Dual-specificity tyrosine-phosphorylation regulated kinase 3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Harmine	IC50	210.0 [1], 410.0 [2], 800.0 [3]
	Leucettine L41	IC50	320.0 [1], 700.0 [2]
	Seliciclib	IC50	10000.0 [1]
	N3-(4-Fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine	IC50	3200.0 [1]
	Leucettamine B	IC50	1400.0 [1]
	CID 72163809	IC50	70.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	5804.0 [1]
	2-N-(4-Aminocyclohexyl)-8-propan-2-yl-4-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazine-2,4-diamine	IC50	380.0 [1]
	(4Z)-2-[4-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]anilino]-4-(1,3-benzodioxol-5-ylmethylidene)-1H-imidazol-5-one	IC50	180.0 [1]
	N-[2-[2-Aminoethyl(methyl)amino]-5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]phenyl]acetamide	IC50	40.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	4-[[4-Cyclopentyloxy-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxy-N-methylbenzamide	IC50	99.0 [1]
	10-Chloro-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	100000.0 [1]
	10-Bromo-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	100000.0 [1]
	10-Fluoro-3-methoxy-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	2300.0 [1]
	10-Chloro-3-methoxy-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	10000.0 [1]
	10-Bromo-3-methoxy-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	1400.0 [1]
	10-Iodo-3-methoxy-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	10000.0 [1]
	10-Chloro-3-ethoxy-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	10000.0 [1]
	10-Fluoro-2-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	10000.0 [1]
	10-Chloro-2-(3-methoxyphenyl)-11H-indolo[3,2-c]quinoline-6-carboxylic acid	IC50	30.0 [1]
	10-Bromo-11H-indolo[3,2-c][1,5]naphthyridine-6-carboxylic acid	IC50	10000.0 [1]
	Clk1-IN-1	IC50	10000.0 [1]
	4-[6-[6-(Propan-2-ylamino)indazol-1-yl]pyrazin-2-yl]benzoic acid	IC50	54.0 [1]
	(4Z)-2-Anilino-4-benzylidene-1H-imidazol-5-one	IC50	10000.0 [1]
	(4Z)-2-[4-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]anilino]-4-(1,3-benzodioxol-5-ylmethylidene)-1H-imidazol-5-one	IC50	200.0 [1]
	(4Z)-2-[4-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]anilino]-4-benzylidene-1H-imidazol-5-one	IC50	10000.0 [1]
	(2S)-2-[[3-[3-[(E)-Hydroxyiminomethyl]phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	920.0 [1]
	6-Methylsulfanyl-3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine	IC50	3000.0 [1]
	(2S)-2-[[3-(2-Amino-5-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	17000.0 [1]
	6-Methoxy-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-b]pyridazine	IC50	7900.0 [1]
	(2S)-2-[[3-(1H-Indol-2-yl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	120.0 [1]
	6-Methoxy-3-(2-methylsulfinylpyrimidin-4-yl)imidazo[1,2-b]pyridazine	IC50	10000.0 [1]
	6-Methoxy-3-[4-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine	IC50	4900.0 [1]
	3-(3-Chlorophenyl)-6-(4-piperidin-1-ylpiperidin-1-yl)imidazo[1,2-b]pyridazine	IC50	1100.0 [1]
	(2S)-2-[[3-(2-Methylsulfonylpyrimidin-4-yl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	10000.0 [1]
	N-[3-[6-[[(2S)-1-Hydroxybutan-2-yl]amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide	IC50	110.0 [1]
	(2S)-2-[[3-(2-Methylsulfinylpyrimidin-4-yl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	10000.0 [1]
	(2S)-2-[[3-(3-Methylsulfonylphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	2100.0 [1]
	Ethyl 3-[6-[[(2S)-1-hydroxybutan-2-yl]amino]imidazo[1,2-b]pyridazin-3-yl]benzoate	IC50	110.0 [1]
	N-[(2S)-1-Hydroxybutan-2-yl]-3-[6-[[(2S)-1-hydroxybutan-2-yl]amino]imidazo[1,2-b]pyridazin-3-yl]benzamide	IC50	8100.0 [1]
	2-[4-[3-(3-Chlorophenyl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl]ethanol	IC50	430.0 [1]
	(2S)-2-[[3-[3-[[(2S)-1-Hydroxybutan-2-yl]iminomethyl]phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	1400.0 [1]
	(NE)-N-[[3-(6-methoxyimidazo[1,2-b]pyridazin-3-yl)phenyl]methylidene]hydroxylamine	IC50	140.0 [1]
	(2S)-3-Methyl-2-[(3-pyridin-3-ylimidazo[1,2-b]pyridazin-6-yl)amino]butan-1-ol	IC50	320.0 [1]
	N-[3-[[3-(3-Chlorophenyl)imidazo[1,2-b]pyridazin-6-yl]amino]phenyl]acetamide	IC50	5300.0 [1]
	3-(1H-Indol-5-yl)-6-methylsulfanylimidazo[1,2-b]pyridazine	IC50	1200.0 [1]
	(2S)-2-[[3-(3-Methylsulfanylphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	1300.0 [1]
	4-Chloro-2-(6-chloroimidazo[1,2-b]pyridazin-3-yl)aniline	IC50	41000.0 [1]
	(2S)-2-[[3-(3-Aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	5100.0 [1]
	(2S)-2-[[3-(1H-Indol-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	1800.0 [1]
	(2S)-2-[[3-[3-(Trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	100000.0 [1]
	6-Methoxy-3-[(E)-2-[3-(trifluoromethyl)phenyl]ethenyl]imidazo[1,2-b]pyridazine	IC50	10000.0 [1]
	(2S)-2-[[3-(2-Aminopyrimidin-4-yl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	320.0 [1]
	(2S)-2-[[3-[(E)-2-[3-(Trifluoromethyl)phenyl]ethenyl]imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	10000.0 [1]
	(2S)-2-[[3-(5-Bromo-1H-indol-2-yl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	610.0 [1]
	3-(6-Fluoroimidazo[1,2-b]pyridazin-3-yl)benzaldehyde	IC50	10000.0 [1]
	(2R)-2-[[3-[3-[[(2R)-1-Hydroxybutan-2-yl]iminomethyl]phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	3100.0 [1]
	Ethyl N-(3-pyridin-3-ylimidazo[1,2-b]pyridazin-6-yl)carbamate	IC50	10000.0 [1]
	(NE)-N-[[3-(6-chloroimidazo[1,2-b]pyridazin-3-yl)phenyl]methylidene]hydroxylamine	IC50	510.0 [1]
	3-(6-Chloroimidazo[1,2-b]pyridazin-3-yl)-N-[(2R)-1-hydroxybutan-2-yl]benzamide	IC50	10000.0 [1]
	N-[(2R)-1-Hydroxybutan-2-yl]-3-[6-[[(2R)-1-hydroxybutan-2-yl]amino]imidazo[1,2-b]pyridazin-3-yl]benzamide	IC50	10000.0 [1]
	3-(1H-Indol-5-yl)-6-methoxyimidazo[1,2-b]pyridazine	IC50	910.0 [1]
	N-[(2S)-1-Hydroxybutan-2-yl]-3-[6-[[(2R)-1-hydroxybutan-2-yl]amino]imidazo[1,2-b]pyridazin-3-yl]benzamide	IC50	3900.0 [1]
	4-(6-Methoxyimidazo[1,2-b]pyridazin-3-yl)pyrimidin-2-amine	IC50	2300.0 [1]
	Ethyl N-[3-(3-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl]carbamate	IC50	7100.0 [1]
	3-[6-[[(2S)-1-Hydroxybutan-2-yl]amino]imidazo[1,2-b]pyridazin-3-yl]benzoic acid	IC50	6600.0 [1]
	N-[3-[6-[Acetyl-[(2S)-1-hydroxybutan-2-yl]amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide	IC50	930.0 [1]
	(2S)-2-[[3-(2-Methylsulfanylpyrimidin-4-yl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	10000.0 [1]
	3-(6-Chloroimidazo[1,2-b]pyridazin-3-yl)-N-[(2S)-1-hydroxybutan-2-yl]benzamide	IC50	1900.0 [1]
	3-[6-[[(2S)-1-Hydroxybutan-2-yl]amino]imidazo[1,2-b]pyridazin-3-yl]benzaldehyde	IC50	460.0 [1]
	N-[3-[6-(3-Acetamidoanilino)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide	IC50	520.0 [1]
	(2S)-2-[[3-[4-(Trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	2100.0 [1]
	(2S)-2-[[3-(3-Chlorophenyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol	IC50	81.0 [1]
	(2S)-2-[(3-Thiophen-3-ylimidazo[1,2-b]pyridazin-6-yl)amino]butan-1-ol	IC50	1700.0 [1]
	N-[(2R)-1-Hydroxybutan-2-yl]-3-[6-[[(2S)-1-hydroxybutan-2-yl]amino]imidazo[1,2-b]pyridazin-3-yl]benzamide	IC50	10000.0 [1]
	(2S)-2-[(3-Pyridin-3-ylimidazo[1,2-b]pyridazin-6-yl)amino]butan-1-ol	IC50	950.0 [1]
	6-Fluoro-3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine	IC50	10000.0 [1]
	6-Chloro-3-[(E)-2-[3-(trifluoromethyl)phenyl]ethenyl]imidazo[1,2-b]pyridazine	IC50	10000.0 [1]
	6-Methoxy-3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine	IC50	5300.0 [1]
	6-Chloro-3-(pyridin-3-yl)imidazo[1,2-b]pyridazine	IC50	16000.0 [1]
	6-Chloro-3-(3-chlorophenyl)imidazo[1,2-b]pyridazine	IC50	3000.0 [1]
	3-(6-Chloroimidazo[1,2-b]pyridazin-3-yl)aniline	IC50	15000.0 [1]
	6-Chloro-3-(3-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine	IC50	10000.0 [1]
	(2S)-N-[5-(6-Aminopyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]-4,4,4-trifluoro-2-methylbutanamide	IC50	10000.0 [1]
	[3-(2-Aminopyrimidin-4-yl)-5-bromoindol-1-yl]-morpholin-4-ylmethanone	IC50	2200.0 [1]
	6,10-Dihydroxy-11-methoxy-3,3-dimethyl-12H-pyrano[2,3-c]acridin-7-one	IC50	1200.0 [1]
	6-Chloro-3-[4-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine	IC50	10000.0 [1]
	3-(6-Chloroimidazo[1,2-b]pyridazin-3-yl)benzaldehyde	IC50	1700.0 [1]
	CID 90388565	IC50	4700.0 [1]
	10-Iodo-11h-Indolo[3,2-C]quinoline-6-Carboxylic Acid	IC50	10000.0 [1]
	10-Chloro-2-Iodo-11h-Indolo[3,2-C]quinoline-6-Carboxylic Acid	IC50	10000.0 [1]
	10-Bromo-2-Iodo-11h-Indolo[3,2-C]quinoline-6-Carboxylic Acid	IC50	10000.0 [1]
	2-(2-(2-Aminoethoxy)ethoxy)ethanol	IC50	10000.0 [1]
	(5Z)-2-(2-Chlorophenyl)imino-5-(quinolin-6-ylmethylidene)-1,3-thiazolidin-4-one	IC50	10.0 [1]
	(5Z)-2-[2-(Dimethylamino)ethylimino]-5-(quinolin-6-ylmethylidene)-1,3-thiazolidin-4-one	IC50	1000.0 [1]
	(5Z)-5-(2,3-Dihydro-1-benzofuran-5-ylmethylidene)-2-[2-(trifluoromethyl)phenyl]imino-1,3-thiazolidin-4-one	IC50	100.0 [1]
	(5Z)-2-(5-Amino-2-chlorophenyl)imino-5-(quinolin-6-ylmethylidene)-1,3-thiazolidin-4-one	IC50	1.0 [1]
	(5Z)-2-[(2-Bromophenyl)amino]-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one	IC50	1.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 99 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Dual-specificity tyrosine-phosphorylation regulated kinase 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/dual-specificity-tyrosine-phosphorylation-regulated-kinase-3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Dual-specificity tyrosine-phosphorylation regulated kinase 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-tyrosine-phosphorylation-regulated-kinase-3-inhibitors-ic50-ki.
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