl)phenyl]methyl]amino]ethyl]thiourea	IC50	21000.0 [1]
	N-(4,6-Dimethylpyridin-2-yl)-4-[4-(trifluoromethyl)phenyl]piperazine-1-carbothioamide	IC50	4300.0 [1]
	N-(4,6-Dimethylpyridin-2-yl)-4-[2-[4-(trifluoromethyl)phenyl]ethyl]piperazine-1-carbothioamide	IC50	23000.0 [1]
	N-(4,6-Dimethylpyridin-2-yl)-4-pyridin-3-ylpiperazine-1-carbothioamide	IC50	50000.0 [1]
	N-(4,6-Dimethylpyridin-2-yl)-4-[[4-(trifluoromethyl)phenyl]methylamino]piperidine-1-carbothioamide	IC50	15000.0 [1]
	N-(4,6-Dimethylpyridin-2-yl)-4-(4-methoxyphenyl)piperazine-1-carbothioamide	IC50	16000.0 [1]
	N-(4,6-Dimethylpyridin-2-yl)-4-[[4-(trifluoromethyl)phenyl]methyl]-1,4-diazepane-1-carbothioamide	IC50	7300.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ D-3-phosphoglycerate dehydrogenase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/d-3-phosphoglycerate-dehydrogenase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ D-3-phosphoglycerate dehydrogenase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/d-3-phosphoglycerate-dehydrogenase-inhibitors-ic50-ki.
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