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DNA polymerase alpha subunit Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
AphidicolinIC502400.0 [1], 2600.0 [2], 3000.0 [3], 16000.0 [4]
[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-acetic acidIC5020000.0 [1]
[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-acetic acidKi7840.0 [1], 13800.0 [2]
2-[[(3S,10R,13R,17R)-17-[(E,2R,5S)-5-Ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]acetic acidIC508000.0 [1]
2-[[(3S,10R,13R,17R)-17-[(E,2R,5S)-5-Ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]acetic acidKi11200.0 [1], 27900.0 [2]
2-[[(3S,10R,13R,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]acetic acidIC5028000.0 [1]
2-[[(3S,10R,13R,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]acetic acidKi3750.0 [1], 18500.0 [2]
CombivirIC5011000.0 [1], 13400.0 [2]
psi-7409IC50100000.0 [1], 550000.0 [2]
5-Methyluridine 5'-(tetrahydrogen triphosphate)IC501000.0 [1], 100000.0 [2]
6H-Purin-6-one, 2-((3,4-dichlorophenyl)amino)-1,9-dihydro-IC5046000.0 [1], 100000.0 [2]
6H-Purin-6-one, 1,7-dihydro-2-((4-butylphenyl)amino)-Ki7500.0 [1], 12000.0 [2]
2,4-Pyrimidinediamine, 6-chloro-N4-(3,4-dichlorophenyl)-IC5028000.0 [1], 1000000.0 [2]
N~2~-(3,4-Dichlorophenyl)-9H-purine-2,6-diamineIC5085000.0 [1], 100000.0 [2]
[[(2S,3R,5S)-5-(4-Amino-5-methyl-2-oxopyrimidin-1-yl)-3-fluorooxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateIC502000.0 [1], 200000.0 [2]
[[(2S,3R,5S)-3-Fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateIC50170.0 [1], 200000.0 [2]
[[(2S,3R,5S)-5-(2,4-Dioxopyrimidin-1-yl)-3-fluorooxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateIC5040000.0 [1], 100000.0 [2]
[[(2S,3R,5S)-5-(4-Amino-2-oxopyrimidin-1-yl)-3-fluorooxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateIC50800.0 [1], 200000.0 [2]
CholesterolIC50500000.0 [1]
FoscarnetIC5020000.0 [1]
DihydrocholesterolIC50500000.0 [1]
Digallic acidKi830.0 [1]
N-[(4-Chlorophenyl)methyl]-1-methyl-6-(morpholin-4-ylmethyl)-4-oxoquinoline-3-carboxamideIC5040000.0 [1]
N(2)-(4-n-Butylphenyl) 2'-deoxyguanosineKi2300.0 [1]
1-(2-Cyclopropylethyl)-3-(1,1-dioxo-4H-1lambda6,2,4-benzothiadiazin-3-yl)-6-fluoro-4-hydroxyquinolin-2-oneIC5050000.0 [1]
N-Methylpyrimidone, 17IC5010000.0 [1]
6H-Purin-6-one, 2-((2,3-dihydro-1H-inden-5-yl)amino)-1,9-dihydro-Ki44000.0 [1]
2-[2-(Dimethylamino)propan-2-yl]-N-[(4-fluorophenyl)methyl]-5-hydroxy-6-oxo-1H-pyrimidine-4-carboxamideIC5010000.0 [1]
3-Hydroxy-3'-nitro-2-naphthanilideIC5032000.0 [1]
6H-Purin-6-one, 1,9-dihydro-2-((3-ethyl-4-methylphenyl)amino)-Ki1760000.0 [1]
2-[4-[[2-(4-Chlorophenyl)-5-(2-oxopyrrolidin-1-yl)phenyl]methoxy]-2-fluorophenyl]-1-cyclohexylbenzimidazole-5-carboxylic acidIC5010000.0 [1]
Remdesivir triphosphateIC50200000.0 [1]
Untenone AIC504300.0 [1]
5-Acetyl-6-(2,4-dichlorophenyl)-9,9-dimethyl-6,8,10,11-tetrahydrobenzo[b][1,4]benzodiazepin-7-oneIC50100000.0 [1]
N-[(4-Chlorophenyl)methyl]-7-methyl-2-(morpholin-4-ylmethyl)-4-oxothieno[2,3-b]pyridine-5-carboxamideIC5040000.0 [1]
N-(4-Chlorobenzyl)-2-(3-hydroxypropyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamideIC5040000.0 [1]
N-(2-Diphosphorylphosphonylmethoxyethyl)guanineIC502500.0 [1]
2-[[2-Chloro-6-methoxy-5-(trifluoromethyl)naphthalene-1-carbonyl]-methoxycarbonyl-amino]acetic acidIC50100000.0 [1]
N-[(4-Chlorophenyl)methyl]-6-(3-hydroxypropyl)-4-oxo-1H-quinoline-3-carboxamideIC5040000.0 [1]
N-[(4-Chlorophenyl)methyl]-2-(2-hydroxyethyl)-6-(morpholin-4-ylmethyl)-9-oxo-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7,10-pentaene-10-carboxamideIC5050000.0 [1]
2-[4-[Bis(4-fluorophenyl)methoxy]-2-fluoro-phenyl]-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
2-[4-[Bis(4-chlorophenyl)methoxy]phenyl]-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
2-(4-Benzhydryloxyphenyl)-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
2-[4-[Bis(4-fluorophenyl)methoxy]phenyl]-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
2-[4-(Bis-p-tolylmethoxy)phenyl]-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
2-[4-[Bis(3-fluorophenyl)methoxy]phenyl]-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
Plakevulin AIC5066000.0 [1]
6-Amino-2-((4-butylphenyl)amino)-9H-purineKi14400.0 [1]
1-Cyclohexyl-2-[2-fluoro-4-(phenyl-pyridin-3-yl-methoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acidIC5010000.0 [1]
2-(4-Benzhydryloxy-2-fluoro-phenyl)-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
2-[4-[Bis[4-(dimethylcarbamoyl)phenyl]methoxy]-2-fluorophenyl]-1-cyclohexylbenzimidazole-5-carboxylic acidIC5010000.0 [1]
1-Cyclohexyl-2-[4-(di-pyridin-3-yl-methoxy)-2-fluoro-phenyl]-1H-benzoimidazole-5-carboxylic acidIC5010000.0 [1]
[[(2R,3R,4R,5S)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateIC50100000.0 [1]
2-[3-(1-Benzyl-1H-pyrazol-3-yl)-benzenesulfonylamino]-benzoic acidIC5020000.0 [1]
5-Acetyl-6-(4-methoxy-3-phenylmethoxyphenyl)-9,9-dimethyl-6,8,10,11-tetrahydrobenzo[b][1,4]benzodiazepin-7-oneIC50100000.0 [1]
3,5-Dihydroxy-N-[(4-nitrophenyl)methyl]naphthalene-2-carboxamideIC50100000.0 [1]
3,5-Dihydroxy-naphthalene-2-carboxylic acid 4-chloro-benzylamideIC5063000.0 [1]
3,7-Dihydroxy-naphthalene-2-carboxylic acid 4-chloro-benzylamideIC5018000.0 [1]
3-Hydroxy-7-methoxy-N-[(4-nitrophenyl)methyl]naphthalene-2-carboxamideIC50100000.0 [1]
N-(4-Chloro-1,3-benzothiazol-2-yl)-3-hydroxy-7-methoxynaphthalene-2-carboxamideIC5093000.0 [1]
N-[(4-Chlorophenyl)methyl]-2-(2-morpholin-4-ylethyl)-6-(morpholin-4-ylmethyl)-9-oxo-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7,10-pentaene-10-carboxamideIC5026000.0 [1]
1-[(2-Amino-4-chloro-5-methylphenyl)sulfonyl]-L-prolineIC50100000.0 [1]
N-[(4-Chlorophenyl)methyl]-4-methyl-7-(morpholin-4-ylmethyl)-3,10-dioxo-1,4-diazatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxamideIC505000.0 [1]
7-[[[(2R)-2-(1-Benzofuran-2-yl)-2-hydroxyethyl]-methylamino]methyl]-N-[(4-chlorophenyl)methyl]-4-methyl-3,10-dioxo-1,4-diazatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxamideIC505000.0 [1]
(3As,4S,7R,7aR)-1,6-dihexadecyl-2,7-bis(methoxycarbonyl)-3-oxo-3a,4,7,7a-tetrahydroindene-4-carboxylic acidIC501900.0 [1]
N-[(4-Chlorophenyl)methyl]-2-(2-hydroxyethoxymethyl)-6-(morpholin-4-ylmethyl)-9-oxo-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7,10-pentaene-10-carboxamideIC5050000.0 [1]
(3As,4S,7R,7aR)-1,6-diethyl-2,7-bis(methoxycarbonyl)-3-oxo-3a,4,7,7a-tetrahydroindene-4-carboxylic acidIC5050000.0 [1]
[[(2R,3R,5R)-5-(7-Aminotriazolo[4,5-d]pyrimidin-3-yl)-3-hydroxyoxolan-2-yl]methoxy-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoateKi156000.0 [1]
[[(2R,3S,5R)-5-(6-Amino-8-bromopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoateKi548000.0 [1]
[[(2R,3R,4S,5R)-4-Chloro-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateIC5020200.0 [1]
2-(2-Amino-6-oxo-1H-purin-9-yl)ethoxymethyl-phosphonooxyphosphinic acidIC50100000.0 [1]
[[(2R,3S,5R)-5-[2-(4-Butylphenyl)imino-6-oxo-5H-purin-9-yl]-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateKi1.0 [1]
9H-Purine, 2-((4-butylphenyl)amino)-6-methoxy-Ki1400.0 [1]
Trimethyl (1aR,1bR,2R,5S,5aS,6aS)-1a,3-dihexadecyl-6-oxo-1b,2,5,5a-tetrahydro-1H-cyclopropa[a]indene-2,5,6a-tricarboxylateIC5012500.0 [1]
6H-Purine-6-thione, 1,9-dihydro-2-((4-butylphenyl)amino)-Ki36000.0 [1]
2-((4-Butylphenyl)amino)-6-(methylthio)-9H-purineKi1000.0 [1]
2-[[(3S,10R,13R,17R)-17-[(E,2R,5S)-5-Ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethanolIC50500000.0 [1]
1-[[(3S,10R,13R,17R)-17-[(E,2R,5S)-5-Ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethane-1,2-diolIC50500000.0 [1]
1-[[(3S,10R,13R,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethane-1,2-diolIC50500000.0 [1]
(3S,10R,13R,17R)-17-[(E,2R,5S)-5-Ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-olIC50500000.0 [1]
(3As,4S,7R,7aR)-1,6-didodecyl-2,7-bis(methoxycarbonyl)-3-oxo-3a,4,7,7a-tetrahydroindene-4-carboxylic acidIC501900.0 [1]
(3As,4S,7R,7aR)-1,6-dihexadecyl-3-oxo-2,7-bis(propan-2-yloxycarbonyl)-3a,4,7,7a-tetrahydroindene-4-carboxylic acidIC503300.0 [1]
Methyl (2S,3S,4R,5E)-2-ethyl-4-hydroxy-5-(2-oxononadecylidene)-1-(2-phenylethyl)pyrrolidine-3-carboxylateIC508900.0 [1]
Methyl (2R,3S,4R,5E)-4-hydroxy-5-(2-oxononadecylidene)-2-phenyl-1-(2-phenylethyl)pyrrolidine-3-carboxylateIC507900.0 [1]
7-O-Ethyl 2-O,4-O-dimethyl (3aR,4R,7S,7aS)-3,5-dihexadecyl-1-oxo-3a,4,7,7a-tetrahydroindene-2,4,7-tricarboxylateIC502300.0 [1]
7-O-Ethyl 2-O,4-O-dimethyl (3aR,4S,7S,7aS)-3,5-dihexadecyl-1-oxo-3a,4,7,7a-tetrahydroindene-2,4,7-tricarboxylateIC503500.0 [1]
Methyl (2S,3S,4R,5E)-2-ethyl-4-hydroxy-5-(2-oxotetradecylidene)-1-(2-phenylethyl)pyrrolidine-3-carboxylateIC5025000.0 [1]
Methyl (2S,3S,4R,5E)-1-benzyl-2-ethyl-4-hydroxy-5-(2-oxotetradecylidene)pyrrolidine-3-carboxylateIC5019900.0 [1]
Methyl (2S,3S,4S,5E)-1-benzyl-2-ethyl-4-hydroxy-5-(2-oxotetradecylidene)pyrrolidine-3-carboxylateIC5019700.0 [1]
Dimethyl (3aR,4R,7S,7aS)-3,5-dihexadecyl-1-oxo-7-(2-phenylethylcarbamoyl)-3a,4,7,7a-tetrahydroindene-2,4-dicarboxylateIC506900.0 [1]
Methyl (2R,3S,4R,5E)-4-hydroxy-1-[2-(1H-indol-3-yl)ethyl]-5-(2-oxotetradecylidene)-2-phenylpyrrolidine-3-carboxylateIC5021000.0 [1]
(E)-Methyl-3,6-dioxo-4-docosenoateIC503700.0 [1]
2-[3-(1-Benzyl-1H-pyrazol-3-yl)-benzenesulfonylamino]-4-fluoro-benzoic acidIC5020000.0 [1]
4-Fluoro-2-[[3-[1-(naphthalen-2-ylmethyl)pyrazol-4-yl]phenyl]sulfonylamino]benzoic acidIC5020000.0 [1]
2-[2-[Bis(2-hydroxyethyl)amino]ethyl]-N-[(4-chlorophenyl)methyl]-6-(morpholin-4-ylmethyl)-9-oxo-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7,10-pentaene-10-carboxamideIC5020000.0 [1]
9H-Purine, 2-((4-butylphenyl)amino)-Ki5000.0 [1]
[[(R)-[(2S,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)oxolan-2-yl]-fluoromethoxy]-hydroxyphosphoryl] phosphono hydrogen phosphateIC50500000.0 [1]
2-[2-Amino-6-(cyclopropylamino)purin-9-yl]ethoxymethyl-phosphonooxyphosphinic acidIC50100000.0 [1]
2-[2-Amino-6-(cyclopropylamino)purin-9-yl]ethoxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acidIC50100000.0 [1]
9H-Purine, 2-((4-butylphenyl)amino)-6-chloro-Ki2600.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ DNA polymerase alpha subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/dna-polymerase-alpha-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ DNA polymerase alpha subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dna-polymerase-alpha-subunit-inhibitors-ic50-ki.
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