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Dual specificity phosphatase Cdc25A Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2Z,5E)-2-[5-(4-Chlorophenyl)thieno[3,2-d][1,3]thiazol-2-yl]imino-5-[(4-methoxyphenyl)methylidene]-1,3-thiazolidin-4-oneIC506200.0 [1]
(2Z,5E)-2-[5-(4-Chlorophenyl)thieno[3,2-d][1,3]thiazol-2-yl]imino-5-[(4-methoxyphenyl)methylidene]-1,3-thiazolidin-4-oneKi4800.0 [1]
DysidiolideIC509400.0 [1]
2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedioneIC5022.0 [1], 55.0 [2], 5490.0 [3], 5500.0 [4]
6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dioneIC50790.0 [1], 30900.0 [2], 100000.0 [3]
6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dioneKi29.0 [1]
(E)-2-((1R,7Ar)-7a-methyl-1-((R)-6-methylheptan-2-yl)-octahydroinden-4-ylidene)acetic acidIC505500.0 [1], 7700.0 [2], 12000.0 [3], 17200.0 [4]
4-(N-Benzyl-C-pentadecylcarbonimidoyl)-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-oneIC504880.0 [1], 7040.0 [2], 16600.0 [3]
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(2-hydroxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-oneIC505550.0 [1], 11900.0 [2], 13500.0 [3]
2-(3,4-Dimethylphenylamino)-5-(3-furan-2-ylallylidene)thiazol-4-oneIC504270.0 [1], 7100.0 [2]
2-(3,4-Dimethylphenylamino)-5-(3-furan-2-ylallylidene)thiazol-4-oneKi21370.0 [1]
3-(3,4,5-Trihydroxy-6-oxoxanthen-9-yl)propanoic acidIC50240.0 [1], 330.0 [2]
3-(3,4,5-Trihydroxy-6-oxoxanthen-9-yl)propanoic acidKi70.0 [1]
(Z)-5-[(4R,4As,6aR,7R,9aS,9bS)-4,6a-dimethyl-7-(6-methylheptan-2-yl)-2-oxo-4a,5,6,7,8,9,9a,9b-octahydro-1H-cyclopenta[f]isochromen-4-yl]pent-2-enenitrileIC5029000.0 [1], 50000.0 [2], 100000.0 [3]
2-[4-(4-Chlorophenyl)-5-p-tolyl-4H-[1,2,4]triazol-3-ylsulfanyl]-1-(3,4-dihydroxyphenyl)ethanoneIC50800.0 [1], 820.0 [2]
2-[4-(4-Chlorophenyl)-5-p-tolyl-4H-[1,2,4]triazol-3-ylsulfanyl]-1-(3,4-dihydroxyphenyl)ethanoneKi37470.0 [1]
3-(2-PYRIDYL)-5,6-bis-[2-(5-FURYL-SULFONIC ACID)]-1,2,4-TRIAZINEIC50110000.0 [1]
3-(2-PYRIDYL)-5,6-bis-[2-(5-FURYL-SULFONIC ACID)]-1,2,4-TRIAZINEKi139000.0 [1]
2-Methoxy-5-((4-methyl-2-oxo-1,2-dihydro-quinolin-6-yl)methyl)benzenesulfonic acidIC5086000.0 [1]
2-Methoxy-5-((4-methyl-2-oxo-1,2-dihydro-quinolin-6-yl)methyl)benzenesulfonic acidKi203000.0 [1]
2-[(1R,3As,4R,5S,7aR)-5-[(2E,5Z)-6-cyanohexa-2,5-dien-2-yl]-7a-methyl-1-(6-methylheptan-2-yl)-1,2,3,3a,4,5,6,7-octahydroinden-4-yl]acetic acidIC5024200.0 [1]
[5-(5-Cyano-1-methylene-pentyl)-1-(1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-acetic acidIC502200.0 [1]
2-[(1R,3As,4R,5S,7aR)-5-[(5Z)-6-cyanohexa-1,5-dien-2-yl]-7a-methyl-1-(6-methylheptan-2-yl)-1,2,3,3a,4,5,6,7-octahydroinden-4-yl]acetic acidIC509700.0 [1]
4-Heptadecyl-2,5-dihydro-2,5-dioxofuran-3-propionic acidIC505100.0 [1]
4-(2-Carboxybenzoyl)phthalic acidIC506000.0 [1]
4-(2-Carboxybenzoyl)phthalic acidKi2300.0 [1]
2-[(E)-2-[5-(4-Chlorophenyl)furan-2-yl]ethenyl]-6-oxo-3-phenyl-4-sulfanyl-1,2-dihydropyrimidine-5-carbonitrileIC503310.0 [1]
2-[(E)-2-[5-(4-Chlorophenyl)furan-2-yl]ethenyl]-6-oxo-3-phenyl-4-sulfanyl-1,2-dihydropyrimidine-5-carbonitrileKi29160.0 [1]
5-[(4R,4As,6aR,7R,9aS,9bS)-4,6a-dimethyl-7-[(2R)-6-methylheptan-2-yl]-2-oxo-4a,5,6,7,8,9,9a,9b-octahydro-1H-cyclopenta[f]isochromen-4-yl]pentanoic acidIC505100.0 [1], 11600.0 [2]
1-(3,4-Dihydroxyphenyl)-2-[2-(4-methoxyphenyl)-2H-tetrazol-5-ylsulfanyl]ethanoneIC504070.0 [1]
1-(3,4-Dihydroxyphenyl)-2-[2-(4-methoxyphenyl)-2H-tetrazol-5-ylsulfanyl]ethanoneKi20350.0 [1]
5-[Benzoyl-[2-[(2,5-diphenyl-1,3-oxazole-4-carbonyl)amino]ethyl]amino]-2-(decanoylamino)-5-oxopentanoic acidIC504000.0 [1], 15000.0 [2]
[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxymethanedithioic acidIC501100.0 [1], 11700.0 [2]
5-[2-(4-Ethoxyphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-oneIC502400.0 [1], 23600.0 [2]
1-Methanesulfonyl-5-[2-(3-methylphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indoleIC505600.0 [1], 31800.0 [2]
4-{2,5-Dimethyl-1-[(oxolan-2-yl)methyl]-1H-pyrrol-3-yl}-2-(4-methoxyphenyl)-1,3-thiazoleIC506400.0 [1], 31100.0 [2]
2-(4-Ethoxyphenyl)-4-(naphthalen-2-yl)-1,3-thiazoleIC5013000.0 [1], 30000.0 [2]
N-[3-(2-Phenyl-1,3-thiazol-4-yl)phenyl]-2-furamideIC5017800.0 [1], 100000.0 [2]
N-{3-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]phenyl}cyclopropanecarboxamideIC5010200.0 [1], 100000.0 [2]
2-(4-Methoxyphenyl)-4-(1-methylsulfonyl-2,3-dihydroindol-5-yl)-1,3-thiazoleIC506500.0 [1], 42900.0 [2]
1-Methanesulfonyl-5-[2-(2-methoxyphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indoleIC504000.0 [1], 41700.0 [2]
5-[2-(4-Ethoxyphenyl)-1,3-thiazol-4-yl]-1-methyl-2,3-dihydro-1H-indol-2-oneIC509500.0 [1], 33600.0 [2]
SodiumIC5010000000.0 [1]
YohimbineIC5022300.0 [1]
2-[Hexadecoxy(hydroxy)phosphoryl]oxyethyl-trimethylazaniumIC5025000.0 [1]
2(5H)-Furanone, 5-hydroxy-IC5012000000.0 [1]
2-((2-Hydroxyethyl)thio)-3-methylnaphthalene-1,4-dioneIC504560.0 [1]
7-((2-(3,5-Dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedioneIC5015000.0 [1]
Brunsvicamide AIC50100000.0 [1]
2-[[5-(3-Chlorophenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]thio]-1-(3,4-dihydroxyphenyl)ethanoneIC503280.0 [1]
5-((1H-Indol-3-yl)methylene)-2-(2,4-dichlorophenylamino)thiazol-4(5H)-oneIC5012600.0 [1]
3-Benzoylnaphtho[1,2-b]furan-4,5-dioneIC505000.0 [1]
2-Benzylidene-1,3-dioxo-2,3-dihydro-1H-indene-5-carboxylic acidIC5013300.0 [1]
1-(Biphenyl-4-yl)-2-(5-(furan-2-yl)-4-methyl-4H-1,2,4-triazol-3-ylthio)ethanoneIC5013000.0 [1]
N-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]pyrazine-2-carboxamideIC5025700.0 [1]
(2S,3S)-2-[[(3S,6S,9S,12S,15S)-3-Benzyl-12-[(2S)-butan-2-yl]-6-(1H-indol-3-ylmethyl)-7-methyl-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazacyclononadec-15-yl]carbamoylamino]-3-methylpentanoic acidIC50100000.0 [1]
CID 10883523IC50890.0 [1]
1-(3,4-Dichlorophenyl)-3-[7-(furan-2-yl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]ureaIC5017800.0 [1]
[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-acetic acidIC50700.0 [1]
Maleimide analogIC501000.0 [1]
2-[(7-Methoxy-2-oxochromen-4-yl)methylsulfanyl]naphthalene-1,4-dioneIC509000.0 [1]
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-methylphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-oneIC50100000.0 [1]
3-Isopropylnaphthalene-1,2-dioneIC5011180.0 [1]
1-Dodecylindoline-2,3-dioneIC5015000.0 [1]
4-(Biphenyl-4-yl)thiazole-2-ylmethyl 2-furylmethyl sulfoneIC502700.0 [1]
2-[(5Z)-5-[[3-[4-[(2-Fluorophenyl)methoxy]phenyl]-1-phenylpyrazol-4-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acidIC502800.0 [1]
3-(1,3-Benzodioxol-5-yl)-N-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]acrylamideIC507500.0 [1]
3-[4,6-Dichloro-7-(3-methylbut-2-enyl)-1H-indol-3-yl]-2,5-dihydroxycyclohexa-2,5-diene-1,4-dioneIC505000.0 [1]
3-[(1S)-2-[(1R,4S,7Ar)-4,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-yl]-1-hydroxyethyl]-2-hydroxy-2H-furan-5-oneIC50440.0 [1]
[[4-[[4-[[4-[Difluoro(phosphono)methyl]phenyl]methoxy]phenoxy]methyl]phenyl]-difluoromethyl]phosphonic acidIC5030000.0 [1]
3-[(1S)-2-[(1S,2R,5S,8As)-1,2,5-trimethyl-5-(4-methylpent-4-enyl)-2,3,6,7,8,8a-hexahydronaphthalen-1-yl]-1-hydroxyethyl]-2-hydroxy-2H-furan-5-oneIC5013000.0 [1]
3-[(1R)-2-[(1R,4R,7Ar)-4,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-yl]-1-hydroxyethyl]-2-hydroxy-2H-furan-5-oneIC50480.0 [1]
Ethyl 2-[[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxycarbothioylsulfanyl]propanoateIC50100000.0 [1]
Ethyl 4-[[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxycarbothioylsulfanyl]-3-oxobutanoateIC50100000.0 [1]
5-[(4R,4As,6aR,7R,9aS,9bS)-4,6a-dimethyl-7-[(2R)-6-methylheptan-2-yl]-2-oxo-4a,5,6,7,8,9,9a,9b-octahydro-1H-cyclopenta[f]isochromen-4-yl]-3-methoxypentanenitrileIC5010500.0 [1]
(Z)-5-[(4S,4As,6aR,7R,9aS,9bS)-4,6a-dimethyl-7-[(2R)-6-methylheptan-2-yl]-2-oxo-4a,5,6,7,8,9,9a,9b-octahydro-1H-cyclopenta[f]isochromen-4-yl]pent-2-enenitrileIC5050000.0 [1]
(Z)-5-[(4S,4As,6aR,7R,9aS,9bS)-4,6a-dimethyl-7-(6-methylheptan-2-yl)-2-oxo-4a,5,6,7,8,9,9a,9b-octahydro-1H-cyclopenta[f]isochromen-4-yl]pent-2-enenitrileIC5013300.0 [1]
2-[(1R,3As,4R,5S,7aR)-5-(6-cyano-5-ethoxyhex-1-en-2-yl)-7a-methyl-1-(6-methylheptan-2-yl)-1,2,3,3a,4,5,6,7-octahydroinden-4-yl]acetic acidIC502900.0 [1]
Ethyl 2-[[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxycarbothioylsulfanyl]acetateIC50100000.0 [1]
2-[[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxycarbothioylsulfanyl]acetic acidIC50900.0 [1]
O-[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] phenacylsulfanylmethanethioateIC50100000.0 [1]
2-[(1R,3As,4R,5S,7aR)-5-[(2Z,5Z)-6-cyanohexa-2,5-dien-2-yl]-7a-methyl-1-(6-methylheptan-2-yl)-1,2,3,3a,4,5,6,7-octahydroinden-4-yl]acetic acidIC5036300.0 [1]
2-[(1R,3As,4R,5S,7aR)-5-[(Z)-6-cyanohex-2-en-2-yl]-7a-methyl-1-(6-methylheptan-2-yl)-1,2,3,3a,4,5,6,7-octahydroinden-4-yl]acetic acidIC502400.0 [1]
O-[[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]] N-phenylcarbamothioateIC502100.0 [1]
3-(1H-Benzo[g]indol-3-yl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dioneIC502500.0 [1]
2,5-Dihydroxy-3-[7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]-1H-indol-3-yl]cyclohexa-2,5-diene-1,4-dioneIC502400.0 [1]
3-(4-Chloro-1H-indol-3-yl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dioneIC5028000.0 [1]
[[4-[[3-[[4-[Difluoro(phosphono)methyl]phenyl]methoxy]phenoxy]methyl]phenyl]-difluoromethyl]phosphonic acidIC50163000.0 [1]
3-[6-Chloro-7-(3-methylbut-2-enyl)-1H-indol-3-yl]-2,5-dihydroxycyclohexa-2,5-diene-1,4-dioneIC504000.0 [1]
2,5-Dihydroxy-3-(7-phenylmethoxy-1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dioneIC504200.0 [1]
2,5-Dihydroxy-3-(7-propyl-1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dioneIC504200.0 [1]
3-(5-Bromo-1H-indol-3-yl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dioneIC505800.0 [1]
2,5-Dihydroxy-3-(5-methyl-1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dioneIC508100.0 [1]
2,5-Dihydroxy-3-(5-phenylmethoxy-1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dioneIC505500.0 [1]
3-(7-Tert-butyl-1H-indol-3-yl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dioneIC507200.0 [1]
3-(2-Cyclopropyl-1H-indole-3-yl)-2,5-dihydroxy-p-benzoquinoneIC5035000.0 [1]
2,5-Dioxo-4-hexylfuran-3-propanoic acidIC50100000.0 [1]
2,5-Dioxo-4-octylfuran-3-propanoic acidIC50100000.0 [1]
2-(4-(7-(4-Methoxybenzoyl)cyclopenta[d][1,2]oxazin-4-yl)phenoxy)acetic acidIC5073300.0 [1]
3-[[(2S)-2-(3-Benzoyl-1-cyanoindolizin-5-yl)oxy-4-methylpentanoyl]amino]-3-phenylpropanoic acidIC5070700.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Dual specificity phosphatase Cdc25A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/dual-specificity-phosphatase-cdc25a-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Dual specificity phosphatase Cdc25A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-phosphatase-cdc25a-inhibitors-ic50-ki.
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