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Discoidin domain-containing receptor 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
NilotinibIC505.2 [1]
DasatinibIC500.4 [1], 1.4 [2], 2.0 [3], 11.7 [4], 833.0 [5]
3-[[2-[3-(Morpholin-4-ylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenolIC506.0 [1], 145.0 [2], 171.0 [3]
DoramapimodIC5010.0 [1], 13.0 [2], 60.0 [3]
1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-(pyridin-4-ylmethoxy)ethyl]-1,3-thiazol-2-yl]ureaIC502.0 [1], 19.0 [2], 65.0 [3]
1-[1-(3-Aminophenyl)-3-Tert-Butyl-1h-Pyrazol-5-Yl]-3-[4-(Quinazolin-4-Ylamino)phenyl]ureaIC501.0 [1], 3.0 [2], 18.0 [3]
1-[2-(3-Aminophenyl)-5-tert-butylpyrazol-3-yl]-3-[3-(quinazolin-4-ylamino)phenyl]ureaIC502.0 [1], 73.0 [2], 75.0 [3]
ImatinibIC50141.0 [1], 675.0 [2]
SorafenibIC507.0 [1], 36.0 [2]
PazopanibIC5050.0 [1], 51.0 [2]
TozasertibIC5018.0 [1], 241.0 [2]
3-Amino-2-phenyl-4H-chromen-4-oneIC5080800.0 [1], 100000.0 [2]
3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamideIC5024.0 [1], 450.0 [2]
Ddr1-IN-2IC50101.4 [1], 175.0 [2]
1-[1-(3-Aminophenyl)-3-Tert-Butyl-1h-Pyrazol-5-Yl]-3-PhenylureaIC502500.0 [1], 9410.0 [2]
1-[1-(4-Methylphenyl)-3-tert-butyl-1H-pyrazole-5-yl]-3-(1-naphthyl)ureaIC50408.0 [1], 100000.0 [2]
1-[1-(3-Aminophenyl)-3-Tert-Butyl-1h-Pyrazol-5-Yl]-3-Naphthalen-1-YlureaIC50487.0 [1], 10800.0 [2]
1-[2-(3-Aminophenyl)-5-tert-butylpyrazol-3-yl]-3-(4-chlorophenyl)ureaIC50558.0 [1], 717.0 [2]
1-(3-Tert-Butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)-3-(naphthalen-1-yl)ureaIC50332.0 [1], 100000.0 [2]
1-(3-Tert-Butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)-3-(4-chlorophenyl)ureaIC50856.0 [1], 1233.0 [2]
(4-{3-Tert-Butyl-5-[(1,3-Thiazol-2-Ylcarbamoyl)amino]-1h-Pyrazol-1-Yl}phenyl)acetic AcidIC50820.0 [1], 9170.0 [2]
1-[2-(3-Aminophenyl)-5-tert-butylpyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]ureaIC508.0 [1], 72.0 [2]
1-(3-Tert-butyl-1-m-tolyl-1H-pyrazol-5-yl)-3-(4-chlorophenyl)ureaIC50183.0 [1], 808.0 [2]
1-[3-Tert-Butyl-1-(4-Methylphenyl)-1h-Pyrazol-5-Yl]-3-(1,3-Thiazol-2-Yl)ureaIC501150.0 [1], 4700.0 [2]
2-[4-[3-Tert-butyl-5-[[4-(2-phenylmethoxyethyl)-1,3-thiazol-2-yl]carbamoylamino]pyrazol-1-yl]phenyl]acetic acidIC50670.0 [1], 2230.0 [2]
1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-[(4-fluorophenyl)methoxy]ethyl]-1,3-thiazol-2-yl]ureaIC50230.0 [1], 3040.0 [2]
2-[3-[3-Tert-butyl-5-[[4-(2-phenylmethoxyethyl)-1,3-thiazol-2-yl]carbamoylamino]pyrazol-1-yl]phenyl]acetic acidIC501670.0 [1], 10700.0 [2]
2-[3-[3-Cyclopentyl-5-[[4-(2-phenylmethoxyethyl)-1,3-thiazol-2-yl]carbamoylamino]pyrazol-1-yl]phenyl]acetic acidIC50380.0 [1], 1560.0 [2]
2-[4-[3-Cyclopentyl-5-[[4-(2-phenylmethoxyethyl)-1,3-thiazol-2-yl]carbamoylamino]pyrazol-1-yl]phenyl]acetic acidIC501840.0 [1], 2170.0 [2]
4-Fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenolIC500.8 [1], 317.2 [2]
2-[4-[3-Tert-butyl-5-[[4-[2-[(4-fluorophenyl)methoxy]ethyl]-1,3-thiazol-2-yl]carbamoylamino]pyrazol-1-yl]phenyl]acetic acidIC5076.0 [1], 1230.0 [2]
N-[3-[3-Tert-butyl-5-[[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]carbamoylamino]pyrazol-1-yl]phenyl]propanamideIC5029.0 [1], 687.0 [2]
DactinomycinIC509000.0 [1]
CID 53469448IC50524.0 [1]
1-(3-Chlorophenyl)-3-{5-[2-(Thieno[3,2-D]pyrimidin-4-Ylamino)ethyl]-1,3-Thiazol-2-Yl}ureaIC5082.0 [1]
CID 59604787IC5010000.0 [1]
Dual DDR1 and DDR2 inhibitor 5nIC5020.4 [1]
Chmfl-abl-053IC50457.0 [1]
Ripk1-IN-7IC50116.0 [1]
3-(2-Aminopropan-2-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamideIC507.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC507000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
CID 71624791IC501000.0 [1]
DDR InhibitorIC503.3 [1]
3-[2-(4-Amino-1-ethylpyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamideIC50128.0 [1]
N-[3-[(Phenylcarbamoylamino)methyl]phenyl]imidazo[1,2-a]pyridine-3-carboxamideIC50280.0 [1]
3-[(4-Methylpiperazin-1-yl)methyl]-N-[(4R)-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinolin-7-yl]-5-(trifluoromethyl)benzamideIC501400.0 [1]
4-Methyl-2-pyrimidin-5-yl-N-[3-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-7-carboxamideIC5010000.0 [1]
N-[3-[(Dimethylamino)methyl]-5-(trifluoromethyl)phenyl]-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC506700.0 [1]
(4R)-4-Methyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC50514.0 [1]
4-Methyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC501800.0 [1]
4-Methyl-N-[3-[2-(4-methylpiperazin-1-yl)ethyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC501500.0 [1]
4,4-Dimethyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-1,3-dihydroisoquinoline-7-carboxamideIC504500.0 [1]
N-[3-Cyclopropyl-5-[(4-methylpiperazin-1-yl)methyl]phenyl]-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC501100.0 [1]
N-[3-Cyclohexyl-5-[(4-methylpiperazin-1-yl)methyl]phenyl]-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC50462.0 [1]
N-[3-[(4-Cyclohexylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC50846.0 [1]
N-[3-[(4-Ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC50944.0 [1]
N-[3-[(4-Methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC508000.0 [1]
N-[3-Ethyl-5-[(4-methylpiperazin-1-yl)methyl]phenyl]-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC501400.0 [1]
4-Methyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-propan-2-ylphenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC50682.0 [1]
N-[3-Tert-butyl-5-[(4-methylpiperazin-1-yl)methyl]phenyl]-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC50940.0 [1]
3-[(4-Methylpiperazin-1-yl)methyl]-N-[(4S)-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinolin-7-yl]-5-(trifluoromethyl)benzamideIC5010000.0 [1]
4-Methyl-2-pyrimidin-5-yl-N-[3-(thiomorpholin-4-ylmethyl)-5-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-7-carboxamideIC503700.0 [1]
4-Methyl-N-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC502100.0 [1]
4-Methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC50354.0 [1]
4-Methyl-2-pyrimidin-5-yl-N-[3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-7-carboxamideIC502600.0 [1]
4-Methyl-N-[3-[(4-methyl-1,4-diazepan-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC50604.0 [1]
3-Methyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC507600.0 [1]
4-Methyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-phenylphenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC501400.0 [1]
4-Methyl-N-[3-(piperidin-1-ylmethyl)-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC502200.0 [1]
1-[4-[4-Amino-3-[4-(2-morpholin-4-ylethoxy)phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)ureaIC5061.0 [1]
Chmfl-abl/kit-155IC50325.0 [1]
4-Methyl-N-[3-(morpholin-4-ylmethyl)-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC504500.0 [1]
(4S)-4-Methyl-N-[3-[(4-methyl-1,4-diazepan-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC502600.0 [1]
4-Methyl-N-[2-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC5010000.0 [1]
(E)-4-(Dimethylamino)-N-[2-methyl-5-[9-(1-methylpyrazol-4-yl)-2-oxobenzo[h]quinolin-1-yl]phenyl]but-2-enamideIC5010000.0 [1]
4-Methyl-N-[3-[(4-methylpiperazin-1-yl)methyl]phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC5010000.0 [1]
4-Ethyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyridin-6-ylethynyl)benzamideIC50203.0 [1]
N-[3-[(4-Methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-(pyrimidin-5-ylmethyl)-3,4-dihydro-1H-isoquinoline-7-carboxamideIC5010000.0 [1]
N-[3-[(4-Methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-4-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC5010000.0 [1]
1-[3-[(4-Methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-3-(4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinolin-7-yl)ureaIC5010000.0 [1]
(4R)-4-Methyl-N-[3-[(4-methyl-1,4-diazepan-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamideIC50255.0 [1]
4-Ethyl-3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]benzamideIC507.0 [1]
4-Ethyl-3-[2-(furan-3-yl)ethynyl]-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]benzamideIC501540.0 [1]
4-Ethyl-3-(2-imidazo[1,2-a]pyridin-3-ylethynyl)-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]benzamideIC5010.4 [1]
3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-ylbenzamideIC5047.4 [1]
4-Ethyl-3-[2-[2-(methylamino)pyrimidin-5-yl]ethynyl]-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]benzamideIC5083.1 [1]
3-(2-Imidazo[1,2-a]pyridin-3-ylethynyl)-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-ylbenzamideIC5061.1 [1]
4-[2-[2-Methyl-5-(morpholin-4-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-propan-2-ylbenzonitrileIC5010000.0 [1]
4-Ethyl-3-[2-(furan-2-yl)ethynyl]-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]benzamideIC502100.0 [1]
3-[2-(2,3-Dimethylimidazol-4-yl)ethynyl]-4-ethyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]benzamideIC5034.1 [1]
4-Ethyl-3-[2-(3-methylimidazol-4-yl)ethynyl]-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]benzamideIC5094.2 [1]
3-[2-[2-(Dimethylamino)pyrimidin-5-yl]ethynyl]-4-ethyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]benzamideIC504800.0 [1]
4-Ethyl-3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]benzamideIC5013.1 [1]
4-Tert-butyl-3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]benzamideIC502200.0 [1]
4-Ethyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrimidin-5-ylethynyl)benzamideIC50221.0 [1]
3-[2-(2-Aminopyrimidin-5-yl)ethynyl]-4-ethyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]benzamideIC5045.3 [1]
4-[2-[2-Methyl-4-(2-morpholin-4-ylethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]benzonitrileIC5010000.0 [1]
4-[2-[2-Methyl-5-(morpholin-4-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]benzonitrileIC5010000.0 [1]
4-[2-[2-Methyl-4-(2-morpholin-4-ylethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-propan-2-ylbenzonitrileIC5010000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Discoidin domain-containing receptor 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/discoidin-domain-containing-receptor-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Discoidin domain-containing receptor 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/discoidin-domain-containing-receptor-2-inhibitors-ic50-ki.
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