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Dipeptidyl peptidase IX Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
SitagliptinIC50100000.0 [1]
VildagliptinIC50230.0 [1]
VildagliptinKi68.0 [1], 95.0 [2]
AlogliptinIC50100000.0 [1]
LinagliptinIC5010000.0 [1], 100000.0 [2]
SaxagliptinIC50100.0 [1], 104.0 [2]
SaxagliptinKi71.0 [1]
TalabostatIC502.0 [1], 2.2 [2]
TalabostatKi0.76 [1]
Ala-boroProIC502.8 [1], 360000.0 [2]
Ala-boroProKi0.53 [1]
Allo-Ile-IsoindolineIC50240.0 [1], 290.0 [2]
(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acidIC5086000.0 [1]
(2S)-1-[2-[[(3Ar,6aS)-5-methoxy-1,2,3,3a,4,5,6,6a-octahydropentalen-2-yl]amino]acetyl]pyrrolidine-2-carbonitrileIC5037.0 [1], 430.0 [2]
N4-(4-Chlorobenzyl)-2,4-diaminobutanoylpiperidineIC5076600.0 [1], 78600.0 [2]
1-Pentanone, 2-amino-3-methyl-1-(3-thiazolidinyl)-, (2S,3S)-IC501600.0 [1], 6600.0 [2]
(R)-1-(2-Aminoacetyl)pyrrolidin-2-ylboronic acidIC5098.0 [1]
(R)-1-(2-Aminoacetyl)pyrrolidin-2-ylboronic acidKi0.41 [1]
N-(1-Napthalenecarbonyl)-Gly-boroProIC50420.0 [1], 2700.0 [2]
N-[4-[(1S)-1-Amino-2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethyl]cyclohexyl]-2,4-difluorobenzenesulfonamideIC502720.0 [1]
Val-boroAlaIC503200.0 [1]
Val-boroAlaKi50.0 [1]
((2S,4S)-4-(4-(4-Nitrophenyl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanoneIC5030.0 [1], 30.2 [2]
Ile-IsoindolineIC504300.0 [1]
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamideIC5069.0 [1], 69000.0 [2]
Sitagliptin HydrochlorideIC50100000.0 [1]
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acidIC50100000.0 [1]
(5-(2,4-Dichlorophenyl)-2-(2-methoxyphenyl)-7-methylimidazo[1,2-a]pyrimidin-6-yl)methanamineKi10000.0 [1]
Glu-boroAlaIC507000000.0 [1]
Glu-boroAlaKi2100.0 [1]
(S)-2,6-Diamino-1-(isoindolin-2-yl)hexan-1-oneIC50500.0 [1]
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acidIC5069000.0 [1]
(S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamideIC5012500.0 [1]
(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-oneIC5086.0 [1], 86000.0 [2]
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)cyclohexyl]butanamideIC503700.0 [1], 28000.0 [2]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)cyclohexyl]butanamideIC502600.0 [1], 25000.0 [2]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)cyclohexyl]butanamideIC5038000.0 [1]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-2-[4-(4-fluorophenyl)cyclohexyl]-N,N-dimethyl-4-oxobutanamideIC5015000.0 [1], 21000.0 [2]
(2r)-4-(2-Benzoyl-1,2-Diazepan-1-Yl)-4-Oxo-1-(2,4,5-Trifluorophenyl)butan-2-AmineIC5048660.0 [1], 48977.88 [2]
(3Ar,6aS)-5-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-N,N,5-trimethyl-1,3,3a,4,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamideIC502430.0 [1], 16900.0 [2]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-2-[4-(2,6-dimethoxypyrimidin-4-yl)cyclohexyl]-N,N-dimethyl-4-oxobutanamideIC5040000.0 [1], 100000.0 [2]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-(5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)cyclohexyl]butanamideIC5050000.0 [1], 100000.0 [2]
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylacetamideIC5012000.0 [1], 63000.0 [2]
(1R)-2-(2,5-Difluorophenyl)-1-[4-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]cyclohexyl]ethanamineIC5014000.0 [1], 93000.0 [2]
1-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]piperidine-3-carboxamideIC5016000.0 [1], 32000.0 [2]
(1R)-2-(2,5-Difluorophenyl)-1-[4-(3,3-difluoropyrrolidin-1-yl)cyclohexyl]ethanamineIC508100.0 [1], 100000.0 [2]
cis-(R)-2-(2,5-Difluorophenyl)-1-(4-(piperidin-1-yl)cyclohexyl)ethanamineIC5012000.0 [1], 28000.0 [2]
(R)-3-Amino-1-(2-benzoylpiperazin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one hydrochlorideIC50100000.0 [1]
Sitagliptin phosphateIC5020000.0 [1]
TeneligliptinIC50540.0 [1]
2-Amino-3-methyl-1-pyrrolidin-1-YL-butan-1-oneIC5011300.0 [1]
OmarigliptinIC5067000.0 [1]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;hydrochlorideIC50100000.0 [1]
DutogliptinIC50663.0 [1]
GosogliptinIC505980.0 [1]
Grassystatin AIC5010000.0 [1]
Py(D)AlaboroProIC503400.0 [1]
Abt-279Ki30000.0 [1]
ImigliptinIC50100000.0 [1]
1-Pentanone, 2-amino-3-methyl-1-(1-pyrrolidinyl)-, (2S,3S)-IC5013700.0 [1]
N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclohexyl]-4-trifluoromethoxy-benzenesulfonamideIC501400.0 [1]
Lys-Pro-CNIC50118.0 [1]
Dbpr-108IC5050000.0 [1]
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamideIC50100000.0 [1]
2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,3-dihydroisoindoleIC50100000.0 [1]
(S)-2,6-Diamino-1-(piperidin-1-yl)hexan-1-oneIC5028000.0 [1]
2-Oxo-2-pyrrolidin-1-ylethanamineIC501000000.0 [1]
6-((3S,5S)-5-(Thiazolidine-3-carbonyl)pyrrolidin-3-ylamino)nicotinonitrileIC503735.0 [1]
Phe-Pro-CNIC50330.0 [1]
(2S)-1-[(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-4-oxobutanoyl]pyrrolidine-2-carbonitrileIC5053.0 [1]
(2R)-2-[4-[[[(2S)-3-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-thiazolidine-2-carbonyl]amino]methyl]anilino]-3-methylbutanoic acidIC5013000.0 [1]
(R)-1-(2-(1-Oxoisoindolin-2-yl)acetyl)pyrrolidin-2-ylboronic acidIC506500.0 [1]
CID 56658139IC5053.0 [1]
Sitagliptin Analog 13IC50100000.0 [1]
(3R)-3-Amino-4-(3,4-difluorophenyl)-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-oneIC50100000.0 [1]
(2S,3S)-2-Amino-1-(3-fluoropyrrolidin-1-yl)-3-methylpentan-1-oneIC5011200.0 [1]
(2S)-1-[2-(Tert-butylamino)acetyl]pyrrolidine-2-carbonitrileKi3300.0 [1]
(2S)-1-[2-(Cyclopentylamino)acetyl]pyrrolidine-2-carbonitrileKi293.0 [1]
(2S)-2-Amino-4-[(2-chlorophenyl)methylamino]-1-piperidin-1-ylbutan-1-oneIC50100000.0 [1]
DPPI 1c hydrochlorideIC5030000.0 [1]
(2S,3S,5S)-5-((S)-2-Cyanopyrrolidine-1-carbonyl)-N,N,2-trimethylpyrrolidine-3-carboxamideIC502500.0 [1]
3-[[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-N-(3,4-dimethoxyphenyl)-3-methylbutanamideIC5020000.0 [1]
Glu-boroProKi2.6 [1]
(5-(2,4-Dichlorophenyl)-7-methyl-2-phenylimidazo[1,2-a]pyrimidin-6-yl)methanamineKi30000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamideIC50100000.0 [1]
(2S)-2-Cyano-1-(4-phenyl-L-phenylalanyl)pyrrolidineIC509420.0 [1]
(2S,3S)-2-Amino-1-pyrrolidin-1-yl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-1-oneIC50100000.0 [1]
(3R)-3-Amino-4-(5-chloro-2-fluorophenyl)-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-oneIC5098000.0 [1]
Gln-boroAlaKi260.0 [1]
(R)-1-((S)-2-Acetamido-3-methylbutanoyl)pyrrolidin-2-ylboronic acidKi4300.0 [1]
2-[[6-[(3R)-3-Amino-3-methylpiperidin-1-yl]-1,3-dimethyl-2,4-dioxopyrrolo[3,2-d]pyrimidin-5-yl]methyl]-4-fluorobenzonitrileIC5050000.0 [1]
N-[[(2S)-1-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl]cyclopropanecarboxamideIC502900.0 [1]
N-[4-[(1S)-1-Amino-2-oxo-2-(1,3-thiazolidin-3-yl)ethyl]cyclohexyl]-4-(trifluoromethoxy)benzamideIC50570.0 [1]
(S)-Pyrrolidin-2-yl(thiazolidin-3-yl)methanoneIC506129.0 [1]
(3R)-3-Amino-4-(2-fluorophenyl)-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-oneIC50100000.0 [1]
(3R)-3-Amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,3,5-trifluorophenyl)butan-1-oneIC50100000.0 [1]
(3R)-3-Amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,3,6-trifluorophenyl)butan-1-oneIC50100000.0 [1]
(3R)-3-Amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,6-trifluorophenyl)butan-1-oneIC50100000.0 [1]
(3R)-3-Amino-1-(3-ethyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-oneIC50100000.0 [1]
6-(4-((3S,5S)-5-(Thiazolidine-3-carbonyl)pyrrolidin-3-yl)piperazin-1-yl)nicotinonitrileIC50110.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Dipeptidyl peptidase IX Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/dipeptidyl-peptidase-ix-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Dipeptidyl peptidase IX Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dipeptidyl-peptidase-ix-inhibitors-ic50-ki.
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