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Diacylglycerol O-acyltransferase 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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[(3R)-1-[2-[1-(4-Chloropyrazol-1-yl)cyclopropyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC501.3 [1], 5.5 [2], 14.0 [3], 35.9 [4]
[(3R)-1-[2-[(1S)-1-(4-Chloropyrazol-1-yl)ethyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC504.6 [1], 20.0 [2], 38.5 [3]
[(3R)-1-[2-[(1R)-1-(4-Chloropyrazol-1-yl)ethyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC505.5 [1], 33.7 [2], 34.0 [3]
2-[4-[4-[1-(Phenylcarbamoyl)indol-5-yl]phenyl]cyclohexyl]acetic acidIC5050000.0 [1]
2-[4-[4-[4-(Phenylcarbamoyl)-2,3-dihydro-1,4-benzoxazin-7-yl]phenyl]cyclohexyl]acetic acidIC5010000.0 [1]
[(3R)-1-[2-(1-Pyrazol-1-ylethyl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC5086.8 [1], 363.0 [2]
[(3R)-1-[2-(1-Pyridin-2-ylcyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC5015.8 [1], 165.0 [2]
Pyrrolidin-1-yl-[(3R)-1-[2-[1-[4-(trifluoromethyl)pyrazol-1-yl]cyclopropyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]methanoneIC509.4 [1], 83.8 [2]
1-[1-[5-[(3R)-3-(Pyrrolidine-1-carbonyl)piperidin-1-yl]-1H-imidazo[4,5-b]pyridin-2-yl]cyclopropyl]pyrazole-4-carbonitrileIC5025.1 [1], 227.0 [2]
[(3R)-1-[2-[1-(4-Fluoropyrazol-1-yl)cyclopropyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC507.9 [1], 96.9 [2]
[(3R)-1-[2-[2-(4-Chloropyrazol-1-yl)propan-2-yl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC5031.0 [1], 31.4 [2]
[(3R)-1-[8-[1-(4-Fluoropyrazol-1-yl)cyclopropyl]-7H-purin-2-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC508.9 [1], 101.0 [2]
[(3R)-1-[8-[1-(4-Chloropyrazol-1-yl)cyclopropyl]-7H-purin-2-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC502.8 [1], 28.7 [2]
[(2R)-4-[2-[1-(4-Chloropyrazol-1-yl)cyclopropyl]-1H-imidazo[4,5-b]pyridin-5-yl]morpholin-2-yl]-pyrrolidin-1-ylmethanoneIC5010.7 [1], 354.0 [2]
[(3R)-1-[8-[(1S)-1-(4-Chloropyrazol-1-yl)ethyl]-7H-purin-2-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC507.8 [1], 43.0 [2]
[(3R)-1-[8-[(1R)-1-(4-Chloropyrazol-1-yl)ethyl]-7H-purin-2-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC502.5 [1], 18.9 [2]
[(2R)-4-[2-[6-(Difluoromethyl)pyridin-2-yl]-1H-imidazo[4,5-b]pyridin-5-yl]morpholin-2-yl]-pyrrolidin-1-ylmethanoneIC5071.7 [1], 91.3 [2]
[(3R)-1-[2-(1-Pyridin-3-ylcyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC5047.7 [1], 789.0 [2]
[(3R)-1-[2-(2-Cyclopropylpyrimidin-4-yl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC5015.9 [1], 18.2 [2]
PF-04620110IC5030000.0 [1]
CID 42636350IC50300000.0 [1]
DGAT-1 inhibitorIC5010000.0 [1]
Unii-G3MY6fge1JIC5010000.0 [1]
2-(trans-4-(4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)cyclohexyl)acetic acidIC5010000.0 [1]
2-[4-[4-[6-[[2-Phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]-1H-benzimidazol-2-yl]phenyl]cyclohexyl]acetic acidIC5020000.0 [1]
N-(2-Cyclobutyltriazol-4-yl)-2-[2-(3-methoxyphenyl)acetyl]-1,3-dihydroisoindole-5-sulfonamideIC50100000.0 [1]
4-[4-[4-[[2-Phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]phenyl]piperidine-1-carbonyl]cyclohexane-1-carboxylic acidIC50100000.0 [1]
Methyl 3-[8-[[(2,3-dichlorophenyl)carbamoylamino]methyl]isoquinolin-5-yl]benzoateIC50120.0 [1]
N-[[5-(3-Methoxyphenyl)isoquinolin-8-yl]methyl]spiro[2.5]octane-2-carboxamideIC50180.0 [1]
N-Tert-butyl-8-[[[(1S,2S)-2-(3-methyl-1,2,4-oxadiazol-5-yl)cyclopropanecarbonyl]amino]methyl]-5-[3-(trifluoromethoxy)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamideIC502.0 [1]
(1R,2R)-N-[[5-(3-Methoxyphenyl)isoquinolin-8-yl]methyl]-2-phenylcyclopropane-1-carboxamideIC50600.0 [1]
N-[5-[(2,4-Difluorophenyl)sulfamoyl]-1-(2-phenylethyl)-2,3-dihydroindol-7-yl]acetamideIC5030000.0 [1]
4-[4-[2-[(4-Phenylbenzoyl)amino]ethylcarbamoyl]phenoxy]adamantane-1-carboxylic acidIC50100000.0 [1]
N-[2-(3-Fluorophenyl)ethyl]-2-[2-(3-methoxyphenyl)acetyl]-1,3-dihydroisoindole-5-sulfonamideIC5040000.0 [1]
1-[(5-Chloroisoquinolin-8-yl)methyl]-3-(2,3-dichlorophenyl)ureaIC5012000.0 [1]
1-(2,3-Dichlorophenyl)-3-[[5-(3-methoxyphenyl)isoquinolin-8-yl]methyl]ureaIC50540.0 [1]
(1R,2R)-N-[5-(3-Methoxyphenyl)isoquinolin-8-yl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)cyclopropane-1-carboxamideIC50500.0 [1]
(1R,2R)-2-Phenyl-N-[[5-[3-(trifluoromethoxy)phenyl]isoquinolin-8-yl]methyl]cyclopropane-1-carboxamideIC502200.0 [1]
N-Tert-butyl-5-(3-methoxyphenyl)-8-[[[(1S,2S)-2-(3-methyl-1,2,4-oxadiazol-5-yl)cyclopropanecarbonyl]amino]methyl]-3,4-dihydro-1H-isoquinoline-2-carboxamideIC503.0 [1]
Methyl 3-[4-[[[(1R,2R)-2-phenylcyclopropanecarbonyl]amino]methyl]naphthalen-1-yl]benzoateIC50140.0 [1]
(1R,2R)-N-[[8-(3-Methoxyphenyl)isoquinolin-5-yl]methyl]-2-phenylcyclopropane-1-carboxamideIC501600.0 [1]
(1R,2R)-N-[[5-(3-Methoxyphenyl)quinolin-8-yl]methyl]-2-phenylcyclopropane-1-carboxamideIC50300.0 [1]
Tert-butyl 5-(3-methoxyphenyl)-8-[[[(1R,2R)-2-phenylcyclopropanecarbonyl]amino]methyl]-3,4-dihydro-1H-isoquinoline-2-carboxylateIC5060.0 [1]
(1R,2R)-N-[[2-Acetyl-5-(3-methoxyphenyl)-3,4-dihydro-1H-isoquinolin-8-yl]methyl]-2-phenylcyclopropane-1-carboxamideIC503460.0 [1]
N-Tert-butyl-5-(3-methoxyphenyl)-8-[[[(1R,2R)-2-phenylcyclopropanecarbonyl]amino]methyl]-3,4-dihydro-1H-isoquinoline-2-carboxamideIC504.0 [1]
2-[(2S)-6-[5-[(3,4-Difluorophenyl)carbamoylamino]pyrazin-2-yl]-1-oxo-2-(2,2,2-trifluoroethyl)-3,4-dihydronaphthalen-2-yl]acetic acidIC5010000.0 [1]
5-[4-(4-Amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)-2,6-dimethylphenyl]-3,3-dimethylpent-4-ynoic acidIC5050000.0 [1]
4-Amino-6-[4-[4-(2-oxopropyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-oneIC5050000.0 [1]
DGAT1 Inhibitor C9IC5010000.0 [1]
2-[[5-(4-Benzamidophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]propanoic acidIC5020000.0 [1]
[5-(3-Methoxyphenyl)isoquinolin-8-yl]methanamineIC5050000.0 [1]
2-[4-[4-(4-Amino-5-oxo-7,8-dihydropyrido[4,3-d]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acidIC5030000.0 [1]
3-[[1-[5-[(3-Methyl-5-phenyl-1-benzofuran-2-carbonyl)amino]pyridin-2-yl]piperidin-4-yl]methoxy]benzoic acidIC501300.0 [1]
3-[[1-[5-[(3-Phenoxybenzoyl)amino]pyridin-2-yl]piperidin-4-yl]methoxy]benzoic acidIC5050000.0 [1]
4-Amino-6-[4-[4-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-oneIC5030000.0 [1]
Ethyl N-[2-(2,6-dichlorophenyl)-3H-benzimidazol-5-yl]carbamateIC5020000.0 [1]
(3S)-N-(2,4-Difluorophenyl)-3-ethyl-3-methyl-2,5-dioxo-1,4-dihydro-1,4-benzodiazepine-7-sulfonamideIC5010000.0 [1]
N-(2,4-Difluorophenyl)-3,3-diethyl-5-oxo-2,4-dihydro-1H-1,4-benzodiazepine-7-sulfonamideIC5010000.0 [1]
(3S)-3-Ethyl-3-methyl-2,5-dioxo-N-[4-(trifluoromethyl)phenyl]-1,4-dihydro-1,4-benzodiazepine-7-sulfonamideIC5010000.0 [1]
(3S)-N-[4-(Difluoromethoxy)phenyl]-3-ethyl-3-methyl-2,5-dioxo-1,4-dihydro-1,4-benzodiazepine-7-sulfonamideIC5010000.0 [1]
3-Ethyl-3-methyl-2,5-dioxo-N-phenyl-1,4-dihydro-1,4-benzodiazepine-7-sulfonamideIC5010000.0 [1]
N-(4-Chlorophenyl)-3-ethyl-3-methyl-2,5-dioxo-1,4-dihydro-1,4-benzodiazepine-7-sulfonamideIC5010000.0 [1]
N-(2-Chlorophenyl)-3-ethyl-3-methyl-2,5-dioxo-1,4-dihydro-1,4-benzodiazepine-7-sulfonamideIC5010000.0 [1]
3-Ethyl-N-(4-methoxyphenyl)-3-methyl-2,5-dioxo-1,4-dihydro-1,4-benzodiazepine-7-sulfonamideIC5010000.0 [1]
3-Ethyl-N,3-dimethyl-2,5-dioxo-N-phenyl-1,4-dihydro-1,4-benzodiazepine-7-sulfonamideIC5010000.0 [1]
N-(4-Chlorophenyl)-3-ethyl-1,3-dimethyl-2,5-dioxo-4H-1,4-benzodiazepine-7-sulfonamideIC5010000.0 [1]
N-(2,4-Difluorophenyl)-3-ethyl-3,4-dimethyl-2,5-dioxo-1H-1,4-benzodiazepine-7-sulfonamideIC5010000.0 [1]
2-[4-[4-[(2R)-2-Methyl-4-(phenylcarbamoyl)-2,3-dihydro-1,4-benzoxazin-7-yl]phenyl]cyclohexyl]acetic acidIC5010000.0 [1]
[(3R)-1-[2-(5-Methylpyridin-3-yl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC5097.0 [1]
[(3R)-1-(2-Tert-butyl-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC50731.0 [1]
[(3R)-1-[2-[(2-Chlorophenyl)methyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC50460.0 [1]
[(3R)-1-[2-(4-Cyclopropylpyridin-2-yl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC5094.4 [1]
[(3R)-1-[2-(2-Phenylpropan-2-yl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC50357.0 [1]
[(3R)-1-[2-[3-(1,3-Oxazol-5-yl)phenyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC5011.5 [1]
N-Methyl-5-[5-[(3R)-3-(pyrrolidine-1-carbonyl)piperidin-1-yl]-1H-imidazo[4,5-b]pyridin-2-yl]pyridine-3-sulfonamideIC5047.8 [1]
N-Methyl-3-[5-[(3R)-3-(pyrrolidine-1-carbonyl)piperidin-1-yl]-1H-imidazo[4,5-b]pyridin-2-yl]benzenesulfonamideIC5021.1 [1]
[(3R)-1-[2-(2-Methyl-1,3-thiazol-4-yl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC50118.0 [1]
[(3R)-1-[2-[6-(Dimethylamino)pyridin-2-yl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC5022.2 [1]
Cyclopentyl-[4-[5-[(3R)-3-(pyrrolidine-1-carbonyl)piperidin-1-yl]-1H-imidazo[4,5-b]pyridin-2-yl]piperidin-1-yl]methanoneIC50122.0 [1]
[(3R)-1-[2-(1-Pyridin-3-ylcyclobutyl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC50190.0 [1]
[(3R)-1-[2-[1-(4-Methoxyphenyl)cyclopropyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC50107.0 [1]
[(3R)-1-[2-[2-(2-Hydroxypropan-2-yl)pyridin-4-yl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC5072.8 [1]
[(3R)-1-[2-[6-(Difluoromethoxy)pyridin-2-yl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC5014.3 [1]
[(3R)-1-[2-[(4-Chlorophenyl)methyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC50188.0 [1]
[(3R)-1-[2-(1-Benzylcyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC50128.0 [1]
N-[[5-[(3R)-3-(Pyrrolidine-1-carbonyl)piperidin-1-yl]-1H-imidazo[4,5-b]pyridin-2-yl]methyl]benzamideIC502750.0 [1]
[(3R)-1-[2-(2-Cyclopropyl-1,3-oxazol-4-yl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC50301.0 [1]
5-[5-[(3R)-3-(Pyrrolidine-1-carbonyl)piperidin-1-yl]-1H-imidazo[4,5-b]pyridin-2-yl]pyridine-3-carbonitrileIC50102.0 [1]
[(3R)-1-[2-(1-Phenylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC5022.1 [1]
[(3R)-1-[2-(1-Pyrazol-1-ylcyclobutyl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC501400.0 [1]
[(3R)-1-(2-Imidazo[1,2-a]pyridin-6-yl-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC50208.0 [1]
[(3R)-1-[2-(1-Pyrazol-1-ylcyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC50230.0 [1]
Azetidin-1-yl-[(3R)-1-[2-(2-cyclopropylpyrimidin-4-yl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]methanoneIC50270.0 [1]
[(3R)-1-[2-(2-Morpholin-4-ylpyrimidin-4-yl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC50297.0 [1]
[(3R)-1-[2-(3-Chlorophenyl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC5040.5 [1]
Pyrrolidin-1-yl-[(3R)-1-[2-[4-(trifluoromethoxy)phenyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]methanoneIC5024.8 [1]
N-[3-[5-[(3R)-3-(Pyrrolidine-1-carbonyl)piperidin-1-yl]-1H-imidazo[4,5-b]pyridin-2-yl]phenyl]methanesulfonamideIC501400.0 [1]
[(3R)-1-[2-(3-Pyrazol-1-ylphenyl)-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC504.82 [1]
[(3R)-1-(2-Cyclobutyl-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC502530.0 [1]
[(3R)-1-[2-[(2-Cyclopropyl-5-methyl-1,3-oxazol-4-yl)methyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanoneIC50166.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Diacylglycerol O-acyltransferase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/diacylglycerol-o-acyltransferase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Diacylglycerol O-acyltransferase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/diacylglycerol-o-acyltransferase-2-inhibitors-ic50-ki.
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