Dual specificity protein kinase CLK2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-[[4-Cyclopentyloxy-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxy-N-methylbenzamide	IC50	6.0 [1], 15.0 [2], 549.0 [3]
	Silmitasertib	IC50	3.8 [1]
	9H-Purine-2,6-diamine, N2-(2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-, cis-	IC50	111.0 [1]
	CID 53246941	IC50	112.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	1902.0 [1]
	CID 59604787	IC50	10000.0 [1]
	CID 46926514	IC50	231.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamine	IC50	692.0 [1]
	[5-[4-[(5-Methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanol	IC50	1648.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	8753.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamide	IC50	211.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-[(2-methyl-4-thiazolyl)methyl]-4-quinazolinamine	IC50	1327.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-methyl-N-[(2-methyl-4-thiazolyl)methyl]-4-quinazolinamine	IC50	186.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-methyl-N-(1,3-thiazol-2-ylmethyl)quinazolin-4-amine	IC50	589.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-methyl-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	173.0 [1]
	6-(Benzo[d][1,3]dioxol-5-yl)-N-(furan-3-ylmethyl)quinazolin-4-amine	IC50	877.0 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(3-oxolanylmethyl)-4-quinazolinamine	IC50	1055.0 [1]
	CID 46926513	IC50	23.0 [1]
	(Z)-3-Pyridin-3-yl-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-enenitrile	IC50	4600.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-one	IC50	1012.0 [1]
	11H-Pyrido[3,4-a]carbazole-6-carbonitrile	IC50	1100.0 [1]
	Clk1-IN-1	IC50	31.0 [1]
	N-(4-Morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	IC50	5.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-2-N-[(3R)-piperidin-3-yl]-9-propan-2-ylpurine-2,6-diamine	IC50	34.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-2-N-[(1R,2S)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine	IC50	16.0 [1]
	N-[3-[[2-[[(1R,2S)-2-Aminocyclohexyl]amino]-9-propan-2-ylpurin-6-yl]amino]-5-chlorophenyl]acetamide	IC50	13.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-2-N-[(1S,2S)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine	IC50	14.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-2-N-[(1R,2R)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine	IC50	163.0 [1]
	N-[3-[[2-[[(1S,2R)-2-Aminocyclohexyl]amino]-9-propan-2-ylpurin-6-yl]amino]-5-chlorophenyl]acetamide	IC50	17.0 [1]
	2-N-[(1S,2R)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine	IC50	26.0 [1]
	2-N-[(1R,2R)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine	IC50	120.0 [1]
	2-N-[(1S,2S)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine	IC50	16.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-2-N-[(1S,2R)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine	IC50	26.0 [1]
	2-N-[(1R,2S)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine	IC50	11.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-9-propan-2-yl-2-N-[(3S)-pyrrolidin-3-yl]purine-2,6-diamine	IC50	28.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-2-N-[(3S)-piperidin-3-yl]-9-propan-2-ylpurine-2,6-diamine	IC50	26.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-9-propan-2-yl-2-N-[(3R)-pyrrolidin-3-yl]purine-2,6-diamine	IC50	92.0 [1]
	5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-one	IC50	10000.0 [1]
	Methyl 2-(2-chloroanilino)-4-hydroxy-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]furan-3-carboxylate	IC50	5.3 [1]
	1-[4-[4-[[5-(Oxan-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]cyclohexyl]piperazin-1-yl]ethanone	IC50	39.0 [1]
	1-[4-[4-[(5-Propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]piperazin-1-yl]ethanone	IC50	175.0 [1]
	(5E)-2-Amino-5-(1,3-benzodioxol-5-ylmethylidene)-3-methylimidazol-4-one	IC50	910.0 [1]
	5-(1,3-Benzodioxol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine	IC50	10000.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-[(3-methylthiophen-2-yl)methyl]quinazolin-4-amine	IC50	2163.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-[2-(1H-imidazol-5-yl)ethyl]quinazolin-4-amine	IC50	2219.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(2-oxolanylmethyl)-4-quinazolinamine	IC50	1810.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]quinazolin-4-amine	IC50	3118.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-[2-(2-furanyl)ethyl]-4-quinazolinamine	IC50	801.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-[(5-methylfuran-2-yl)methyl]quinazolin-4-amine	IC50	651.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(1H-imidazol-2-ylmethyl)quinazolin-4-amine	IC50	3594.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-[(5-methylthiophen-2-yl)methyl]quinazolin-4-amine	IC50	10000.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-[(2-methyl-3-furanyl)methyl]-4-quinazolinamine	IC50	2725.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-methyl-N-[(3-methylthiophen-2-yl)methyl]quinazolin-4-amine	IC50	962.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-ethyl-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	447.0 [1]
	Ethyl 5-(4-(thiophen-2-ylmethylamino)quinazolin-6-yl)furan-2-carboxylate	IC50	8510.0 [1]
	Ethyl 5-(4-((5-methylfuran-2-yl)methylamino)quinazolin-6-yl)furan-2-carboxylate	IC50	6181.0 [1]
	6-(3-Furanyl)-N-methyl-N-[(3-methyl-2-thiophenyl)methyl]-4-quinazolinamine	IC50	1209.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(1H-imidazol-2-ylmethyl)-N-methylquinazolin-4-amine	IC50	3331.0 [1]
	(5-(4-(Methyl((3-methylthiophen-2-yl)methyl)amino)quinazolin-6-yl)furan-2-yl)methanol	IC50	889.0 [1]
	N-[(3,4-Dichlorophenyl)methyl]-4-(3-methoxyphenyl)pyrimidin-2-amine	IC50	10000.0 [1]
	N-[(4-Chlorophenyl)methyl]-4-(3-methoxyphenyl)pyrimidin-2-amine	IC50	10000.0 [1]
	N-[(3,4-Dichlorophenyl)methyl]-4-(4-methoxyphenyl)pyrimidin-2-amine	IC50	409.0 [1]
	N-[(4-Chlorophenyl)methyl]-4-(4-methoxyphenyl)pyrimidin-2-amine	IC50	1092.0 [1]
	5-(4-((5-Methylfuran-2-yl)methylamino)quinazolin-6-yl)furan-2-carboxylic acid	IC50	1361.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(2-thiazolylmethyl)-4-quinazolinamine	IC50	414.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-methyl-N-[(4-methyl-1,3-thiazol-2-yl)methyl]quinazolin-4-amine	IC50	195.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(2,2-dimethylpropyl)quinazolin-4-amine	IC50	584.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(furan-2-ylmethyl)quinazolin-4-amine	IC50	301.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(cyclopentylmethyl)-4-quinazolinamine	IC50	486.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(3-oxanylmethyl)-4-quinazolinamine	IC50	882.0 [1]
	4-(1,3-Benzodioxol-5-yl)-N-[3-bromo-5-(trifluoromethyl)phenyl]pyrimidin-2-amine	IC50	345.0 [1]
	4-(1,3-Benzodioxol-5-yl)-N-[3-(trifluoromethyl)phenyl]pyrimidin-2-amine	IC50	52.0 [1]
	4-(1,3-Benzodioxol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amine	IC50	60.0 [1]
	N-[(3,4-Dichlorophenyl)methyl]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-2-amine	IC50	39.0 [1]
	5-(1,3-Benzodioxol-5-yl)-N-[(3,4-dichlorophenyl)methyl]pyrimidin-4-amine	IC50	1557.0 [1]
	N,4-Bis(1,3-benzodioxol-5-yl)pyrimidin-2-amine	IC50	259.0 [1]
	4-(1,3-Benzodioxol-5-yl)-N-[(3,5-dibromophenyl)methyl]pyrimidin-2-amine	IC50	41.0 [1]
	4-(1,3-Benzodioxol-5-yl)-N-[(3,4-dichlorophenyl)methyl]pyrimidin-2-amine	IC50	20.0 [1]
	5-(1,3-Benzodioxol-5-yl)-N-[(4-chlorophenyl)methyl]pyrimidin-4-amine	IC50	8791.0 [1]
	4-(1,3-Benzodioxol-5-yl)-N-(4-chlorophenyl)pyrimidin-2-amine	IC50	10000.0 [1]
	4-(1,3-Benzodioxol-5-yl)-N-[(3,4-dibromophenyl)methyl]pyrimidin-2-amine	IC50	30.0 [1]
	N-[(3,4-Dichlorophenyl)methyl]-4-(1H-indazol-6-yl)pyrimidin-2-amine	IC50	429.0 [1]
	N-[(3,4-Dichlorophenyl)methyl]-2-(1H-indazol-5-yl)pyrimidin-4-amine	IC50	238.0 [1]
	2-(1H-Indazol-6-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine	IC50	1903.0 [1]
	4-(1H-Indazol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amine	IC50	462.0 [1]
	N-[(3,4-Dichlorophenyl)methyl]-4-(1H-indazol-5-yl)pyrimidin-2-amine	IC50	190.0 [1]
	2-(1H-Indazol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine	IC50	665.0 [1]
	N2-[(1R,2S)-2-Aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine	IC50	498.0 [1]
	N-(2,2-Dimethylpropyl)-6-[5-(ethylaminomethyl)furan-2-yl]quinazolin-4-amine	IC50	8480.0 [1]
	1-[2-(2-Ethyltetrazol-5-yl)ethyl]-3-[5-(3-fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]urea	IC50	117.0 [1]
	2-N-[(1S,2S)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine	IC50	190.0 [1]
	2-N-(1H-Indazol-6-yl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamine	IC50	6440.0 [1]
	N~4~-Cyclopropyl-N~2~-(3-Methyl-1h-Indazol-6-Yl)furo[3,2-D]pyrimidine-2,4-Diamine	IC50	10000.0 [1]
	2-N-(3-Chloro-4-morpholin-4-ylphenyl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamine	IC50	10000.0 [1]
	(9-Methoxy-11H-pyrido[4,3-a]carbazol-6-yl)methanamine	IC50	1600.0 [1]
	(Z)-2-(6-Methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-pyridin-3-ylprop-2-enenitrile	IC50	2300.0 [1]
	9-Methoxy-11H-pyrido[4,3-a]carbazole-6-carbonitrile	IC50	80.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Dual specificity protein kinase CLK2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/dual-specificity-protein-kinase-clk2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Dual specificity protein kinase CLK2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-protein-kinase-clk2-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan