DNA excision repair protein ERCC-1/DNA repair endonuclease XPF Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-(2,4-Dichlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamide	IC50	630.0 [1], 15600.0 [2]
	5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid	IC50	3900.0 [1]
	5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid	IC50	2900.0 [1]
	N-(4-Fluorobenzyl)-5,6-dihydroxy-2-thien-2-ylpyrimidine-4-carboxamide	IC50	4200.0 [1]
	3-Hydroxyquinazoline-2,4(1H,3H)-dione	IC50	18100.0 [1]
	N-Hydroxynaphthalimide	IC50	30000.0 [1]
	6-Chloro-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione	IC50	12000.0 [1]
	5-Hydroxy-1-methyl-6-oxo-2-(2-thienyl)pyrimidine-4-carboxylic acid	IC50	48800.0 [1]
	3-Hydroxy-1H-thieno[2,3-d]pyrimidine-2,4-dione	IC50	3900.0 [1]
	5-Bromopyridine-2,3-diol	IC50	24000.0 [1]
	5,6-Dihydroxy-2-(2-thienyl)pyrimidine-4-carboxamide	IC50	1000.0 [1]
	5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid methyl ester	IC50	27300.0 [1]
	5-Hydroxy-6-methoxy-2-(2-thienyl)pyrimidine-4-carboxylic acid	IC50	100000.0 [1]
	2(1H)-Pyridinone, 5-(4-fluorophenyl)-3-hydroxy-	IC50	8700.0 [1]
	6-(4-Fluorophenyl)-3-hydroxy-1H-pyridin-2-one	IC50	55200.0 [1]
	3-Hydroxy-7-phenyl-1H-thieno[3,2-d]pyrimidine-2,4-dione	IC50	1800.0 [1]
	3-Hydroxy-7-(4-methylphenyl)furo[3,2-d]pyrimidine-2,4(1H,3H)-dione	IC50	1500.0 [1]
	1-Benzyl-3-hydroxythieno[2,3-d]pyrimidine-2,4(1H,3H)-dione	IC50	80400.0 [1]
	2(1H)-Pyridinone, 4-(4-fluorophenyl)-3-hydroxy-	IC50	100000.0 [1]
	2-Anilino-N-[2-(3,4-dihydroxyphenyl)ethyl]acetamide	IC50	15200.0 [1]
	2-Anilino-N-[(3,4-dihydroxyphenyl)methyl]acetamide	IC50	900.0 [1]
	2-Anilino-N-(3,4-dihydroxyphenyl)acetamide	IC50	1600.0 [1]
	N-[(3,4-Dihydroxyphenyl)methyl]-3-phenylpropanamide	IC50	7300.0 [1]
	N-[(3,4-Dihydroxyphenyl)methyl]-2-phenoxyacetamide	IC50	12100.0 [1]
	N-[(3,4-Dihydroxyphenyl)methyl]-2-phenylacetamide	IC50	13300.0 [1]
	N-[(3,4-Dihydroxyphenyl)methyl]-2-phenylpropanamide	IC50	1800.0 [1]
	2-(4-Chlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamide	IC50	1000.0 [1]
	2-(2-Chlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamide	IC50	800.0 [1]
	N-[(3,4-Dihydroxyphenyl)methyl]-2-(4-methoxyphenyl)acetamide	IC50	2600.0 [1]
	N-[(3,4-Dihydroxyphenyl)methyl]-1-phenylcyclohexane-1-carboxamide	IC50	1600.0 [1]
	N-[(3,4-Dihydroxyphenyl)methyl]cyclopentanecarboxamide	IC50	24600.0 [1]
	2-Cyclohexyl-N-[(3,4-dihydroxyphenyl)methyl]acetamide	IC50	1400.0 [1]
	2-(3-Cyanophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamide	IC50	4000.0 [1]
	N-[(3,4-Dihydroxyphenyl)methyl]-2-pyridin-3-ylacetamide	IC50	25600.0 [1]
	N-[(3,4-Dihydroxyphenyl)methyl]-2-(4-morpholin-4-ylphenyl)acetamide	IC50	7900.0 [1]
	2-(4-Acetylpiperazin-1-yl)-N-[(3,4-dihydroxyphenyl)methyl]acetamide	IC50	100000.0 [1]
	N-[(3,4-Dihydroxyphenyl)methyl]-1-[(4-fluorophenyl)methyl]piperidine-4-carboxamide	IC50	5800.0 [1]
	2-(2,4-Dichlorophenyl)-1-(6,7-dihydroxy-3,4-dihydro-1H-isoquinolin-2-yl)ethanone	IC50	1000.0 [1]
	2-(2,4-Dichlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]-N-methylacetamide	IC50	800.0 [1]
	N-[(2-Chloro-3,4-dihydroxyphenyl)methyl]-2-(2,4-dichlorophenyl)acetamide	IC50	1600.0 [1]
	2-(2,4-Dichlorophenyl)-N-[(2-fluoro-4,5-dihydroxyphenyl)methyl]acetamide	IC50	1100.0 [1]
	1-(2,4-Dichlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]methanesulfonamide	IC50	2900.0 [1]
	N-[(2,4-Dichlorophenyl)methyl]-2-(3,4-dihydroxyphenyl)acetamide	IC50	740.0 [1]
	1-(4-Chlorophenyl)-3-[(3,4-dihydroxyphenyl)methyl]urea	IC50	4800.0 [1]
	1-[(4-Chlorophenyl)methyl]-3-[(3,4-dihydroxyphenyl)methyl]imidazolidin-2-one	IC50	4100.0 [1]
	4-[[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]benzene-1,2-diol	IC50	12200.0 [1]
	3-Hydroxy-5-(3-pyrazol-1-ylphenyl)-1H-pyridin-2-one	IC50	5200.0 [1]
	5-(3-Chloro-4-fluorophenyl)-3-hydroxy-1H-pyridin-2-one	IC50	13100.0 [1]
	N-[4-(5-Hydroxy-6-oxo-1H-pyridin-3-yl)phenyl]acetamide	IC50	13500.0 [1]
	3-Hydroxy-5-(1-methylindazol-6-yl)-1H-pyridin-2-one	IC50	14600.0 [1]
	5-(4-Fluorophenyl)-3-hydroxy-1-methylpyridin-2-one	IC50	100000.0 [1]
	2-(2,4-Dichlorophenyl)-N-[(5-hydroxy-6-oxo-1H-pyridin-3-yl)methyl]acetamide	IC50	100000.0 [1]
	7-Anilino-3-hydroxy-1H-quinazoline-2,4-dione	IC50	3900.0 [1]
	3-Hydroxy-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione	IC50	9100.0 [1]
	N-(3-Hydroxy-2,4-dioxo-1H-quinazolin-8-yl)acetamide	IC50	6100.0 [1]
	N-(3-Hydroxy-2,4-dioxo-1H-quinazolin-6-yl)acetamide	IC50	6600.0 [1]
	3-Hydroxy-6-phenyl-1H-pyrimidine-2,4-dione	IC50	1500.0 [1]
	N-[(3,4-Dihydroxyphenyl)methyl]benzamide	IC50	24500.0 [1]
	N-[(E)-(2,5-Dibromo-3,4-dihydroxyphenyl)methylideneamino]-2-(3-methylanilino)acetamide	IC50	33000.0 [1]
	Methyl 5,6-dihydroxy-2-phenylpyrimidine-4-carboxylate	IC50	16400.0 [1]
	2-Anilino-N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]acetamide	IC50	2000.0 [1]
	4-[3-[(4-Chlorophenyl)methyl]-1,2,4-oxadiazol-5-yl]benzene-1,2-diol	IC50	7800.0 [1]
	5-Hydroxy-N-methyl-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide	IC50	600.0 [1]
	5-Hydroxy-6-oxo-N-propyl-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide	IC50	2700.0 [1]
	5-Hydroxy-N-(2-hydroxyethyl)-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide	IC50	700.0 [1]
	5-Hydroxy-4-(pyrrolidine-1-carbonyl)-2-thiophen-2-yl-1H-pyrimidin-6-one	IC50	4600.0 [1]
	N-Butan-2-yl-5-hydroxy-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide	IC50	600.0 [1]
	5-Hydroxy-N-(3-methylbutyl)-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide	IC50	500.0 [1]
	N-(2-Acetamidoethyl)-5-hydroxy-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide	IC50	800.0 [1]
	N-(4-Fluorophenyl)-5-hydroxy-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide	IC50	800.0 [1]
	5-Hydroxy-6-oxo-N-pyridin-3-yl-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide	IC50	700.0 [1]
	5-Hydroxy-N-(2-morpholin-4-ylethyl)-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide	IC50	1000.0 [1]
	5-Hydroxy-N-(3-methylbutyl)-2-[4-(morpholin-4-ylmethyl)phenyl]-6-oxo-1H-pyrimidine-4-carboxamide	IC50	800.0 [1]
	2-[4-[(Dimethylamino)methyl]phenyl]-5-hydroxy-N-(3-methylbutyl)-6-oxo-1H-pyrimidine-4-carboxamide	IC50	1700.0 [1]
	5-Hydroxy-N-(3-methylbutyl)-6-oxo-2-piperidin-2-yl-1H-pyrimidine-4-carboxamide	IC50	6300.0 [1]
	5-Hydroxy-N-(3-methylbutyl)-2-(1-methylpiperidin-3-yl)-6-oxo-1H-pyrimidine-4-carboxamide	IC50	25300.0 [1]
	5-Hydroxy-N-(3-methylbutyl)-2-(1-methylpiperidin-4-yl)-6-oxo-1H-pyrimidine-4-carboxamide	IC50	6900.0 [1]
	5-Hydroxy-N-(3-methylbutyl)-2-(1-methylpiperidin-2-yl)-6-oxo-1H-pyrimidine-4-carboxamide	IC50	8400.0 [1]
	3-Hydroxy-1-methylquinazoline-2,4(1H,3H)-dione	IC50	96200.0 [1]
	N-(3-Hydroxy-2,4-dioxo-1H-quinazolin-7-yl)acetamide	IC50	6400.0 [1]
	N-[(3,4-Dihydroxyphenyl)methyl]-2-methylpropanamide	IC50	24000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 81 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ DNA excision repair protein ERCC-1/DNA repair endonuclease XPF Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/dna-excision-repair-protein-ercc-1-dna-repair-endonuclease-xpf-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ DNA excision repair protein ERCC-1/DNA repair endonuclease XPF Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dna-excision-repair-protein-ercc-1-dna-repair-endonuclease-xpf-inhibitors-ic50-ki.
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