Dual specificity mitogen-activated protein kinase kinase; MEK1/2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	IC50	16.0 [1], 46.0 [2]
	3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)benzamide	IC50	1.2 [1], 2.0 [2]
	4-(2-Fluoro-4-iodoanilino)-1-methyl-6-oxopyridine-3-carboxamide	IC50	4.0 [1], 23.0 [2]
	3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide	IC50	17.4 [1], 30.0 [2]
	4-(2-Fluoro-4-iodoanilino)-6-oxo-1-propylpyridine-3-carboxamide	IC50	430.0 [1], 2540.0 [2]
	4-(2-Fluoro-4-iodoanilino)-N-(3-hydroxypropyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	61.0 [1], 95.0 [2]
	4-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	180.0 [1], 206.0 [2]
	4-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	5.0 [1], 18.0 [2]
	4-(2-Fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid	IC50	425.0 [1], 5000.0 [2]
	4-(3,4-Dichloro-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amide	IC50	3900.0 [1], 5720.0 [2]
	Ethyl 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate	IC50	63.0 [1], 669.0 [2]
	4-(4-Ethynyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	21.0 [1], 100.0 [2]
	4-(2-Fluoro-4-methylsulfanylanilino)-1-methyl-6-oxopyridine-3-carboxamide	IC50	150.0 [1], 356.0 [2]
	4-(2-Fluoro-4-iodoanilino)-6-oxo-1H-pyridine-3-carboxamide	IC50	100.0 [1], 630.0 [2]
	4-(4-Ethyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	110.0 [1], 2620.0 [2]
	4-(4-Bromo-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	93.0 [1], 1910.0 [2]
	4-(2-Fluoro-4-iodoanilino)-1-(2-hydroxyethyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	2540.0 [1], 5000.0 [2]
	3,4-Difluoro-2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethyl)benzamide	IC50	68.0 [1], 84.2 [2]
	4-(4-Bromo-2-fluoroanilino)-N-(2-hydroxyethoxy)-6-oxo-1H-pyridine-3-carboxamide	IC50	120.0 [1], 3630.0 [2]
	4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole	IC50	61000.0 [1]
	Dasatinib	IC50	1700.0 [1]
	Vemurafenib	IC50	1500.0 [1]
	Dabrafenib	IC50	20000.0 [1]
	Saracatinib	IC50	14000.0 [1]
	Cobimetinib	IC50	0.2 [1]
	Pyridone 6	IC50	160.0 [1]
	Azd-1152hqpa	Ki	10000.0 [1]
	N6,N6-Dimethyl-N4-[1-(phenylmethyl)-5-indazolyl]pyrido[3,4-d]pyrimidine-4,6-diamine	IC50	9700.0 [1]
	LY-3009120	IC50	20000.0 [1]
	N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[2-(triazol-1-yl)ethoxy]quinazolin-4-amine	IC50	10000.0 [1]
	4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol	IC50	100000.0 [1]
	N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide	IC50	0.9 [1]
	4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyridin-2-amine	IC50	10000.0 [1]
	4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyrimidin-2-amine	IC50	10000.0 [1]
	3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid	IC50	102.0 [1]
	Vandetanib hydrochloride	IC50	20000.0 [1]
	4-(4-Cyano-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	10000.0 [1]
	(5-(Aminocarbonyl)-4-(2-fluoro-4-iodoanilino)-2-oxo-1(2H)-pyridinyl)acetic acid	IC50	10000.0 [1]
	1-Allyl-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	91.0 [1]
	1-(2,3-Dihydroxypropyl)-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	10000.0 [1]
	4-[2-Fluoro-4-(1,1,2,2,3,3,4,4,4-nonafluorobutyl)anilino]-1-methyl-6-oxopyridine-3-carboxamide	IC50	10000.0 [1]
	4-(2-Fluoro-4-iodoanilino)-N,N,1-trimethyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	627.0 [1]
	4-(2-Fluoro-4-iodoanilino)-N,1-dimethyl-6-oxopyridine-3-carboxamide	IC50	195.0 [1]
	1-(3-Cyanopropyl)-4-(2-fluoro-4-iodoanilino)-6-oxopyridine-3-carboxamide	IC50	4890.0 [1]
	4-(2-Fluoro-4-iodoanilino)-1-[2-(2-methoxyethoxy)ethyl]-6-oxopyridine-3-carboxamide	IC50	1130.0 [1]
	1-Ethyl-4-(2-fluoro-4-iodoanilino)-6-oxopyridine-3-carboxamide	IC50	1000.0 [1]
	4-[2-Fluoro-4-(3-hydroxypropyl)anilino]-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	10000.0 [1]
	4-(2-Fluoro-4-iodoanilino)-1-(3-hydroxypropyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	3000.0 [1]
	4-(2-Fluoro-4-methylanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	2970.0 [1]
	1-Methyl-4-(2-naphthylamino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide	IC50	3000.0 [1]
	N-[(R)-Cyclopropyl(pyridin-2-yl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamide	IC50	57.0 [1]
	1-(3-Tert-butyl-1,2-oxazol-5-yl)-3-[2-fluoro-5-[7-(methylamino)-2-oxo-1-[(3S)-oxolan-3-yl]-1,6-naphthyridin-3-yl]phenyl]urea	IC50	2900.0 [1]
	1-(3,3-Dimethylbutyl)-3-[5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluoro-4-methylphenyl]urea	IC50	2500.0 [1]
	Tert-butyl N-[2-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-2-oxoethyl]carbamate	IC50	7350.0 [1]
	Tert-butyl N-[(2R)-3-methyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]butan-2-yl]carbamate	IC50	100000.0 [1]
	3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(3-methoxyphenyl)-N-phenyl-3,4-dihydropyrazole-2-carbothioamide	IC50	195000.0 [1]
	5-(4-Bromophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-phenyl-3,4-dihydropyrazole-2-carbothioamide	IC50	188000.0 [1]
	3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-phenyl-5-(4-phenylmethoxyphenyl)-3,4-dihydropyrazole-2-carbothioamide	IC50	176000.0 [1]
	[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-(pyrrolidin-1-ylmethyl)azetidin-1-yl]methanone	IC50	50.0 [1]
	[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-[(dimethylamino)methyl]-3-hydroxyazetidin-1-yl]methanone	IC50	14.0 [1]
	[3-(Aminomethyl)-3-hydroxyazetidin-1-yl]-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanone	IC50	57.0 [1]
	3-[(1S)-1-Aminoethyl]-1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)azetidin-3-ol	IC50	46.0 [1]
	[3-[(1R)-1-Aminoethyl]-3-hydroxyazetidin-1-yl]-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanone	IC50	164.0 [1]
	[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-(morpholin-4-ylmethyl)azetidin-1-yl]methanone	IC50	331.0 [1]
	[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(propan-2-ylamino)methyl]azetidin-1-yl]methanone	IC50	3.7 [1]
	1-[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)benzoyl]-3-hydroxyazetidine-3-carboxamide	IC50	81.0 [1]
	[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-(ethylaminomethyl)-3-hydroxyazetidin-1-yl]methanone	IC50	6.9 [1]
	[3-[(Tert-butylamino)methyl]-3-hydroxyazetidin-1-yl]-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanone	IC50	11.0 [1]
	1-({3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)azetidin-3-ol	IC50	29.0 [1]
	Azetidin-1-yl-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanone	IC50	111.0 [1]
	1-({3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-(hydroxymethyl)azetidin-3-ol	IC50	29.0 [1]
	[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-(3-hydroxy-3-methylazetidin-1-yl)methanone	IC50	51.0 [1]
	(2Z,3Z)-2,3-Bis[amino-(2-methoxyphenyl)sulfanylmethylidene]butanedinitrile	IC50	16500.0 [1]
	(2Z,3Z)-2,3-Bis[amino-(2-chlorophenyl)sulfanylmethylidene]butanedinitrile	IC50	6600.0 [1]
	(2Z,3Z)-2,3-Bis[amino-(2-fluorophenyl)sulfanylmethylidene]butanedinitrile	IC50	7600.0 [1]
	(2Z,3Z)-2,3-Bis[amino-(2-hydroxyphenyl)sulfanylmethylidene]butanedinitrile	IC50	400.0 [1]
	(2Z,3Z)-2,3-Bis[amino-(4-aminophenyl)sulfanylmethylidene]butanedinitrile	IC50	10500.0 [1]
	2-Amino-5-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4-dicarbonitrile	IC50	25100.0 [1]
	(2Z,3Z)-2,3-Bis[amino(thiophen-2-ylsulfanyl)methylidene]butanedinitrile	IC50	1200.0 [1]
	(2Z,3Z)-2,3-Bis[amino-(2,6-dichlorophenyl)sulfanylmethylidene]butanedinitrile	IC50	6500.0 [1]
	(2Z,3Z)-2,3-Bis(3H-1,3-benzothiazol-2-ylidene)butanedinitrile	IC50	42500.0 [1]
	(2Z,3Z)-2,3-Bis[amino-(4-chlorophenyl)sulfanylmethylidene]butanedinitrile	IC50	21700.0 [1]
	(2Z,3Z)-2,3-Bis[amino-(3-chlorophenyl)sulfanylmethylidene]butanedinitrile	IC50	18400.0 [1]
	(2Z,3Z)-2,3-Bis[amino-(2-bromophenyl)sulfanylmethylidene]butanedinitrile	IC50	7900.0 [1]
	2,5-Bis-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4-dicarbonitrile	IC50	28900.0 [1]
	N-[3,4-Dicyano-5-(naphthalen-2-ylsulfanyl)-1H-pyrrol-2-yl]-benzenesulfonamide	IC50	8000.0 [1]
	2-Amino-5-(2-amino-phenylsulfanyl)-1H-pyrrole-3,4-dicarbonitrile	IC50	26200.0 [1]
	(2Z,3Z)-2,3-Bis[amino-(2-methylphenyl)sulfanylmethylidene]butanedinitrile	IC50	13300.0 [1]
	(2Z,3Z)-2-[Amino-(2-aminophenyl)sulfanylmethylidene]-3-(3H-1,3-benzothiazol-2-ylidene)butanedinitrile	IC50	18700.0 [1]
	10,11-Difluoro-12-(2-fluoro-4-iodoanilino)-2,2-dioxospiro[4,5,6,7-tetrahydro-1H-8,2lambda6,1-benzoxathiazecine-3,1'-cyclopropane]-5,6-diol	IC50	16.0 [1]
	2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-N-[(3R)-piperidin-3-yl]-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide	IC50	22.0 [1]
	N-(2-Amino-2-methylpropyl)-2-(2-fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide	IC50	14.0 [1]
	2-(2-Chloro-4-iodoanilino)-N-[(3R)-3,4-dihydroxybutyl]-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide	IC50	200.0 [1]
	2-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide	IC50	7.0 [1]
	2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-N-[[(2R)-pyrrolidin-2-yl]methyl]-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide	IC50	42.0 [1]
	2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxylic acid	IC50	14.0 [1]
	2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide	IC50	9.0 [1]
	2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-N-[(3R)-pyrrolidin-3-yl]-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide	IC50	8.0 [1]
	2-(2-Fluoro-4-iodoanilino)-7,7-dimethyl-6,8-dihydro-5H-[1,3]thiazolo[5,4-c]azepin-4-one	IC50	946.0 [1]
	Ethyl 2-(2-chloro-4-iodoanilino)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxylate	IC50	2617.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Dual specificity mitogen-activated protein kinase kinase; MEK1/2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Dual specificity mitogen-activated protein kinase kinase; MEK1/2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan