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Dipeptidyl peptidase IV Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
▲
▼
SitagliptinIC5018.0 [1]
VildagliptinIC5034.0 [1]
VildagliptinKi3.0 [1], 4.0 [2]
TalabostatIC5022.0 [1]
TalabostatKi0.18 [1], 2.0 [2], 2000.0 [3]
(2S)-1-(2-((2-((5-Cyano-2-pyridyl)amino)ethyl)amino)acetyl)pyrrolidine-2-carbonitrileIC5022.0 [1]
(2S)-1-(2-((2-((5-Cyano-2-pyridyl)amino)ethyl)amino)acetyl)pyrrolidine-2-carbonitrileKi27.0 [1]
LinagliptinIC501.0 [1]
AlogliptinIC505.3 [1]
SaxagliptinIC503.4 [1]
SaxagliptinKi0.6 [1]
1-Pentanone, 2-amino-3-methyl-1-(3-thiazolidinyl)-, (2S,3S)-IC501660.0 [1]
1-Pentanone, 2-amino-3-methyl-1-(3-thiazolidinyl)-, (2S,3S)-Ki126.0 [1]
Ala-boroProIC5015.0 [1]
Ala-boroProKi0.03 [1], 0.27 [2], 2.0 [3]
Chg-Pro-CNIC503.2 [1]
Chg-Pro-CNKi1.4 [1]
(S)-2-Amino-2-cyclohexyl-1-(pyrrolidin-1-YL)ethanoneIC50320.0 [1], 1034.0 [2], 17000.0 [3]
(S)-2-Amino-2-cyclohexyl-1-(pyrrolidin-1-YL)ethanoneKi64.0 [1], 121.0 [2]
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acidIC5018.0 [1]
2-Amino-3-methyl-1-pyrrolidin-1-YL-butan-1-oneIC503000.0 [1], 4000.0 [2], 5400.0 [3]
2-Amino-3-methyl-1-pyrrolidin-1-YL-butan-1-oneKi470.0 [1], 2000.0 [2]
Allo-Ile-IsoindolineIC5090000.0 [1]
1-Pentanone, 2-amino-3-methyl-1-(1-pyrrolidinyl)-, (2S,3S)-IC504000.0 [1]
1-Pentanone, 2-amino-3-methyl-1-(1-pyrrolidinyl)-, (2S,3S)-Ki218.0 [1], 410.0 [2]
N4-(4-Chlorobenzyl)-2,4-diaminobutanoylpiperidineIC50165000.0 [1], 196000.0 [2]
(2S)-1-[(2S)-Pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrileIC502.9 [1], 20.0 [2]
(2S)-1-[(2S)-Pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrileKi22.0 [1]
(S)-Pyrrolidin-1-yl(pyrrolidin-2-yl)methanoneIC509700.0 [1], 15000.0 [2]
(S)-Pyrrolidin-1-yl(pyrrolidin-2-yl)methanoneKi2100.0 [1]
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)cyclohexyl]butanamideIC502.3 [1], 26.0 [2], 310.0 [3], 820.0 [4]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)cyclohexyl]butanamideIC502.5 [1], 4.8 [2], 23.0 [3], 260.0 [4], 670.0 [5]
Sitagliptin phosphateIC506.0 [1], 21.88 [2], 50.0 [3], 87.0 [4]
TrelagliptinIC501.3 [1], 1.43 [2], 4.0 [3]
TrelagliptinKi5.1 [1]
(R)-3-Amino-1-((R)-2-benzylpiperazin-1-yl)-4-(2-fluorophenyl)butan-1-oneIC50139.0 [1]
(R)-1-(2-Aminoacetyl)pyrrolidin-2-ylboronic acidIC5013.0 [1], 7000.0 [2], 16000.0 [3]
(R)-1-(2-Aminoacetyl)pyrrolidin-2-ylboronic acidKi0.4 [1]
(S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butanoic acidIC50122000.0 [1]
(S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butanoic acidKi14500.0 [1]
(S)-2-Amino-1-(pyrrolidin-1-yl)propan-1-oneIC5041000.0 [1]
(S)-2-Amino-1-(pyrrolidin-1-yl)propan-1-oneKi7000.0 [1]
[(2R)-1-[(2R)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acidIC500.3 [1], 2300.0 [2], 116000.0 [3]
1-{2-[2-(5-Nitro-pyridin-2-ylamino)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrileIC508.0 [1], 8.7 [2], 8.73 [3]
DPPI 1c hydrochlorideIC5069.0 [1], 92.0 [2], 104.0 [3], 109.0 [4]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)cyclohexyl]butanamideIC504.8 [1], 32.0 [2], 130.0 [3]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-2-[4-(4-fluorophenyl)cyclohexyl]-N,N-dimethyl-4-oxobutanamideIC5011.0 [1], 150.0 [2], 290.0 [3], 1500.0 [4]
(2r)-4-(2-Benzoyl-1,2-Diazepan-1-Yl)-4-Oxo-1-(2,4,5-Trifluorophenyl)butan-2-AmineIC5070.0 [1], 707.95 [2]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-2-[4-(2,6-dimethoxypyrimidin-4-yl)cyclohexyl]-N,N-dimethyl-4-oxobutanamideIC50100.0 [1], 260.0 [2], 1900.0 [3], 2700.0 [4]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-(5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)cyclohexyl]butanamideIC5038.0 [1], 120.0 [2], 220.0 [3], 450.0 [4]
[(4S,10S)-10-Amino-3,9,16,19,22-pentaoxo-2,8,15,18,21-pentazatricyclo[21.3.1.04,8]heptacosa-1(27),23,25-trien-24-yl]methyl-dimethylsulfanium;2,2,2-trifluoroacetate;2,2,2-trifluoroacetic acidIC5012.0 [1], 1000.0 [2]
[(4S,10S)-10-Amino-3,9,16,19,22-pentaoxo-2,8,15,18,21-pentazatricyclo[21.3.1.04,8]heptacosa-1(27),23,25-trien-24-yl]methyl-dimethylsulfanium;2,2,2-trifluoroacetate;2,2,2-trifluoroacetic acidKi85.0 [1], 470.0 [2]
(2S)-1-[2-[[(3Ar,6aS)-5-methoxy-1,2,3,3a,4,5,6,6a-octahydropentalen-2-yl]amino]acetyl]pyrrolidine-2-carbonitrileIC508.0 [1], 27.0 [2], 47.0 [3]
QuercetinIC502920.0 [1], 32730.0 [2], 130000.0 [3]
Diprotin AIC502530.0 [1], 3000.0 [2], 4210.0 [3]
OmarigliptinIC502.22 [1], 2.6 [2]
OmarigliptinKi0.8 [1]
GosogliptinIC5011.3 [1], 12.9 [2]
Pro-boroproIC5020.0 [1], 23000.0 [2]
Pro-boroproKi3.0 [1]
1-(1-Phenylcyclopentyl)methanamineIC5033000.0 [1], 40000.0 [2]
N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclohexyl]-4-trifluoromethoxy-benzenesulfonamideIC5022.0 [1]
Lys-Pro-CNIC50320.0 [1]
Lys-Pro-CNKi5.2 [1]
Dbpr-108IC505.0 [1], 10.0 [2], 15.0 [3]
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamideIC504.0 [1], 4.3 [2]
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamideKi4.3 [1]
(2-Diphenoxyphosphorylpyrrolidin-1-yl)-[(2S)-pyrrolidin-2-yl]methanoneIC5015000.0 [1], 32000.0 [2], 55000.0 [3]
2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,3-dihydroisoindoleIC5015.0 [1]
2-Oxo-2-pyrrolidin-1-ylethanamineIC501000000.0 [1]
N-[4-[(1S)-1-Amino-2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethyl]cyclohexyl]-2,4-difluorobenzenesulfonamideIC5048.0 [1]
(2S)-1-[(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-4-oxobutanoyl]pyrrolidine-2-carbonitrileIC50227.0 [1], 274.0 [2], 100000.0 [3]
Val-boroAlaIC500.89 [1], 9.0 [2]
Val-boroAlaKi3.9 [1]
1-Biphenyl-2-YlmethanamineIC5030000.0 [1]
N-[4-[(1S)-1-Amino-2-oxo-2-pyrrolidin-1-ylethyl]cyclohexyl]-4-(2,2,2-trifluoroethylsulfonylamino)benzenesulfonamideIC502.6 [1]
((2S,4S)-4-(4-(4-Nitrophenyl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanoneIC501.6 [1]
(S)-2-Amino-2-cyclohexyl-1-(3,3-difluoro-pyrrolidin-1-yl)-ethanoneIC5073.0 [1]
(S)-2-Amino-2-cyclohexyl-1-(3,3-difluoro-pyrrolidin-1-yl)-ethanoneKi28.0 [1]
(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acidIC5064.0 [1]
CID 56658139IC5050000.0 [1], 100000.0 [2]
Sitagliptin Analog 13IC5027.0 [1]
N-[4-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl]-2,4-difluoro-benzenesulfonamideIC5088.0 [1]
1-(3-Cyclohexylalanyl)pyrrolidineIC5017000.0 [1]
1-(3-Cyclohexylalanyl)pyrrolidineKi2150.0 [1]
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acidIC504.0 [1], 4.3 [2], 44.0 [3]
8-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-7-(3-methylbut-2-enyl)-1-phenacylpurine-2,6-dioneIC501.0 [1], 1.1 [2], 6.0 [3]
[(2R)-1-[(2R)-2-Aminopropanoyl]pyrrolidin-2-yl]boronic acidIC500.8 [1], 21000.0 [2]
5-(Aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dimethoxyphenyl)pyrimidin-4-amineIC500.1 [1]
N-({(2S)-1-[(3R)-3-Amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-YL}methyl)benzamideIC5090.0 [1]
(S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamideIC50100000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC50100000.0 [1]
5-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC50100000.0 [1]
N-[3-Bromo-4-[[(2R,5S)-5-[(2S)-2-cyanopyrrolidine-1-carbonyl]pyrrolidin-2-yl]methoxy]phenyl]benzenesulfonamideKi0.59 [1], 0.73 [2], 2.3 [3]
4-{[(2R,5S)-5-{[(2S)-2-Cyanopyrrolidin-1-yl]carbonyl}pyrrolidin-2-yl]methoxy}-3-methoxybenzoic acidKi1.6 [1], 2.3 [2], 2.4 [3]
6-Chloro-5-[[(2R,5S)-5-[(2S)-2-cyanopyrrolidine-1-carbonyl]pyrrolidin-2-yl]methoxy]pyridine-3-carboxylic acidKi0.4 [1], 0.48 [2], 0.68 [3]
3-Chloro-4-{[(2R,5S)-5-{[(2S)-2-cyanopyrrolidin-1-yl]carbonyl}pyrrolidin-2-yl]methoxy}benzoic acidKi0.93 [1], 1.4 [2], 1.5 [3]
4-[[(2R,5S)-5-[(2S)-2-Cyanopyrrolidine-1-carbonyl]pyrrolidin-2-yl]methoxy]naphthalene-1-carboxylic acidKi0.96 [1], 1.5 [2], 1.6 [3]
3-Bromo-4-{[(2R,5S)-5-{[(2S)-2-cyanopyrrolidin-1-yl]carbonyl}pyrrolidin-2-yl]methoxy}benzoic acidKi0.4 [1], 0.62 [2], 0.66 [3]
(2S)-1-[(2S,5R)-5-[(2,4-Dichloro-5-nitrophenoxy)methyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrileKi0.35 [1], 0.63 [2], 1.4 [3]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Dipeptidyl peptidase IV Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/dipeptidyl-peptidase-iv-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Dipeptidyl peptidase IV Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dipeptidyl-peptidase-iv-inhibitors-ic50-ki.
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