Diacylglycerol O-acyltransferase 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	DGAT-1 inhibitor	IC50	15.0 [1]
	PF-04620110	IC50	19.0 [1]
	CID 42636350	IC50	10.0 [1], 70.0 [2], 80.0 [3], 430.0 [4]
	2-[4-[4-[[5-(3,4-Difluoroanilino)-1,3,4-oxadiazole-2-carbonyl]amino]phenyl]cyclohexyl]acetic acid	IC50	0.5 [1], 0.6 [2], 2.0 [3], 36.0 [4]
	2-[4-[4-[(5-Benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	29.0 [1], 36.0 [2], 578.0 [3]
	CID 24768261	IC50	7.0 [1], 7.8 [2], 20.0 [3]
	N-[6-[2-Methoxyethyl(methyl)amino]pyridin-3-yl]-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide	IC50	38.0 [1]
	2-[4-[4-[[5-[(4-Fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	130.0 [1], 131.0 [2], 600.0 [3]
	4-[4-[[5-[(3,5-Difluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenoxy]cyclohexane-1-carboxylic acid	IC50	11.0 [1], 13.0 [2], 76.0 [3], 160.0 [4]
	4-[5-[5-(6-Fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid	IC50	2.0 [1], 2.5 [2], 10000.0 [3]
	4-[5-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid	IC50	1.7 [1], 3.0 [2], 1093.0 [3], 1232.0 [4]
	4-[5-[5-(6-Chloro-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid	IC50	2.0 [1], 2.1 [2], 1344.0 [3], 3528.0 [4]
	4-[5-[5-(1H-Benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid	IC50	4.0 [1], 5.3 [2], 6065.0 [3], 8080.0 [4]
	4-[5-[5-(5,6-Difluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid	IC50	1.3 [1], 1.4 [2], 8440.0 [3], 10000.0 [4]
	4-[5-[5-(6-Cyano-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid	IC50	3.2 [1], 6.0 [2], 10000.0 [3]
	4-[5-[5-(6-Methylsulfonyl-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid	IC50	101.0 [1], 137.0 [2], 10000.0 [3]
	4-[5-[5-(5-Methyl-1H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid	IC50	32.0 [1], 54.0 [2], 8782.0 [3], 10000.0 [4]
	4-[5-[5-(5-Methoxy-1H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid	IC50	11.0 [1], 14.0 [2], 2475.0 [3], 4903.0 [4]
	4-[4-[4-[[2-Phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]phenyl]piperidine-1-carbonyl]cyclohexane-1-carboxylic acid	IC50	57.0 [1], 82.0 [2], 114.0 [3]
	2-[4-[4-[4-(Phenylcarbamoyl)-2,3-dihydro-1,4-benzoxazin-7-yl]phenyl]cyclohexyl]acetic acid	IC50	52.0 [1], 65.0 [2]
	4-[4-[2-(Naphthalene-2-carbonylamino)ethylcarbamoyl]phenoxy]adamantane-1-carboxylic acid	IC50	34.0 [1], 44.0 [2], 48.0 [3]
	4-[4-[2-[(4-Phenylbenzoyl)amino]ethylcarbamoyl]phenoxy]adamantane-1-carboxylic acid	IC50	5.0 [1], 12.0 [2], 25.0 [3]
	4-[4-[(5-Benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenoxy]cyclohexane-1-carboxylic acid	IC50	16.0 [1], 28.0 [2], 280.0 [3]
	CID 49846226	IC50	3.98 [1], 7.94 [2]
	2-(4'-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)-2-chlorobiphenyl-4-yl)acetic acid	IC50	6.31 [1]
	3-[4-[4-(4-Amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]propanoic acid	IC50	31.0 [1], 31.62 [2], 131.0 [3]
	Unii-G3MY6fge1J	IC50	3.0 [1], 4.0 [2]
	2-(trans-4-(4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)cyclohexyl)acetic acid	IC50	8.0 [1], 78.0 [2]
	(1R,2R)-2-[4-[3-Fluoro-4-[(6-fluoro-1,3-benzothiazol-2-yl)amino]phenyl]benzoyl]cyclopentane-1-carboxylic acid	IC50	73.0 [1]
	2-[4-[4-[1-(Phenylcarbamoyl)indol-5-yl]phenyl]cyclohexyl]acetic acid	IC50	37.0 [1]
	1-Methylsulfonyl-1'-[5-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]spiro[2H-indole-3,4'-piperidine]	IC50	68.0 [1]
	1'-[5-(6-Chloro-1H-benzimidazol-2-yl)pyridin-2-yl]spiro[2-benzofuran-3,4'-piperidine]-1-one	IC50	52.0 [1]
	4-[1-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]piperidin-4-yl]oxycyclohexane-1-carboxylic acid	IC50	2.5 [1], 3.9 [2]
	2-[4-[4-(4-Amino-2,7,7-trimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl]acetic acid	IC50	8.0 [1], 30.0 [2]
	2-[6-(4-Amino-7,7-dimethylpyrano[2,3-d]pyrimidin-6-yl)spiro[1,2-dihydroindene-3,4'-cyclohexane]-1'-yl]acetic acid	IC50	9.0 [1], 13.0 [2]
	2-[4-[4-(4-Amino-7,7-dimethylpyrano[2,3-d]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acid	IC50	8.0 [1], 50.0 [2]
	2-[(2R)-2-Ethyl-1-oxo-6-[4-[[3-(trifluoromethyl)phenyl]carbamoylamino]phenyl]-3,4-dihydronaphthalen-2-yl]acetic acid	IC50	126.0 [1], 251.0 [2]
	4-[4-[(5-Anilino-1,3,4-thiadiazol-2-yl)carbamoyl]phenoxy]cyclohexane-1-carboxylic acid	IC50	3.0 [1], 4.0 [2]
	2-[(2S)-6-[4-[(4-Chlorophenyl)carbamoylamino]phenyl]-2-ethyl-1-oxo-3,4-dihydronaphthalen-2-yl]acetic acid	IC50	2.0 [1], 8.0 [2]
	4-[4-[4-[[2-Phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]phenyl]piperazine-1-carbonyl]cyclohexane-1-carboxylic acid	IC50	77.0 [1], 277.0 [2]
	2-[4-[4-(4-Amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]acetonitrile	IC50	41.0 [1], 64.0 [2]
	6-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)spiro[1,2-dihydroindene-3,4'-cyclohexane]-1'-carboxylic acid	IC50	170.0 [1], 240.0 [2]
	2-[4-[4-[[5-(2-Phenylethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	70.0 [1], 590.0 [2]
	2-[4-[4-[[5-[2-(4-Fluorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	66.0 [1], 173.0 [2]
	2-[4-[4-[[5-[3-(4-Fluorophenyl)propyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	50.0 [1], 181.0 [2]
	2-[4-[4-[[5-[(4-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	44.0 [1], 91.0 [2]
	2-[4-[4-[[5-(Cyclopentylmethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	24.0 [1], 33.0 [2]
	2-[4-[4-[[5-(Cyclopentyloxymethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	38.0 [1], 66.0 [2]
	4-Amino-6-(4-tert-butylphenyl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one	IC50	43.0 [1], 134.0 [2]
	2-[4-[4-(4-Amino-5-oxo-7,8-dihydropyrido[4,3-d]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acid	IC50	60.0 [1], 71.0 [2]
	2-[4-[4-[[5-[(4-Methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	142.0 [1], 728.0 [2]
	2-[4-[4-[[5-(2-Cyclopentylethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	12.0 [1], 19.0 [2]
	2-[4-[4-[[5-(Phenoxymethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	47.0 [1], 107.0 [2]
	2-[4-[4-[(5-Phenyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	85.0 [1], 588.0 [2]
	4-[5-[(5-Benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid	IC50	45.0 [1], 135.0 [2]
	4-[5-[[5-[(3-Chlorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid	IC50	55.0 [1], 85.0 [2]
	4-[4-[[5-(Cyclopentyloxymethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenoxy]cyclohexane-1-carboxylic acid	IC50	12.0 [1], 17.0 [2]
	4-[4-[[5-(Cyclopentylamino)-1,3,4-thiadiazol-2-yl]carbamoyl]phenoxy]cyclohexane-1-carboxylic acid	IC50	9.0 [1], 22.0 [2]
	3-[5-[2-Ethyl-4-(phenylcarbamoyl)-2,3-dihydro-1,4-benzoxazin-7-yl]pyridin-2-yl]oxy-2,2-dimethylpropanoic acid	IC50	100.0 [1], 131.0 [2]
	2,2-Dimethyl-3-(5-(2-methyl-4-(phenylcarbamoyl)quinolin-7-yl)pyridin-2-yloxy)propanoic acid	IC50	275.0 [1]
	Ethyl 6-(3-tert-butyl-1,2,4-oxadiazol-5-yl)-2-morpholin-4-yl-4-phenyl-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylate	IC50	19.0 [1], 48.0 [2]
	Ethyl 6-(3-cyclopentyl-1,2,4-oxadiazol-5-yl)-2-morpholin-4-yl-4-phenyl-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylate	IC50	30.0 [1], 48.0 [2]
	Methyl 4-[4-[[2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]phenyl]piperidine-1-carboxylate	IC50	84.0 [1], 500.0 [2]
	Ethyl 6-(3-cyclohexyl-1,2,4-oxadiazol-5-yl)-2-morpholin-4-yl-4-phenyl-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylate	IC50	31.0 [1], 56.0 [2]
	Ethyl 7-(2-hydroxyethyl)-6-[3-(2-hydroxyethyl)-1,2,4-oxadiazol-5-yl]-2-morpholin-4-yl-4-phenylpyrrolo[1,2-b]pyridazine-5-carboxylate	IC50	180.0 [1], 260.0 [2]
	Ethyl 2-morpholin-4-yl-4-phenyl-6-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylate	IC50	51.0 [1], 57.0 [2]
	Ethyl 6-(3-butyl-1,2,4-oxadiazol-5-yl)-2-morpholin-4-yl-4-phenyl-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylate	IC50	69.0 [1], 73.0 [2]
	Ethyl 2-morpholin-4-yl-4-phenyl-6-(3-phenyl-1,2,4-oxadiazol-5-yl)-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylate	IC50	180.0 [1], 200.0 [2]
	Ethyl 2-morpholin-4-yl-4-phenyl-7-propyl-6-(3-pyrrolidin-1-yl-1,2,4-oxadiazol-5-yl)pyrrolo[1,2-b]pyridazine-5-carboxylate	IC50	100.0 [1]
	2-[4-[4-[(6S)-4-Amino-6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidin-6-yl]phenyl]cyclohexyl]acetic acid	IC50	10.0 [1], 34.0 [2]
	4-[4-[[3-[(3,5-Difluorophenyl)methyl]-1,2,4-oxadiazol-5-yl]carbamoyl]phenoxy]cyclohexane-1-carboxylic acid	IC50	120.0 [1], 310.0 [2]
	2-[4-[4-[(6S)-4-Amino-6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidin-6-yl]phenyl]cyclohexyl]acetonitrile	IC50	175.0 [1], 249.0 [2]
	2-[4-[4-(4-Amino-6-methyl-7H-[1,4]dioxino[2,3-d]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acid	IC50	245.0 [1], 735.0 [2]
	2-[4-[4-[(6R)-4-Amino-6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidin-6-yl]phenyl]cyclohexyl]acetic acid	IC50	18.0 [1], 77.0 [2]
	2-[4-[4-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]phenyl]cyclohexyl]acetic acid	IC50	3.5 [1], 293.0 [2]
	2-[4-[4-[5-(6-Chloro-1H-benzimidazol-2-yl)pyridin-2-yl]phenyl]cyclohexyl]acetic acid	IC50	1.1 [1], 167.0 [2]
	2-[4-[4-[[5-[(3-Fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	30.0 [1], 46.0 [2]
	2-[4-[4-[[5-[(2-Fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	35.0 [1], 45.0 [2]
	2-[4-[4-[[5-[(3-Chlorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acid	IC50	30.0 [1], 57.0 [2]
	2-[4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]cyclohexyl]acetic acid	IC50	60.0 [1], 120.0 [2]
	2-[4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)-2-chlorophenyl]cyclohexyl]acetic acid	IC50	30.0 [1], 70.0 [2]
	2-[4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]phenyl]acetic acid	IC50	630.96 [1]
	2-[4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)-2-chlorophenyl]phenyl]acetic acid	IC50	100.0 [1]
	[4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl]methanesulfonamide	IC50	20.0 [1], 90.0 [2]
	7,7-Dimethyl-6-[4-[4-(2H-tetrazol-5-ylmethyl)cyclohexyl]phenyl]pyrimido[4,5-b][1,4]oxazin-4-amine	IC50	7.0 [1], 2500.0 [2]
	2-[4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl]acetamide	IC50	15.0 [1], 70.0 [2]
	2-[4-[4-(4-Amino-2,7,7-trimethylpyrano[2,3-d]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acid	IC50	50.0 [1], 1000.0 [2]
	3-[4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl]propanoic acid	IC50	6.0 [1], 100.0 [2]
	4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexan-1-ol	IC50	50.0 [1], 180.0 [2]
	2-[4-[4-[4-Amino-7,7-dimethyl-2-(trifluoromethyl)pyrimido[4,5-b][1,4]oxazin-6-yl]phenyl]cyclohexyl]acetic acid	IC50	5.0 [1], 60.0 [2]
	2-[4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]phenyl]acetic acid	IC50	6.0 [1], 3000.0 [2]
	6-(4-Cyclohexylphenyl)-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-4-amine	IC50	60.0 [1], 390.0 [2]
	4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexane-1-carboxylic acid	IC50	10.0 [1], 120.0 [2]
	6-[4-(4,4-Difluorocyclohexyl)phenyl]-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-4-amine	IC50	60.0 [1], 470.0 [2]
	4-Amino-6-[4-[4-(2H-tetrazol-5-ylmethyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one	IC50	76.0 [1], 774.0 [2]
	2-[4-[4-[(8R)-4-Amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl]phenyl]cyclohexyl]acetic acid	IC50	8.0 [1], 19.0 [2]
	4-Amino-6-[4-[4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one	IC50	25.0 [1], 54.0 [2]
	4-Amino-6-[4-[4-(2-amino-2-methylpropyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one	IC50	40.0 [1], 70.0 [2]
	4-Amino-6-[4-[4-(2-oxo-2-pyrrolidin-1-ylethyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one	IC50	45.0 [1], 110.0 [2]
	4-Amino-6-[4-[4-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one	IC50	23.0 [1], 60.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Diacylglycerol O-acyltransferase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/diacylglycerol-o-acyltransferase-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Diacylglycerol O-acyltransferase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/diacylglycerol-o-acyltransferase-1-inhibitors-ic50-ki.
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