Dual specificity mitogen-activated protein kinase kinase 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	45.8 [1]
	Selumetinib	IC50	9.0 [1], 14.0 [2], 31.0 [3], 80.0 [4], 3700.0 [5]
	N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide	IC50	5.2 [1], 7.0 [2], 13.0 [3], 15.0 [4]
	Unii-M58joz0T53	IC50	12.0 [1], 22.0 [2], 25.0 [3], 69.0 [4], 82.0 [5]
	4-(4-Phenoxyanilino)-6-methoxy-7-(3-morpholinopropoxy)-3-quinolinecarbonitrile	IC50	2.4 [1], 4.0 [2], 7.0 [3], 1000.0 [4]
	1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene	IC50	70.0 [1], 72.0 [2], 13000.0 [3]
	Tak-733	IC50	1.79 [1], 3.2 [2], 5.0 [3], 6.92 [4]
	6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrile	IC50	6.2 [1], 9.0 [2], 30.0 [3], 34.0 [4]
	(4S,5R,6Z,9S,10S,12E)-9,10,18-Trihydroxy-4,5-dimethyl-16-(methylamino)-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione	IC50	2.8 [1], 10.0 [2], 70.0 [3]
	2-[(2S)-2,3-Dihydroxypropyl]-8-(2-fluoro-4-iodoanilino)pyrido[3,4-d]pyridazin-1-one	IC50	1.63 [1], 1.95 [2], 35.5 [3], 58.0 [4]
	2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	IC50	2000.0 [1], 4000.0 [2], 10000.0 [3]
	5Z-7-Oxozeaenol	IC50	2.9 [1], 6.0 [2], 80.0 [3]
	3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)benzamide	IC50	2.0 [1], 13.0 [2]
	4-(3-Phenoxyanilino)-6,7-dimethoxy-3-quinolinecarbonitrile	IC50	60.0 [1], 100.0 [2], 160.0 [3]
	4-(2-Phenoxyanilino)-6,7-dimethoxy-3-quinolinecarbonitrile	IC50	10000.0 [1]
	3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-{3-[(sulfamoylamino)methyl]phenoxy}benzamide	IC50	1.8 [1], 8.7 [2], 21.0 [3]
	2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	IC50	2.0 [1], 130.0 [2]
	Cobimetinib	IC50	0.9 [1], 4.2 [2]
	Pimasertib	IC50	1.81 [1], 3.39 [2]
	Hymenialdisine	IC50	6.0 [1], 2500.0 [2]
	CID 24866313	IC50	10000.0 [1]
	Ulixertinib	IC50	10000.0 [1]
	CID 46209401	IC50	300.0 [1], 3700.0 [2]
	4-[3-Chloro-4-(1-methylimidazol-2-yl)sulfanylanilino]-7-[3-(4-ethylpiperazin-1-yl)propoxy]-6-methoxyquinoline-3-carbonitrile	IC50	3.0 [1]
	4-[3-Chloro-4-(1-methylimidazol-2-yl)sulfanylanilino]-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinoline-3-carbonitrile	IC50	2.0 [1], 8.0 [2]
	N-[2-[2-[2-[2-[4-[4-[2-(Difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide	IC50	0.01 [1], 398.0 [2]
	5-(2,3-Dichlorophenylamino)-3-hydroxy-N-(1-hydroxypropan-2-yl)isothiazole-4-carboxamidine	IC50	38.0 [1]
	[4-Methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	IC50	110.0 [1]
	[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	IC50	7.0 [1]
	3-[[2-Fluoro-3-(methylsulfamoylamino)phenyl]methyl]-4-methyl-7-pyrimidin-2-yloxychromen-2-one	IC50	97.0 [1]
	5-Acetyl-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrole-3-carboxamide	IC50	18.0 [1]
	3-Hydroxy-N-(2-hydroxy-1-methyl-ethyl)-5-(4-phenylamino-phenylamino)-isothiazole-4-carboxamidine	IC50	240.0 [1], 266.0 [2]
	3-Hydroxy-5-(4-iodo-2-methylphenylamino)-N-isopropylisothiazole-4-carboxamidine	IC50	62.0 [1]
	5-(2-Chloro-4-iodophenylamino)-3-hydroxy-N-isopropylisothiazole-4-carboxamidine	IC50	42.0 [1]
	3-Hydroxy-5-(4-iodophenylamino)-N-isopropylisothiazole-4-carboxamidine	IC50	510.0 [1]
	2-[3-[[(Dimethylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamide	IC50	21.0 [1]
	4-Fluoro-2-(2-fluoro-4-iodoanilino)-6-[3-(sulfamoylmethyl)phenoxy]benzamide	IC50	32.0 [1]
	7-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,2-benzothiazole-6-carboxamide	IC50	12.0 [1], 15.0 [2]
	4-Fluoro-2-(2-fluoro-4-iodoanilino)-6-[3-(sulfamoylamino)phenoxy]benzamide	IC50	14.0 [1]
	[4,6-Dimethyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	IC50	29.0 [1]
	(+/-)-Hymenin	IC50	6.0 [1], 2500.0 [2]
	4-[4-(4-Pyridinylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile	IC50	190.0 [1], 650.0 [2]
	4-[4-(2-Pyridinylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile	IC50	18.0 [1], 72.0 [2]
	4-[4-(3-Furanylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile	IC50	14.0 [1], 43.0 [2]
	4-[4-(3-Pyridinylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile	IC50	29.0 [1], 100.0 [2]
	4-[4-(2-Furanylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile	IC50	20.0 [1], 66.0 [2]
	4-(4-Benzylphenylamino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile	IC50	2.7 [1], 14.0 [2]
	4-[4-(4-Pyridinyloxy)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile	IC50	26.0 [1], 81.0 [2]
	4-[4-(3-Thienylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile	IC50	4.2 [1], 23.0 [2]
	6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenethyl-phenylamino)-quinoline-3-carbonitrile	IC50	33.0 [1], 150.0 [2]
	4-[4-(2-Thienylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile	IC50	4.4 [1], 20.0 [2]
	6,7-Dimethoxy-4-(4-methylsulfanyl-phenylamino)-quinoline-3-carbonitrile	IC50	280.0 [1], 1300.0 [2]
	3-[(2R)-2,3-Dihydroxypropyl]-5-(4-ethynyl-2-fluoroanilino)-6-fluoro-8-methylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	4.8 [1], 5.0 [2]
	5-(4-Bromo-2-fluoroanilino)-3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-8-methylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	16.0 [1]
	3-[(2S)-2,3-Dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	3.2 [1], 5.0 [2]
	6-Fluoro-5-(2-fluoro-4-iodoanilino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	8.6 [1], 10.0 [2]
	5-(2-Fluoro-4-iodophenylamino)-3,8-dimethylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione	IC50	16.0 [1], 26.0 [2]
	5-(2-Fluoro-4-iodoanilino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	9.8 [1], 10.0 [2]
	3-[(2S)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	8.3 [1], 10.0 [2]
	3-[(2R)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	3.8 [1], 5.0 [2]
	3-[(2S)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	5.0 [1]
	5-(2-Fluoro-4-iodoanilino)-3-(2-hydroxyethyl)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	4.0 [1], 5.0 [2]
	3-[(2S)-2,4-Dihydroxybutyl]-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	16.0 [1], 53.0 [2]
	3-[2-(Dimethylamino)ethyl]-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	16.0 [1], 740.0 [2]
	5-(2-Fluoro-4-iodophenylamino)-3-(3-hydroxypropyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3h,8h)-dione	IC50	4.9 [1], 5.0 [2]
	3-[(2R)-2,3-Dihydroxypropoxy]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	3.1 [1], 5.0 [2]
	3-(1,3-Dihydroxypropan-2-yl)-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	3.3 [1], 5.0 [2]
	4-[3-Chloro-4-(1-methylimidazol-2-yl)sulfanylanilino]-7-[(E)-4-(4-ethylpiperazin-1-yl)but-1-enyl]quinoline-3-carbonitrile	IC50	12.0 [1], 225.0 [2]
	4-(4-Biphenylylamino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	1100.0 [1], 9500.0 [2]
	4-[4-(Phenylamino)phenylamino]-6,7-dimethoxyquinoline-3-carbonitrile	IC50	160.0 [1], 1200.0 [2]
	4-(4-Benzylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	3.6 [1], 36.0 [2]
	4-[4-(4-Chlorophenoxy)phenylamino]-6,7-dimethoxyquinoline-3-carbonitrile	IC50	43.0 [1], 210.0 [2]
	4-(4-Hydroxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	550.0 [1], 2200.0 [2]
	4-(4-Methoxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile	IC50	520.0 [1], 3000.0 [2]
	4-(4-Cyclohexyloxyanilino)-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinoline-3-carbonitrile	IC50	110.0 [1], 320.0 [2]
	4-(4-Methoxyphenylamino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile	IC50	99.0 [1], 250.0 [2]
	4-[4-(Cyclohexylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile	IC50	200.0 [1], 3300.0 [2]
	4-[4-(Cyclohexylthio)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile	IC50	21.0 [1], 300.0 [2]
	N'-(1-Hydroxypropan-2-yl)-3-oxo-5-(4-phenoxyanilino)-1,2-thiazole-4-carboximidamide	IC50	26.0 [1], 33.0 [2]
	3-[(2R)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione	IC50	4.6 [1], 5.0 [2]
	N-[(2R)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamide	IC50	30.2 [1], 56.6 [2]
	N-(1,3-Dihydroxypropan-2-yl)-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamide	IC50	31.3 [1], 55.2 [2]
	3-[(2R)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrido[3,4-d]pyrimidin-4-one	IC50	33.6 [1], 142.0 [2]
	5-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethyl)pyrimidine-4-carboxamide	IC50	49.6 [1], 101.6 [2]
	5-(2-Fluoro-4-iodoanilino)-N-(3-hydroxypropyl)pyrimidine-4-carboxamide	IC50	60.1 [1], 101.4 [2]
	N-[(2S)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamide	IC50	3.41 [1], 5.37 [2]
	2-[(2S)-2,3-Dihydroxypropyl]-8-(2-fluoro-4-iodoanilino)-4-methylpyrido[3,4-d]pyridazin-1-one	IC50	11.4 [1], 13.9 [2]
	2-Chloro-N-[(2S)-2,3-dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamide	IC50	13.0 [1], 44.3 [2]
	3-[(2S)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrido[3,4-d]pyrimidin-4-one	IC50	12.3 [1], 108.0 [2]
	6-Methoxy-7-[3-(morpholin-4-yl)propoxy]-4-{[4-(phenylsulfanyl)phenyl]amino}quinoline-3-carbonitrile	IC50	1.1 [1], 5.7 [2]
	Quercetin	IC50	10000.0 [1]
	U0126	IC50	500.0 [1]
	1,4-Naphthoquinone	IC50	380.0 [1]
	Trametinib	IC50	3.4 [1]
	Bosutinib	IC50	1.0 [1]
	Arctigenin	IC50	1.0 [1]
	PD173074	IC50	50000.0 [1]
	4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine	IC50	10500.0 [1]
	Oroidin	IC50	2500.0 [1]
	4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Dual specificity mitogen-activated protein kinase kinase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/dual-specificity-mitogen-activated-protein-kinase-kinase-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Dual specificity mitogen-activated protein kinase kinase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-mitogen-activated-protein-kinase-kinase-1-inhibitors-ic50-ki.
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