Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	8-[4-Methyl-3-[(5Z)-5-[(Z)-[5-[[2-methyl-5-[(4,6,8-trisulfo-2H-naphthalen-1-ylidene)carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]iminocyclohexa-1,3-diene-1-carbonyl]iminocyclohexa-1,4-diene-1-carbonyl]imino-7H-naphthalene-1,3,5-trisulfonic acid	IC50	8670.0 [1]
	8-[4-Methyl-3-[(5Z)-5-[(Z)-[5-[[2-methyl-5-[(4,6,8-trisulfo-2H-naphthalen-1-ylidene)carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]iminocyclohexa-1,3-diene-1-carbonyl]iminocyclohexa-1,4-diene-1-carbonyl]imino-7H-naphthalene-1,3,5-trisulfonic acid	Ki	260.0 [1], 780.0 [2], 1030.0 [3], 1070.0 [4]
	Phosphomethylphosphonic acid adenosyl ester	Ki	1280.0 [1], 16500.0 [2], 24300.0 [3], 25800.0 [4]
	Adenosine 5'-diphosphate 2',3'-dialdehyde	Ki	3420.0 [1], 5030.0 [2], 5090.0 [3], 5140.0 [4], 5620.0 [5]
	6,7-Dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	59.0 [1], 59.3 [2], 64.2 [3], 215.0 [4], 420.0 [5]
	Diphosphomethylphosphonic acid adenosyl ester	Ki	3320.0 [1], 8190.0 [2], 13000.0 [3], 26900.0 [4]
	2-Mesatp	Ki	4470.0 [1], 21300.0 [2], 25300.0 [3], 39900.0 [4]
	2-Methylthio-adenosine-5'-diphosphate	Ki	2180.0 [1], 23700.0 [2], 32800.0 [3], 35400.0 [4]
	2',3'-Dialdehyde ATP	Ki	4090.0 [1], 5080.0 [2], 6820.0 [3], 6960.0 [4]
	N-(3,4-Dimethoxyphenyl)-2-[(5-methoxy-1H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]acetamide	Ki	29.6 [1], 5340.0 [2], 14900.0 [3]
	[[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-hydroxyphosphoryl]methylphosphonic acid	Ki	-71500.0 [1], 1300.0 [2], 4500.0 [3]
	[[[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-hydroxyphosphoryl]-dichloromethyl]phosphonic acid	Ki	-12500.0 [1], 685.0 [2], 15200.0 [3], 192000.0 [4]
	N-(3,4-Dimethoxy-phenyl)-2-(3H-imidazo[4,5-b]pyridin-2-ylsulfanyl)-acetamide	Ki	217.0 [1], 22300.0 [2]
	2-[(6-Amino-7H-purin-8-yl)sulfanyl]-N-(3,4-dimethoxyphenyl)acetamide	Ki	5.0 [1], 18000.0 [2]
	N-(3,4-Dimethoxyphenyl)-2-(3H-imidazo[4,5-c]pyridin-2-ylsulfanyl)acetamide	Ki	44.2 [1], 29200.0 [2]
	N-(3,4-Dimethoxyphenyl)-2-(7H-purin-8-ylsulfanyl)acetamide	Ki	281.0 [1], 15700.0 [2]
	N-(3,4-Dimethoxyphenyl)-2-(1H-imidazo[4,5-b]pyrazin-2-ylsulfanyl)acetamide	Ki	131.0 [1], 30200.0 [2]
	N-(3,4-Dimethoxyphenyl)-2-[(7-methyl-1H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]acetamide	Ki	127.0 [1], 7590.0 [2]
	2-[(2-Amino-6-methoxy-7H-purin-8-yl)sulfanyl]-N-(3,4-dimethoxyphenyl)acetamide	Ki	8040.0 [1], 42200.0 [2]
	2-[(2-Amino-6-ethoxy-7H-purin-8-yl)sulfanyl]-N-(3,4-dimethoxyphenyl)acetamide	Ki	1010.0 [1], 33600.0 [2]
	2-[(2-Amino-6-propan-2-yloxy-7H-purin-8-yl)sulfanyl]-N-(3,4-dimethoxyphenyl)acetamide	Ki	11000.0 [1], 89700.0 [2]
	2-[(2,6-Diamino-7H-purin-8-yl)sulfanyl]-N-(3,4-dimethoxyphenyl)acetamide	Ki	3480.0 [1], 78000.0 [2]
	2-[(2-Amino-6-methylsulfanyl-7H-purin-8-yl)sulfanyl]-N-(3,4-dimethoxyphenyl)acetamide	Ki	3650.0 [1], 67900.0 [2]
	2-[(6-Amino-2-methylsulfanyl-7H-purin-8-yl)sulfanyl]-N-(3,4-dimethoxyphenyl)acetamide	Ki	152.0 [1], 26700.0 [2]
	N-(3,4-Dimethoxyphenyl)-2-[(2,6-dioxo-3,7-dihydropurin-8-yl)sulfanyl]acetamide	Ki	35.8 [1], 22500.0 [2]
	N-(3,4-Dimethoxyphenyl)-2-[(6-oxo-1,7-dihydropurin-8-yl)sulfanyl]acetamide	Ki	20.0 [1], 14300.0 [2]
	2-[(6-Bromo-1H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]-N-(3,4-dimethoxyphenyl)acetamide	Ki	192.0 [1], 10800.0 [2]
	2-[(6-Chloro-1H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]-N-(3,4-dimethoxyphenyl)acetamide	Ki	137.0 [1], 9780.0 [2]
	BzATP	Ki	2960.0 [1], 14600.0 [2]
	[Dibromo-[[[(2R,3S,4R,5R)-5-[6-(diethylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]methyl]phosphonic acid	Ki	12000.0 [1]
	5-[3-(5-Mercapto-1,3,4-oxadiazol-2-yl)propyl]-1,3,4-oxadiazole-2-thiol	IC50	467000.0 [1]
	5-[3-(5-Mercapto-1,3,4-oxadiazol-2-yl)propyl]-1,3,4-oxadiazole-2-thiol	Ki	150000.0 [1]
	5-[4-Hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione	IC50	900000.0 [1]
	5-[4-Hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione	Ki	850000.0 [1]
	5-[4-Benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione	IC50	628000.0 [1]
	5-[4-Benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione	Ki	850000.0 [1]
	5-[3-Benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione	IC50	494000.0 [1]
	5-[3-Benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione	Ki	360000.0 [1]
	5-[4-t-Butyldimethylsilyloxy phenyl]-1,3,4-oxadiazole-2(3H)-thione	IC50	368000.0 [1]
	5-[4-t-Butyldimethylsilyloxy phenyl]-1,3,4-oxadiazole-2(3H)-thione	Ki	360000.0 [1]
	Tetrasodium;[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]methyl-oxidophosphoryl]oxy-oxidophosphoryl]methyl]phosphinate	Ki	13000.0 [1], 147000.0 [2]
	[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[dihydroxyphosphinothioyloxy(hydroxy)phosphoryl]methyl]phosphinic acid	Ki	-9000.0 [1], 20.0 [2]
	CID 49856887	IC50	63000.0 [1]
	CID 49856887	Ki	31000.0 [1]
	CID 49856889	Ki	9000.0 [1], 145000.0 [2]
	[(2R,3S,5R)-5-(6-Aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-[[[[[(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methyl-hydroxyphosphoryl]oxy-hydroxyphosphoryl]methyl]phosphinic acid	Ki	51000.0 [1], 80000.0 [2]
	Reactive Blue 2	Ki	520.0 [1]
	(2Z)-2-(Pyridin-2-ylmethylidene)-[1,3]thiazolo[3,2-a]benzimidazol-1-one	Ki	10000.0 [1]
	5-(Pyridin-4-yl)-1,3,4-thiadiazole-2-thiol	IC50	998000.0 [1]
	1H-Pyrazole, 3,5-dimethyl-1-(4-pyridinylcarbonyl)-	IC50	100000.0 [1]
	1-(4-Chlorobenzoyl)-3,5-dimethyl-1H-pyrazole	IC50	100000.0 [1]
	(2Z)-2-[4-(Morpholin-4-yl)benzylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one	Ki	8910.0 [1]
	5-(4-(Tert-butyldimethylsilyloxy)phenyl)-1,3,4-thiadiazole-2(3H)-thione	IC50	1000000.0 [1]
	2-(3-Phenyl-allylidene)-benzo[4,5]imidazo[2,1-b]thiazol-3-one	Ki	10000.0 [1]
	Bis-(5-mercapto-1,3,4-oxadiazol-2-yl)-methane	IC50	1000000.0 [1]
	(2Z)-2-(2-Furylmethylene)thiazolo[3,2-a]benzimidazol-1-one	Ki	981.0 [1]
	(2Z)-2-(Thiophen-2-ylmethylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one	Ki	10000.0 [1]
	[[[[(2R,3S,4R,5R)-5-(6-Amino-2-methylsulfanylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]-difluoromethyl]phosphonic acid	Ki	37000.0 [1]
	[[[(2R,3S,4R,5R)-5-(6-Amino-2-methylsulfanylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]-difluoromethyl]phosphonic acid	Ki	26000.0 [1]
	6,7-Dimethoxy-2-[(E)-2-pyridin-3-ylethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	58.0 [1]
	2-(Phenylmethylene)thiazolo(3,2-a)benzimidazol-3(2H)-one	Ki	10000.0 [1]
	(4-Chloro-3,5-dimethyl-1H-pyrazol-1-yl)(4-chlorophenyl)methanone	IC50	5340.0 [1]
	(2Z)-2-[(5-Methyl-2-furyl)methylene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one	Ki	2110.0 [1]
	4-Chloro-6-ethoxy-7-methoxyquinazoline	Ki	1311.0 [1]
	4-Chloro-3,5-dimethylpyrazolyl 4-pyridyl ketone	IC50	5420.0 [1]
	(2Z)-2-Ethylidene-[1,3]thiazolo[3,2-a]benzimidazol-1-one	Ki	10000.0 [1]
	(2Z)-2-[(3-Benzylphenyl)methylidene]-[1,3]thiazolo[3,2-a]benzimidazol-1-one	Ki	10000.0 [1]
	Methanone, (4-aminophenyl)(3,5-dimethyl-1H-pyrazol-1-yl)-	IC50	100000.0 [1]
	(E)-1-(4-Chloro-3,5-dimethylpyrazol-1-yl)-3-phenylprop-2-en-1-one	IC50	100000.0 [1]
	(2Z)-2-[(3-Phenylmethoxyphenyl)methylidene]-[1,3]thiazolo[3,2-a]benzimidazol-1-one	Ki	10000.0 [1]
	(2Z)-2-[(5-Phenylsulfanylfuran-2-yl)methylidene]-[1,3]thiazolo[3,2-a]benzimidazol-1-one	Ki	10000.0 [1]
	6-Methoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	242.0 [1]
	4-(2-Aminoethyl)-1-(6,7-dimethoxyquinazolin-4-yl)piperidine	Ki	699.0 [1]
	2-[2-(4-Fluorophenyl)ethyl]-6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	366.0 [1]
	2-[(E)-2-(2-Fluorophenyl)ethenyl]-6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	211.0 [1]
	[(E)-3-(4-Chloro-7-methoxyquinazolin-6-yl)oxyprop-1-enyl]-pentafluoro-lambda6-sulfane	Ki	7965.0 [1]
	3,4,8-Tris(4-methylphenyl)-2-(trifluoromethyl)quinoline	IC50	730.0 [1]
	6,7-Dimethoxy-2-[(E)-2-(2-methoxyphenyl)ethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	302.0 [1]
	3-Bromo-4-chloro-8-(4-methoxyphenyl)-2-(trifluoromethyl)quinoline	IC50	390.0 [1]
	3,4,8-Tris(4-methoxyphenyl)-2-(trifluoromethyl)quinoline	IC50	9870.0 [1]
	3-Bromo-4-chloro-2-(trifluoromethyl)-8-[4-(trifluoromethyl)phenyl]quinoline	IC50	310.0 [1]
	6,7-Dimethoxy-2-[(E)-2-phenylethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	1840.0 [1]
	3,4,8-Triphenyl-2-(trifluoromethyl)quinoline	IC50	180.0 [1]
	2-[(E)-2-(3-Fluorophenyl)ethenyl]-6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	3583.0 [1]
	Methyl 4-[(E)-2-[6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazolin-2-yl]ethenyl]benzoate	Ki	1340.0 [1]
	6,7-Dimethoxy-2-[(E)-2-(4-methoxyphenyl)ethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	231.0 [1]
	3-Bromo-4-chloro-8-thiophen-3-yl-2-(trifluoromethyl)quinoline	IC50	5760.0 [1]
	2-[(E)-2-(4-Fluorophenyl)ethenyl]-6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	465.0 [1]
	4-Chloro-3,8-diphenyl-2-(trifluoromethyl)quinoline	IC50	2810.0 [1]
	6,7-Dimethoxy-2-[(3-oxo-1H-2-benzofuran-1-yl)methyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	90.0 [1]
	3-[3-Bromo-4-chloro-2-(trifluoromethyl)quinolin-8-yl]benzonitrile	IC50	350.0 [1]
	3,8-Dibromo-4-chloro-2-(trifluoromethyl)quinoline	IC50	7650.0 [1]
	3-Bromo-4-chloro-8-(2,5-dimethoxyphenyl)-2-(trifluoromethyl)quinoline	IC50	250.0 [1]
	6,7-Dimethoxy-2-[(E)-2-(3-methoxyphenyl)ethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	101.0 [1]
	Methyl 3-[(E)-2-[6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazolin-2-yl]ethenyl]benzoate	Ki	297.0 [1]
	3,4,8-Tris(4-fluorophenyl)-2-(trifluoromethyl)quinoline	IC50	510.0 [1]
	6,7-Dimethoxy-2-[(E)-2-pyridin-4-ylethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	218.0 [1]
	3,4,8-Tris(3-methylphenyl)-2-(trifluoromethyl)quinoline	IC50	20700.0 [1]
	6,7-Dimethoxy-2-[(E)-2-pyridin-2-ylethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline	Ki	71.0 [1]
	[[[(2R,3S,4R,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-sulfanylphosphinothioyl]oxy-hydroxyphosphoryl]methylphosphonic acid	IC50	4300.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/ectonucleotide-pyrophosphatase-phosphodiesterase-family-member-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ectonucleotide-pyrophosphatase-phosphodiesterase-family-member-1-inhibitors-ic50-ki.
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