Dual specificity phosphatase Cdc25B Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3-[7-(3-Methyl-2-butenyl)-1H-indole-3-yl]-2,5-dihydroxy-p-benzoquinone	IC50	12000.0 [1]
	3-[7-(3-Methyl-2-butenyl)-1H-indole-3-yl]-2,5-dihydroxy-p-benzoquinone	Ki	640.0 [1]
	3-(1H-Indole-3-yl)-2,5-dihydroxy-p-benzoquinone	IC50	50000.0 [1]
	3-(1H-Indole-3-yl)-2,5-dihydroxy-p-benzoquinone	Ki	13000.0 [1]
	2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione	IC50	100.0 [1], 125.0 [2], 3770.0 [3], 19170.0 [4], 19200.0 [5]
	6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione	IC50	210.0 [1], 740.0 [2], 29200.0 [3], 100000.0 [4]
	6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione	Ki	95.0 [1]
	(1S)-1-Methyl-7,7-dioxo-18-oxa-7lambda6-thia-10-azahexacyclo[15.6.1.02,15.04,13.06,11.020,24]tetracosa-2(15),3,6(11),13,17(24),19-hexaene-5,12,16-trione	IC50	70.0 [1], 80.0 [2], 110.0 [3]
	4-(N-Benzyl-C-pentadecylcarbonimidoyl)-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	IC50	8420.0 [1], 15600.0 [2], 16900.0 [3]
	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(2-hydroxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	IC50	4260.0 [1], 9980.0 [2], 10900.0 [3]
	3-[4,6-Dichloro-7-(3-methylbut-2-enyl)-1H-indol-3-yl]-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione	IC50	2300.0 [1], 8600.0 [2]
	3-[4,6-Dichloro-7-(3-methylbut-2-enyl)-1H-indol-3-yl]-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione	Ki	430.0 [1]
	(5Z)-5-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-2-[7-[[(5Z)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]amino]heptylimino]-1,3-thiazolidin-4-one	IC50	1380.0 [1], 3100.0 [2], 3200.0 [3]
	(5Z)-5-[(4-Hydroxyphenyl)methylidene]-2-[7-[[(5Z)-5-[(4-hydroxyphenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]amino]heptylimino]-1,3-thiazolidin-4-one	IC50	3400.0 [1], 16500.0 [2], 20000.0 [3]
	6-(3-Aminophenyl)-3-(phenylamino)isoquinoline-1(2H)-one	IC50	3180.0 [1], 33600.0 [2]
	6-(3-Aminophenyl)-3-(phenylamino)isoquinoline-1(2H)-one	Ki	1900.0 [1]
	Menadione	IC50	2200.0 [1], 3380.0 [2]
	7-((2-(3,5-Dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione	IC50	640.0 [1], 35000.0 [2]
	2-(3,4-Dimethylphenylamino)-5-(3-furan-2-ylallylidene)thiazol-4-one	IC50	1800.0 [1], 5440.0 [2]
	(E)-2-((1R,7Ar)-7a-methyl-1-((R)-6-methylheptan-2-yl)-octahydroinden-4-ylidene)acetic acid	IC50	5900.0 [1], 8000.0 [2]
	2-[4-(4-Chlorophenyl)-5-p-tolyl-4H-[1,2,4]triazol-3-ylsulfanyl]-1-(3,4-dihydroxyphenyl)ethanone	IC50	1980.0 [1], 2000.0 [2]
	4-Heptadecyl-2,5-dihydro-2,5-dioxofuran-3-propionic acid	IC50	3600.0 [1]
	(E)-2-(2-Chlorophenyl)-N-[4-(4-chlorophenyl)-5-propyl-1,3-thiazol-2-yl]ethenesulfonamide	IC50	26000.0 [1]
	(E)-2-(2-Chlorophenyl)-N-[4-(4-chlorophenyl)-5-propyl-1,3-thiazol-2-yl]ethenesulfonamide	Ki	4600.0 [1]
	(E)-N-(4,5-Diphenyl-1,3-thiazol-2-yl)-2-naphthalen-2-ylethenesulfonamide	IC50	22000.0 [1]
	(E)-N-(4,5-Diphenyl-1,3-thiazol-2-yl)-2-naphthalen-2-ylethenesulfonamide	Ki	36000.0 [1]
	5-[2-(4-Ethoxyphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-one	IC50	8900.0 [1], 17900.0 [2]
	1-Methanesulfonyl-5-[2-(3-methylphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indole	IC50	19000.0 [1], 34400.0 [2]
	4-{2,5-Dimethyl-1-[(oxolan-2-yl)methyl]-1H-pyrrol-3-yl}-2-(4-methoxyphenyl)-1,3-thiazole	IC50	12100.0 [1], 23600.0 [2]
	2-(4-Ethoxyphenyl)-4-(naphthalen-2-yl)-1,3-thiazole	IC50	13600.0 [1], 100000.0 [2]
	N-[3-(2-Phenyl-1,3-thiazol-4-yl)phenyl]-2-furamide	IC50	100000.0 [1]
	N-{3-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]phenyl}cyclopropanecarboxamide	IC50	14900.0 [1], 100000.0 [2]
	2-(4-Methoxyphenyl)-4-(1-methylsulfonyl-2,3-dihydroindol-5-yl)-1,3-thiazole	IC50	17500.0 [1], 26100.0 [2]
	1-Methanesulfonyl-5-[2-(2-methoxyphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indole	IC50	10100.0 [1], 31300.0 [2]
	5-[2-(4-Ethoxyphenyl)-1,3-thiazol-4-yl]-1-methyl-2,3-dihydro-1H-indol-2-one	IC50	22700.0 [1], 50000.0 [2]
	1,4-Benzoquinone	IC50	50000.0 [1]
	Oleanolic acid	IC50	980.0 [1]
	Anthraquinone	IC50	9510.0 [1]
	1,4-Naphthoquinone	IC50	2760.0 [1]
	Juglone	IC50	1980.0 [1]
	alpha-Tocopherolquinone	IC50	23230.0 [1]
	5,8-Dihydroxy-1,4-naphthoquinone	IC50	1000.0 [1]
	Ilimaquinone	IC50	92000.0 [1]
	Dysidiolide	IC50	87000.0 [1]
	3-(2-PYRIDYL)-5,6-bis-[2-(5-FURYL-SULFONIC ACID)]-1,2,4-TRIAZINE	Ki	159000.0 [1]
	2-((2-Hydroxyethyl)thio)-3-methylnaphthalene-1,4-dione	IC50	23630.0 [1]
	RK-682, Streptomyces sp.	IC50	12400.0 [1]
	6,7-Dichloroquinoline-5,8-dione	IC50	4600.0 [1]
	5,8-Quinolinedione	IC50	3000.0 [1]
	3-Anilinoisoquinolin-1(2H)-one	IC50	3300.0 [1]
	Streptonigrin methyl ester	IC50	370.0 [1]
	o-(4-Biphenylylcarbonyl)benzoic acid	IC50	23100.0 [1]
	2-[[5-(3-Chlorophenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]thio]-1-(3,4-dihydroxyphenyl)ethanone	IC50	4670.0 [1]
	5,8-Phthalazinedione, 6,7-dichloro-	IC50	8900.0 [1]
	2-[4-(Methylamino)-3-nitrobenzoyl]benzoic acid	IC50	7900.0 [1]
	5,5'-Methylenedianthranilic acid	IC50	23800.0 [1]
	5-((1H-Indol-3-yl)methylene)-2-(2,4-dichlorophenylamino)thiazol-4(5H)-one	IC50	2600.0 [1]
	3-Benzoylnaphtho[1,2-b]furan-4,5-dione	IC50	5000.0 [1]
	2-Benzylidene-1,3-dioxo-2,3-dihydro-1H-indene-5-carboxylic acid	IC50	8600.0 [1]
	3-(4-Fluoroanilino)-2H-isoquinolin-1-one	IC50	830.0 [1]
	1-(Biphenyl-4-yl)-2-(5-(furan-2-yl)-4-methyl-4H-1,2,4-triazol-3-ylthio)ethanone	IC50	2000.0 [1]
	N-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]pyrazine-2-carboxamide	IC50	16000.0 [1]
	3-Anilino-6-bromo-isocarbostyril	IC50	1160.0 [1]
	3-(2-Pyridylamino)isocarbostyril	IC50	3310.0 [1]
	3-(2-Chloroanilino)isocarbostyril	IC50	4190.0 [1]
	3-(2,5-Dimethoxyanilino)isocarbostyril	IC50	5250.0 [1]
	3-(Morpholin-4-yl)-1,2-dihydroisoquinolin-1-one	IC50	3370.0 [1]
	7-[(1-Hydroxy-1-phenylpropan-2-yl)amino]quinoline-5,8-dione	IC50	510.0 [1]
	Ethyl 4-[(1-oxo-2H-isoquinolin-3-yl)amino]benzoate	IC50	10750.0 [1]
	1,4-Dioxo-3-methyl-2-naphthalenebutyric acid	IC50	100000.0 [1]
	2-Methoxy-5-((4-methyl-2-oxo-1,2-dihydro-quinolin-6-yl)methyl)benzenesulfonic acid	Ki	84000.0 [1]
	3-(3,4,5-Trihydroxy-6-oxoxanthen-9-yl)propanoic acid	Ki	80.0 [1]
	1-(3,4-Dichlorophenyl)-3-[7-(furan-2-yl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]urea	IC50	13700.0 [1]
	4-Ethoxynaphthalene-1,2-dione	IC50	270.0 [1]
	1,4-Naphthalenedione, 2-[(2-hydroxyethyl)amino]-	IC50	50000.0 [1]
	Benzimidazo[1,2-b]isoquinolin-11(5H)-one	IC50	5300.0 [1]
	4-Phenyl-[1,2]naphthoquinone	IC50	9520.0 [1]
	Maleimide analog	IC50	10000.0 [1]
	3-[5-[(E)-(2-Amino-3,7-dicyano-4,6-dimethylcyclopenta[b]pyridin-5-ylidene)methyl]furan-2-yl]benzoic acid	IC50	19000.0 [1]
	1,1-Dioxo-3,4-dihydro-2H-benzo[g][1,4]benzothiazine-5,10-dione	IC50	940.0 [1]
	2-[(7-Methoxy-2-oxochromen-4-yl)methylsulfanyl]naphthalene-1,4-dione	IC50	9000.0 [1]
	2-[(3,4-Dioxonaphthalen-1-yl)amino]-6-oxo-1H-pyrimidine-4-carboxylic acid	IC50	9900.0 [1]
	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-methylphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	IC50	100000.0 [1]
	3-Isopropylnaphthalene-1,2-dione	IC50	24100.0 [1]
	6,7-Dichloro-5,8-isoquinolinedione	IC50	1500.0 [1]
	4-(2-Carboxybenzoyl)phthalic acid	Ki	5300.0 [1]
	4-(Biphenyl-4-yl)thiazole-2-ylmethyl 2-furylmethyl sulfone	IC50	1700.0 [1]
	3-Hexadecanoyl-4-hydroxy-5-methylenefuran-2(5H)-one	IC50	7400.0 [1]
	2-[(E)-2-[5-(4-Chlorophenyl)furan-2-yl]ethenyl]-6-oxo-3-phenyl-4-sulfanyl-1,2-dihydropyrimidine-5-carbonitrile	IC50	12640.0 [1]
	2-(Cyclopentanecarbonyl)-7-[(2,6-dichlorophenyl)methoxy]-6,8-diiodo-3,4-dihydro-1H-isoquinoline-3-carboxylic acid	IC50	100000.0 [1]
	3-(1,3-Benzodioxol-5-yl)-N-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]acrylamide	IC50	2690.0 [1]
	3-[(1S)-2-[(1R,4S,7Ar)-4,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-yl]-1-hydroxyethyl]-2-hydroxy-2H-furan-5-one	IC50	1900.0 [1]
	2-(2-Hydroxyethylamino)-3-methyl-1,4-naphthoquinone	IC50	50000.0 [1]
	3-[(1S)-2-[(1S,2R,5S,8As)-1,2,5-trimethyl-5-(4-methylpent-4-enyl)-2,3,6,7,8,8a-hexahydronaphthalen-1-yl]-1-hydroxyethyl]-2-hydroxy-2H-furan-5-one	IC50	18000.0 [1]
	(3S)-7-[(2,4-Dichlorophenyl)methoxy]-6,8-diiodo-2-[(E)-3-[3-(trifluoromethyl)phenyl]prop-2-enoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid	IC50	15000.0 [1]
	(2R,5R,6R)-6,10-Dimethyl-5-[(2R)-6-methylheptan-2-yl]-13-oxotricyclo[13.2.2.02,6]nonadeca-1(17),15,18-triene-17-carboxylic acid	IC50	3400.0 [1]
	4-Cyclohexyl-1,2-naphthoquinone	IC50	3000.0 [1]
	(E)-2-(3,4-Difluorophenyl)-N-[5-propyl-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]ethenesulfonamide	IC50	25000.0 [1]
	3-[(1R)-2-[(1R,4R,7Ar)-4,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-yl]-1-hydroxyethyl]-2-hydroxy-2H-furan-5-one	IC50	1440.0 [1]
	3-(1H-Benzo[g]indol-3-yl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione	IC50	24000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Dual specificity phosphatase Cdc25B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/dual-specificity-phosphatase-cdc25b-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Dual specificity phosphatase Cdc25B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-phosphatase-cdc25b-inhibitors-ic50-ki.
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