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Deoxycytidine kinase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-[2-[5-[4-[(4,6-Diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethyl]methanesulfonamideIC504.89 [1], 4.9 [2], 14.1 [3]
N-[2-[5-[4-[(4,6-Diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethyl]methanesulfonamideKi0.5 [1]
1-[5-[4-[(4,6-Diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]-2-methylpropan-2-olIC501.4 [1], 1.44 [2], 14.5 [3]
1-[5-[4-[(4,6-Diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]-2-methylpropan-2-olKi0.8 [1]
2-(5-(4-(((4,6-Diaminopyrimidin-2-Yl)thio)methyl)-5-Propylthiazol-2-Yl)-2-Methoxyphenoxy)ethan-1-OlIC501.15 [1], 14.6 [2]
2-(5-(4-(((4,6-Diaminopyrimidin-2-Yl)thio)methyl)-5-Propylthiazol-2-Yl)-2-Methoxyphenoxy)ethan-1-OlKi0.5 [1]
2-[4-[4-[(4,6-Diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-(2-hydroxyethoxy)phenoxy]ethanolIC500.9 [1], 2.59 [2], 17.9 [3]
2-[4-[4-[(4,6-Diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-(2-hydroxyethoxy)phenoxy]ethanolKi2.0 [1]
N-[2-[3-[4-[(4,6-Diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]phenoxy]ethyl]methanesulfonamideIC5011.58 [1], 11.6 [2], 16.8 [3]
N-[2-[3-[4-[(4,6-Diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]phenoxy]ethyl]methanesulfonamideKi1.9 [1]
5-(4-(((4,6-Diaminopyrimidin-2-Yl)thio)methyl)-5-Propylthiazol-2-Yl)-2-MethoxyphenolIC5018.6 [1], 18.62 [2], 26.1 [3]
5-(4-(((4,6-Diaminopyrimidin-2-Yl)thio)methyl)-5-Propylthiazol-2-Yl)-2-MethoxyphenolKi8.9 [1]
4-(1-Benzothiophen-2-yl)-6-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]pyrimidineIC50510.0 [1], 4000.0 [2], 510000.0 [3]
2-[1-[2-[3-(2-Fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl]ethylsulfanyl]pyrimidine-4,6-diamineIC507.0 [1], 24.7 [2]
2-[1-[2-[3-(2-Fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl]ethylsulfanyl]pyrimidine-4,6-diamineKi6.8 [1]
1-[5-[4-[(4-Aminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]-2-methylpropan-2-olIC5011.2 [1], 21.8 [2]
1-[5-[4-[(4-Aminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]-2-methylpropan-2-olKi1.8 [1]
2-[(1S)-1-[2-[3-Ethoxy-4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-5-methyl-1,3-thiazol-4-yl]ethyl]sulfanylpyrimidine-4,6-diamineIC50429.5 [1], 5632.0 [2]
2-[(1S)-1-[2-[3-Ethoxy-4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-5-methyl-1,3-thiazol-4-yl]ethyl]sulfanylpyrimidine-4,6-diamineKi5607.0 [1]
2-[1-[2-[3-(2-Fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl]ethylsulfanyl]pyrimidine-4,6-diamineIC5010.0 [1], 37.2 [2]
2-[1-[2-[3-(2-Fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl]ethylsulfanyl]pyrimidine-4,6-diamineKi16.6 [1]
N-[2-[5-[4-[(1S)-1-(4,6-Diaminopyrimidin-2-yl)sulfanylethyl]-5-methyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethyl]methanesulfonamideIC5094.0 [1], 605.0 [2]
N-[2-[5-[4-[(1S)-1-(4,6-Diaminopyrimidin-2-yl)sulfanylethyl]-5-methyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethyl]methanesulfonamideKi585.0 [1]
2-[(1R)-1-[2-[3-Ethoxy-4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-5-methyl-1,3-thiazol-4-yl]ethyl]sulfanylpyrimidine-4,6-diamineIC501.25 [1], 31.7 [2]
2-[(1R)-1-[2-[3-Ethoxy-4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-5-methyl-1,3-thiazol-4-yl]ethyl]sulfanylpyrimidine-4,6-diamineKi14.0 [1]
1-[5-[4-[(2,6-Diaminopyrimidin-4-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]-2-methylpropan-2-olIC50395.0 [1], 754.0 [2]
1-[5-[4-[(2,6-Diaminopyrimidin-4-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]-2-methylpropan-2-olKi735.0 [1]
N-[2-[5-[4-[(1R)-1-(4,6-Diaminopyrimidin-2-yl)sulfanylethyl]-5-methyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethyl]methanesulfonamideIC503.7 [1], 27.8 [2]
N-[2-[5-[4-[(1R)-1-(4,6-Diaminopyrimidin-2-yl)sulfanylethyl]-5-methyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethyl]methanesulfonamideKi9.2 [1]
ZalcitabineKi360000.0 [1], 1000000.0 [2]
5-Fluoro-2'-deoxycytidineIC504000.0 [1], 120000.0 [2]
2',3'-Didehydro-2',3'-dideoxycytidineKi1100000.0 [1], 4600000.0 [2]
2-[[2-[3-(2-Fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamineIC503.0 [1]
2-[[2-[3-(2-Fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamineKi1.5 [1]
2-[[2-[3-(2-Fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamineIC5018.0 [1]
2-[[2-[3-(2-Fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamineKi9.5 [1]
2-[({2-[3-(2-Fluoroethoxy)-4-Methoxyphenyl]-1,3-Thiazol-4-Yl}methyl)sulfanyl]pyrimidine-4,6-DiamineIC50230.0 [1]
2-[[5-Ethyl-2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamineIC507.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-4-(1-benzothiophen-2-yl)pyridine-2-carboxamideIC501.7 [1]
2-[1-[6-(2-Ethylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy-5-fluoropyrimidin-4-amineIC5010.0 [1]
5-Fluoro-2-(1-(5-fluoro-6-(4-methoxyphenoxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amineIC504.0 [1]
2-[1-[6-(1-Benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]oxy-5-fluoropyrimidin-4-amineIC5038.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]benzenesulfonamideIC503600.0 [1]
5-Fluoro-2-[1-[6-(4-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxypyrimidin-4-amineIC5033.0 [1]
2-[1-[6-(3-Chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy-5-fluoropyrimidin-4-amineIC5022.0 [1]
2-[1-[6-(2-Chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy-5-fluoropyrimidin-4-amineIC503.0 [1]
2-[1-[6-(4-Chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy-5-fluoropyrimidin-4-amineIC5019.0 [1]
5-Fluoro-2-[1-[6-(3-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxypyrimidin-4-amineIC5023.0 [1]
2-[1-[6-(4-Chloro-2-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy-5-fluoropyrimidin-4-amineIC509.0 [1]
3-[6-[4-(4-Amino-5-fluoropyrimidin-2-yl)oxypiperidin-1-yl]-5-fluoropyrimidin-4-yl]oxy-4-methoxybenzonitrileIC501.0 [1]
2-[6-[4-(4-Amino-5-fluoropyrimidin-2-yl)oxypiperidin-1-yl]-5-fluoropyrimidin-4-yl]oxy-5-methoxybenzonitrileIC502.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-4-nitrobenzenesulfonamideIC503200.0 [1]
N-((1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)cyclopentyl)-4-bromobenzenesulfonamideIC502700.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-4-phenylbenzenesulfonamideIC50350.0 [1]
N-((1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)cyclopentyl)-3-bromobenzenesulfonamideIC501900.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-phenylbenzenesulfonamideIC50120.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-(4-methylphenyl)benzenesulfonamideIC50110.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-(4-methoxyphenyl)benzenesulfonamideIC5064.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-(4-cyanophenyl)benzenesulfonamideIC5049.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-(4-methylsulfonylphenyl)benzenesulfonamideIC5063.0 [1]
4-[3-[[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]sulfamoyl]phenyl]benzamideIC5089.0 [1]
2-(6-(Benzo[b]thiophen-2-yl)pyrimidin-4-yloxy)-5-fluoropyrimidin-4-amineIC50720.0 [1]
4-[3-[[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]sulfamoyl]phenyl]benzoic acidIC5015300.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-(4-chlorophenyl)benzenesulfonamideIC5051.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-(3-chlorophenyl)benzenesulfonamideIC5079.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-(2-chlorophenyl)benzenesulfonamideIC5045.0 [1]
2-[[1-[6-(1-Benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]methoxy]-5-fluoropyrimidin-4-amineIC5034.0 [1]
2-[2-[1-[6-(1-Benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]ethoxy]-5-fluoropyrimidin-4-amineIC503.0 [1]
5-Fluoro-2-(1-(6-phenoxypyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amineIC5095.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-(2,4-dichlorophenyl)benzenesulfonamideIC5021.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-(4-chloro-2-methylphenyl)benzenesulfonamideIC5021.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-phenylbenzamideIC50260.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-(4-methoxyphenyl)benzamideIC5030.0 [1]
5-Fluoro-2-[1-[6-(2-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxypyrimidin-4-amineIC505.0 [1]
5-Fluoro-2-[1-[6-(4-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxypyrimidin-4-amineIC5021.0 [1]
5-Fluoro-2-[1-[6-(2-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxypyrimidin-4-amineIC509.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-(4-chlorophenyl)benzamideIC5042.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-(3-chlorophenyl)benzamideIC5023.0 [1]
N-[(1S,3S)-3-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-3-(4-chloro-2-methylphenyl)benzamideIC5021.0 [1]
5-Fluoro-2-[1-[6-(2-phenylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxypyrimidin-4-amineIC503.0 [1]
2-(6-(4-(4-Amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)pyrimidin-4-yloxy)benzonitrileIC503.0 [1]
3-[6-[4-(4-Amino-5-fluoropyrimidin-2-yl)oxypiperidin-1-yl]pyrimidin-4-yl]oxybenzonitrileIC5013.0 [1]
5-Fluoro-2-[1-[6-(2-fluorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxypyrimidin-4-amineIC506.0 [1]
2-[6-[4-(4-Amino-5-fluoropyrimidin-2-yl)oxypiperidin-1-yl]pyrimidin-4-yl]oxy-5-methoxybenzonitrileIC503.0 [1]
2-[6-[4-(4-Amino-5-fluoropyrimidin-2-yl)oxypiperidin-1-yl]-5-methylpyrimidin-4-yl]oxybenzonitrileIC5021.0 [1]
2-[6-[4-(4-Amino-5-fluoropyrimidin-2-yl)oxypiperidin-1-yl]-2-methylpyrimidin-4-yl]oxybenzonitrileIC5010.0 [1]
2-[6-[4-(4-Amino-5-fluoropyrimidin-2-yl)oxypiperidin-1-yl]-5-bromopyrimidin-4-yl]oxybenzonitrileIC505.0 [1]
2-[6-[4-(4-Amino-5-fluoropyrimidin-2-yl)oxypiperidin-1-yl]-5-fluoropyrimidin-4-yl]oxybenzonitrileIC501.0 [1]
3-[6-[4-(4-Amino-5-fluoropyrimidin-2-yl)oxypiperidin-1-yl]-5-fluoropyrimidin-4-yl]oxybenzonitrileIC504.0 [1]
4-[6-[4-(4-Amino-5-fluoropyrimidin-2-yl)oxypiperidin-1-yl]-5-fluoropyrimidin-4-yl]oxybenzonitrileIC505.0 [1]
2-[6-[4-(4-Aminopyrimidin-2-yl)oxypiperidin-1-yl]-5-fluoropyrimidin-4-yl]oxybenzonitrileIC500.7 [1]
2-[6-[4-(4-Amino-2-oxopyrimidin-1-yl)oxypiperidin-1-yl]-5-fluoropyrimidin-4-yl]oxybenzonitrileIC5063.0 [1]
2-[[2-(4-Fluorophenyl)-5-propyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamineIC5037.0 [1]
2-[[2-(3-Fluorophenyl)-5-methyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamineIC5092.0 [1]
2-[[5-Ethyl-2-(3-fluorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamineIC5011.0 [1]
2-[[2-(3-Fluorophenyl)-5-propyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamineIC5031.0 [1]
2-[5-[4-[(4-Aminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethanolIC502.9 [1]
2-[3-[4-[(4,6-Diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]phenoxy]ethanolIC502.45 [1]
2-[5-[4-[(4,6-Diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-fluorophenoxy]ethanolIC501.07 [1]
2-[3-[4-[(4,6-Diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-5-fluorophenoxy]ethanolIC502.83 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Deoxycytidine kinase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/deoxycytidine-kinase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Deoxycytidine kinase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/deoxycytidine-kinase-inhibitors-ic50-ki.
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