Dual specificity phosphatase Cdc25C Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Menadione	IC50	18800.0 [1], 19000.0 [2]
	2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione	IC50	56.9 [1], 78.0 [2]
	6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione	IC50	250.0 [1]
	6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione	Ki	89.0 [1]
	4-Heptadecyl-2,5-dihydro-2,5-dioxofuran-3-propionic acid	IC50	4300.0 [1]
	2,5-Dihydroxy-3-[7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]-1H-indol-3-yl]cyclohexa-2,5-diene-1,4-dione	IC50	3500.0 [1]
	2,5-Dihydroxy-3-[7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]-1H-indol-3-yl]cyclohexa-2,5-diene-1,4-dione	Ki	640.0 [1]
	5-[2-(4-Ethoxyphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-one	IC50	10200.0 [1], 47300.0 [2]
	1-Methanesulfonyl-5-[2-(3-methylphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indole	IC50	24300.0 [1], 37800.0 [2]
	4-{2,5-Dimethyl-1-[(oxolan-2-yl)methyl]-1H-pyrrol-3-yl}-2-(4-methoxyphenyl)-1,3-thiazole	IC50	24700.0 [1], 100000.0 [2]
	2-(4-Ethoxyphenyl)-4-(naphthalen-2-yl)-1,3-thiazole	IC50	31500.0 [1], 71500.0 [2]
	N-[3-(2-Phenyl-1,3-thiazol-4-yl)phenyl]-2-furamide	IC50	100000.0 [1]
	N-{3-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]phenyl}cyclopropanecarboxamide	IC50	16800.0 [1], 42200.0 [2]
	2-(4-Methoxyphenyl)-4-(1-methylsulfonyl-2,3-dihydroindol-5-yl)-1,3-thiazole	IC50	18000.0 [1], 42500.0 [2]
	1-Methanesulfonyl-5-[2-(2-methoxyphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indole	IC50	14200.0 [1], 42600.0 [2]
	5-[2-(4-Ethoxyphenyl)-1,3-thiazol-4-yl]-1-methyl-2,3-dihydro-1H-indol-2-one	IC50	47600.0 [1], 100000.0 [2]
	7-((2-(3,5-Dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione	IC50	35000.0 [1]
	4,7-Benzothiazoledione, 5-((2-(dimethylamino)ethyl)amino)-2-methyl-	IC50	150.0 [1]
	3-Benzoylnaphtho[1,2-b]furan-4,5-dione	IC50	5000.0 [1]
	N-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]pyrazine-2-carboxamide	IC50	40000.0 [1]
	2-[4-[2-Acetamido-3-[[5-[[(1S)-1-carboxy-3-methylsulfanylpropyl]amino]-5-oxopentyl]amino]-3-oxopropyl]-2-ethyl-N-oxaloanilino]benzoic acid	Ki	300000.0 [1]
	2-[4-[(2S)-3-[4-(3-Hydroxy-2-methoxycarbonylphenoxy)butylamino]-3-oxo-2-(prop-2-enoxycarbonylamino)propyl]-N-oxaloanilino]benzoic acid	Ki	178000.0 [1]
	2-[[4-[2-Acetamido-3-oxo-3-(pentylamino)propyl]naphthalen-1-yl]-oxaloamino]benzoic acid	Ki	300000.0 [1]
	[5-(5-Cyano-1-methylene-pentyl)-1-(1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-acetic acid	IC50	6500.0 [1]
	Maleimide analog	IC50	40000.0 [1]
	2-[(7-Methoxy-2-oxochromen-4-yl)methylsulfanyl]naphthalene-1,4-dione	IC50	9000.0 [1]
	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-methylphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	IC50	100000.0 [1]
	4-(Biphenyl-4-yl)thiazole-2-ylmethyl 2-furylmethyl sulfone	IC50	9700.0 [1]
	3-Methoxy-N,N,4-trimethyl-5-[[methyl-[2-(4-nitrophenyl)ethyl]amino]methyl]aniline	IC50	5400.0 [1]
	2-[4-[2-Acetamido-3-[4-(5-chloro-3-hydroxy-2-methoxycarbonylphenoxy)butylamino]-3-oxopropyl]-2-ethyl-N-oxaloanilino]benzoic acid	Ki	3000.0 [1]
	3-(1,3-Benzodioxol-5-yl)-N-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]acrylamide	IC50	11000.0 [1]
	3-[4,6-Dichloro-7-(3-methylbut-2-enyl)-1H-indol-3-yl]-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione	IC50	8800.0 [1]
	5-[2-(Dimethylamino)ethylamino]-2-phenyl-1,3-benzoxazole-4,7-dione	IC50	230.0 [1]
	6-[2-(Dimethylamino)ethylamino]-2-phenyl-1,3-benzoxazole-4,7-dione	IC50	230.0 [1]
	2-(1-Carboxyethoxy)-5-[(2S)-3-[4-(3-hydroxy-2-methoxycarbonylphenoxy)butylamino]-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]-3-oxopropyl]benzoic acid	Ki	30000.0 [1]
	Methylbenzyl(4-nitrophenethyl)amine	IC50	80000.0 [1]
	3-(1H-Benzo[g]indol-3-yl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione	IC50	15000.0 [1]
	3-(4-Chloro-1H-indol-3-yl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione	IC50	50000.0 [1]
	3-[6-Chloro-7-(3-methylbut-2-enyl)-1H-indol-3-yl]-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione	IC50	11000.0 [1]
	2,5-Dihydroxy-3-(7-phenylmethoxy-1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione	IC50	6900.0 [1]
	2,5-Dihydroxy-3-(7-propyl-1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione	IC50	50000.0 [1]
	3-(7-Tert-butyl-1H-indol-3-yl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione	IC50	50000.0 [1]
	3-(2-Cyclopropyl-1H-indole-3-yl)-2,5-dihydroxy-p-benzoquinone	IC50	50000.0 [1]
	2,5-Dioxo-4-hexylfuran-3-propanoic acid	IC50	100000.0 [1]
	2,5-Dioxo-4-octylfuran-3-propanoic acid	IC50	100000.0 [1]
	4-Dimethylamino-2-{[2-(4-nitro-phenyl)-ethylamino]-methyl}-phenol	IC50	3900.0 [1]
	4-(Dimethylamino)-2-methoxy-6-({[2-(4-nitrophenyl)ethyl]amino}methyl)phenol	IC50	4000.0 [1]
	2-(4-(7-(4-Methoxybenzoyl)cyclopenta[d][1,2]oxazin-4-yl)phenoxy)acetic acid	IC50	61700.0 [1]
	2,5-Dihydroxy-3-(7-phenyl-1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione	IC50	27000.0 [1]
	2,5-Dihydroxy-3-[7-[(2-methylphenyl)methyl]-1H-indol-3-yl]cyclohexa-2,5-diene-1,4-dione	IC50	3500.0 [1]
	3-(7-Benzyl-1H-indol-3-yl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione	IC50	15000.0 [1]
	3-(6-Chloro-1h-indol-3-yl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione	IC50	40000.0 [1]
	4-[N-[[3-(Dimethylamino)phenyl]methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	IC50	100000.0 [1]
	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-hydroxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	IC50	100000.0 [1]
	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(2-methylphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	IC50	100000.0 [1]
	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(4-methylphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	IC50	56700.0 [1]
	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-methoxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	IC50	100000.0 [1]
	4-[N-[(3-Chlorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	IC50	100000.0 [1]
	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(4-hydroxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	IC50	44100.0 [1]
	4-(N-Benzyl-C-pentadecylcarbonimidoyl)-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	IC50	100000.0 [1]
	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(2-hydroxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	IC50	100000.0 [1]
	4-[N-[(4-Chlorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	IC50	100000.0 [1]
	4-[N-[(4-Fluorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	IC50	100000.0 [1]
	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(4-methoxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	IC50	100000.0 [1]
	4-[N-[[4-(Dimethylamino)phenyl]methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	IC50	100000.0 [1]
	4-[N-[(2-Chlorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	IC50	100000.0 [1]
	4-[N-[(2-Fluorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	IC50	47100.0 [1]
	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(2-methoxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	IC50	100000.0 [1]
	4-[N-[[2-(Dimethylamino)phenyl]methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	IC50	100000.0 [1]
	4-[N-[(3-Fluorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	IC50	78200.0 [1]
	8-(Diethylamino)naphtho[1,2-c]chromene-1,4,5-trione	IC50	300.0 [1]
	8-Methoxynaphtho[1,2-c]chromene-1,4,5-trione	IC50	980.0 [1]
	8-Fluoro-6H-benzo[i]phenanthridine-1,4,5-trione	IC50	4460.0 [1]
	9-Chloro-6H-benzo[i]phenanthridine-1,4,5-trione	IC50	5720.0 [1]
	8-Fluoronaphtho[1,2-c]chromene-1,4,5-trione	IC50	690.0 [1]
	8-Hydroxynaphtho[1,2-c]chromene-1,4,5-trione	IC50	800.0 [1]
	6-Methylbenzo[i]phenanthridine-1,4,5-trione	IC50	14900.0 [1]
	8-Chloro-6H-benzo[i]phenanthridine-1,4,5-trione	IC50	5500.0 [1]
	9-Fluoronaphtho[1,2-c]chromene-1,4,5-trione	IC50	400.0 [1]
	9-Chloronaphtho[1,2-c]chromene-1,4,5-trione	IC50	1440.0 [1]
	12-Oxapentacyclo[12.8.0.02,11.05,10.015,20]docosa-1(14),2(11),3,5,7,9,15(20),17,21-nonaene-13,16,19-trione	IC50	100.0 [1]
	9-Fluoro-6H-benzo[i]phenanthridine-1,4,5-trione	IC50	4670.0 [1]
	8-Methylnaphtho[1,2-c]chromene-1,4,5-trione	IC50	1000.0 [1]
	8-Phenylmethoxynaphtho[1,2-c]chromene-1,4,5-trione	IC50	7120.0 [1]
	6H-Benzo[i]phenanthridine-1,4,5-trione	IC50	3640.0 [1]
	12-Azapentacyclo[12.8.0.02,11.05,10.015,20]docosa-1(14),2(11),3,5,7,9,15(20),17,21-nonaene-13,16,19-trione	IC50	4370.0 [1]
	8-Chloronaphtho[1,2-c]chromene-1,4,5-trione	IC50	770.0 [1]
	4-(2-Carboxyethyl)-3-decylfuran-2,5-dione	IC50	53900.0 [1]
	3-(4-Nonyl-2,5-dioxofuran-3-yl)propanoic acid	IC50	100000.0 [1]
	3-(2,5-Dioxo-4-pentadecylfuran-3-yl)propanoic acid	IC50	8600.0 [1]
	3-(2,5-Dioxo-4-tridecylfuran-3-yl)propanoic acid	IC50	5700.0 [1]
	3-(2,5-Dioxo-4-tetradecylfuran-3-yl)propanoic acid	IC50	12600.0 [1]
	2-[4-[3-[4-(3-Hydroxy-2-methoxycarbonylphenoxy)butylamino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-oxopropyl]phenoxy]propanedioic acid	Ki	30000.0 [1]
	3-(1H-Indole-3-yl)-2,5-dihydroxy-p-benzoquinone	IC50	30000.0 [1]
	2-Dimethylamino-6-methoxy-4-({methyl-[2-(4-nitro-phenyl)-ethyl]-amino}-methyl)-phenol	IC50	20700.0 [1]
	4-[2-[4-(1,2,3-Thiadiazole-4-yl)phenyl]-4-thiazolyl]benzonitrile	IC50	8800.0 [1]
	(2S)-3-[(1R)-2-[(1S,2S,5S,8Ar)-1,2,5,8a-tetramethyl-5-(4-methylpent-4-enyl)-3,6,7,8-tetrahydro-2H-naphthalen-1-yl]-1-hydroxyethyl]-2-hydroxy-2H-furan-5-one	IC50	2000000.0 [1]
	2-[[4-[(2S)-3-[4-(3-Hydroxy-2-methoxycarbonylphenoxy)butylamino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-oxopropyl]-N-oxaloanilino]methyl]butanoic acid	Ki	30000.0 [1]
	2-({Methyl-[2-(4-nitro-phenyl)-ethyl]-amino}-methyl)-phenol	IC50	80000.0 [1]
	Dimethyl-[4-({methyl-[2-(4-nitro-phenyl)-ethyl]-amino}-methyl)-phenyl]-amine	IC50	80000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Dual specificity phosphatase Cdc25C Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/dual-specificity-phosphatase-cdc25c-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Dual specificity phosphatase Cdc25C Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-phosphatase-cdc25c-inhibitors-ic50-ki.
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