Dual specificity protein kinase CLK4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	6-(1,3-Benzodioxol-5-yl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	39.0 [1], 63.0 [2]
	CID 46926514	IC50	68.0 [1], 130.0 [2]
	6-(3-Methoxyphenyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	891.0 [1], 1051.0 [2]
	6-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	126.0 [1], 141.0 [2]
	6-(Furan-2-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine	IC50	250.0 [1], 1090.0 [2]
	6-(Benzo[d][1,3]dioxol-5-yl)-N-(furan-3-ylmethyl)quinazolin-4-amine	IC50	38.0 [1], 63.0 [2]
	CID 46926513	IC50	4.0 [1], 50.0 [2]
	5-(1,3-Benzodioxol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine	IC50	7535.0 [1], 9230.0 [2]
	N-[(3,4-Dichlorophenyl)methyl]-4-(3-methoxyphenyl)pyrimidin-2-amine	IC50	3680.0 [1], 3858.0 [2]
	N-[(4-Chlorophenyl)methyl]-4-(3-methoxyphenyl)pyrimidin-2-amine	IC50	5820.0 [1], 6806.0 [2]
	N-[(3,4-Dichlorophenyl)methyl]-4-(4-methoxyphenyl)pyrimidin-2-amine	IC50	92.0 [1], 210.0 [2]
	N-[(4-Chlorophenyl)methyl]-4-(4-methoxyphenyl)pyrimidin-2-amine	IC50	290.0 [1], 319.0 [2]
	N-[(3,4-Dichlorophenyl)methyl]-4-(3,4-dimethoxyphenyl)pyrimidin-2-amine	IC50	10000.0 [1], 26020.0 [2]
	4-(1,3-Benzodioxol-5-yl)-N-[3-bromo-5-(trifluoromethyl)phenyl]pyrimidin-2-amine	IC50	86.0 [1], 130.0 [2]
	4-(1,3-Benzodioxol-5-yl)-N-[3-(trifluoromethyl)phenyl]pyrimidin-2-amine	IC50	42.0 [1], 70.0 [2]
	4-(1,3-Benzodioxol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amine	IC50	16.0 [1], 20.0 [2]
	N-[(3,4-Dichlorophenyl)methyl]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-2-amine	IC50	13.0 [1], 120.0 [2]
	5-(1,3-Benzodioxol-5-yl)-N-[(3,4-dichlorophenyl)methyl]pyrimidin-4-amine	IC50	526.0 [1], 580.0 [2]
	N,4-Bis(1,3-benzodioxol-5-yl)pyrimidin-2-amine	IC50	75.0 [1], 120.0 [2]
	4-(1,3-Benzodioxol-5-yl)-N-[(3,5-dibromophenyl)methyl]pyrimidin-2-amine	IC50	9.0 [1], 40.0 [2]
	4-(1,3-Benzodioxol-5-yl)-N-[(3,4-dichlorophenyl)methyl]pyrimidin-2-amine	IC50	14.0 [1], 40.0 [2]
	5-(1,3-Benzodioxol-5-yl)-N-[(4-chlorophenyl)methyl]pyrimidin-4-amine	IC50	5820.0 [1], 9284.0 [2]
	4-(1,3-Benzodioxol-5-yl)-N-(4-chlorophenyl)pyrimidin-2-amine	IC50	370.0 [1], 5450.0 [2]
	4-(1,3-Benzodioxol-5-yl)-N-[(3,4-dibromophenyl)methyl]pyrimidin-2-amine	IC50	18.0 [1], 80.0 [2]
	N-[(3,4-Dichlorophenyl)methyl]-4-(1H-indazol-6-yl)pyrimidin-2-amine	IC50	123.0 [1], 5820.0 [2]
	N-[(3,4-Dichlorophenyl)methyl]-2-(1H-indazol-5-yl)pyrimidin-4-amine	IC50	241.0 [1], 290.0 [2]
	2-(1H-Indazol-6-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine	IC50	290.0 [1], 1294.0 [2]
	4-(1H-Indazol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amine	IC50	30.0 [1], 60.0 [2]
	N-[(3,4-Dichlorophenyl)methyl]-4-(1H-indazol-5-yl)pyrimidin-2-amine	IC50	30.0 [1]
	2-(1H-Indazol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine	IC50	150.0 [1], 574.0 [2]
	9H-Purine-2,6-diamine, N2-(2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-, cis-	IC50	104.0 [1]
	Tomivosertib	IC50	787.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamine	IC50	36.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine	IC50	126.0 [1]
	6-(3-Furanyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	249.0 [1]
	6-(3-Methoxyphenyl)-N-(3-pyridinylmethyl)-4-quinazolinamine	IC50	3550.0 [1]
	6-(3-Methoxyphenyl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine	IC50	1122.0 [1]
	6-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine	IC50	631.0 [1]
	6-(2-Chlorophenyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	7943.0 [1]
	6-(3-Chlorophenyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	10000.0 [1]
	6-(3-Pyridinyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	3981.0 [1]
	6-(3-Methylphenyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	7943.0 [1]
	6-(1-Methyl-5-indolyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	10000.0 [1]
	6-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-(3-pyridinylmethyl)-4-quinazolinamine	IC50	447.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-[(3-fluorophenyl)methyl]-4-quinazolinamine	IC50	126.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(3-pyridinylmethyl)-4-quinazolinamine	IC50	100.0 [1]
	6-(3-Methoxyphenyl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine	IC50	1000.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine	IC50	178.0 [1]
	6-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine	IC50	501.0 [1]
	pi3K|A Inhibitor C52	IC50	700.0 [1]
	Chembl4126445	IC50	125.89 [1]
	[5-[4-[(5-Methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanol	IC50	136.0 [1]
	JH-VIII-157-02	IC50	14.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	8951.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	6,9-Dichloro[1]benzothieno[3,2-d]pyrimidin-4(3H)-one	Ki	89.6 [1]
	6-(Furan-2-yl)-N-(pyridin-3-ylmethyl)quinazolin-4-amine	IC50	794.0 [1]
	N-(3-Fluorobenzyl)-6-(3-methoxyphenyl)quinazolin-4-amine	IC50	708.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-[(2-methyl-4-thiazolyl)methyl]-4-quinazolinamine	IC50	40.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-methyl-N-[(2-methyl-4-thiazolyl)methyl]-4-quinazolinamine	IC50	11.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-methyl-N-(1,3-thiazol-2-ylmethyl)quinazolin-4-amine	IC50	20.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-methyl-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	12.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(3-oxolanylmethyl)-4-quinazolinamine	IC50	141.0 [1]
	(Z)-3-Pyridin-3-yl-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-enenitrile	IC50	47.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	2-(4-Methoxyphenyl)pyrimidine	IC50	29200.0 [1]
	(5Z)-5-(Quinolin-6-ylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one	IC50	17.8 [1]
	11H-Pyrido[3,4-a]carbazole-6-carbonitrile	IC50	180.0 [1]
	2-(3-Methoxyphenyl)pyrimidine	IC50	16400.0 [1]
	(5Z)-5-(1,3-Benzothiazol-6-ylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one	IC50	31.8 [1]
	8-[1-[3-(Dimethylamino)propyl]pyrazol-4-yl]-9-ethyl-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	4.0 [1]
	3-[1-[3-(Dimethylamino)propyl]pyrazol-4-yl]-7-(1H-pyrazol-4-yl)-5H-indeno[1,2-b]indol-10-one	IC50	142.0 [1]
	Clk1-IN-1	IC50	8.0 [1]
	N-(4-Morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	IC50	8.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-2-N-[(3R)-piperidin-3-yl]-9-propan-2-ylpurine-2,6-diamine	IC50	102.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-2-N-[(1R,2S)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine	IC50	25.0 [1]
	N-[3-[[2-[[(1R,2S)-2-Aminocyclohexyl]amino]-9-propan-2-ylpurin-6-yl]amino]-5-chlorophenyl]acetamide	IC50	30.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-2-N-[(1S,2S)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine	IC50	124.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-2-N-[(1R,2R)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine	IC50	648.0 [1]
	N-[3-[[2-[[(1S,2R)-2-Aminocyclohexyl]amino]-9-propan-2-ylpurin-6-yl]amino]-5-chlorophenyl]acetamide	IC50	31.0 [1]
	2-N-[(1S,2R)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine	IC50	70.0 [1]
	2-N-[(1R,2R)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine	IC50	634.0 [1]
	2-N-[(1S,2S)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine	IC50	86.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-2-N-[(1S,2R)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine	IC50	28.0 [1]
	2-N-[(1R,2S)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine	IC50	50.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-9-propan-2-yl-2-N-[(3S)-pyrrolidin-3-yl]purine-2,6-diamine	IC50	77.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-2-N-[(3S)-piperidin-3-yl]-9-propan-2-ylpurine-2,6-diamine	IC50	61.0 [1]
	6-N-(3-Amino-5-chlorophenyl)-9-propan-2-yl-2-N-[(3R)-pyrrolidin-3-yl]purine-2,6-diamine	IC50	299.0 [1]
	8-(4-Hydroxyphenyl)-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-3H-[1]benzothiolo[3,2-d]pyrimidin-4-one	Ki	1000.0 [1]
	1-[4-[4-[[5-(Oxan-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]cyclohexyl]piperazin-1-yl]ethanone	IC50	99.0 [1]
	1-[4-[4-[(5-Propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]piperazin-1-yl]ethanone	IC50	147.0 [1]
	6-(3,5-Dimethylisoxazol-4-yl)-N-((4-methylthiophen-2-yl)methyl)quinazolin-4-amine	IC50	501.0 [1]
	6-(3,5-Dimethylisoxazol-4-yl)-N-(3-fluorobenzyl)quinazolin-4-amine	IC50	178.0 [1]
	3-[4-(Benzylamino)pyrimidin-2-yl]benzonitrile	IC50	14100.0 [1]
	5-(1,3-Benzodioxol-5-yl)-N-[(2-methoxyphenyl)methyl]pyrimidin-4-amine	IC50	2200.0 [1]
	2-(1,3-Benzodioxol-5-yl)-N-benzylpyrimidin-4-amine	IC50	23200.0 [1]
	N-Benzyl-2-pyridin-3-ylpyrimidin-4-amine	IC50	31600.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine	IC50	6540.0 [1]
	N-Benzyl-2-(3-methoxyphenyl)pyrimidin-4-amine	IC50	15800.0 [1]
	4-Imidazol-1-yl-6-pyridin-3-ylpyrimidine	IC50	790.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Dual specificity protein kinase CLK4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/dual-specificity-protein-kinase-clk4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Dual specificity protein kinase CLK4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-protein-kinase-clk4-inhibitors-ic50-ki.
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