Dual specificity tyrosine-phosphorylation-regulated kinase 1B Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Harmine	IC50	28.0 [1], 160.0 [2], 166.0 [3], 180.0 [4]
	Harmine	Ki	166.0 [1]
	Leucettine L41	IC50	44.0 [1], 77.0 [2]
	CID 71529770	IC50	4.74 [1]
	CID 71529752	IC50	0.24 [1], 6.55 [2]
	CID 72716071	IC50	3.0 [1], 42.0 [2]
	3-(2-Methylpyrimidin-4-yl)-1H-pyrrolo[2,3-c]pyridine	IC50	17.0 [1], 3069.0 [2]
	Methyl 9-(2-bromo-4-fluoroanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	0.24 [1], 6.55 [2]
	6-(1H-Indol-3-yl)-N-[4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-4-amine	IC50	85.0 [1], 9965.0 [2]
	N-[4-(4-Methylpiperazin-1-yl)phenyl]-6-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-4-amine	IC50	2.0 [1], 453.0 [2]
	N-[2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl]-6-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-4-amine	IC50	1.0 [1], 282.0 [2]
	N-[2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine	IC50	4.0 [1], 85.0 [2]
	N-[2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(7-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine	IC50	5.0 [1], 83.0 [2]
	4-(1,7-Dimethylpyrrolo[2,3-c]pyridin-3-yl)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine	IC50	9.0 [1], 168.0 [2]
	3-[2-(4-Methylsulfonylphenyl)pyrimidin-4-yl]-1H-pyrrolo[2,3-c]pyridine	IC50	21.0 [1], 898.0 [2]
	1-Methyl-3-[2-(4-methylsulfonylphenyl)pyrimidin-4-yl]pyrrolo[2,3-c]pyridine	IC50	12.0 [1], 810.0 [2]
	7-Methyl-3-[2-(4-methylsulfonylphenyl)pyrimidin-4-yl]-1H-pyrrolo[2,3-c]pyridine	IC50	14.0 [1], 2118.0 [2]
	3-[2-[(E)-2-Phenylethenyl]pyrimidin-4-yl]-1H-pyrrolo[2,3-c]pyridine	IC50	7.0 [1], 192.0 [2]
	AZ Dyrk1B 33	IC50	7.0 [1], 194.0 [2]
	3-(1H-Pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrrolo[2,3-c]pyridine	IC50	3.0 [1], 378.0 [2]
	Methyl 9-(3-fluoro-4-hydroxyanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	11.0 [1]
	Methyl 9-(4-hydroxy-3-nitroanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	5.68 [1]
	Methyl 9-(2,4-dichloroanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboxylate	IC50	7.7 [1]
	9-(2-Bromo-4-fluoroanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboxamide	IC50	31.5 [1]
	Methyl 9-(3,4,5-trimethoxyanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	485.8 [1]
	Methyl 9-(2,4-dimethoxyanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	11.13 [1]
	Methyl 9-anilino-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	3.48 [1]
	Methyl 9-(4-methylanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	2.83 [1]
	Methyl 9-(4-fluoroanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	9.64 [1]
	Methyl 9-(3-cyanoanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	71.98 [1]
	Methyl 9-(4-cyanoanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	7.69 [1]
	Methyl 9-(2,4-dichloroanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	0.28 [1]
	Methyl 9-(4-tert-butylanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	93.84 [1]
	Methyl 9-(3-chloroanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	18.78 [1]
	Methyl 9-[4-(dimethylamino)anilino]-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	64.28 [1]
	Methyl 9-(2,4-difluoroanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	1.07 [1]
	Methyl 9-[4-(trifluoromethyl)anilino]-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	25.21 [1]
	Ethyl 9-(1,3-benzodioxol-5-ylamino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	7.72 [1]
	Benzyl 9-(1,3-benzodioxol-5-ylamino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	37.34 [1]
	Methyl 9-(4-methoxyanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	19.22 [1]
	Methyl 9-(1,3-benzodioxol-5-ylamino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	IC50	4.2 [1]
	Seliciclib	IC50	1200.0 [1]
	Silmitasertib	IC50	6.4 [1]
	5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione	IC50	80.0 [1]
	Leucettamine B	IC50	4100.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	697.0 [1]
	CID 46926514	IC50	1156.0 [1]
	3-(4-Methoxy-benzylidene)-dihydro-furan-2-one	IC50	3800.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamine	IC50	452.0 [1]
	(5Z)-5-(4-Methoxybenzylidene)imidazolidine-2,4-dione	IC50	10000.0 [1]
	3-(1,3-Benzodioxol-5-ylmethylene)dihydro-2(3H)-furanone	IC50	2630.0 [1]
	[5-[4-[(5-Methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanol	IC50	4420.0 [1]
	4-[3-(4-Hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenol	IC50	15.0 [1]
	Mirk-IN-1	IC50	68.0 [1]
	N-Cyclopentyl-4-[4-(4-oxo-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-2-yl)pyridin-2-yl]benzamide	IC50	43.0 [1]
	(4-Fluoro-3-hydroxyphenyl)-(5-hydroxy-1-benzothiophen-2-yl)methanone	IC50	400.0 [1]
	2-N-(4-Aminocyclohexyl)-8-propan-2-yl-4-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazine-2,4-diamine	IC50	110.0 [1]
	5-(1,3-Benzodioxol-5-Ylmethyl)-2-(Phenylamino)-4h-Imidazol-4-One	IC50	37.0 [1]
	(4Z)-2-[4-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]anilino]-4-(1,3-benzodioxol-5-ylmethylidene)-1H-imidazol-5-one	IC50	72.0 [1]
	5-(4-Pyridin-3-ylthiophen-2-yl)pyridin-3-amine	IC50	154.3 [1]
	2-(4-Fluorophenyl)-N-[5-(4-pyridin-3-ylthiophen-2-yl)pyridin-3-yl]acetamide	IC50	383.0 [1]
	N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamide	IC50	1530.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-[(2-methyl-4-thiazolyl)methyl]-4-quinazolinamine	IC50	1510.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-methyl-N-[(2-methyl-4-thiazolyl)methyl]-4-quinazolinamine	IC50	25.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-methyl-N-(1,3-thiazol-2-ylmethyl)quinazolin-4-amine	IC50	180.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-methyl-N-(thiophen-2-ylmethyl)-4-quinazolinamine	IC50	73.0 [1]
	6-(Benzo[d][1,3]dioxol-5-yl)-N-(furan-3-ylmethyl)quinazolin-4-amine	IC50	938.0 [1]
	3-(4-Pyridin-3-ylthiophen-2-yl)pyridine	IC50	300.0 [1]
	6-(1,3-Benzodioxol-5-yl)-N-(3-oxolanylmethyl)-4-quinazolinamine	IC50	734.0 [1]
	CID 46926513	IC50	7.0 [1]
	(Z)-3-Pyridin-3-yl-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-enenitrile	IC50	240.0 [1]
	N-[2-[2-Aminoethyl(methyl)amino]-5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]phenyl]acetamide	IC50	40.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	(5Z)-5-(Quinolin-6-ylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one	IC50	60.0 [1]
	4-[[4-Cyclopentyloxy-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxy-N-methylbenzamide	IC50	157.0 [1]
	(5-Hydroxy-1-benzothiophen-2-yl)-(3-hydroxyphenyl)methanone	IC50	200.0 [1]
	(5-Hydroxy-1-benzofuran-2-yl)-(3-hydroxyphenyl)methanone	IC50	6100.0 [1]
	(5-Hydroxy-1-methylindol-2-yl)-(3-hydroxyphenyl)methanone	IC50	2700.0 [1]
	(5-Hydroxy-1-benzothiophen-2-yl)-(4-hydroxyphenyl)methanone	IC50	800.0 [1]
	(5-Hydroxy-1-benzofuran-2-yl)-(4-hydroxyphenyl)methanone	IC50	1300.0 [1]
	(5-Hydroxy-1-benzothiophen-2-yl)-(3-hydroxy-4-methylphenyl)methanone	IC50	200.0 [1]
	(5-Hydroxy-1-benzothiophen-2-yl)-(4-hydroxy-3-methylphenyl)methanone	IC50	7000.0 [1]
	(2-Fluoro-5-hydroxyphenyl)-(5-hydroxy-1-benzothiophen-2-yl)methanone	IC50	400.0 [1]
	3-(5-Hydroxy-1-benzothiophene-2-carbonyl)benzonitrile	IC50	2300.0 [1]
	(5-Hydroxy-1-benzothiophen-2-yl)-phenylmethanone	IC50	1000.0 [1]
	(6-Hydroxynaphthalen-2-yl)-(3-hydroxyphenyl)methanone	IC50	2300.0 [1]
	1-[4-[3-Methoxy-4-[[6-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-4-yl]amino]phenyl]piperazin-1-yl]ethanone	IC50	16.0 [1]
	1-[4-[3-Methoxy-4-[[6-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-4-yl]amino]phenyl]piperazin-1-yl]ethanone	IC50	34.0 [1]
	1-[4-[3-Methoxy-4-[[4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]ethanone	IC50	9.0 [1]
	N-[2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(5-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine	IC50	4.0 [1]
	5-Chloro-N-[4-(4-methylpiperazin-1-yl)phenyl]-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine	IC50	25.0 [1]
	N-Cyclopentyl-4-[4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-yl]benzamide	IC50	98.0 [1]
	10-Chloro-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	210.0 [1]
	10-Bromo-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	80.0 [1]
	10-Fluoro-3-methoxy-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	3000.0 [1]
	10-Chloro-3-methoxy-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	1000.0 [1]
	10-Bromo-3-methoxy-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	230.0 [1]
	10-Iodo-3-methoxy-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	10000.0 [1]
	10-Chloro-3-ethoxy-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	10000.0 [1]
	10-Fluoro-2-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Dual specificity tyrosine-phosphorylation-regulated kinase 1B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/dual-specificity-tyrosine-phosphorylation-regulated-kinase-1b-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Dual specificity tyrosine-phosphorylation-regulated kinase 1B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-tyrosine-phosphorylation-regulated-kinase-1b-inhibitors-ic50-ki.
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