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Dipeptidyl peptidase VIII Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
SitagliptinIC5048000.0 [1]
VildagliptinIC509000.0 [1]
VildagliptinKi810.0 [1], 1342.0 [2]
AlogliptinIC50100000.0 [1]
1-Pentanone, 2-amino-3-methyl-1-(3-thiazolidinyl)-, (2S,3S)-IC502170.0 [1]
Allo-Ile-IsoindolineIC50120.0 [1]
LinagliptinIC5040000.0 [1], 100000.0 [2]
N4-(4-Chlorobenzyl)-2,4-diaminobutanoylpiperidineIC50142000.0 [1]
SaxagliptinIC50240.0 [1], 244.0 [2]
SaxagliptinKi130.0 [1]
TalabostatIC505.5 [1], 17.0 [2]
TalabostatKi1.5 [1]
(2S)-1-(2-((2-((5-Cyano-2-pyridyl)amino)ethyl)amino)acetyl)pyrrolidine-2-carbonitrileIC504573.0 [1]
Chg-Pro-CNIC5027.0 [1]
2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,3-dihydroisoindoleIC5020000.0 [1], 100000.0 [2]
(2S)-1-[(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-4-oxobutanoyl]pyrrolidine-2-carbonitrileIC5014.0 [1], 16.0 [2]
(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acidIC5087000.0 [1], 88000.0 [2]
CID 56658139IC5012.0 [1], 14.0 [2]
(2S)-1-[2-[[(3Ar,6aS)-5-methoxy-1,2,3,3a,4,5,6,6a-octahydropentalen-2-yl]amino]acetyl]pyrrolidine-2-carbonitrileIC5023.0 [1], 235.0 [2], 3570.0 [3]
2-Amino-3-methyl-1-pyrrolidin-1-YL-butan-1-oneIC505200.0 [1]
OmarigliptinIC5067000.0 [1], 100000.0 [2]
Ala-boroProIC5013.0 [1]
Ala-boroProKi2.0 [1]
(R)-1-(2-Aminoacetyl)pyrrolidin-2-ylboronic acidIC50180.0 [1]
(R)-1-(2-Aminoacetyl)pyrrolidin-2-ylboronic acidKi3.1 [1]
N-(1-Napthalenecarbonyl)-Gly-boroProIC501200.0 [1], 3700.0 [2]
N-[4-[(1S)-1-Amino-2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethyl]cyclohexyl]-2,4-difluorobenzenesulfonamideIC50993.0 [1]
Val-boroAlaIC50670.0 [1]
Val-boroAlaKi96.0 [1]
((2S,4S)-4-(4-(4-Nitrophenyl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanoneIC5012.0 [1], 12.2 [2]
Ile-IsoindolineIC501300.0 [1], 1320.0 [2]
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamideIC50100.0 [1], 100000.0 [2]
Sitagliptin HydrochlorideIC5048000.0 [1]
3-[[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-N-(2-phenylethyl)propanamideIC502592.0 [1]
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acidIC50100000.0 [1]
3-[[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-N-(3,4-dimethoxyphenyl)-3-methylbutanamideIC5020000.0 [1], 50000.0 [2]
(5-(2,4-Dichlorophenyl)-2-(2-methoxyphenyl)-7-methylimidazo[1,2-a]pyrimidin-6-yl)methanamineKi7800.0 [1], 10000.0 [2]
3-[2-(2-Cyanopyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-N-(1-methyl-1-phenylethyl)butyramideIC5020000.0 [1], 100000.0 [2]
N-Benzyl-3-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]propanamideIC5010744.0 [1]
3-[2-(2-Cyano-(S)-pyrrolidin-1-yl)-2-oxoethylamino]-N-phenylpropionamideIC50855.0 [1], 855.5 [2]
3-[2-(2-Cyano-(S)-pyrrolidin-1-yl)-2-oxoethylamino]-N-(1-methyl-1-phenylethyl)propionamideIC508338.0 [1]
(2S,3S)-2-Amino-1-pyrrolidin-1-yl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-1-oneIC50100000.0 [1]
(2S)-1-[(2S)-2-Amino-4-oxo-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)butanoyl]pyrrolidine-2-carbonitrileIC5019.0 [1], 120.0 [2]
4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-2-oneIC5042000.0 [1], 82000.0 [2]
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amineIC50100000.0 [1]
(3R)-3-Amino-4-(2-fluorophenyl)-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-oneIC5075000.0 [1]
(2S,4S)-1-[(2S,3R)-2-Amino-3-methylpentanoyl]-4-azidopyrrolidine-2-carbonitrileIC5011.0 [1]
(S)-2,6-Diamino-1-(isoindolin-2-yl)hexan-1-oneIC50200.0 [1]
(S)-Benzyl 5-amino-6-(isoindolin-2-yl)-6-oxohexylcarbamateIC50200.0 [1]
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acidIC50100000.0 [1]
(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-oneIC5088.0 [1], 88000.0 [2]
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)cyclohexyl]butanamideIC5053000.0 [1], 100000.0 [2]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)cyclohexyl]butanamideIC5033000.0 [1], 95000.0 [2]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)cyclohexyl]butanamideIC5030000.0 [1], 100000.0 [2]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-2-[4-(4-fluorophenyl)cyclohexyl]-N,N-dimethyl-4-oxobutanamideIC5041000.0 [1], 100000.0 [2]
(2r)-4-(2-Benzoyl-1,2-Diazepan-1-Yl)-4-Oxo-1-(2,4,5-Trifluorophenyl)butan-2-AmineIC5089120.0 [1], 89125.09 [2]
(3Ar,6aS)-5-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-N,N,5-trimethyl-1,3,3a,4,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamideIC504890.0 [1], 38480.0 [2]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-2-[4-(2,6-dimethoxypyrimidin-4-yl)cyclohexyl]-N,N-dimethyl-4-oxobutanamideIC50100000.0 [1]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-(5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)cyclohexyl]butanamideIC5022000.0 [1], 100000.0 [2]
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylacetamideIC505800.0 [1], 100000.0 [2]
(1R)-2-(2,5-Difluorophenyl)-1-[4-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]cyclohexyl]ethanamineIC5010000.0 [1], 100000.0 [2]
1-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]piperidine-3-carboxamideIC5014000.0 [1], 68000.0 [2]
(1R)-2-(2,5-Difluorophenyl)-1-[4-(3,3-difluoropyrrolidin-1-yl)cyclohexyl]ethanamineIC5022000.0 [1], 100000.0 [2]
cis-(R)-2-(2,5-Difluorophenyl)-1-(4-(piperidin-1-yl)cyclohexyl)ethanamineIC5021000.0 [1], 56000.0 [2]
(2S)-2-Amino-4-[(3R)-4-[bis(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acidIC5050.0 [1]
(2S)-2-Amino-4-[(3R)-4-[bis(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acidKi37.0 [1]
(2S)-2-Amino-4-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acidIC509.9 [1]
(2S)-2-Amino-4-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acidKi6.5 [1]
(R)-3-Amino-1-(2-benzoylpiperazin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one hydrochlorideIC50100000.0 [1]
Sitagliptin phosphateIC5011000.0 [1]
TeneligliptinIC50260.0 [1]
Diprotin AKi39000.0 [1]
TrelagliptinIC50100000.0 [1]
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;hydrochlorideIC50100000.0 [1]
DutogliptinIC508427.0 [1]
GosogliptinIC507000.0 [1]
(S)-2-Amino-2-cyclohexyl-1-(pyrrolidin-1-YL)ethanoneIC5078.0 [1]
Grassystatin AIC5010000.0 [1]
Py(D)AlaboroProIC505600.0 [1]
Abt-279Ki30000.0 [1]
ImigliptinIC50100000.0 [1]
1-Pentanone, 2-amino-3-methyl-1-(1-pyrrolidinyl)-, (2S,3S)-IC506600.0 [1]
N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclohexyl]-4-trifluoromethoxy-benzenesulfonamideIC50930.0 [1]
Lys-Pro-CNIC50340.0 [1]
(S)-Pyrrolidin-1-yl(pyrrolidin-2-yl)methanoneIC5050000.0 [1]
Dbpr-108IC50100000.0 [1]
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamideIC50100000.0 [1]
(2-Diphenoxyphosphorylpyrrolidin-1-yl)-[(2S)-pyrrolidin-2-yl]methanoneIC5071000.0 [1]
(S)-2,6-Diamino-1-(piperidin-1-yl)hexan-1-oneIC5040500.0 [1]
2-Oxo-2-pyrrolidin-1-ylethanamineIC501000000.0 [1]
(S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butanoic acidIC501000000.0 [1]
2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dioneIC5014.0 [1]
(S)-2-Amino-1-(pyrrolidin-1-yl)propan-1-oneIC50411000.0 [1]
6-((3S,5S)-5-(Thiazolidine-3-carbonyl)pyrrolidin-3-ylamino)nicotinonitrileIC504756.0 [1]
Phe-Pro-CNIC50210.0 [1]
(2R)-2-[4-[[[(2S)-3-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-thiazolidine-2-carbonyl]amino]methyl]anilino]-3-methylbutanoic acidIC5021000.0 [1]
(R)-1-(2-(1-Oxoisoindolin-2-yl)acetyl)pyrrolidin-2-ylboronic acidIC5011000.0 [1]
4,5,6,7-Tetrachloro-2-[3-(2-phenylethyl)phenyl]isoindole-1,3-dioneIC5021000.0 [1]
Sitagliptin Analog 13IC5069000.0 [1]
(3R)-3-Amino-4-(3,4-difluorophenyl)-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-oneIC5046000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Dipeptidyl peptidase VIII Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/dipeptidyl-peptidase-viii-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Dipeptidyl peptidase VIII Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dipeptidyl-peptidase-viii-inhibitors-ic50-ki.
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