DNA-(apurinic or apyrimidinic site) lyase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Aurintricarboxylic acid	IC50	55.0 [1], 10000.0 [2]
	(2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]undecanoic acid	IC50	10000.0 [1]
	2,4,9-Trimethylbenzo[b][1,8]naphthyridin-5-amine	IC50	1500.0 [1], 2100.0 [2], 32000.0 [3]
	Myricetin	IC50	320.0 [1]
	Lucanthone	IC50	5000.0 [1]
	2,5-Dihydroxytyrosine	IC50	110.0 [1]
	7-Nitro-1H-indole-2-carboxylic acid	IC50	3000.0 [1], 3060.0 [2]
	N-[3-(1,3-Benzothiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide	IC50	2000.0 [1], 12000.0 [2]
	N-[3-(1,3-Benzothiazol-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl]acetamide	IC50	1000.0 [1], 3300.0 [2]
	N-[3-(1,3-Benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide	IC50	2900.0 [1], 5000.0 [2]
	N-[3-(1,3-Benzothiazol-2-yl)-7-propan-2-yl-4,5,6,8-tetrahydrothieno[2,3-c]azepin-2-yl]acetamide	IC50	12900.0 [1], 14000.0 [2]
	N-[3-(1,3-Benzothiazol-2-yl)-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide	IC50	3800.0 [1], 5000.0 [2]
	N-[3-(1,3-Benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]-2,2-difluoroacetamide	IC50	3800.0 [1], 4000.0 [2]
	N-[3-(1,3-Benzothiazol-2-yl)-6-propan-2-yl-4,5,7,8-tetrahydrothieno[2,3-d]azepin-2-yl]acetamide	IC50	13000.0 [1], 17600.0 [2]
	N-[3-(1,3-Benzothiazol-2-yl)-5-propan-2-yl-4,6-dihydrothieno[2,3-c]pyrrol-2-yl]acetamide	IC50	3100.0 [1], 4000.0 [2]
	N-[3-(4-Phenyl-2-thiazolyl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide	IC50	2900.0 [1], 3000.0 [2]
	N-[3-(1,3-Benzoxazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide	IC50	13000.0 [1], 20400.0 [2]
	Sodium	IC50	8850.0 [1]
	Mitoxantrone hydrochloride	IC50	2000.0 [1]
	Hycanthone	IC50	80.0 [1]
	Thiolactomycin	IC50	1000.0 [1]
	Tyrphostin AG 538	IC50	280.0 [1]
	Galloflavin	IC50	400.0 [1]
	3,3',4,4',5,5'-Hexabromobiphenyl	IC50	200.0 [1]
	1,3,6-Trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione	IC50	200000.0 [1]
	4-[Methyl(Nitroso)amino]benzene-1,2-Diol	IC50	500.0 [1]
	3-(4-Chloro-phenyl)-1,6-dimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione	IC50	200000.0 [1]
	3-[3-(2-Carboxyethyl)-2-sulfanylidene-2,3-dihydro-1H-1,3-benzodiazol-1-yl]propanoic acid	IC50	15000.0 [1]
	3-(6-Amino-9H-purin-8-ylsulfanyl)-propionic acid	IC50	20000.0 [1]
	N-[3-[(1,1-Dioxo-1,2-benzothiazol-3-ylidene)amino]-2,2-dimethylpropyl]-2-methoxybenzamide	IC50	100000.0 [1]
	4-(3,5-Dioxo-2,3,4,5-tetrahydro-[1,2,4]triazin-6-ylamino)-butyric acid	IC50	100000.0 [1]
	5-({2-[(4-Carboxy-5-methyl(2-furyl))methylthio]ethylthio}methyl)-2-methylfuran-3-carboxylic acid	IC50	5000.0 [1]
	N-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)-N-[(4-sulfamoylphenyl)methyl]propanamide	IC50	100000.0 [1]
	(2E)-3-{3-[(1,1-Dioxidotetrahydrothiophen-3-yl)sulfamoyl]-4-methoxyphenyl}prop-2-enoic acid	IC50	100000.0 [1]
	3-(Pyridin-2-ylsulfanylmethyl)-benzofuran-2-carboxylic acid	IC50	27000.0 [1]
	4-({[(3-Carboxy-5-methylfuran-2-yl)methyl]sulfanyl}methyl)-5-methylfuran-2-carboxylic acid	IC50	20000.0 [1]
	1,3-Bis(1,3-benzothiazol-2-ylthio)acetone	IC50	3000.0 [1]
	4-[4-(4-Carboxy-phenoxy)-benzenesulfonyl]-phthalic acid	IC50	10000.0 [1]
	3,3'-(2,4,6-Trioxo-1,3,5-triazinane-1,3-diyl)dipropanoic acid	IC50	33000.0 [1]
	1-Phenyl-5-[(E)-4-(1-phenyltetrazol-5-yl)sulfanylbut-2-enyl]sulfanyltetrazole	IC50	100000.0 [1]
	2-[(5Z)-5-[1-(Carboxymethyl)-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid	IC50	3000.0 [1]
	1,6-Dimethyl-3-propylpyrimido[5,4-e][1,2,4]triazine-5,7-dione	IC50	200000.0 [1]
	3,6,7-Trimethoxyphenanthrene-2,5-diol	IC50	400.0 [1]
	3-[1-(Carboxymethyl)-5-(4-methylphenyl)pyrrol-2-yl]propanoic acid	IC50	12000.0 [1]
	2-Chloro-5-(diethylsulfamoyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzamide	IC50	100000.0 [1]
	N-[2-Chloro-4-(toluene-4-sulfonylamino)-phenyl]-2-piperidin-1-yl-acetamide	IC50	100000.0 [1]
	CID 1270554	IC50	6800.0 [1]
	3-[3-[3-[(2-Chlorophenyl)methyl]-7-oxo-6H-triazolo[4,5-d]pyrimidin-5-yl]piperidin-1-yl]sulfonylbenzoic acid	IC50	87000.0 [1]
	5-(1-Benzenesulfonyl-piperidin-3-yl)-3-(4-methyl-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol	IC50	100000.0 [1]
	3-[3-[3-[(4-Fluorophenyl)methyl]-7-oxo-6H-triazolo[4,5-d]pyrimidin-5-yl]piperidin-1-yl]sulfonylbenzoic acid	IC50	33000.0 [1]
	3-[(4-Fluorophenyl)methyl]-5-[1-(4-fluorophenyl)sulfonylpiperidin-3-yl]-6H-triazolo[4,5-d]pyrimidin-7-one	IC50	100000.0 [1]
	2-[(Furan-2-carbonyl)-amino]-4-methyl-thiazole-5-carboxylic acid	IC50	100000.0 [1]
	N-Cyclopentyl-3-methyl-4-tetrazol-1-yl-benzenesulfonamide	IC50	100000.0 [1]
	3-[(4-{3-[4-(Dimethylamino)phenyl]-1,2,4-oxadiazol-5-yl}piperidino)sulfonyl]benzoic acid	IC50	40000.0 [1]
	[7-(Carboxymethyl-sulfamoyl)-9-oxo-9H-fluorene-2-sulfonylamino]-acetic acid	IC50	50000.0 [1]
	(5E)-1-(Furan-2-ylmethyl)-5-[(E)-3-(furan-2-yl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione	IC50	2800.0 [1]
	N-[4-(5-Ethyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-succinamic acid	IC50	80000.0 [1]
	Fluorene-9,9-dipropionic acid	IC50	50000.0 [1]
	4-{4-[(4-Carboxyphenyl)sulfonyl]phenylthio}benzene-1,2-dicarboxylic acid	IC50	6000.0 [1]
	4-(3-Allyl-5-benzyl-4-oxo-thiazolidin-2-ylideneamino)-benzoic acid	IC50	100000.0 [1]
	2-Methyl-5-[(oxolan-2-ylmethylthio)methyl]furan-3-carboxylic acid	IC50	16000.0 [1]
	N-[5-(Diethylsulfamoyl)-2-methoxyphenyl]oxolane-2-carboxamide	IC50	100000.0 [1]
	5-O-Methyl 2-O-(oxolan-2-ylmethyl) 3,6-dimethyl-4-oxo-1,5,6,7-tetrahydroindole-2,5-dicarboxylate	IC50	100000.0 [1]
	2-O-Cyclohexyl 5-O-methyl 3,6-dimethyl-4-oxo-1,5,6,7-tetrahydroindole-2,5-dicarboxylate	IC50	100000.0 [1]
	Methyl 2-(4-{ethyl[(4-methylphenyl)sulfonyl]amino}phenyl)-3,3,3-trifluoro-2-hydroxypropanoate	IC50	100000.0 [1]
	2-[[5-(Dimethylsulfamoyl)-1H-indol-3-yl]methylidene]propanedioic acid diethyl ester	IC50	100000.0 [1]
	3-Methoxy-N-(2-methylcyclohexyl)-4-(tetrazol-1-yl)benzenesulfonamide	IC50	100000.0 [1]
	N-{2-[4-Methyl-5-(pyridin-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-ethyl}-benzenesulfonamide	IC50	100000.0 [1]
	Oxolan-2-ylmethyl 6-(furan-2-yl)-3-methyl-4-oxo-1,5,6,7-tetrahydroindole-2-carboxylate	IC50	7070.0 [1]
	3-[(3,4-Dimethylphenoxy)methyl]-2-furoic acid	IC50	11000.0 [1]
	2-[2-Methyl-4-(morpholine-4-sulfonyl)-phenoxy]-1-pyrrolidin-1-yl-ethanone	IC50	100000.0 [1]
	3-[1-(Carboxymethyl)-5-(4-fluorophenyl)-1H-pyrrol-2-yl]propanoic acid	IC50	9000.0 [1]
	N-[(1,1-Dioxobenzo[d]1,2-thiazolin-3-yl)methylamino]-2-phenoxyacetamide	IC50	100000.0 [1]
	3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]benzoic acid	IC50	100000.0 [1]
	3-[1-(Carboxymethyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]propanoic acid	IC50	4000.0 [1]
	3-{4-Methoxy-3-[(pyridin-3-ylmethyl)-sulfamoyl]-phenyl}-acrylic acid	IC50	100000.0 [1]
	4-[3-[(2-Methylphenyl)carbamoyl]anilino]-4-oxobutanoic acid	IC50	35000.0 [1]
	10-Methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione	IC50	200000.0 [1]
	Walrycin B	IC50	200000.0 [1]
	5-Bromo-2-[(2-carboxyethyl)amino]benzoic acid	IC50	32000.0 [1]
	2-({3-[(Diethylamino)sulfonyl]benzoyl}amino)benzoic acid	IC50	100000.0 [1]
	1H-Benzimidazole-2-propanoic acid, 6-carboxy-	IC50	80000.0 [1]
	Methyl [2-methyl-4-(piperidin-1-ylsulfonyl)phenoxy]acetate	IC50	100000.0 [1]
	(2E)-2-[(E)-4-(1,3-Benzodioxol-5-yl)butan-2-ylidenehydrazinylidene]-4-oxo-1,3-thiazinane-6-carboxylic acid	IC50	50000.0 [1]
	N-[2,5-Diethoxy-4-(tetrazol-1-yl)phenyl]-8-methoxy-2-oxochromene-3-carboxamide	IC50	100000.0 [1]
	2-{[1-(1-Carboxyethoxy)-6-oxo-6H-benzo[c]chromen-3-yl]oxy}propanoic acid	IC50	8000.0 [1]
	Dibenzofuran-2,8-disulfonic acid bis-tert-butylamide	IC50	100000.0 [1]
	Unii-M50YL7zlbc	IC50	250.0 [1]
	3-[(2-Carboxycyclohexyl)carbonylamino]benzoic acid	IC50	55000.0 [1]
	3-[4-Ethyl-5-(2-pyrrolidin-1-ylethylsulfanyl)-1,2,4-triazol-3-yl]-1-methylsulfonylpiperidine	IC50	100000.0 [1]
	[2-Methyl-4-(morpholin-4-ylsulfonyl)phenoxy]acetic acid	IC50	100000.0 [1]
	2,7-Naphthalenedisulfonic acid, 4-(benzoylamino)-5-hydroxy-	IC50	27000.0 [1]
	2,4-Dioxo-10-[3-(1h-Tetrazol-5-Yl)phenyl]-2,3,4,10-Tetrahydropyrimido[4,5-B]quinoline-8-Carbonitrile	IC50	200000.0 [1]
	N-(2-Hydroxy-phenyl)-3-(pyrrolidine-1-sulfonyl)-benzamide	IC50	100000.0 [1]
	3,3'-(2-Oxo-cyclohexylidene)-di-propionic acid	IC50	100000.0 [1]
	4-[(5-Carboxy-2-methylfuran-3-yl)methylsulfanylmethyl]-5-methylfuran-2-carboxylic acid	IC50	40000.0 [1]
	N-[(E)-1,3-Benzodioxol-5-ylmethylideneamino]-6-methyl-[1,3]dioxolo[4,5-g]quinolin-8-amine	IC50	2900.0 [1]
	2-[(3Z)-3-[3-(Carboxymethyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]acetic acid	IC50	13000.0 [1]
	[3-(Carboxymethyl)-2-oxo-2,3-dihydro-1h-benzimidazol-1-yl]acetic acid	IC50	16000.0 [1]
	2-Aminobenzene-1,3,5-trisulfonamide	IC50	1400.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ DNA-(apurinic or apyrimidinic site) lyase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/dna-apurinic-or-apyrimidinic-site-lyase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ DNA-(apurinic or apyrimidinic site) lyase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dna-apurinic-or-apyrimidinic-site-lyase-inhibitors-ic50-ki.
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